TW200635910A - Dipeptide nitriles - Google Patents

Dipeptide nitriles

Info

Publication number
TW200635910A
TW200635910A TW094143968A TW94143968A TW200635910A TW 200635910 A TW200635910 A TW 200635910A TW 094143968 A TW094143968 A TW 094143968A TW 94143968 A TW94143968 A TW 94143968A TW 200635910 A TW200635910 A TW 200635910A
Authority
TW
Taiwan
Prior art keywords
dipeptide nitriles
dipeptide
nitriles
cyanomethyl
piperazin
Prior art date
Application number
TW094143968A
Other languages
Chinese (zh)
Inventor
Sabine Pfeffer
Frederic Nobs
Piotr H Karpinski
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TW200635910A publication Critical patent/TW200635910A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention is directed to novel salts and modifications of N-[1-(cyanomethyl-carbamoyl)-cyclohexyl]-4-(4-propyl-piperazin-1-yl)-benzamide, their use in medicine, processes for their preparation and their use in the manufacture of pharmaceutical preparations.
TW094143968A 2004-12-14 2005-12-13 Dipeptide nitriles TW200635910A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0427380.1A GB0427380D0 (en) 2004-12-14 2004-12-14 Organic compounds

Publications (1)

Publication Number Publication Date
TW200635910A true TW200635910A (en) 2006-10-16

Family

ID=34090027

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094143968A TW200635910A (en) 2004-12-14 2005-12-13 Dipeptide nitriles

Country Status (6)

Country Link
AR (1) AR052161A1 (en)
GB (1) GB0427380D0 (en)
GT (1) GT200500365A (en)
PE (1) PE20060742A1 (en)
TW (1) TW200635910A (en)
WO (1) WO2006063762A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2678717A1 (en) 2007-02-28 2008-09-04 Sanofi-Aventis Imaging probes
WO2009103432A2 (en) * 2008-02-21 2009-08-27 Sanofi-Aventis Covalently binding imaging probes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200001189T2 (en) * 1997-11-05 2000-09-21 Novartis Ag. Dipeptide nitriles.
GB0003111D0 (en) * 2000-02-10 2000-03-29 Novartis Ag Organic compounds
AU2004262903B2 (en) * 2003-07-21 2007-08-23 Novartis Ag Combinations of a Cathepsin K inhibitor and a bisphophonate in the treatment of bone metastasis, tumor growth and tumor-induced bone loss
US20070135448A1 (en) * 2003-11-19 2007-06-14 Martin Missbach Use of cathepsin k inhibitors for treating of severe bone loss diseases

Also Published As

Publication number Publication date
GT200500365A (en) 2006-07-17
GB0427380D0 (en) 2005-01-19
WO2006063762A1 (en) 2006-06-22
AR052161A1 (en) 2007-03-07
PE20060742A1 (en) 2006-09-08

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