MX2009006884A - Procedimiento para preparar (1r,2s,5s)-n-[(1s)-3-amino-1-(ciclobut ilmetil)-2,3-dioxopropil]-3-[(2s)-2-[[[(1,1-dimetiletil)amino]-ca rbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3. 1.0]hexan-2-carboxamida. - Google Patents
Procedimiento para preparar (1r,2s,5s)-n-[(1s)-3-amino-1-(ciclobut ilmetil)-2,3-dioxopropil]-3-[(2s)-2-[[[(1,1-dimetiletil)amino]-ca rbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3. 1.0]hexan-2-carboxamida.Info
- Publication number
- MX2009006884A MX2009006884A MX2009006884A MX2009006884A MX2009006884A MX 2009006884 A MX2009006884 A MX 2009006884A MX 2009006884 A MX2009006884 A MX 2009006884A MX 2009006884 A MX2009006884 A MX 2009006884A MX 2009006884 A MX2009006884 A MX 2009006884A
- Authority
- MX
- Mexico
- Prior art keywords
- amino
- dimethyl
- preparing
- cyclobutylmet
- dioxopropyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere también a un procedimiento para la preparación de compuestos intermedios útiles para preparar los compuestos de la Fórmula I (ver fórmula (I)) utilizando el procedimiento del Esquema II (ver esquema (II)).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87644706P | 2006-12-20 | 2006-12-20 | |
PCT/US2007/025804 WO2008079216A1 (en) | 2006-12-20 | 2007-12-18 | Process for preparing (1r,2s,5s)-n-[(1s)-3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2s)-2-[[[(1,1-dimethylethyl)amino]-carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009006884A true MX2009006884A (es) | 2009-07-03 |
Family
ID=39232899
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009006884A MX2009006884A (es) | 2006-12-20 | 2007-12-18 | Procedimiento para preparar (1r,2s,5s)-n-[(1s)-3-amino-1-(ciclobut ilmetil)-2,3-dioxopropil]-3-[(2s)-2-[[[(1,1-dimetiletil)amino]-ca rbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3. 1.0]hexan-2-carboxamida. |
Country Status (14)
Country | Link |
---|---|
US (1) | US8163937B2 (es) |
EP (1) | EP2121605B1 (es) |
JP (1) | JP4955779B2 (es) |
CN (1) | CN101611000B (es) |
AR (1) | AR064465A1 (es) |
CA (1) | CA2672620A1 (es) |
ES (1) | ES2439246T3 (es) |
HK (1) | HK1133261A1 (es) |
HR (1) | HRP20131156T1 (es) |
MX (1) | MX2009006884A (es) |
PL (1) | PL2121605T3 (es) |
PT (1) | PT2121605E (es) |
WO (1) | WO2008079216A1 (es) |
ZA (1) | ZA200904330B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200924774A (en) * | 2007-10-26 | 2009-06-16 | Astrazeneca Ab | Fused pyrrolidine 1,2,4-triazole derivatives as modulators of mGluR5 |
EP2704570A4 (en) * | 2011-05-04 | 2015-02-18 | Merck Sharp & Dohme | ACTIVE SUBSTANCES, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF |
CN103508918B (zh) * | 2012-06-18 | 2015-09-09 | 上海医药工业研究院 | 带有环丁基的α-羟基β-氨基酯类化合物及其制备方法 |
WO2014061034A1 (en) * | 2012-10-18 | 2014-04-24 | Msn Laboratories Limited | Process for preparation of boceprevir and intermediates thereof |
WO2014083575A2 (en) | 2012-11-29 | 2014-06-05 | Mylan Laboratories Ltd | Improved process for the preparation of boceprevir intermediate |
CN103936652B (zh) * | 2013-01-18 | 2016-07-06 | 上海医药工业研究院 | 抗丙肝药物Boceprevir的中间体IV及其制备方法和应用 |
CN103936651B (zh) * | 2013-01-18 | 2016-06-22 | 上海医药工业研究院 | 抗丙肝药物Boceprevir的中间体Ⅲ及其制备方法和应用 |
CN103936818B (zh) * | 2013-01-18 | 2017-09-29 | 上海医药工业研究院 | 抗丙肝药物Boceprevir的中间体Ⅰ及其制备方法和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL206255B1 (pl) * | 2000-07-21 | 2010-07-30 | Dendreon Corporationdendreon Corporation | Inhibitor proteazy wirusa zapalenia wątroby C, zawierająca go kompozycja farmaceutyczna i zastosowanie inhibitora do wytwarzania leku do leczenia chorób związanych z HCV oraz zastosowanie do wytwarzania kompozycji do stosowania w kombinowanej terapii |
AR044694A1 (es) * | 2003-06-17 | 2005-09-21 | Schering Corp | Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo |
AR049635A1 (es) * | 2004-05-06 | 2006-08-23 | Schering Corp | (1r,2s,5s)-n-((1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil)-3-((2s)-2-((((1,1-dimetiletil)amino)carbonil)amino)-3,3-dimetil-1-oxobutil)-6,6-dimetil-3-azabiciclo(3.1.0)hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de la hepatitis c |
-
2007
- 2007-12-18 WO PCT/US2007/025804 patent/WO2008079216A1/en active Application Filing
- 2007-12-18 CN CN200780051535XA patent/CN101611000B/zh not_active Expired - Fee Related
- 2007-12-18 CA CA002672620A patent/CA2672620A1/en not_active Abandoned
- 2007-12-18 US US12/519,485 patent/US8163937B2/en not_active Expired - Fee Related
- 2007-12-18 PT PT78677986T patent/PT2121605E/pt unknown
- 2007-12-18 EP EP07867798.6A patent/EP2121605B1/en active Active
- 2007-12-18 JP JP2009542866A patent/JP4955779B2/ja not_active Expired - Fee Related
- 2007-12-18 PL PL07867798T patent/PL2121605T3/pl unknown
- 2007-12-18 MX MX2009006884A patent/MX2009006884A/es active IP Right Grant
- 2007-12-18 ES ES07867798.6T patent/ES2439246T3/es active Active
- 2007-12-19 AR ARP070105744A patent/AR064465A1/es not_active Application Discontinuation
-
2009
- 2009-06-19 ZA ZA200904330A patent/ZA200904330B/xx unknown
-
2010
- 2010-01-25 HK HK10100773.1A patent/HK1133261A1/xx not_active IP Right Cessation
-
2013
- 2013-12-03 HR HRP20131156TT patent/HRP20131156T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
WO2008079216A1 (en) | 2008-07-03 |
AR064465A1 (es) | 2009-04-01 |
PT2121605E (pt) | 2014-02-11 |
EP2121605A1 (en) | 2009-11-25 |
CN101611000B (zh) | 2013-08-21 |
JP2010513499A (ja) | 2010-04-30 |
PL2121605T3 (pl) | 2014-05-30 |
JP4955779B2 (ja) | 2012-06-20 |
ES2439246T3 (es) | 2014-01-22 |
ZA200904330B (en) | 2010-04-28 |
US20100145013A1 (en) | 2010-06-10 |
EP2121605B1 (en) | 2013-11-20 |
CA2672620A1 (en) | 2008-07-03 |
HK1133261A1 (en) | 2010-03-19 |
HRP20131156T1 (hr) | 2014-01-03 |
CN101611000A (zh) | 2009-12-23 |
US8163937B2 (en) | 2012-04-24 |
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Legal Events
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HH | Correction or change in general | ||
HC | Change of company name or juridical status |
Owner name: CORD BLOOD SCIENCE INC. |
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FG | Grant or registration |