MX2009008546A - Derivados de 3-amino-pirrolo[3,4-c]pirazol-5(1h,4h,6h)carbaldehido como inhibidores de la proteina quinasa c. - Google Patents

Derivados de 3-amino-pirrolo[3,4-c]pirazol-5(1h,4h,6h)carbaldehido como inhibidores de la proteina quinasa c.

Info

Publication number
MX2009008546A
MX2009008546A MX2009008546A MX2009008546A MX2009008546A MX 2009008546 A MX2009008546 A MX 2009008546A MX 2009008546 A MX2009008546 A MX 2009008546A MX 2009008546 A MX2009008546 A MX 2009008546A MX 2009008546 A MX2009008546 A MX 2009008546A
Authority
MX
Mexico
Prior art keywords
pyrrolo
pyrazole
amino
pkc inhibitors
compounds
Prior art date
Application number
MX2009008546A
Other languages
English (en)
Inventor
Min Teng
Hui Li
Seiji Nukui
Chunfeng Yin
Stephanie Anne Scales
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2009008546A publication Critical patent/MX2009008546A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

La presente invención se refiere a compuestos y sales farmacéuticamente aceptables de Fórmulas A y B: (ver fórmulas (A y B)) en las que A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9 y R10 son como se han definido anteriormente. La invención también se refiere a composiciones farmacéuticas que comprenden los compuestos y sales farmacéuticamente aceptables y a procedimientos de tratamiento de la diabetes mellitus y sus complicaciones, cáncer, isquemia, inflamación, trastornos del sistema nervioso central, enfermedad cardiovascular, enfermedad de Alzheimer y presión de enfermedad dermatológica, enfermedades virales, trastornos inflamatorios o enfermedades en las que el hígado es un órgano diana.
MX2009008546A 2007-02-07 2008-02-04 Derivados de 3-amino-pirrolo[3,4-c]pirazol-5(1h,4h,6h)carbaldehido como inhibidores de la proteina quinasa c. MX2009008546A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88874907P 2007-02-07 2007-02-07
US98908607P 2007-11-19 2007-11-19
US2096508P 2008-01-14 2008-01-14
PCT/IB2008/000297 WO2008096260A1 (en) 2007-02-07 2008-02-04 3-amino-pyrrolo[3,4-c] pyrazole- 5 (1h, 4h, 6h) carbaldehyde derivatives as pkc inhibitors

Publications (1)

Publication Number Publication Date
MX2009008546A true MX2009008546A (es) 2009-10-08

Family

ID=39493354

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008546A MX2009008546A (es) 2007-02-07 2008-02-04 Derivados de 3-amino-pirrolo[3,4-c]pirazol-5(1h,4h,6h)carbaldehido como inhibidores de la proteina quinasa c.

Country Status (20)

Country Link
US (6) US8183255B2 (es)
EP (1) EP2118112B1 (es)
JP (1) JP5161245B2 (es)
KR (1) KR101060892B1 (es)
AP (1) AP2009004958A0 (es)
AU (1) AU2008212625B2 (es)
BR (1) BRPI0807346B8 (es)
CA (1) CA2677572C (es)
CR (1) CR10968A (es)
DO (1) DOP2009000201A (es)
EA (1) EA017937B1 (es)
EC (1) ECSP099569A (es)
HK (1) HK1139130A1 (es)
IL (1) IL200270A (es)
MA (1) MA31178B1 (es)
MX (1) MX2009008546A (es)
NZ (1) NZ578876A (es)
TN (1) TN2009000331A1 (es)
WO (1) WO2008096260A1 (es)
ZA (1) ZA200906032B (es)

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MX2009008546A (es) 2007-02-07 2009-10-08 Pfizer Derivados de 3-amino-pirrolo[3,4-c]pirazol-5(1h,4h,6h)carbaldehido como inhibidores de la proteina quinasa c.
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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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CN106279202A (zh) * 2012-05-03 2017-01-04 霍夫曼-拉罗奇有限公司 作为lrrk2调节剂用于治疗帕金森病的吡唑氨基嘧啶衍生物
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JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
JP6421170B2 (ja) 2013-03-14 2018-11-07 ライジェル ファーマシューティカルズ， インコーポレイテッド プロテインキナーゼｃ阻害剤およびその使用
EP3057956B1 (en) 2013-10-18 2021-05-05 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
US20160264551A1 (en) 2013-10-18 2016-09-15 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of prolferative diseases
WO2015164604A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
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CN105377852B (zh) * 2014-05-23 2018-08-28 深圳明赛瑞霖药业有限公司 自身免疫疾病的治疗
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Also Published As

Publication number Publication date
IL200270A (en) 2014-07-31
BRPI0807346A2 (pt) 2016-07-26
JP2010518069A (ja) 2010-05-27
US20170217991A1 (en) 2017-08-03
MA31178B1 (fr) 2010-02-01
TN2009000331A1 (fr) 2010-12-31
US20200002359A1 (en) 2020-01-02
US8183255B2 (en) 2012-05-22
CA2677572A1 (en) 2008-08-14
CA2677572C (en) 2012-12-18
KR20090119883A (ko) 2009-11-20
DOP2009000201A (es) 2009-08-31
WO2008096260A1 (en) 2008-08-14
US11220518B2 (en) 2022-01-11
US20100130501A1 (en) 2010-05-27
KR101060892B1 (ko) 2011-08-31
EP2118112B1 (en) 2015-07-08
CR10968A (es) 2009-08-27
ZA200906032B (en) 2013-03-27
US20120202809A1 (en) 2012-08-09
EA017937B1 (ru) 2013-04-30
AU2008212625B2 (en) 2012-07-19
US11780853B2 (en) 2023-10-10
US8877761B2 (en) 2014-11-04
AU2008212625A1 (en) 2008-08-14
NZ578876A (en) 2012-12-21
JP5161245B2 (ja) 2013-03-13
ECSP099569A (es) 2009-09-29
IL200270A0 (en) 2010-04-29
US9518060B2 (en) 2016-12-13
EA200970670A1 (ru) 2010-02-26
AP2009004958A0 (en) 2009-08-31
US10316045B2 (en) 2019-06-11
HK1139130A1 (en) 2010-09-10
EP2118112A1 (en) 2009-11-18
US20220089613A1 (en) 2022-03-24
BRPI0807346B1 (pt) 2020-01-07
US20150099743A1 (en) 2015-04-09
BRPI0807346B8 (pt) 2021-05-25

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