MX2009006884A - Procedimiento para preparar (1r,2s,5s)-n-[(1s)-3-amino-1-(ciclobut ilmetil)-2,3-dioxopropil]-3-[(2s)-2-[[[(1,1-dimetiletil)amino]-ca rbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3. 1.0]hexan-2-carboxamida. - Google Patents

Procedimiento para preparar (1r,2s,5s)-n-[(1s)-3-amino-1-(ciclobut ilmetil)-2,3-dioxopropil]-3-[(2s)-2-[[[(1,1-dimetiletil)amino]-ca rbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3. 1.0]hexan-2-carboxamida.

Info

Publication number
MX2009006884A
MX2009006884A MX2009006884A MX2009006884A MX2009006884A MX 2009006884 A MX2009006884 A MX 2009006884A MX 2009006884 A MX2009006884 A MX 2009006884A MX 2009006884 A MX2009006884 A MX 2009006884A MX 2009006884 A MX2009006884 A MX 2009006884A
Authority
MX
Mexico
Prior art keywords
amino
dimethyl
preparing
cyclobutylmet
dioxopropyl
Prior art date
Application number
MX2009006884A
Other languages
English (en)
Inventor
Tetsuo Iwama
Hong-Chang Lee
George S K Wong
Weidong Tong
Jennifer A Vance
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2009006884A publication Critical patent/MX2009006884A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere también a un procedimiento para la preparación de compuestos intermedios útiles para preparar los compuestos de la Fórmula I (ver fórmula (I)) utilizando el procedimiento del Esquema II (ver esquema (II)).
MX2009006884A 2006-12-20 2007-12-18 Procedimiento para preparar (1r,2s,5s)-n-[(1s)-3-amino-1-(ciclobut ilmetil)-2,3-dioxopropil]-3-[(2s)-2-[[[(1,1-dimetiletil)amino]-ca rbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3. 1.0]hexan-2-carboxamida. MX2009006884A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87644706P 2006-12-20 2006-12-20
PCT/US2007/025804 WO2008079216A1 (en) 2006-12-20 2007-12-18 Process for preparing (1r,2s,5s)-n-[(1s)-3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2s)-2-[[[(1,1-dimethylethyl)amino]-carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

Publications (1)

Publication Number Publication Date
MX2009006884A true MX2009006884A (es) 2009-07-03

Family

ID=39232899

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006884A MX2009006884A (es) 2006-12-20 2007-12-18 Procedimiento para preparar (1r,2s,5s)-n-[(1s)-3-amino-1-(ciclobut ilmetil)-2,3-dioxopropil]-3-[(2s)-2-[[[(1,1-dimetiletil)amino]-ca rbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3. 1.0]hexan-2-carboxamida.

Country Status (14)

Country Link
US (1) US8163937B2 (es)
EP (1) EP2121605B1 (es)
JP (1) JP4955779B2 (es)
CN (1) CN101611000B (es)
AR (1) AR064465A1 (es)
CA (1) CA2672620A1 (es)
ES (1) ES2439246T3 (es)
HK (1) HK1133261A1 (es)
HR (1) HRP20131156T1 (es)
MX (1) MX2009006884A (es)
PL (1) PL2121605T3 (es)
PT (1) PT2121605E (es)
WO (1) WO2008079216A1 (es)
ZA (1) ZA200904330B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200924774A (en) * 2007-10-26 2009-06-16 Astrazeneca Ab Fused pyrrolidine 1,2,4-triazole derivatives as modulators of mGluR5
CN103476260A (zh) * 2011-05-04 2013-12-25 默沙东公司 用于制备丙型肝炎病毒抑制剂的方法
CN103508918B (zh) * 2012-06-18 2015-09-09 上海医药工业研究院 带有环丁基的α-羟基β-氨基酯类化合物及其制备方法
WO2014061034A1 (en) * 2012-10-18 2014-04-24 Msn Laboratories Limited Process for preparation of boceprevir and intermediates thereof
WO2014083575A2 (en) 2012-11-29 2014-06-05 Mylan Laboratories Ltd Improved process for the preparation of boceprevir intermediate
CN103936652B (zh) * 2013-01-18 2016-07-06 上海医药工业研究院 抗丙肝药物Boceprevir的中间体IV及其制备方法和应用
CN103936818B (zh) * 2013-01-18 2017-09-29 上海医药工业研究院 抗丙肝药物Boceprevir的中间体Ⅰ及其制备方法和应用
CN103936651B (zh) * 2013-01-18 2016-06-22 上海医药工业研究院 抗丙肝药物Boceprevir的中间体Ⅲ及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL206255B1 (pl) * 2000-07-21 2010-07-30 Dendreon Corporationdendreon Corporation Inhibitor proteazy wirusa zapalenia wątroby C, zawierająca go kompozycja farmaceutyczna i zastosowanie inhibitora do wytwarzania leku do leczenia chorób związanych z HCV oraz zastosowanie do wytwarzania kompozycji do stosowania w kombinowanej terapii
AR044694A1 (es) * 2003-06-17 2005-09-21 Schering Corp Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo
AR049635A1 (es) * 2004-05-06 2006-08-23 Schering Corp (1r,2s,5s)-n-((1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil)-3-((2s)-2-((((1,1-dimetiletil)amino)carbonil)amino)-3,3-dimetil-1-oxobutil)-6,6-dimetil-3-azabiciclo(3.1.0)hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de la hepatitis c

Also Published As

Publication number Publication date
ZA200904330B (en) 2010-04-28
CN101611000A (zh) 2009-12-23
WO2008079216A1 (en) 2008-07-03
US8163937B2 (en) 2012-04-24
HK1133261A1 (en) 2010-03-19
CA2672620A1 (en) 2008-07-03
PL2121605T3 (pl) 2014-05-30
CN101611000B (zh) 2013-08-21
US20100145013A1 (en) 2010-06-10
HRP20131156T1 (hr) 2014-01-03
EP2121605B1 (en) 2013-11-20
JP2010513499A (ja) 2010-04-30
EP2121605A1 (en) 2009-11-25
PT2121605E (pt) 2014-02-11
ES2439246T3 (es) 2014-01-22
JP4955779B2 (ja) 2012-06-20
AR064465A1 (es) 2009-04-01

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