MX2009006720A - Preparacion de clorhidrato de 3-amino-3-(ciclobutilmetil)-2(hidrox i)-propionamida. - Google Patents

Preparacion de clorhidrato de 3-amino-3-(ciclobutilmetil)-2(hidrox i)-propionamida.

Info

Publication number
MX2009006720A
MX2009006720A MX2009006720A MX2009006720A MX2009006720A MX 2009006720 A MX2009006720 A MX 2009006720A MX 2009006720 A MX2009006720 A MX 2009006720A MX 2009006720 A MX2009006720 A MX 2009006720A MX 2009006720 A MX2009006720 A MX 2009006720A
Authority
MX
Mexico
Prior art keywords
amino
cyclobutylmethyl
hydroxy
preparation
ide hydrochloride
Prior art date
Application number
MX2009006720A
Other languages
English (en)
Inventor
Ramani R Raghavan
Tetsuo Iwama
Hong-Chang Lee
George S K Wong
Eugene J Vater
Jeonghan Park
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2009006720A publication Critical patent/MX2009006720A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/26—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2529/00—Catalysts comprising molecular sieves
    • C07C2529/04—Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites, pillared clays
    • C07C2529/06—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof
    • C07C2529/40—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se describe un procedimiento para preparar clorhidrato de 3-(amino)-3-ciclobutilmetil-2-hidroxi-propionamida, un intermedio útil en la preparación del inhibidor de proteasa HCV (1R,5S)-N-[3-amino-1-(ciclobutilmetil)-2,3-dioxopropil]-3-[2(S)-[ [[(1,1-dimetiletil)amino]carbonjl]amjno]-3,3-dimetil-1-oxobutil]- 6,6-dimetil-3-azabiciclo[3.1.0]hexan-2(S)-carboxamida.
MX2009006720A 2006-12-19 2007-12-17 Preparacion de clorhidrato de 3-amino-3-(ciclobutilmetil)-2(hidrox i)-propionamida. MX2009006720A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87602806P 2006-12-19 2006-12-19
PCT/US2007/025759 WO2008082486A2 (en) 2006-12-19 2007-12-17 Preparation of 3-amino-3-(cyclobutylmethyl)-2-(hydroxy)-propionamide hydrochloride

Publications (1)

Publication Number Publication Date
MX2009006720A true MX2009006720A (es) 2009-08-28

Family

ID=39473152

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006720A MX2009006720A (es) 2006-12-19 2007-12-17 Preparacion de clorhidrato de 3-amino-3-(ciclobutilmetil)-2(hidrox i)-propionamida.

Country Status (8)

Country Link
US (1) US20100113821A1 (es)
EP (1) EP2121568A2 (es)
JP (1) JP2010513492A (es)
CN (1) CN101610991A (es)
CA (1) CA2672570A1 (es)
MX (1) MX2009006720A (es)
SG (1) SG177906A1 (es)
WO (1) WO2008082486A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010119902A1 (ja) * 2009-04-16 2010-10-21 三井化学アグロ株式会社 ２-アルキル-３-アミノチオフェン誘導体の製造方法
WO2014153113A2 (en) * 2013-03-14 2014-09-25 Virobay, Inc. Processes and intermediates for the preparation of 3 amino-n-cyclopropyl-2 hydroxypropionamide derivatives
WO2015004685A2 (en) 2013-07-12 2015-01-15 Mylan Laboratories Ltd An improved process for the purification of boceprevir
CN103420951A (zh) * 2013-09-03 2013-12-04 天津全和诚科技有限责任公司 一种合成氧杂环丁烷-3-甲醛的方法
KR101663312B1 (ko) * 2014-04-23 2016-10-06 아주대학교산학협력단 α, β- 치환 카르보닐 화합물 및 그 합성방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1467989B1 (en) * 2002-01-23 2009-09-23 Schering Corporation Proline compounds as ns3-serine protease inhibitors for use in treatment of hepatitis c virus infection
CA2526634C (en) 2003-06-17 2012-09-18 Schering Corporation Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof
AR044694A1 (es) * 2003-06-17 2005-09-21 Schering Corp Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo
US7309717B2 (en) * 2003-06-17 2007-12-18 Schering Corporation Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof
AR049635A1 (es) 2004-05-06 2006-08-23 Schering Corp (1r,2s,5s)-n-((1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil)-3-((2s)-2-((((1,1-dimetiletil)amino)carbonil)amino)-3,3-dimetil-1-oxobutil)-6,6-dimetil-3-azabiciclo(3.1.0)hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de la hepatitis c

Also Published As

Publication number Publication date
CA2672570A1 (en) 2008-07-10
SG177906A1 (en) 2012-02-28
WO2008082486A2 (en) 2008-07-10
EP2121568A2 (en) 2009-11-25
CN101610991A (zh) 2009-12-23
WO2008082486A3 (en) 2008-09-04
US20100113821A1 (en) 2010-05-06
JP2010513492A (ja) 2010-04-30

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