KR101588468B1 - 디스피로 1,2,4-트리옥솔란 항말라리아제 - Google Patents

디스피로 1,2,4-트리옥솔란 항말라리아제 Download PDF

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Publication number
KR101588468B1
KR101588468B1 KR1020107012029A KR20107012029A KR101588468B1 KR 101588468 B1 KR101588468 B1 KR 101588468B1 KR 1020107012029 A KR1020107012029 A KR 1020107012029A KR 20107012029 A KR20107012029 A KR 20107012029A KR 101588468 B1 KR101588468 B1 KR 101588468B1
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South Korea
Prior art keywords
decane
phenyl
trioxaspiro
spiro
cis
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Expired - Fee Related
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KR1020107012029A
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English (en)
Korean (ko)
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KR20100087199A (ko
Inventor
조나탄 엘. 벤네르스트롬
유시앙 동
수산 에이. 차르만
세르기오 위트린
자쿠에스 졸레트
다렌 제이. 크레크
시아오팡 왕
카마라이 스리랑하반
린 조우
후구에스 마틸레
윌리암 엔. 차르만
Original Assignee
엠엠브이 메디슨즈 포 말라리아 벤처
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Publication of KR20100087199A publication Critical patent/KR20100087199A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020107012029A 2007-10-31 2008-10-29 디스피로 1,2,4-트리옥솔란 항말라리아제 Expired - Fee Related KR101588468B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/930,606 US8067620B2 (en) 2005-05-04 2007-10-31 Dispiro 1,2,4-trioxolane antimalarials
US11/930,606 2007-10-31

Publications (2)

Publication Number Publication Date
KR20100087199A KR20100087199A (ko) 2010-08-03
KR101588468B1 true KR101588468B1 (ko) 2016-01-25

Family

ID=40228026

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107012029A Expired - Fee Related KR101588468B1 (ko) 2007-10-31 2008-10-29 디스피로 1,2,4-트리옥솔란 항말라리아제

Country Status (19)

Country Link
US (1) US8067620B2 (enExample)
EP (1) EP2203457B1 (enExample)
JP (1) JP5559057B2 (enExample)
KR (1) KR101588468B1 (enExample)
CN (1) CN101842377B (enExample)
AU (1) AU2008318819C1 (enExample)
BR (1) BRPI0818121B8 (enExample)
CA (1) CA2702256C (enExample)
CY (1) CY1115148T1 (enExample)
DK (1) DK2203457T3 (enExample)
ES (1) ES2466319T3 (enExample)
HR (1) HRP20140435T1 (enExample)
MX (1) MX2010004601A (enExample)
PL (1) PL2203457T3 (enExample)
PT (1) PT2203457E (enExample)
RU (1) RU2493159C2 (enExample)
SI (1) SI2203457T1 (enExample)
UA (1) UA99742C2 (enExample)
WO (1) WO2009058859A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067620B2 (en) * 2005-05-04 2011-11-29 Medicines For Malaria Venture Mmv Dispiro 1,2,4-trioxolane antimalarials
US8846647B2 (en) 2011-01-31 2014-09-30 Bristol-Myers Squibb Company C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity
SG11201407434XA (en) * 2012-06-13 2014-12-30 Univ Wien Med Amidophenoxypropanolamines
JP6889433B2 (ja) * 2014-02-14 2021-06-18 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア 薬剤の選択的送達のためのプロドラッグとしての環状ペルオキシド
EP3309156A1 (en) 2016-10-13 2018-04-18 MMV Medicines for Malaria Venture New anti-malarial agents
BR112019006456A2 (pt) 2016-10-13 2019-06-25 Medicines For Malaria Venture Mmv diespiro 1,2,4-trioxolano, formulação farmacêutica, processo para a preparação de um derivado de diespiro 1,2,4-trioxolano, intermediário, e, método para prevenir e/ou tratar malária e esquistossomose ou um câncer.
US11246854B2 (en) * 2017-05-16 2022-02-15 The Johns Hopkins University Ozonides for treating or preventing virus infections
WO2019005977A1 (en) 2017-06-27 2019-01-03 The Regents Of The University Of California Trioxolane agents
CN110878069A (zh) * 2019-12-09 2020-03-13 南京杰运医药科技有限公司 一种4-吗琳基-2-乙基哌嗪的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050256185A1 (en) * 2002-06-21 2005-11-17 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials

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US3673222A (en) * 1969-11-26 1972-06-27 Sydney Archer 2-(8-cyclohexyloctyl or 7-cyclohexylheptyl)-1,4-naphthoquinone and process for preparation and use thereof
US3682991A (en) * 1970-10-19 1972-08-08 Sterling Drug Inc 3,3,5-trimethylcyclohexyl-alkyl-carboxylic acids
US4978678A (en) * 1986-11-20 1990-12-18 Hoechst-Roussel Pharmaceuticals Inc. 12-halogenated forskolin derivatives
US4916204A (en) 1987-07-31 1990-04-10 Massachusetts Institute Of Technology Pure polyanhydride from dicarboxylic acid and coupling agent
US4816478A (en) * 1987-08-24 1989-03-28 Thornfeldt Carl R Treatment of acquired immunodeficiency syndrome
US5053342A (en) * 1987-12-24 1991-10-01 Litmus Concepts, Inc. Fecal occult blood test reagents
US5559145A (en) * 1988-06-01 1996-09-24 Oxaco S.A. 1,2,4-trioxane derivatives
US5270344A (en) * 1988-06-24 1993-12-14 Stephen Herman Method of treating a systemic disorder using trioxolane and diperoxide compounds
JP2867529B2 (ja) * 1990-01-22 1999-03-08 三菱電機株式会社 投写型表示装置
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US5219880A (en) * 1991-03-29 1993-06-15 Dermatologic Research Corporation Treatment of viral tumors and hemorrhoids with artemisinin and derivatives
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US5171676A (en) * 1991-10-31 1992-12-15 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of introducing hydroxyl groups into artemisinin and its derivatives
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AU4673993A (en) * 1992-07-28 1994-02-14 Procter & Gamble Company, The Pharmaceutical composition for topical use containing a crosslinked cationic polymer and an alkoxylated ether
US5721209A (en) * 1995-02-03 1998-02-24 The Regents Of The University Of California Iron chelator and inhibitor of iron-mediated oxidant injury
US5780675A (en) * 1995-04-28 1998-07-14 The University Of New Mexico Deoxygossylic compounds
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US5672624A (en) * 1995-11-22 1997-09-30 The Johns Hopkins University Endoperoxides useful as antiparasitic agents
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US6486199B1 (en) * 2001-06-21 2002-11-26 Medicines For Malaria Venture Mmv International Centre Cointrin Spiro and dispiro 1,2,4-trioxolane antimalarials
US6906205B2 (en) * 2002-06-21 2005-06-14 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US6825230B2 (en) * 2002-06-21 2004-11-30 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trixolane antimalarials
US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US8067620B2 (en) 2005-05-04 2011-11-29 Medicines For Malaria Venture Mmv Dispiro 1,2,4-trioxolane antimalarials
US20090042821A1 (en) * 2005-05-18 2009-02-12 Arno Appavoo Enose Stable dosage forms of spiro and dispiro 1,2,4-trioxolane antimalarials

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050256185A1 (en) * 2002-06-21 2005-11-17 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials

Also Published As

Publication number Publication date
US20080125411A1 (en) 2008-05-29
BRPI0818121B1 (pt) 2020-12-08
CA2702256A1 (en) 2009-05-07
UA99742C2 (en) 2012-09-25
AU2008318819A1 (en) 2009-05-07
BRPI0818121B8 (pt) 2021-05-25
HK1147092A1 (en) 2011-07-29
JP2011502131A (ja) 2011-01-20
RU2010121919A (ru) 2011-12-10
AU2008318819C1 (en) 2014-04-24
AU2008318819B2 (en) 2013-11-21
SI2203457T1 (sl) 2014-06-30
PL2203457T3 (pl) 2014-08-29
BRPI0818121A2 (pt) 2015-11-17
KR20100087199A (ko) 2010-08-03
RU2493159C2 (ru) 2013-09-20
ES2466319T3 (es) 2014-06-17
WO2009058859A3 (en) 2009-06-18
CA2702256C (en) 2017-09-26
CN101842377A (zh) 2010-09-22
PT2203457E (pt) 2014-06-06
EP2203457B1 (en) 2014-03-05
HRP20140435T1 (hr) 2014-06-20
CY1115148T1 (el) 2016-12-14
DK2203457T3 (da) 2014-05-12
JP5559057B2 (ja) 2014-07-23
US8067620B2 (en) 2011-11-29
MX2010004601A (es) 2010-05-27
CN101842377B (zh) 2015-07-01
EP2203457A2 (en) 2010-07-07
WO2009058859A2 (en) 2009-05-07

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