UA96618C2 - 3-amino-pyrrolo[3,4-c] pyrazole- 5 (1h, 4h, 6h) carbaldehyde derivatives as pkc inhibitors - Google Patents

3-amino-pyrrolo[3,4-c] pyrazole- 5 (1h, 4h, 6h) carbaldehyde derivatives as pkc inhibitors

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Publication number
UA96618C2
UA96618C2 UAA200908264A UAA200908264A UA96618C2 UA 96618 C2 UA96618 C2 UA 96618C2 UA A200908264 A UAA200908264 A UA A200908264A UA A200908264 A UAA200908264 A UA A200908264A UA 96618 C2 UA96618 C2 UA 96618C2
Authority
UA
Ukraine
Prior art keywords
pyrrolo
pyrazole
amino
disease
pkc inhibitors
Prior art date
Application number
UAA200908264A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Гуи Ли
Сейдж Нукуи
Стефани Анн Скалес
Мин Тенг
Чюнфенг Юн
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of UA96618C2 publication Critical patent/UA96618C2/en

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Abstract

The present invention relates to compounds and pharmaceutically acceptable salts of Formulas A and B: (A) and (B) wherein A, B, R, R, R, R, R, R, R, R, Rand Rare as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications, cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disease pression, virus diseases, inflammatory disorders, or diseases in which the liver is a target organ.(A) and(B).
UAA200908264A 2007-02-07 2008-02-04 3-amino-pyrrolo[3,4-c] pyrazole- 5 (1h, 4h, 6h) carbaldehyde derivatives as pkc inhibitors UA96618C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88874907P 2007-02-07 2007-02-07

Publications (1)

Publication Number Publication Date
UA96618C2 true UA96618C2 (en) 2011-11-25

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ID=41658006

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UAA200908264A UA96618C2 (en) 2007-02-07 2008-02-04 3-amino-pyrrolo[3,4-c] pyrazole- 5 (1h, 4h, 6h) carbaldehyde derivatives as pkc inhibitors

Country Status (2)

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CN (1) CN101646673B (en)
UA (1) UA96618C2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6211061B2 (en) * 2012-05-03 2017-10-11 ジェネンテック， インコーポレイテッド Pyrazole aminopyrimidine derivatives as LRRK2 modulators for use in the treatment of Parkinson's disease
CN103435557B (en) * 2013-08-08 2015-05-20 爱斯特（成都）生物制药有限公司 5-fluorocytosine preparation method
AU2015263884B2 (en) * 2014-05-23 2019-11-14 Mingsight Pharmaceuticals, Inc. Treatment of autoimmune disease
CN104926735A (en) * 2015-06-16 2015-09-23 上海合全药物研发有限公司 Industrial preparation method for 4-chlorine-5-fluorine-2-methyl pyrimidine
CN111568905A (en) * 2015-11-20 2020-08-25 深圳明赛瑞霖药业有限公司 Treatment of autoimmune diseases
JP2019524700A (en) 2016-07-14 2019-09-05 ミングサイト ファーマシューティカルズ，インク． Cancer treatment
CN108929325A (en) * 2017-05-25 2018-12-04 深圳明赛瑞霖药业有限公司 Pkc inhibitor solid-state form
CN113563346A (en) * 2021-08-19 2021-10-29 守恒(厦门)医疗科技有限公司 Pyrrole [3,4-c ] pyrazole diamide derivatives and application thereof in antitumor drugs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81790C2 (en) * 2002-12-19 2008-02-11 Фармация Италия С.П.А. Substituted derivatives of pyrolopyrazol as kinaze inhibitors
US8067591B2 (en) * 2005-01-10 2011-11-29 Agouron Pharmaceuticals, Inc. Pyrrolopyrazole, potent kinase inhibitors

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Publication number Publication date
CN101646673A (en) 2010-02-10
CN101646673B (en) 2014-06-25

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