ATE390412T1 - Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-3-azabicyclo(3,1,0)hexane-2- carboxamide,n-(3-amino-1-(cyclobutylmethyl)-2,3 dioxopropyl) )-3-((2s)-2-(((1,1- dimethylethyl)amino)carbonylamino)-3,3-dimethyl 1-oxobutyl)-6,6-dimethyl - Google Patents

Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-3-azabicyclo(3,1,0)hexane-2- carboxamide,n-(3-amino-1-(cyclobutylmethyl)-2,3 dioxopropyl) )-3-((2s)-2-(((1,1- dimethylethyl)amino)carbonylamino)-3,3-dimethyl 1-oxobutyl)-6,6-dimethyl

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Publication number
ATE390412T1
ATE390412T1 AT04755225T AT04755225T ATE390412T1 AT E390412 T1 ATE390412 T1 AT E390412T1 AT 04755225 T AT04755225 T AT 04755225T AT 04755225 T AT04755225 T AT 04755225T AT E390412 T1 ATE390412 T1 AT E390412T1
Authority
AT
Austria
Prior art keywords
dimethyl
amino
dioxopropyl
oxobutyl
cyclobutylmethyl
Prior art date
Application number
AT04755225T
Other languages
English (en)
Inventor
Anantha Sudhakar
Vilas Dahanukar
Ilia Zavialov
Cecilia Orr
Hoa Nguyen
Juergen Weber
Ingyu Jeon
Minzhang Chen
Michael Green
George Wong
Jeonghan Park
Tetsuo Iwama
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE390412T1 publication Critical patent/ATE390412T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT04755225T 2003-06-17 2004-06-15 Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-3-azabicyclo(3,1,0)hexane-2- carboxamide,n-(3-amino-1-(cyclobutylmethyl)-2,3 dioxopropyl) )-3-((2s)-2-(((1,1- dimethylethyl)amino)carbonylamino)-3,3-dimethyl 1-oxobutyl)-6,6-dimethyl ATE390412T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47951703P 2003-06-17 2003-06-17

Publications (1)

Publication Number Publication Date
ATE390412T1 true ATE390412T1 (de) 2008-04-15

Family

ID=33539185

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04755225T ATE390412T1 (de) 2003-06-17 2004-06-15 Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-3-azabicyclo(3,1,0)hexane-2- carboxamide,n-(3-amino-1-(cyclobutylmethyl)-2,3 dioxopropyl) )-3-((2s)-2-(((1,1- dimethylethyl)amino)carbonylamino)-3,3-dimethyl 1-oxobutyl)-6,6-dimethyl

Country Status (13)

Country Link
US (1) US7326795B2 (de)
EP (1) EP1641754B1 (de)
JP (1) JP5219368B2 (de)
CN (2) CN102199111B (de)
AR (1) AR044694A1 (de)
AT (1) ATE390412T1 (de)
CA (1) CA2526629C (de)
DE (1) DE602004012746T2 (de)
ES (1) ES2299850T3 (de)
HK (1) HK1084387A1 (de)
MX (1) MXPA05013753A (de)
WO (1) WO2004113294A1 (de)
ZA (1) ZA200509100B (de)

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WO2006130686A2 (en) 2005-06-02 2006-12-07 Schering Corporation Hcv protease inhibitors in combination with food
US20070237818A1 (en) * 2005-06-02 2007-10-11 Malcolm Bruce A Controlled-release formulation of HCV protease inhibitor and methods using the same
WO2006130666A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Medicaments and methods combining a hcv protease inhibitor and an akr competitor
CA2611155A1 (en) * 2005-06-02 2006-12-07 Schering Corporation Pharmaceutical formulations and methods of treatment using the same
KR20080059270A (ko) * 2005-09-30 2008-06-26 싸이넥시스, 인크. Ｃ형 간염 감염의 치료 및 예방을 위한 방법 및 제약조성물
AR056805A1 (es) 2005-11-14 2007-10-24 Schering Corp Un proceso para oxidacion para la preparcion de n- (3- amino-1- ( ciclobutilmetil) -2,3- dioxopropil ) -3-(n-(( ter-butilamino) carbonil )-3- metil- l- valil) -6,6- dimetil-3- azabiciclo (3.1.0) hexano -2- carboxamida y compuestos ralacionados
CA2634397A1 (en) * 2005-12-22 2007-07-05 Schering Corporation Process for the preparation of 6,6-dimethyl-3-azabicyclo[3.1.0|-hexane compounds and enantiomeric salts thereof
JP5092289B2 (ja) * 2006-06-13 2012-12-05 三菱瓦斯化学株式会社 光学活性Ｎ−ｔｅｒｔ−ブチルカルバモイル−Ｌ−ｔｅｒｔ−ロイシンの製造方法
CA2672268A1 (en) * 2006-12-15 2008-06-26 Schering Corporation Bisulfite purification of an alpha-keto amide
JP2010513492A (ja) 2006-12-19 2010-04-30 シェーリング コーポレイション ３−（アミノ）−３−（シクロブチルメチル）−２−（ヒドロキシ）−プロピオンアミド塩酸塩の調製
JP4955779B2 (ja) * 2006-12-20 2012-06-20 シェーリング コーポレイション （１ｒ，２ｓ，５ｓ）−ｎ−［（１ｓ）−３−アミノ−１−（シクロブチルメチル）−２，３−ジオキソプロピル］−３−［（２ｓ）−２−［［［（１，１−ジメチルエチル）アミノ］カルボニル］−アミノ］−３，３−ジメチル−１−オキソブチル］−６，６−ジメチル−３−アザビシクロ［３．１．０］ヘキサン−２−カルボキサミドを調製するための方法
AR064432A1 (es) * 2006-12-20 2009-04-01 Schering Corp Proceso para la preparacion de compuestos 6, 6-dimetil-3-aza-biciclo[3.1.0]-hexano utilizando intermediarios bisulfiticos derivados de pirrolidinas biciclicas, dichos intermediarios y un metodo para su obtencion.
WO2009039361A2 (en) * 2007-09-20 2009-03-26 Virobay, Inc. Process for the preparation of (s)-2-(3-tert-butylureido)-3,3-dimethylbutanoic acid
JP5647790B2 (ja) 2007-11-16 2015-01-07 株式会社カネカ Ｎ−カルバモイル−ｔｅｒｔ−ロイシンの製造法
JP2011503231A (ja) * 2007-11-20 2011-01-27 コンサート ファーマシューティカルズ インコーポレイテッド Ｈｃｖ感染処置のためのペプチド
EP2225203A1 (de) * 2007-11-28 2010-09-08 Schering Corporation Dehydrohalogenierungsverfahren zur herstellung von für die bereitstellung von 6,6-dimethyl-3-azabicyclo[3.1.0]hexanverbindungen nützlichen zwischenprodukten
WO2009085858A1 (en) * 2007-12-21 2009-07-09 Schering Corporation Process for the synthesis of 3-amino-3-cyclobutylmethyl-2-hydroxypropionamide or salts thereof
MX2011000104A (es) * 2008-07-03 2011-02-22 Vertex Pharma Preparacion de alfa-ceto beta-amino esteres y amidas protegidos.
US8188137B2 (en) 2008-08-15 2012-05-29 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
US20120244122A1 (en) 2009-05-28 2012-09-27 Masse Craig E Peptides for the Treatment of HCV Infections
KR20140030169A (ko) * 2011-05-04 2014-03-11 머크 샤프 앤드 돔 코포레이션 약물 물질, 제약 조성물 및 그의 제조 방법
EP2864321A1 (de) * 2012-06-20 2015-04-29 Sandoz AG Synthese von telaprevir und boceprevir oder pharmazeutisch akzeptablen salzen oder solvaten sowie zwischenprodukte davon mit ss-aminosäuren, hergestellt durch zugabe von mukaiyamaaldol
WO2014061034A1 (en) * 2012-10-18 2014-04-24 Msn Laboratories Limited Process for preparation of boceprevir and intermediates thereof
US10238771B2 (en) * 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
CN103936627B (zh) * 2013-01-18 2016-08-31 上海医药工业研究院 抗丙肝药物Boceprevir的中间体Ⅶ及其制备方法和应用
WO2014164844A1 (en) * 2013-03-11 2014-10-09 Virobay, Inc. Cathepsin inhibitors
WO2015004685A2 (en) 2013-07-12 2015-01-15 Mylan Laboratories Ltd An improved process for the purification of boceprevir
CA2926950C (en) 2013-10-10 2022-10-11 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
CN104744291B (zh) * 2015-02-13 2017-01-11 宁波九胜创新医药科技有限公司 N-苄基-4-环丁基-2-羟基-3-硝基丁酰胺及其用途
WO2018035249A1 (en) * 2016-08-16 2018-02-22 Imago Biosciences, Inc. Compositions and methods for producing stereoisomerically pure aminocyclopropanes

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PL179417B1 (en) * 1993-10-01 2000-09-29 Novartis Ag Pharmacologically active derivatives of pyridine and methods of obtaining them
CN102372764A (zh) * 2000-07-21 2012-03-14 先灵公司 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽
US7244721B2 (en) * 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus

Also Published As

Publication number Publication date
CN102199111A (zh) 2011-09-28
US20050059800A1 (en) 2005-03-17
MXPA05013753A (es) 2006-03-08
JP5219368B2 (ja) 2013-06-26
WO2004113294A1 (en) 2004-12-29
CN1805932A (zh) 2006-07-19
CN1805932B (zh) 2011-05-18
ZA200509100B (en) 2011-06-29
DE602004012746T2 (de) 2009-04-09
ES2299850T3 (es) 2008-06-01
CA2526629A1 (en) 2004-12-29
JP2006528133A (ja) 2006-12-14
CN102199111B (zh) 2012-07-04
HK1084387A1 (en) 2006-07-28
EP1641754B1 (de) 2008-03-26
CA2526629C (en) 2012-10-02
AR044694A1 (es) 2005-09-21
US7326795B2 (en) 2008-02-05
EP1641754A1 (de) 2006-04-05
DE602004012746D1 (de) 2008-05-08

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