AR064465A1 - Procesopatra preparar (1r, 2s, 5s) -n- [(1s)]-3- amino-1- ( ciclobutimetil) -2,3- dioxopropil] -3- [2s)-2- [[[(1,1- dimetiletil) amino]- carbonil] amino ]-3,3- dimetil -1- oxobutil] 6,6- dimetil-3- azabicoiclo (3.1.0] hexan -2- carboxamida - Google Patents

Procesopatra preparar (1r, 2s, 5s) -n- [(1s)]-3- amino-1- ( ciclobutimetil) -2,3- dioxopropil] -3- [2s)-2- [[[(1,1- dimetiletil) amino]- carbonil] amino ]-3,3- dimetil -1- oxobutil] 6,6- dimetil-3- azabicoiclo (3.1.0] hexan -2- carboxamida

Info

Publication number
AR064465A1
AR064465A1 ARP070105744A ARP070105744A AR064465A1 AR 064465 A1 AR064465 A1 AR 064465A1 AR P070105744 A ARP070105744 A AR P070105744A AR P070105744 A ARP070105744 A AR P070105744A AR 064465 A1 AR064465 A1 AR 064465A1
Authority
AR
Argentina
Prior art keywords
amino
dimetil
procesopatra
oxobutil
dioxopropil
Prior art date
Application number
ARP070105744A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR064465A1 publication Critical patent/AR064465A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente se refiere además a un proceso para la preparacion de compuestos intermedios utiles para preparar los compuestos de formula (1) utilizando el proceso del esquema (2).
ARP070105744A 2006-12-20 2007-12-19 Procesopatra preparar (1r, 2s, 5s) -n- [(1s)]-3- amino-1- ( ciclobutimetil) -2,3- dioxopropil] -3- [2s)-2- [[[(1,1- dimetiletil) amino]- carbonil] amino ]-3,3- dimetil -1- oxobutil] 6,6- dimetil-3- azabicoiclo (3.1.0] hexan -2- carboxamida AR064465A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87644706P 2006-12-20 2006-12-20

Publications (1)

Publication Number Publication Date
AR064465A1 true AR064465A1 (es) 2009-04-01

Family

ID=39232899

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070105744A AR064465A1 (es) 2006-12-20 2007-12-19 Procesopatra preparar (1r, 2s, 5s) -n- [(1s)]-3- amino-1- ( ciclobutimetil) -2,3- dioxopropil] -3- [2s)-2- [[[(1,1- dimetiletil) amino]- carbonil] amino ]-3,3- dimetil -1- oxobutil] 6,6- dimetil-3- azabicoiclo (3.1.0] hexan -2- carboxamida

Country Status (14)

Country Link
US (1) US8163937B2 (es)
EP (1) EP2121605B1 (es)
JP (1) JP4955779B2 (es)
CN (1) CN101611000B (es)
AR (1) AR064465A1 (es)
CA (1) CA2672620A1 (es)
ES (1) ES2439246T3 (es)
HK (1) HK1133261A1 (es)
HR (1) HRP20131156T1 (es)
MX (1) MX2009006884A (es)
PL (1) PL2121605T3 (es)
PT (1) PT2121605E (es)
WO (1) WO2008079216A1 (es)
ZA (1) ZA200904330B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009054791A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Fused pyrrolidine 1,2,4-triazole derivatives as modulators of mglur5
MX2013012773A (es) * 2011-05-04 2013-11-21 Merck Sharp & Dohme Sustancias farmacologicas, composiciones farmaceuticas y metodos para la preparacion de las mismas.
CN103508918B (zh) * 2012-06-18 2015-09-09 上海医药工业研究院 带有环丁基的α-羟基β-氨基酯类化合物及其制备方法
WO2014061034A1 (en) * 2012-10-18 2014-04-24 Msn Laboratories Limited Process for preparation of boceprevir and intermediates thereof
WO2014083575A2 (en) 2012-11-29 2014-06-05 Mylan Laboratories Ltd Improved process for the preparation of boceprevir intermediate
CN103936652B (zh) * 2013-01-18 2016-07-06 上海医药工业研究院 抗丙肝药物Boceprevir的中间体IV及其制备方法和应用
CN103936818B (zh) * 2013-01-18 2017-09-29 上海医药工业研究院 抗丙肝药物Boceprevir的中间体Ⅰ及其制备方法和应用
CN103936651B (zh) * 2013-01-18 2016-06-22 上海医药工业研究院 抗丙肝药物Boceprevir的中间体Ⅲ及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL206255B1 (pl) * 2000-07-21 2010-07-30 Dendreon Corporationdendreon Corporation Inhibitor proteazy wirusa zapalenia wątroby C, zawierająca go kompozycja farmaceutyczna i zastosowanie inhibitora do wytwarzania leku do leczenia chorób związanych z HCV oraz zastosowanie do wytwarzania kompozycji do stosowania w kombinowanej terapii
AR044694A1 (es) * 2003-06-17 2005-09-21 Schering Corp Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo
WO2005107745A1 (en) * 2004-05-06 2005-11-17 Schering Corporation An inhibitor of hepatitis c

Also Published As

Publication number Publication date
MX2009006884A (es) 2009-07-03
WO2008079216A1 (en) 2008-07-03
ZA200904330B (en) 2010-04-28
CA2672620A1 (en) 2008-07-03
EP2121605A1 (en) 2009-11-25
JP4955779B2 (ja) 2012-06-20
CN101611000B (zh) 2013-08-21
ES2439246T3 (es) 2014-01-22
JP2010513499A (ja) 2010-04-30
HK1133261A1 (en) 2010-03-19
US20100145013A1 (en) 2010-06-10
CN101611000A (zh) 2009-12-23
US8163937B2 (en) 2012-04-24
PT2121605E (pt) 2014-02-11
EP2121605B1 (en) 2013-11-20
PL2121605T3 (pl) 2014-05-30
HRP20131156T1 (hr) 2014-01-03

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