CN101842377B - 二螺1,2,4-三氧杂环戊烷抗疟药 - Google Patents

二螺1,2,4-三氧杂环戊烷抗疟药 Download PDF

Info

Publication number
CN101842377B
CN101842377B CN200880114154.6A CN200880114154A CN101842377B CN 101842377 B CN101842377 B CN 101842377B CN 200880114154 A CN200880114154 A CN 200880114154A CN 101842377 B CN101842377 B CN 101842377B
Authority
CN
China
Prior art keywords
trioxolane
mmol
nmr
cis
spiro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200880114154.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN101842377A (zh
Inventor
J·L·韦纳斯特罗姆
Y·董
S·A·查曼
S·威特林
J·乔列特
D·J·克里克
X·王
K·斯里拉加万
L·周
H·马蒂勒
W·N·查曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MMV Medicines for Malaria Venture
Original Assignee
MMV Medicines for Malaria Venture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MMV Medicines for Malaria Venture filed Critical MMV Medicines for Malaria Venture
Publication of CN101842377A publication Critical patent/CN101842377A/zh
Application granted granted Critical
Publication of CN101842377B publication Critical patent/CN101842377B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880114154.6A 2007-10-31 2008-10-29 二螺1,2,4-三氧杂环戊烷抗疟药 Active CN101842377B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/930,606 US8067620B2 (en) 2005-05-04 2007-10-31 Dispiro 1,2,4-trioxolane antimalarials
US11/930,606 2007-10-31
PCT/US2008/081579 WO2009058859A2 (en) 2007-10-31 2008-10-29 Dispiro 1,2,4-trioxolane antimalarials

Publications (2)

Publication Number Publication Date
CN101842377A CN101842377A (zh) 2010-09-22
CN101842377B true CN101842377B (zh) 2015-07-01

Family

ID=40228026

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880114154.6A Active CN101842377B (zh) 2007-10-31 2008-10-29 二螺1,2,4-三氧杂环戊烷抗疟药

Country Status (19)

Country Link
US (1) US8067620B2 (enExample)
EP (1) EP2203457B1 (enExample)
JP (1) JP5559057B2 (enExample)
KR (1) KR101588468B1 (enExample)
CN (1) CN101842377B (enExample)
AU (1) AU2008318819C1 (enExample)
BR (1) BRPI0818121B8 (enExample)
CA (1) CA2702256C (enExample)
CY (1) CY1115148T1 (enExample)
DK (1) DK2203457T3 (enExample)
ES (1) ES2466319T3 (enExample)
HR (1) HRP20140435T1 (enExample)
MX (1) MX2010004601A (enExample)
PL (1) PL2203457T3 (enExample)
PT (1) PT2203457E (enExample)
RU (1) RU2493159C2 (enExample)
SI (1) SI2203457T1 (enExample)
UA (1) UA99742C2 (enExample)
WO (1) WO2009058859A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067620B2 (en) 2005-05-04 2011-11-29 Medicines For Malaria Venture Mmv Dispiro 1,2,4-trioxolane antimalarials
MA34909B1 (fr) 2011-01-31 2014-02-01 Bristol Myers Squibb Co Triterpénoïdes modifi2s en c-17 et c-3 presentant une activité inhibitrice de la maturation du vih
BR112014030631A2 (pt) * 2012-06-13 2017-06-27 Univ Wien Med amidofenóxi propanolaminas
WO2015123595A1 (en) 2014-02-14 2015-08-20 The Regents Of The University Of California Cyclic peroxides as prodrugs for selective delivery of agents
EP3309156A1 (en) 2016-10-13 2018-04-18 MMV Medicines for Malaria Venture New anti-malarial agents
JP2019530712A (ja) 2016-10-13 2019-10-24 エムエムヴィ メディシンズ フォア マラリア ヴェンチャーＭｍｖ Ｍｅｄｉｃｉｎｅｓ Ｆｏｒ Ｍａｌａｒｉａ Ｖｅｎｔｕｒｅ 新規抗マラリア薬
WO2018213220A1 (en) * 2017-05-16 2018-11-22 The Johns Hopkins University Ozonides for treating or preventing virus infections
WO2019005977A1 (en) 2017-06-27 2019-01-03 The Regents Of The University Of California Trioxolane agents
CN110878069A (zh) * 2019-12-09 2020-03-13 南京杰运医药科技有限公司 一种4-吗琳基-2-乙基哌嗪的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040039008A1 (en) * 2002-06-21 2004-02-26 Medicines For Malaria Ventures Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3621062A (en) * 1966-10-25 1971-11-16 Sterling Drug Inc 2-(8-cyclohexyloctanoyl or 7-cyclohexylheptanoyl)-1-naphthol
US3673222A (en) * 1969-11-26 1972-06-27 Sydney Archer 2-(8-cyclohexyloctyl or 7-cyclohexylheptyl)-1,4-naphthoquinone and process for preparation and use thereof
US3682991A (en) * 1970-10-19 1972-08-08 Sterling Drug Inc 3,3,5-trimethylcyclohexyl-alkyl-carboxylic acids
US4978678A (en) * 1986-11-20 1990-12-18 Hoechst-Roussel Pharmaceuticals Inc. 12-halogenated forskolin derivatives
US4916204A (en) 1987-07-31 1990-04-10 Massachusetts Institute Of Technology Pure polyanhydride from dicarboxylic acid and coupling agent
US4816478A (en) * 1987-08-24 1989-03-28 Thornfeldt Carl R Treatment of acquired immunodeficiency syndrome
US5053342A (en) * 1987-12-24 1991-10-01 Litmus Concepts, Inc. Fecal occult blood test reagents
US5559145A (en) * 1988-06-01 1996-09-24 Oxaco S.A. 1,2,4-trioxane derivatives
US5270344A (en) * 1988-06-24 1993-12-14 Stephen Herman Method of treating a systemic disorder using trioxolane and diperoxide compounds
JP2867529B2 (ja) * 1990-01-22 1999-03-08 三菱電機株式会社 投写型表示装置
US5216175A (en) * 1990-03-23 1993-06-01 Sri International Antimalarial analogs of artemisinin
US5219880A (en) * 1991-03-29 1993-06-15 Dermatologic Research Corporation Treatment of viral tumors and hemorrhoids with artemisinin and derivatives
US5510356A (en) * 1991-10-03 1996-04-23 University Of Nebraska Board Of Regents Bisquinolines and processes for their production and use to treat malaria
US5171676A (en) * 1991-10-31 1992-12-15 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of introducing hydroxyl groups into artemisinin and its derivatives
US5430148A (en) * 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
WO1994002176A1 (en) * 1992-07-28 1994-02-03 The Procter & Gamble Company Pharmaceutical composition for topical use containing a crosslinked cationic polymer and an alkoxylated ether
US5721209A (en) * 1995-02-03 1998-02-24 The Regents Of The University Of California Iron chelator and inhibitor of iron-mediated oxidant injury
US5780675A (en) * 1995-04-28 1998-07-14 The University Of New Mexico Deoxygossylic compounds
US5578637A (en) * 1995-05-03 1996-11-26 University Of Washington Methods of inhibition or killing cancer cells using an endoperoxide
US5817692A (en) * 1995-11-22 1998-10-06 The Johns Hopkins University Endoperoxides useful as antiparasitic agents
US5672624A (en) * 1995-11-22 1997-09-30 The Johns Hopkins University Endoperoxides useful as antiparasitic agents
US5932591A (en) * 1996-12-02 1999-08-03 Johns Hopkins University C3 substituted trioxanes useful as antiparasitic drugs
US6486199B1 (en) * 2001-06-21 2002-11-26 Medicines For Malaria Venture Mmv International Centre Cointrin Spiro and dispiro 1,2,4-trioxolane antimalarials
US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US6906205B2 (en) * 2002-06-21 2005-06-14 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US8067620B2 (en) * 2005-05-04 2011-11-29 Medicines For Malaria Venture Mmv Dispiro 1,2,4-trioxolane antimalarials
HUE033191T2 (en) * 2005-05-18 2017-11-28 Sun Pharmaceutical Ind Ltd Stable dosage forms of spiro and dispiro-1,2,4-trioxolane anti-malarial agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040039008A1 (en) * 2002-06-21 2004-02-26 Medicines For Malaria Ventures Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials

Also Published As

Publication number Publication date
PL2203457T3 (pl) 2014-08-29
WO2009058859A3 (en) 2009-06-18
US20080125411A1 (en) 2008-05-29
EP2203457B1 (en) 2014-03-05
AU2008318819A1 (en) 2009-05-07
US8067620B2 (en) 2011-11-29
DK2203457T3 (da) 2014-05-12
EP2203457A2 (en) 2010-07-07
CY1115148T1 (el) 2016-12-14
PT2203457E (pt) 2014-06-06
BRPI0818121A2 (pt) 2015-11-17
SI2203457T1 (sl) 2014-06-30
RU2010121919A (ru) 2011-12-10
BRPI0818121B1 (pt) 2020-12-08
JP5559057B2 (ja) 2014-07-23
CA2702256C (en) 2017-09-26
HK1147092A1 (en) 2011-07-29
BRPI0818121B8 (pt) 2021-05-25
CA2702256A1 (en) 2009-05-07
KR101588468B1 (ko) 2016-01-25
JP2011502131A (ja) 2011-01-20
KR20100087199A (ko) 2010-08-03
AU2008318819B2 (en) 2013-11-21
MX2010004601A (es) 2010-05-27
AU2008318819C1 (en) 2014-04-24
HRP20140435T1 (hr) 2014-06-20
CN101842377A (zh) 2010-09-22
RU2493159C2 (ru) 2013-09-20
ES2466319T3 (es) 2014-06-17
UA99742C2 (en) 2012-09-25
WO2009058859A2 (en) 2009-05-07

Similar Documents

Publication Publication Date Title
CN101842377B (zh) 二螺1,2,4-三氧杂环戊烷抗疟药
CN1545508B (zh) 1,2,4-三噁茂烷抗疟药
JP7044392B2 (ja) マラリアの治療のための化合物及び方法
US20080125441A1 (en) Spiro and dispiro 1,2,4-trioxolane antimalarials
IL269390B (en) Compounds and methods for the treatment of parasitic diseases
DK1514871T3 (en) Dispiro-1,2,4-trioxolanes as antimalarials
US9428507B2 (en) Compounds for the treatment of malaria
HK1147092B (en) Dispiro 1,2,4-trioxolane antimalarials
AU711713B2 (en) HIV protease inhibitors useful for the treatment of AIDS
AU2013273836A1 (en) Dispiro 1,2,4-trioxolane antimalarials
HK40032676A (en) Fused polycyclic pyridone compounds as influenza virus replication inhibitors
BR112019019494B1 (pt) Compostos, composições farmacêuticas e usos para o tratamento de doenças parasitárias

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1147092

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1147092

Country of ref document: HK