MX2010007022A - Proceso para la síntesis de 3-amino-3-ciclobutilmetil-2-hidroxipro pionamida o sus sales. - Google Patents

Proceso para la síntesis de 3-amino-3-ciclobutilmetil-2-hidroxipro pionamida o sus sales.

Info

Publication number
MX2010007022A
MX2010007022A MX2010007022A MX2010007022A MX2010007022A MX 2010007022 A MX2010007022 A MX 2010007022A MX 2010007022 A MX2010007022 A MX 2010007022A MX 2010007022 A MX2010007022 A MX 2010007022A MX 2010007022 A MX2010007022 A MX 2010007022A
Authority
MX
Mexico
Prior art keywords
formula
cyclobutylmethyl
amino
compound
synthesis
Prior art date
Application number
MX2010007022A
Other languages
English (en)
Inventor
Jeonghan Park
Shuan Dong
Eugene John Vater
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2010007022A publication Critical patent/MX2010007022A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Un procedimiento para preparar 3-amino-3-ciclobutilmetil-2-hidroxi propionamida de la fórmula I: (ver fórmula (I)) a una sal de la misma implica proveer un compuesto de la fórmula VI que se describe en la presente en una solución que comprende predominantemente sulfóxido de dimetilo (DMSO) y convertir este compuesto directamente en el compuesto de la fórmula VIII que se describe en la presente sin elaborar o aislar el compuesto intermediario de la fórmula VII que se describe en la presente.
MX2010007022A 2007-12-21 2008-12-17 Proceso para la síntesis de 3-amino-3-ciclobutilmetil-2-hidroxipro pionamida o sus sales. MX2010007022A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US889507P 2007-12-21 2007-12-21
PCT/US2008/087228 WO2009085858A1 (en) 2007-12-21 2008-12-17 Process for the synthesis of 3-amino-3-cyclobutylmethyl-2-hydroxypropionamide or salts thereof

Publications (1)

Publication Number Publication Date
MX2010007022A true MX2010007022A (es) 2010-10-05

Family

ID=40578166

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010007022A MX2010007022A (es) 2007-12-21 2008-12-17 Proceso para la síntesis de 3-amino-3-ciclobutilmetil-2-hidroxipro pionamida o sus sales.

Country Status (8)

Country Link
US (1) US8586765B2 (es)
EP (1) EP2238100B1 (es)
JP (1) JP5203468B2 (es)
CN (1) CN102089274B (es)
AR (1) AR071270A1 (es)
CA (1) CA2710236A1 (es)
MX (1) MX2010007022A (es)
WO (1) WO2009085858A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013066734A1 (en) * 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Process and intermediates for the preparation of 3-amino-4-cyclobutyl-2-hydroxybutanamide and salts thereof
WO2014083575A2 (en) 2012-11-29 2014-06-05 Mylan Laboratories Ltd Improved process for the preparation of boceprevir intermediate
WO2015004685A2 (en) 2013-07-12 2015-01-15 Mylan Laboratories Ltd An improved process for the purification of boceprevir
CN103387510B (zh) * 2013-08-08 2015-09-09 苏州永健生物医药有限公司 一种β-氨基-alpha-羟基环丁基丁酰胺盐酸盐的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
DK1385870T3 (da) 2000-07-21 2010-07-05 Schering Corp Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus
AR044694A1 (es) * 2003-06-17 2005-09-21 Schering Corp Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo
WO2004113272A1 (en) 2003-06-17 2004-12-29 Schering Corporation Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof

Also Published As

Publication number Publication date
EP2238100B1 (en) 2014-03-26
EP2238100A1 (en) 2010-10-13
WO2009085858A1 (en) 2009-07-09
US20110034705A1 (en) 2011-02-10
JP2011507876A (ja) 2011-03-10
CN102089274B (zh) 2014-09-10
CA2710236A1 (en) 2009-07-09
JP5203468B2 (ja) 2013-06-05
US8586765B2 (en) 2013-11-19
CN102089274A (zh) 2011-06-08
AR071270A1 (es) 2010-06-09

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