RU2493159C2 - Диспиро 1,2,4-триоксоланы как противомалярийные средства - Google Patents
Диспиро 1,2,4-триоксоланы как противомалярийные средства Download PDFInfo
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- RU2493159C2 RU2493159C2 RU2010121919/04A RU2010121919A RU2493159C2 RU 2493159 C2 RU2493159 C2 RU 2493159C2 RU 2010121919/04 A RU2010121919/04 A RU 2010121919/04A RU 2010121919 A RU2010121919 A RU 2010121919A RU 2493159 C2 RU2493159 C2 RU 2493159C2
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- trioxolane
- mmol
- dispiro
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- mhz
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- RZYIPLSVRHWROD-UHFFFAOYSA-N 1,2,4-trioxolane Chemical class C1OCOO1 RZYIPLSVRHWROD-UHFFFAOYSA-N 0.000 title claims abstract description 26
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 62
- MAAKQSASDHJHIR-UHFFFAOYSA-N trioxolane Chemical compound C1COOO1 MAAKQSASDHJHIR-UHFFFAOYSA-N 0.000 claims description 61
- NAUWDMTWMDTGJV-UHFFFAOYSA-N CS(O)(=O)=O.CCCCCCCCCC Chemical compound CS(O)(=O)=O.CCCCCCCCCC NAUWDMTWMDTGJV-UHFFFAOYSA-N 0.000 claims description 38
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 36
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- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 20
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
- C07D323/02—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US11/930,606 | 2007-10-31 | ||
| US11/930,606 US8067620B2 (en) | 2005-05-04 | 2007-10-31 | Dispiro 1,2,4-trioxolane antimalarials |
| PCT/US2008/081579 WO2009058859A2 (en) | 2007-10-31 | 2008-10-29 | Dispiro 1,2,4-trioxolane antimalarials |
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| RU2010121919A RU2010121919A (ru) | 2011-12-10 |
| RU2493159C2 true RU2493159C2 (ru) | 2013-09-20 |
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| RU2010121919/04A RU2493159C2 (ru) | 2007-10-31 | 2008-10-29 | Диспиро 1,2,4-триоксоланы как противомалярийные средства |
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| US (1) | US8067620B2 (enExample) |
| EP (1) | EP2203457B1 (enExample) |
| JP (1) | JP5559057B2 (enExample) |
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| BR (1) | BRPI0818121B8 (enExample) |
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| HR (1) | HRP20140435T1 (enExample) |
| MX (1) | MX2010004601A (enExample) |
| PL (1) | PL2203457T3 (enExample) |
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| SI (1) | SI2203457T1 (enExample) |
| UA (1) | UA99742C2 (enExample) |
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| US8067620B2 (en) * | 2005-05-04 | 2011-11-29 | Medicines For Malaria Venture Mmv | Dispiro 1,2,4-trioxolane antimalarials |
| CN103429607B (zh) | 2011-01-31 | 2016-02-17 | 百时美施贵宝公司 | 具有hiv成熟抑制活性的c-17和c-3经修饰的三萜系化合物 |
| CA2874295A1 (en) * | 2012-06-13 | 2013-12-19 | Medizinische Universitat Wien | Amidophenoxypropanolamines |
| US10287312B2 (en) | 2014-02-14 | 2019-05-14 | The Regents Of The University Of California | Cyclic peroxides as prodrugs for selective delivery of agents |
| EP3526214A1 (en) | 2016-10-13 | 2019-08-21 | MMV Medicines for Malaria Venture | New anti-malarial agent |
| EP3309156A1 (en) | 2016-10-13 | 2018-04-18 | MMV Medicines for Malaria Venture | New anti-malarial agents |
| US11246854B2 (en) | 2017-05-16 | 2022-02-15 | The Johns Hopkins University | Ozonides for treating or preventing virus infections |
| US11072594B2 (en) | 2017-06-27 | 2021-07-27 | The Regents Of The University Of California | Trioxolane agents |
| CN110878069A (zh) * | 2019-12-09 | 2020-03-13 | 南京杰运医药科技有限公司 | 一种4-吗琳基-2-乙基哌嗪的制备方法 |
Citations (4)
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| US20040039008A1 (en) * | 2002-06-21 | 2004-02-26 | Medicines For Malaria Ventures Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| RU2004101409A (ru) * | 2001-06-21 | 2005-06-10 | Медсинз Фор Малэрия Венчер (Ch) | Спиро- и диспиро-1, 2, 4-триоксолановые противомалярийные средства |
| US20050256185A1 (en) * | 2002-06-21 | 2005-11-17 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| WO2006123314A2 (en) * | 2005-05-18 | 2006-11-23 | Ranbaxy Laboratories Limited | Stable dosage forms of spiro and dispiro 1,2,4-trioxolane antimalarials |
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| US3621062A (en) * | 1966-10-25 | 1971-11-16 | Sterling Drug Inc | 2-(8-cyclohexyloctanoyl or 7-cyclohexylheptanoyl)-1-naphthol |
| US3673222A (en) * | 1969-11-26 | 1972-06-27 | Sydney Archer | 2-(8-cyclohexyloctyl or 7-cyclohexylheptyl)-1,4-naphthoquinone and process for preparation and use thereof |
| US3682991A (en) * | 1970-10-19 | 1972-08-08 | Sterling Drug Inc | 3,3,5-trimethylcyclohexyl-alkyl-carboxylic acids |
| US4978678A (en) * | 1986-11-20 | 1990-12-18 | Hoechst-Roussel Pharmaceuticals Inc. | 12-halogenated forskolin derivatives |
| US4916204A (en) | 1987-07-31 | 1990-04-10 | Massachusetts Institute Of Technology | Pure polyanhydride from dicarboxylic acid and coupling agent |
| US4816478A (en) * | 1987-08-24 | 1989-03-28 | Thornfeldt Carl R | Treatment of acquired immunodeficiency syndrome |
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- 2008-10-29 MX MX2010004601A patent/MX2010004601A/es active IP Right Grant
- 2008-10-29 WO PCT/US2008/081579 patent/WO2009058859A2/en not_active Ceased
- 2008-10-29 CA CA2702256A patent/CA2702256C/en active Active
- 2008-10-29 RU RU2010121919/04A patent/RU2493159C2/ru active
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- 2008-10-29 PT PT88453113T patent/PT2203457E/pt unknown
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- 2008-10-29 BR BRPI0818121A patent/BRPI0818121B8/pt active IP Right Grant
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- 2008-10-29 EP EP08845311.3A patent/EP2203457B1/en active Active
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| RU2004101409A (ru) * | 2001-06-21 | 2005-06-10 | Медсинз Фор Малэрия Венчер (Ch) | Спиро- и диспиро-1, 2, 4-триоксолановые противомалярийные средства |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2011502131A (ja) | 2011-01-20 |
| UA99742C2 (en) | 2012-09-25 |
| PL2203457T3 (pl) | 2014-08-29 |
| MX2010004601A (es) | 2010-05-27 |
| CA2702256C (en) | 2017-09-26 |
| WO2009058859A2 (en) | 2009-05-07 |
| RU2010121919A (ru) | 2011-12-10 |
| DK2203457T3 (da) | 2014-05-12 |
| BRPI0818121A2 (pt) | 2015-11-17 |
| AU2008318819A1 (en) | 2009-05-07 |
| AU2008318819B2 (en) | 2013-11-21 |
| US20080125411A1 (en) | 2008-05-29 |
| KR101588468B1 (ko) | 2016-01-25 |
| HK1147092A1 (en) | 2011-07-29 |
| JP5559057B2 (ja) | 2014-07-23 |
| CY1115148T1 (el) | 2016-12-14 |
| KR20100087199A (ko) | 2010-08-03 |
| CN101842377B (zh) | 2015-07-01 |
| ES2466319T3 (es) | 2014-06-17 |
| BRPI0818121B8 (pt) | 2021-05-25 |
| SI2203457T1 (sl) | 2014-06-30 |
| AU2008318819C1 (en) | 2014-04-24 |
| BRPI0818121B1 (pt) | 2020-12-08 |
| EP2203457A2 (en) | 2010-07-07 |
| PT2203457E (pt) | 2014-06-06 |
| HRP20140435T1 (hr) | 2014-06-20 |
| WO2009058859A3 (en) | 2009-06-18 |
| CA2702256A1 (en) | 2009-05-07 |
| CN101842377A (zh) | 2010-09-22 |
| EP2203457B1 (en) | 2014-03-05 |
| US8067620B2 (en) | 2011-11-29 |
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