MXPA05013753A - Procedimiento y compuestos intermedios para la preparacion de (1r, 2s, 5s)-3 -azabiciclo [3, 1, 0]hexano-2 -carboxamida, n-[3-amino -1-(ciclobutilmetil) -2, 3-dioxopropil] -3-[(2s)-2 -[[[1, 1-dimetiletil] amino] carbonilamino] -3, 3-dimetil -1-oxobut - Google Patents

Procedimiento y compuestos intermedios para la preparacion de (1r, 2s, 5s)-3 -azabiciclo [3, 1, 0]hexano-2 -carboxamida, n-[3-amino -1-(ciclobutilmetil) -2, 3-dioxopropil] -3-[(2s)-2 -[[[1, 1-dimetiletil] amino] carbonilamino] -3, 3-dimetil -1-oxobut

Info

Publication number
MXPA05013753A
MXPA05013753A MXPA05013753A MXPA05013753A MXPA05013753A MX PA05013753 A MXPA05013753 A MX PA05013753A MX PA05013753 A MXPA05013753 A MX PA05013753A MX PA05013753 A MXPA05013753 A MX PA05013753A MX PA05013753 A MXPA05013753 A MX PA05013753A
Authority
MX
Mexico
Prior art keywords
dimethyl
amino
dioxopropyl
oxobutyl
cyclobutylmethyl
Prior art date
Application number
MXPA05013753A
Other languages
English (en)
Inventor
Tetsuo Iwama
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MXPA05013753A publication Critical patent/MXPA05013753A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

En una modalidad, la presente solicitud se refiere a un procedimiento para la preparacion de un compuesto de la formula I (ver formula I): y a ciertos compuestos intermedios que son fabricados dentro del procedimiento de preparacion del compuesto de la formula I.
MXPA05013753A 2003-06-17 2004-06-15 Procedimiento y compuestos intermedios para la preparacion de (1r, 2s, 5s)-3 -azabiciclo [3, 1, 0]hexano-2 -carboxamida, n-[3-amino -1-(ciclobutilmetil) -2, 3-dioxopropil] -3-[(2s)-2 -[[[1, 1-dimetiletil] amino] carbonilamino] -3, 3-dimetil -1-oxobut MXPA05013753A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47951703P 2003-06-17 2003-06-17
PCT/US2004/018914 WO2004113294A1 (en) 2003-06-17 2004-06-15 Process and intermediates for the preparation of (1r, 2s, 5s)-3-azabicyclo[3, 1, 0]hexane-2-carboxamide, n-[3-amino-1-(cyclobutylmethyl)-2, 3-dioxopropyl] ]-3-[(2s)-2-[[[1, 1-dimethylethyl]amino]carbonylamino]-3, 3-dimethyl-1-oxobutyl]-6, 6-dimethyl

Publications (1)

Publication Number Publication Date
MXPA05013753A true MXPA05013753A (es) 2006-03-08

Family

ID=33539185

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05013753A MXPA05013753A (es) 2003-06-17 2004-06-15 Procedimiento y compuestos intermedios para la preparacion de (1r, 2s, 5s)-3 -azabiciclo [3, 1, 0]hexano-2 -carboxamida, n-[3-amino -1-(ciclobutilmetil) -2, 3-dioxopropil] -3-[(2s)-2 -[[[1, 1-dimetiletil] amino] carbonilamino] -3, 3-dimetil -1-oxobut

Country Status (13)

Country Link
US (1) US7326795B2 (es)
EP (1) EP1641754B1 (es)
JP (1) JP5219368B2 (es)
CN (2) CN1805932B (es)
AR (1) AR044694A1 (es)
AT (1) ATE390412T1 (es)
CA (1) CA2526629C (es)
DE (1) DE602004012746T2 (es)
ES (1) ES2299850T3 (es)
HK (1) HK1084387A1 (es)
MX (1) MXPA05013753A (es)
WO (1) WO2004113294A1 (es)
ZA (1) ZA200509100B (es)

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US20050249702A1 (en) * 2004-05-06 2005-11-10 Schering Corporation (1R,2S,5S)-N-[(1S)-3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide as inhibitor of hepatitis C virus NS3/NS4a serine protease
NZ563365A (en) * 2005-06-02 2011-02-25 Schering Corp Combination of HCV protease inhibitors with a surfactant
AU2006252519B2 (en) * 2005-06-02 2012-08-30 Merck Sharp & Dohme Corp. HCV protease inhibitors in combination with food
US20060276404A1 (en) * 2005-06-02 2006-12-07 Anima Ghosal Medicaments and methods combining a HCV protease inhibitor and an AKR competitor
US20070237818A1 (en) * 2005-06-02 2007-10-11 Malcolm Bruce A Controlled-release formulation of HCV protease inhibitor and methods using the same
WO2007041632A2 (en) * 2005-09-30 2007-04-12 Scynexis, Inc. Methods and pharmaceutical compositions for the treatment and prevention of hepatitis c infection
AR056805A1 (es) 2005-11-14 2007-10-24 Schering Corp Un proceso para oxidacion para la preparcion de n- (3- amino-1- ( ciclobutilmetil) -2,3- dioxopropil ) -3-(n-(( ter-butilamino) carbonil )-3- metil- l- valil) -6,6- dimetil-3- azabiciclo (3.1.0) hexano -2- carboxamida y compuestos ralacionados
CN101384551B (zh) * 2005-12-22 2012-08-29 先灵公司 制备6,6-二甲基-3-氮杂双环-[3.1.0]-己烷化合物和其对映体盐的方法
JP5092289B2 (ja) * 2006-06-13 2012-12-05 三菱瓦斯化学株式会社 光学活性Ｎ−ｔｅｒｔ−ブチルカルバモイル−Ｌ−ｔｅｒｔ−ロイシンの製造方法
WO2008076316A2 (en) * 2006-12-15 2008-06-26 Schering Corporation Bisulfite purification of an alpha-keto amide
WO2008082486A2 (en) 2006-12-19 2008-07-10 Schering Corporation Preparation of 3-amino-3-(cyclobutylmethyl)-2-(hydroxy)-propionamide hydrochloride
WO2008082508A2 (en) * 2006-12-20 2008-07-10 Schering Corporation Process for the preparation of 6,6-dimethyl-3-azabicyclo- [3.1.0]- hexane compounds utilizing bisulfite intermediate
ES2439246T3 (es) * 2006-12-20 2014-01-22 Merck Sharp & Dohme Corp. Procedimiento de preparación de (1R,2S,5S)-N-[(1S)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil]-3-[(2S)-2-[[[(1,1-dimetiletil)amino]carbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3.1.0]hexan-2-carboxamida
WO2009039361A2 (en) * 2007-09-20 2009-03-26 Virobay, Inc. Process for the preparation of (s)-2-(3-tert-butylureido)-3,3-dimethylbutanoic acid
US8183408B2 (en) 2007-11-16 2012-05-22 Kaneka Corporation Process for production of N-carbamoyl-tert-leucine
JP2011503231A (ja) * 2007-11-20 2011-01-27 コンサート ファーマシューティカルズ インコーポレイテッド Ｈｃｖ感染処置のためのペプチド
WO2009073380A1 (en) * 2007-11-28 2009-06-11 Schering Corporation Dehydrohalogenation process for the preparation of intermediates useful in providing 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds
MX2010007022A (es) * 2007-12-21 2010-10-05 Schering Corp Proceso para la síntesis de 3-amino-3-ciclobutilmetil-2-hidroxipro pionamida o sus sales.
WO2010002474A1 (en) * 2008-07-03 2010-01-07 Vertex Pharmaceuticals Incorporated Preparation of protected alpha-keto beta-amino esters and amides
US8188137B2 (en) 2008-08-15 2012-05-29 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
US20120244122A1 (en) 2009-05-28 2012-09-27 Masse Craig E Peptides for the Treatment of HCV Infections
WO2012151271A1 (en) * 2011-05-04 2012-11-08 Merck Sharp & Dohme Corp. Processes for preparing inhibitors of the hepatitis c virus
IN2014DN10328A (es) 2012-06-20 2015-08-07 Sandoz Ag
WO2014061034A1 (en) * 2012-10-18 2014-04-24 Msn Laboratories Limited Process for preparation of boceprevir and intermediates thereof
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
CN103936627B (zh) * 2013-01-18 2016-08-31 上海医药工业研究院 抗丙肝药物Boceprevir的中间体Ⅶ及其制备方法和应用
US20140256698A1 (en) * 2013-03-11 2014-09-11 Virobay, Inc. Cathepsin inhibitors
WO2015004685A2 (en) 2013-07-12 2015-01-15 Mylan Laboratories Ltd An improved process for the purification of boceprevir
WO2015054662A1 (en) 2013-10-10 2015-04-16 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as 12-lipoxygenase inhibitors
CN104744291B (zh) * 2015-02-13 2017-01-11 宁波九胜创新医药科技有限公司 N-苄基-4-环丁基-2-羟基-3-硝基丁酰胺及其用途
WO2018035249A1 (en) * 2016-08-16 2018-02-22 Imago Biosciences, Inc. Compositions and methods for producing stereoisomerically pure aminocyclopropanes

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KR100330553B1 (ko) * 1993-10-01 2002-11-27 노파르티스 아게 약물학적활성피리딘유도체및그의제조방법
US7244721B2 (en) * 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
DK1385870T3 (da) * 2000-07-21 2010-07-05 Schering Corp Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus

Also Published As

Publication number Publication date
CN1805932B (zh) 2011-05-18
HK1084387A1 (en) 2006-07-28
US20050059800A1 (en) 2005-03-17
CN102199111A (zh) 2011-09-28
CN102199111B (zh) 2012-07-04
EP1641754B1 (en) 2008-03-26
EP1641754A1 (en) 2006-04-05
ATE390412T1 (de) 2008-04-15
CA2526629C (en) 2012-10-02
AR044694A1 (es) 2005-09-21
ZA200509100B (en) 2011-06-29
ES2299850T3 (es) 2008-06-01
WO2004113294A1 (en) 2004-12-29
CN1805932A (zh) 2006-07-19
JP2006528133A (ja) 2006-12-14
DE602004012746T2 (de) 2009-04-09
US7326795B2 (en) 2008-02-05
CA2526629A1 (en) 2004-12-29
DE602004012746D1 (de) 2008-05-08
JP5219368B2 (ja) 2013-06-26

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