MX2010003656A - Sistema de administracion vaginal. - Google Patents

Sistema de administracion vaginal.

Info

Publication number
MX2010003656A
MX2010003656A MX2010003656A MX2010003656A MX2010003656A MX 2010003656 A MX2010003656 A MX 2010003656A MX 2010003656 A MX2010003656 A MX 2010003656A MX 2010003656 A MX2010003656 A MX 2010003656A MX 2010003656 A MX2010003656 A MX 2010003656A
Authority
MX
Mexico
Prior art keywords
drospirenone
membrane
delivery system
estrogen
core
Prior art date
Application number
MX2010003656A
Other languages
English (en)
Inventor
Antti Kein Nen
Vladimir Hanes
Christine Talling
Svante Holmberg
Hannu Nikander
Original Assignee
Bayer Schering Pharma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40394262&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010003656(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP07397043A external-priority patent/EP2062569B1/en
Priority claimed from EP07397042A external-priority patent/EP2062568A1/en
Application filed by Bayer Schering Pharma Oy filed Critical Bayer Schering Pharma Oy
Publication of MX2010003656A publication Critical patent/MX2010003656A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invenci?n se refiere a un sistema de administraci?n intravaginal para la liberaci?n controlada de drospirenona y un estr?geno y, opcionalmente, tambi?n comprende una o m?s sustancias terap?uticamente activas o promotoras de la salud capaces de brindar y/o mejorar la protecci?n contra infecciones bacterianas y f?ngicas, y/o mejorar la protecci?n contra enfermedades de transmisi?n sexual. El sistema de administraci?n comprende uno o m?s compartimientos, cada uno de los cuales comprende un n?cleo y una membrana que recubre el n?cleo, dicho. n?cleo y dicha membrana est?n compuestos esencialmente por la misma composici?n de pol?mero o una composici?n de pol?mero diferente, donde al menos un compartimiento comprende drospirenona y al menos un compartimiento, que puede ser igual o diferente del que comprende drospirenona, comprende un estr?geno o una mezcla de drospirenona y un estr?geno, y donde la membrana o la superficie de la membrana o al menos uno de los n?cleos comprende dicha sustancia terap?uticamente activa o promotora de la salud.
MX2010003656A 2007-11-22 2008-11-19 Sistema de administracion vaginal. MX2010003656A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07397043A EP2062569B1 (en) 2007-11-22 2007-11-22 Vaginal delivery system
EP07397042A EP2062568A1 (en) 2007-11-22 2007-11-22 Vaginal delivery system
PCT/FI2008/050670 WO2009066006A1 (en) 2007-11-22 2008-11-19 Vaginal delivery system

Publications (1)

Publication Number Publication Date
MX2010003656A true MX2010003656A (es) 2010-04-21

Family

ID=40394262

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003656A MX2010003656A (es) 2007-11-22 2008-11-19 Sistema de administracion vaginal.

Country Status (26)

Country Link
US (2) US20100285097A1 (es)
EP (1) EP2227220A1 (es)
JP (1) JP2011504484A (es)
KR (1) KR20100090708A (es)
CN (1) CN101873850A (es)
AR (1) AR069379A1 (es)
AU (1) AU2008327813A1 (es)
BR (1) BRPI0815936A2 (es)
CA (1) CA2705734A1 (es)
CL (1) CL2008003421A1 (es)
CO (1) CO6290642A2 (es)
CR (1) CR11493A (es)
DO (1) DOP2010000154A (es)
EA (1) EA018112B1 (es)
EC (1) ECSP10010104A (es)
IL (1) IL205588A0 (es)
MX (1) MX2010003656A (es)
NZ (1) NZ584216A (es)
PA (1) PA8805001A1 (es)
PE (1) PE20091025A1 (es)
SG (1) SG186002A1 (es)
SV (1) SV2010003513A (es)
TW (1) TW200927141A (es)
UY (1) UY31475A1 (es)
WO (1) WO2009066006A1 (es)
ZA (1) ZA201002122B (es)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI121000B (fi) * 2008-11-19 2010-06-15 Bayer Schering Pharma Oy Intravaginaalinen antojärjestelmä ja menetelmä sen valmistamiseksi
US8815971B2 (en) 2008-12-22 2014-08-26 ATRP Solutions, Inc. Control over controlled radical polymerization processes
US8822610B2 (en) 2008-12-22 2014-09-02 ATRP Solutions, Inc. Control over controlled radical polymerization processes
US8173750B2 (en) * 2009-04-23 2012-05-08 ATRP Solutions, Inc. Star macromolecules for personal and home care
US8569421B2 (en) 2009-04-23 2013-10-29 ATRP Solutions, Inc. Star macromolecules for personal and home care
US9783628B2 (en) 2009-04-23 2017-10-10 ATRP Solutions, Inc. Dual-mechanism thickening agents for hydraulic fracturing fluids
FI20095550A0 (fi) * 2009-05-19 2009-05-19 Bayer Schering Pharma Oy Vaginaalinen antojärjestelmä
FI20095563A (fi) * 2009-05-20 2010-11-21 Bayer Schering Pharma Oy Vaginaalinen antojärjestelmä
US20110236462A1 (en) * 2010-03-28 2011-09-29 Shaked Ze Ev Intravaginal drug delivery device
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
MX2013000003A (es) * 2010-06-22 2013-04-29 Teva Womens Health Inc Dispositivos intravaginales que comprenden agentes anticolinergicos y metodos para prepararlos.
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
JP6139408B2 (ja) 2010-11-12 2017-05-31 ザ ユニバーシティ オブ ユタ リサーチ ファウンデーション 潤滑剤の制御送達のための膣内デバイス
SG190719A1 (en) * 2010-11-29 2013-07-31 Meiji Co Ltd Endometriosis prevention and/or improving agent, and food or drink composition containing same
WO2014121188A1 (en) 2013-02-04 2014-08-07 ATRP Solutions, Inc. Salt-tolerant star macromolecules
US9587064B2 (en) 2010-12-08 2017-03-07 ATRP Solutions, Inc. Salt-tolerant star macromolecules
KR101263916B1 (ko) 2011-01-11 2013-05-13 이장희 성 호르몬 방출 장치 및 이를 이용한 동물 피임 및 발정 유도 방법
CN103747765B (zh) * 2011-06-06 2016-04-06 橡冠科学研究院 采用芯吸释放窗口的药物递送装置
WO2013010915A1 (en) 2011-07-15 2013-01-24 Universiteit Gent Intravaginal delivery system
KR20140074281A (ko) * 2011-07-20 2014-06-17 패트릭 에프. 카이저 약물 전달용 질내 장치
CN104168902A (zh) 2011-08-26 2014-11-26 智利圣地亚哥大学 阴道内给药非类固醇抗炎药物美洛昔康和吡罗昔康用于中断女性排卵过程的用途
CN103007427B (zh) * 2011-09-21 2016-01-20 上海市计划生育科学研究所 缓控释宫内释药器及其制备方法
TWI615155B (zh) * 2011-11-01 2018-02-21 拜耳股份有限公司 滲透活性的陰道遞送系統
AR089765A1 (es) 2012-01-23 2014-09-17 Bayer Oy Un sistema para el suministro de un farmaco
WO2013174735A1 (en) 2012-05-21 2013-11-28 Bayer Pharma Aktiengesellschaft Substituted benzothienopyrimidines
MX365905B (es) 2012-06-13 2019-06-18 Evofem Inc Composiciones y métodos para mejorar la eficacia de microbicidas anticonceptivos.
MX368683B (es) 2012-08-30 2019-10-11 Pilot Polymer Tech Inc Agentes espesantes de mecanismo dual para fluidos de fracturación hidráulica.
KR20150051234A (ko) 2012-09-03 2015-05-11 에쏘세아 파르밍 에쎄.아. 수생 생물종의 배향 및／또는 억제를 위한 저장조 케이지 침지 시스템
TW201412740A (zh) 2012-09-20 2014-04-01 Bayer Pharma AG 經取代之吡咯并嘧啶胺基苯并噻唑酮
WO2014066480A1 (en) * 2012-10-23 2014-05-01 Estech Usa, Llc Treating conditions caused by abnormal growth of pathogens in body cavities
SE539540C2 (sv) * 2013-09-12 2017-10-10 Qpharma Ab Ett läkemedelsavgivningssystem för en eller flera aktiva beståndsdelar
EP3065807A1 (en) * 2013-11-05 2016-09-14 TARIS Biomedical LLC Osmotic drug delivery devices, kits, and methods
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
US10413504B2 (en) * 2013-12-11 2019-09-17 Merck Sharp & Dohme Corp. Intravaginal ring drug delivery system
JP2017501227A (ja) 2013-12-19 2017-01-12 エヴォフェム，インク． アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法
CA2944436C (en) * 2014-04-01 2023-08-22 Poly-Med, Inc. Contraceptive and related device
WO2016004357A1 (en) 2014-07-03 2016-01-07 ATRP Solutions, Inc. Surfactant-compatible star macromolecules
CN105250280B (zh) 2014-07-14 2020-03-10 诺维科国际控股股份有限公司 包含辛苯聚醇和喹诺里西啶生物碱化合物或其来源的杀微生物组合物
CN104117135A (zh) * 2014-08-11 2014-10-29 崔仁海 阴道内植入式治疗装置
CN104558491A (zh) * 2014-12-25 2015-04-29 中南大学 能促进组织内膜生长的聚氨酯材料的制备方法
CN108135910B (zh) * 2015-05-13 2022-12-02 拜耳股份有限公司 长效药物递送装置及其在避孕中的用途
CN108587968A (zh) * 2015-08-31 2018-09-28 科.汉森有限公司 乳杆菌细菌和组合物以及采用其生产产品的方法和用途
KR20180093255A (ko) * 2015-12-21 2018-08-21 바이엘 오와이 질용 고리의 제조 방법
MY193641A (en) * 2015-12-21 2022-10-21 Bayer Oy Method for manufacturing a drug delivery device and a drug delivery device manufactured according to the method
US20190290474A1 (en) * 2016-01-04 2019-09-26 Jurox Pty Ltd Drug release device and use
KR101720145B1 (ko) * 2016-07-08 2017-04-07 (주)정가진면역연구소 여성 질염 예방 및 개선 기능성 조성물
AU2017338748A1 (en) 2016-10-04 2019-05-02 Evofem Inc. Method of treatment and prevention of bacterial vaginosis
KR20200059224A (ko) * 2017-09-27 2020-05-28 베이어 오와이 엘라스토머 매트릭스로부터의 치료 활성제의 방출을 변형시키는 방법
MX2020011321A (es) * 2018-04-27 2021-02-09 Evestra Inc Profármacos de estrógeno y métodos de administración de profármacos de estrógeno.
AU2019275409A1 (en) 2018-05-24 2020-07-16 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
CA3087238A1 (en) 2018-05-24 2019-11-28 Celanese EVA Performance Polymers Corporation Implantable device for sustained release of a macromolecular drug compound
WO2020007780A1 (en) * 2018-07-02 2020-01-09 Artpred B.V. Method and kit for altering the outcome of an assisted reproductive technology procedure
KR102078462B1 (ko) * 2018-07-24 2020-02-17 주식회사 디네이쳐 질환경 개선 조성물 및 이를 포함하는 개선제
DE102019115343A1 (de) * 2019-06-06 2020-12-10 EVESTRA GmbH Vaginalring für die hormonelle Kontrazeption
CN110585246B (zh) * 2019-09-22 2020-06-02 深圳市多微生保健食品有限公司 一种阴道抑菌制剂及其制备方法
JP2023501570A (ja) * 2019-11-12 2023-01-18 ポリ－メッド インコーポレイテッド 避妊用医療器具
KR20210097421A (ko) * 2020-01-30 2021-08-09 주식회사 디네이쳐 펄스형 질내 약산성 환경 유지 조성물
IT202000029267A1 (it) * 2020-12-01 2022-06-01 Francesca FRIZZI Dispositivo vaginale
WO2023200974A1 (en) * 2022-04-14 2023-10-19 Yale University Nanoparticles and nanoparticle-releasing vaginal rings
WO2024030116A1 (en) * 2022-08-01 2024-02-08 Lupin Inc. Drug delivery system for ultra-low dose estrogen combinations and methods and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48277A (en) * 1974-10-18 1978-03-10 Schering Ag Vaginal ring
US4237885A (en) * 1978-10-23 1980-12-09 Alza Corporation Delivery system with mated members for storing and releasing a plurality of beneficial agents
DE3040978A1 (de) * 1980-10-28 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Vaginalring
US4596576A (en) * 1984-10-12 1986-06-24 Akzo N.V. Release system for two or more active substances
FR2618329B1 (fr) * 1987-07-22 1997-03-28 Dow Corning Sa Procede de fabrication d'un anneau capable d'assurer la liberation d'un agent therapeutique, et anneau fabrique par ce procede
FI95768C (fi) * 1993-06-17 1996-03-25 Leiras Oy Emättimensisäinen antosysteemi
US6544546B1 (en) * 1995-07-04 2003-04-08 Akzo Nobel, N.V. Ring-shaped devices
US5972372A (en) * 1996-07-31 1999-10-26 The Population Council, Inc. Intravaginal rings with insertable drug-containing core
DE19651000A1 (de) * 1996-12-01 1998-06-04 Schering Ag Oxyiminopregnancarbolactone
US6063395A (en) * 1998-11-12 2000-05-16 Leiras Oy Drug delivery device especially for the delivery of progestins and estrogens
US6476079B1 (en) * 1999-12-23 2002-11-05 Leiras Oy Devices for the delivery of drugs having antiprogestinic properties
EP1406634A1 (en) * 2001-07-13 2004-04-14 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
AU2002313517B2 (en) * 2001-08-31 2007-09-06 Bayer Schering Pharma Oy Drug delivery system
JP5041651B2 (ja) * 2001-09-28 2012-10-03 ティーエヌティーギャンブル・インコーポレーテッド 生物体成分の送達系
US20040247574A1 (en) * 2003-05-27 2004-12-09 Christopherson Kent W. Methods for enhancing stem cell engraftment during transplantation
MY144021A (en) * 2003-09-19 2011-07-29 Drugtech Corp Pharmaceutical delivery system
CN100531800C (zh) * 2004-03-24 2009-08-26 奥尔加侬股份有限公司 基于聚乙烯乙酸乙烯酯共聚物的药物递送系统
WO2006084082A1 (en) * 2005-02-03 2006-08-10 Duramed Pharmaceuticals, Inc. Compositions of unconjugated estrogens and methods for their use
JP2009501722A (ja) * 2005-07-15 2009-01-22 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト ドロスピレノン含有経皮用薬剤供給装置及びその供給方法

Also Published As

Publication number Publication date
CO6290642A2 (es) 2011-06-20
US20100285097A1 (en) 2010-11-11
EA201070639A1 (ru) 2010-10-29
CL2008003421A1 (es) 2009-08-07
IL205588A0 (en) 2010-11-30
CN101873850A (zh) 2010-10-27
UY31475A1 (es) 2009-07-17
JP2011504484A (ja) 2011-02-10
TW200927141A (en) 2009-07-01
AR069379A1 (es) 2010-01-20
WO2009066006A1 (en) 2009-05-28
EA018112B1 (ru) 2013-05-30
PE20091025A1 (es) 2009-08-17
AU2008327813A1 (en) 2009-05-28
DOP2010000154A (es) 2010-07-31
ZA201002122B (en) 2011-06-29
SV2010003513A (es) 2010-08-09
PA8805001A1 (es) 2009-06-23
NZ584216A (en) 2012-03-30
CA2705734A1 (en) 2009-05-28
CR11493A (es) 2010-08-23
KR20100090708A (ko) 2010-08-16
US20090142313A1 (en) 2009-06-04
BRPI0815936A2 (pt) 2019-08-27
SG186002A1 (en) 2012-12-28
EP2227220A1 (en) 2010-09-15
ECSP10010104A (es) 2010-06-29

Similar Documents

Publication Publication Date Title
MX2010003656A (es) Sistema de administracion vaginal.
MX2009007254A (es) Composiciones de tableta en tableta.
WO2012027065A3 (en) Combination therapy for treatment of disease
WO2006013441A3 (en) Use of probiotic bacteria for the preparation of topical compositions for skin protection
MX2009007337A (es) Indazoles sustituidos con 5-piridinona.
WO2008049516A3 (de) Transdermales therapeutisches system enthaltend norelgestromin zur kontrazeption und hormonsubstitution
GEP20115139B (en) Polycyclic cinnamide derivative
MX2009005724A (es) Comprimidos bicapa de estrogenos/serm y estrogenos/progestina.
UA91337C2 (ru) Система доставки
GB201104241D0 (en) Dosages for menstrual suppression, contraception, and hormone replacement therapy, and methods of administrating same
WO2009048594A3 (en) Multicomponent bioactive intravaginal ring
WO2007138110A3 (en) Compounds that interact with ion channels, in particular with ion channels from the kv family
WO2007130663A3 (en) Method, device, and system for delivery of therapeutic agents to the eye
IL178094A0 (en) Improvements in or relating to compounds for use in the treatment of aids and other viral diseases and hiv-related infections and compositions containing such compounds, methods of treating such diseases and infections and methods of making such compounds and compositions
WO2005123134A3 (en) A controlled release delivery system for metformin
WO2006121979A3 (en) Modified-release pharmaceutical compositions
WO2013041963A3 (en) A composition and method for treating an autoimmune disease
WO2007138112A3 (en) Compounds that interact with ion channels, in particular with ion channels from the kv family
WO2009111218A3 (en) Ccr5 antagonists as prophylactics for preventing hiv infection and methods of inhibiting transmission of same
PT2062569E (pt) Sistema de administração vaginal
JP2007277213A5 (es)
WO2008033543A3 (en) Halogenated alkyl di- and trisaccharides, pharmaceutical formulations, diagnostic kits and methods of treatment
WO2002024659A3 (en) Substituted imidazoles as dual histamine h1 and h3 agonists or antgonists
WO2011035120A3 (en) Therapeutic composition to treat lesions caused by herpes simplex virus
WO2007022082A3 (en) Vector delivery-based microbicides

Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status