JP5559057B2 - ジスピロ１，２，４−トリオキソラン抗マラリア剤 - Google Patents

ジスピロ１，２，４−トリオキソラン抗マラリア剤 Download PDF

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Publication number
JP5559057B2
JP5559057B2 JP2010531331A JP2010531331A JP5559057B2 JP 5559057 B2 JP5559057 B2 JP 5559057B2 JP 2010531331 A JP2010531331 A JP 2010531331A JP 2010531331 A JP2010531331 A JP 2010531331A JP 5559057 B2 JP5559057 B2 JP 5559057B2
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Japan
Prior art keywords
trioxolane
mmol
dispiro
nmr
mhz
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JP2010531331A
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English (en)
Japanese (ja)
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JP2011502131A (ja
JP2011502131A5 (enExample
Inventor
ヴェンナーストゥローム，ジョナサン，エル．
ドング，ユーシャン
チャーマン，スーザン，エー．
ヴィットゥリン，セルジオ
ショレ，ジャック
クリーク，ダレン，ジェイ．
ワン，シャオファング
スリラガヴァン，カマラジ
ゾウ，リン
マーティレ，ヒューグ
チャーマン，ウィリアム，エヌ．
Original Assignee
メディスィンズ フォー マラリア ヴェンチュアー エムエムヴィ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2010531331A 2007-10-31 2008-10-29 ジスピロ１，２，４−トリオキソラン抗マラリア剤 Active JP5559057B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/930,606 2007-10-31
US11/930,606 US8067620B2 (en) 2005-05-04 2007-10-31 Dispiro 1,2,4-trioxolane antimalarials
PCT/US2008/081579 WO2009058859A2 (en) 2007-10-31 2008-10-29 Dispiro 1,2,4-trioxolane antimalarials

Publications (3)

Publication Number Publication Date
JP2011502131A JP2011502131A (ja) 2011-01-20
JP2011502131A5 JP2011502131A5 (enExample) 2011-12-15
JP5559057B2 true JP5559057B2 (ja) 2014-07-23

Family

ID=40228026

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010531331A Active JP5559057B2 (ja) 2007-10-31 2008-10-29 ジスピロ１，２，４−トリオキソラン抗マラリア剤

Country Status (19)

Country Link
US (1) US8067620B2 (enExample)
EP (1) EP2203457B1 (enExample)
JP (1) JP5559057B2 (enExample)
KR (1) KR101588468B1 (enExample)
CN (1) CN101842377B (enExample)
AU (1) AU2008318819C1 (enExample)
BR (1) BRPI0818121B8 (enExample)
CA (1) CA2702256C (enExample)
CY (1) CY1115148T1 (enExample)
DK (1) DK2203457T3 (enExample)
ES (1) ES2466319T3 (enExample)
HR (1) HRP20140435T1 (enExample)
MX (1) MX2010004601A (enExample)
PL (1) PL2203457T3 (enExample)
PT (1) PT2203457E (enExample)
RU (1) RU2493159C2 (enExample)
SI (1) SI2203457T1 (enExample)
UA (1) UA99742C2 (enExample)
WO (1) WO2009058859A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067620B2 (en) * 2005-05-04 2011-11-29 Medicines For Malaria Venture Mmv Dispiro 1,2,4-trioxolane antimalarials
CN103429607B (zh) 2011-01-31 2016-02-17 百时美施贵宝公司 具有hiv成熟抑制活性的c-17和c-3经修饰的三萜系化合物
CA2874295A1 (en) * 2012-06-13 2013-12-19 Medizinische Universitat Wien Amidophenoxypropanolamines
US10287312B2 (en) 2014-02-14 2019-05-14 The Regents Of The University Of California Cyclic peroxides as prodrugs for selective delivery of agents
EP3526214A1 (en) 2016-10-13 2019-08-21 MMV Medicines for Malaria Venture New anti-malarial agent
EP3309156A1 (en) 2016-10-13 2018-04-18 MMV Medicines for Malaria Venture New anti-malarial agents
US11246854B2 (en) 2017-05-16 2022-02-15 The Johns Hopkins University Ozonides for treating or preventing virus infections
US11072594B2 (en) 2017-06-27 2021-07-27 The Regents Of The University Of California Trioxolane agents
CN110878069A (zh) * 2019-12-09 2020-03-13 南京杰运医药科技有限公司 一种4-吗琳基-2-乙基哌嗪的制备方法

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US3621062A (en) * 1966-10-25 1971-11-16 Sterling Drug Inc 2-(8-cyclohexyloctanoyl or 7-cyclohexylheptanoyl)-1-naphthol
US3673222A (en) * 1969-11-26 1972-06-27 Sydney Archer 2-(8-cyclohexyloctyl or 7-cyclohexylheptyl)-1,4-naphthoquinone and process for preparation and use thereof
US3682991A (en) * 1970-10-19 1972-08-08 Sterling Drug Inc 3,3,5-trimethylcyclohexyl-alkyl-carboxylic acids
US4978678A (en) * 1986-11-20 1990-12-18 Hoechst-Roussel Pharmaceuticals Inc. 12-halogenated forskolin derivatives
US4916204A (en) 1987-07-31 1990-04-10 Massachusetts Institute Of Technology Pure polyanhydride from dicarboxylic acid and coupling agent
US4816478A (en) * 1987-08-24 1989-03-28 Thornfeldt Carl R Treatment of acquired immunodeficiency syndrome
US5053342A (en) * 1987-12-24 1991-10-01 Litmus Concepts, Inc. Fecal occult blood test reagents
US5559145A (en) * 1988-06-01 1996-09-24 Oxaco S.A. 1,2,4-trioxane derivatives
US5270344A (en) * 1988-06-24 1993-12-14 Stephen Herman Method of treating a systemic disorder using trioxolane and diperoxide compounds
JP2867529B2 (ja) * 1990-01-22 1999-03-08 三菱電機株式会社 投写型表示装置
US5216175A (en) * 1990-03-23 1993-06-01 Sri International Antimalarial analogs of artemisinin
US5219880A (en) * 1991-03-29 1993-06-15 Dermatologic Research Corporation Treatment of viral tumors and hemorrhoids with artemisinin and derivatives
US5510356A (en) * 1991-10-03 1996-04-23 University Of Nebraska Board Of Regents Bisquinolines and processes for their production and use to treat malaria
US5171676A (en) * 1991-10-31 1992-12-15 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of introducing hydroxyl groups into artemisinin and its derivatives
US5430148A (en) * 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
ATE152630T1 (de) * 1992-07-28 1997-05-15 Procter & Gamble Pharmazeutische zusammensetzung zur topischen anwendung die ein vernetztes kationisches polymer und einen alkoxylierte äther enthält
US5721209A (en) * 1995-02-03 1998-02-24 The Regents Of The University Of California Iron chelator and inhibitor of iron-mediated oxidant injury
US5780675A (en) * 1995-04-28 1998-07-14 The University Of New Mexico Deoxygossylic compounds
US5578637A (en) * 1995-05-03 1996-11-26 University Of Washington Methods of inhibition or killing cancer cells using an endoperoxide
US5817692A (en) * 1995-11-22 1998-10-06 The Johns Hopkins University Endoperoxides useful as antiparasitic agents
US5672624A (en) * 1995-11-22 1997-09-30 The Johns Hopkins University Endoperoxides useful as antiparasitic agents
US5932591A (en) * 1996-12-02 1999-08-03 Johns Hopkins University C3 substituted trioxanes useful as antiparasitic drugs
US6486199B1 (en) * 2001-06-21 2002-11-26 Medicines For Malaria Venture Mmv International Centre Cointrin Spiro and dispiro 1,2,4-trioxolane antimalarials
US6906205B2 (en) * 2002-06-21 2005-06-14 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US6825230B2 (en) * 2002-06-21 2004-11-30 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trixolane antimalarials
US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US8067620B2 (en) 2005-05-04 2011-11-29 Medicines For Malaria Venture Mmv Dispiro 1,2,4-trioxolane antimalarials
WO2006123314A2 (en) * 2005-05-18 2006-11-23 Ranbaxy Laboratories Limited Stable dosage forms of spiro and dispiro 1,2,4-trioxolane antimalarials

Also Published As

Publication number Publication date
JP2011502131A (ja) 2011-01-20
UA99742C2 (en) 2012-09-25
PL2203457T3 (pl) 2014-08-29
MX2010004601A (es) 2010-05-27
CA2702256C (en) 2017-09-26
WO2009058859A2 (en) 2009-05-07
RU2010121919A (ru) 2011-12-10
DK2203457T3 (da) 2014-05-12
BRPI0818121A2 (pt) 2015-11-17
AU2008318819A1 (en) 2009-05-07
AU2008318819B2 (en) 2013-11-21
US20080125411A1 (en) 2008-05-29
KR101588468B1 (ko) 2016-01-25
HK1147092A1 (en) 2011-07-29
CY1115148T1 (el) 2016-12-14
KR20100087199A (ko) 2010-08-03
CN101842377B (zh) 2015-07-01
ES2466319T3 (es) 2014-06-17
RU2493159C2 (ru) 2013-09-20
BRPI0818121B8 (pt) 2021-05-25
SI2203457T1 (sl) 2014-06-30
AU2008318819C1 (en) 2014-04-24
BRPI0818121B1 (pt) 2020-12-08
EP2203457A2 (en) 2010-07-07
PT2203457E (pt) 2014-06-06
HRP20140435T1 (hr) 2014-06-20
WO2009058859A3 (en) 2009-06-18
CA2702256A1 (en) 2009-05-07
CN101842377A (zh) 2010-09-22
EP2203457B1 (en) 2014-03-05
US8067620B2 (en) 2011-11-29

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