MX2010004601A - Diespiro-1,2,4-trioxolano antimalarial. - Google Patents
Diespiro-1,2,4-trioxolano antimalarial.Info
- Publication number
- MX2010004601A MX2010004601A MX2010004601A MX2010004601A MX2010004601A MX 2010004601 A MX2010004601 A MX 2010004601A MX 2010004601 A MX2010004601 A MX 2010004601A MX 2010004601 A MX2010004601 A MX 2010004601A MX 2010004601 A MX2010004601 A MX 2010004601A
- Authority
- MX
- Mexico
- Prior art keywords
- trioxolane
- compounds
- dispiro
- group
- cancer
- Prior art date
Links
- RZYIPLSVRHWROD-UHFFFAOYSA-N 1,2,4-trioxolane Chemical compound C1OCOO1 RZYIPLSVRHWROD-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003430 antimalarial agent Substances 0.000 title 1
- 229940033495 antimalarials Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 201000004792 malaria Diseases 0.000 abstract 2
- 201000004409 schistosomiasis Diseases 0.000 abstract 2
- MAAKQSASDHJHIR-UHFFFAOYSA-N trioxolane Chemical group C1COOO1 MAAKQSASDHJHIR-UHFFFAOYSA-N 0.000 abstract 2
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 abstract 1
- 229960004191 artemisinin Drugs 0.000 abstract 1
- 229930101531 artemisinin Natural products 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 125000003003 spiro group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
- C07D323/02—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/930,606 US8067620B2 (en) | 2005-05-04 | 2007-10-31 | Dispiro 1,2,4-trioxolane antimalarials |
| PCT/US2008/081579 WO2009058859A2 (en) | 2007-10-31 | 2008-10-29 | Dispiro 1,2,4-trioxolane antimalarials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010004601A true MX2010004601A (es) | 2010-05-27 |
Family
ID=40228026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010004601A MX2010004601A (es) | 2007-10-31 | 2008-10-29 | Diespiro-1,2,4-trioxolano antimalarial. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8067620B2 (enExample) |
| EP (1) | EP2203457B1 (enExample) |
| JP (1) | JP5559057B2 (enExample) |
| KR (1) | KR101588468B1 (enExample) |
| CN (1) | CN101842377B (enExample) |
| AU (1) | AU2008318819C1 (enExample) |
| BR (1) | BRPI0818121B8 (enExample) |
| CA (1) | CA2702256C (enExample) |
| CY (1) | CY1115148T1 (enExample) |
| DK (1) | DK2203457T3 (enExample) |
| ES (1) | ES2466319T3 (enExample) |
| HR (1) | HRP20140435T1 (enExample) |
| MX (1) | MX2010004601A (enExample) |
| PL (1) | PL2203457T3 (enExample) |
| PT (1) | PT2203457E (enExample) |
| RU (1) | RU2493159C2 (enExample) |
| SI (1) | SI2203457T1 (enExample) |
| UA (1) | UA99742C2 (enExample) |
| WO (1) | WO2009058859A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8067620B2 (en) * | 2005-05-04 | 2011-11-29 | Medicines For Malaria Venture Mmv | Dispiro 1,2,4-trioxolane antimalarials |
| JP6001560B2 (ja) | 2011-01-31 | 2016-10-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｈｉｖ成熟阻害活性を有するｃ−１７およびｃ−３修飾トリテルペノイド |
| WO2013186153A2 (en) * | 2012-06-13 | 2013-12-19 | Medizinische Universität Wien | Amidophenoxypropanolamines |
| WO2015123595A1 (en) | 2014-02-14 | 2015-08-20 | The Regents Of The University Of California | Cyclic peroxides as prodrugs for selective delivery of agents |
| CA3040335A1 (en) | 2016-10-13 | 2018-04-19 | Mmv Medicines For Malaria Venture | New anti-malarial agents |
| EP3309156A1 (en) | 2016-10-13 | 2018-04-18 | MMV Medicines for Malaria Venture | New anti-malarial agents |
| US11246854B2 (en) * | 2017-05-16 | 2022-02-15 | The Johns Hopkins University | Ozonides for treating or preventing virus infections |
| WO2019005977A1 (en) | 2017-06-27 | 2019-01-03 | The Regents Of The University Of California | Trioxolane agents |
| CN110878069A (zh) * | 2019-12-09 | 2020-03-13 | 南京杰运医药科技有限公司 | 一种4-吗琳基-2-乙基哌嗪的制备方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3621062A (en) | 1966-10-25 | 1971-11-16 | Sterling Drug Inc | 2-(8-cyclohexyloctanoyl or 7-cyclohexylheptanoyl)-1-naphthol |
| US3673222A (en) | 1969-11-26 | 1972-06-27 | Sydney Archer | 2-(8-cyclohexyloctyl or 7-cyclohexylheptyl)-1,4-naphthoquinone and process for preparation and use thereof |
| US3682991A (en) | 1970-10-19 | 1972-08-08 | Sterling Drug Inc | 3,3,5-trimethylcyclohexyl-alkyl-carboxylic acids |
| US4978678A (en) * | 1986-11-20 | 1990-12-18 | Hoechst-Roussel Pharmaceuticals Inc. | 12-halogenated forskolin derivatives |
| US4916204A (en) | 1987-07-31 | 1990-04-10 | Massachusetts Institute Of Technology | Pure polyanhydride from dicarboxylic acid and coupling agent |
| US4816478A (en) | 1987-08-24 | 1989-03-28 | Thornfeldt Carl R | Treatment of acquired immunodeficiency syndrome |
| US5053342A (en) | 1987-12-24 | 1991-10-01 | Litmus Concepts, Inc. | Fecal occult blood test reagents |
| US5559145A (en) | 1988-06-01 | 1996-09-24 | Oxaco S.A. | 1,2,4-trioxane derivatives |
| US5270344A (en) | 1988-06-24 | 1993-12-14 | Stephen Herman | Method of treating a systemic disorder using trioxolane and diperoxide compounds |
| JP2867529B2 (ja) | 1990-01-22 | 1999-03-08 | 三菱電機株式会社 | 投写型表示装置 |
| US5216175A (en) | 1990-03-23 | 1993-06-01 | Sri International | Antimalarial analogs of artemisinin |
| US5219880A (en) | 1991-03-29 | 1993-06-15 | Dermatologic Research Corporation | Treatment of viral tumors and hemorrhoids with artemisinin and derivatives |
| US5510356A (en) | 1991-10-03 | 1996-04-23 | University Of Nebraska Board Of Regents | Bisquinolines and processes for their production and use to treat malaria |
| US5171676A (en) | 1991-10-31 | 1992-12-15 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of introducing hydroxyl groups into artemisinin and its derivatives |
| US5430148A (en) | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
| KR950702436A (ko) | 1992-07-28 | 1995-07-29 | 자코부스 코르넬리스 라세르 | 가교 결합 양이온성 중합체 및 알콜실화 에테르를 함유하는 국소용 약학 조성물(pharmaceutical composition for topical use containing a crosslinked cationic polymer and an alkoxylated ether) |
| US5721209A (en) | 1995-02-03 | 1998-02-24 | The Regents Of The University Of California | Iron chelator and inhibitor of iron-mediated oxidant injury |
| US5780675A (en) | 1995-04-28 | 1998-07-14 | The University Of New Mexico | Deoxygossylic compounds |
| US5578637A (en) | 1995-05-03 | 1996-11-26 | University Of Washington | Methods of inhibition or killing cancer cells using an endoperoxide |
| US5817692A (en) | 1995-11-22 | 1998-10-06 | The Johns Hopkins University | Endoperoxides useful as antiparasitic agents |
| US5672624A (en) | 1995-11-22 | 1997-09-30 | The Johns Hopkins University | Endoperoxides useful as antiparasitic agents |
| US5932591A (en) | 1996-12-02 | 1999-08-03 | Johns Hopkins University | C3 substituted trioxanes useful as antiparasitic drugs |
| US6486199B1 (en) * | 2001-06-21 | 2002-11-26 | Medicines For Malaria Venture Mmv International Centre Cointrin | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US7371778B2 (en) * | 2002-06-21 | 2008-05-13 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US20080125441A1 (en) * | 2002-06-21 | 2008-05-29 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US6825230B2 (en) * | 2002-06-21 | 2004-11-30 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trixolane antimalarials |
| US6906205B2 (en) * | 2002-06-21 | 2005-06-14 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US8067620B2 (en) * | 2005-05-04 | 2011-11-29 | Medicines For Malaria Venture Mmv | Dispiro 1,2,4-trioxolane antimalarials |
| EP1898901B1 (en) * | 2005-05-18 | 2016-11-23 | Sun Pharmaceutical Industries Limited | Stable dosage forms of spiro and dispiro 1,2,4-trioxolane antimalarials |
-
2007
- 2007-10-31 US US11/930,606 patent/US8067620B2/en not_active Expired - Lifetime
-
2008
- 2008-10-29 PL PL08845311T patent/PL2203457T3/pl unknown
- 2008-10-29 JP JP2010531331A patent/JP5559057B2/ja active Active
- 2008-10-29 MX MX2010004601A patent/MX2010004601A/es active IP Right Grant
- 2008-10-29 BR BRPI0818121A patent/BRPI0818121B8/pt active IP Right Grant
- 2008-10-29 AU AU2008318819A patent/AU2008318819C1/en not_active Ceased
- 2008-10-29 DK DK08845311.3T patent/DK2203457T3/da active
- 2008-10-29 EP EP08845311.3A patent/EP2203457B1/en active Active
- 2008-10-29 HR HRP20140435AT patent/HRP20140435T1/hr unknown
- 2008-10-29 CN CN200880114154.6A patent/CN101842377B/zh active Active
- 2008-10-29 KR KR1020107012029A patent/KR101588468B1/ko not_active Expired - Fee Related
- 2008-10-29 WO PCT/US2008/081579 patent/WO2009058859A2/en not_active Ceased
- 2008-10-29 PT PT88453113T patent/PT2203457E/pt unknown
- 2008-10-29 CA CA2702256A patent/CA2702256C/en active Active
- 2008-10-29 SI SI200831204T patent/SI2203457T1/sl unknown
- 2008-10-29 UA UAA201005157A patent/UA99742C2/ru unknown
- 2008-10-29 RU RU2010121919/04A patent/RU2493159C2/ru active
- 2008-10-29 ES ES08845311.3T patent/ES2466319T3/es active Active
-
2014
- 2014-05-16 CY CY20141100349T patent/CY1115148T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2493159C2 (ru) | 2013-09-20 |
| KR20100087199A (ko) | 2010-08-03 |
| BRPI0818121B1 (pt) | 2020-12-08 |
| ES2466319T3 (es) | 2014-06-17 |
| UA99742C2 (en) | 2012-09-25 |
| BRPI0818121A2 (pt) | 2015-11-17 |
| US20080125411A1 (en) | 2008-05-29 |
| JP2011502131A (ja) | 2011-01-20 |
| PT2203457E (pt) | 2014-06-06 |
| PL2203457T3 (pl) | 2014-08-29 |
| US8067620B2 (en) | 2011-11-29 |
| EP2203457A2 (en) | 2010-07-07 |
| EP2203457B1 (en) | 2014-03-05 |
| DK2203457T3 (da) | 2014-05-12 |
| HRP20140435T1 (hr) | 2014-06-20 |
| WO2009058859A2 (en) | 2009-05-07 |
| CA2702256A1 (en) | 2009-05-07 |
| SI2203457T1 (sl) | 2014-06-30 |
| KR101588468B1 (ko) | 2016-01-25 |
| AU2008318819B2 (en) | 2013-11-21 |
| HK1147092A1 (en) | 2011-07-29 |
| CN101842377A (zh) | 2010-09-22 |
| JP5559057B2 (ja) | 2014-07-23 |
| AU2008318819C1 (en) | 2014-04-24 |
| CA2702256C (en) | 2017-09-26 |
| BRPI0818121B8 (pt) | 2021-05-25 |
| WO2009058859A3 (en) | 2009-06-18 |
| AU2008318819A1 (en) | 2009-05-07 |
| RU2010121919A (ru) | 2011-12-10 |
| CN101842377B (zh) | 2015-07-01 |
| CY1115148T1 (el) | 2016-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |