MX2009004112A - Imidazoles sustituidos como moduladores del receptor de bombesina subtipo-3. - Google Patents
Imidazoles sustituidos como moduladores del receptor de bombesina subtipo-3.Info
- Publication number
- MX2009004112A MX2009004112A MX2009004112A MX2009004112A MX2009004112A MX 2009004112 A MX2009004112 A MX 2009004112A MX 2009004112 A MX2009004112 A MX 2009004112A MX 2009004112 A MX2009004112 A MX 2009004112A MX 2009004112 A MX2009004112 A MX 2009004112A
- Authority
- MX
- Mexico
- Prior art keywords
- bombesin receptor
- receptor subtype
- modulators
- substituted imidazoles
- brs
- Prior art date
Links
- 102100028628 Bombesin receptor subtype-3 Human genes 0.000 title abstract 3
- 108010063504 bombesin receptor subtype 3 Proteins 0.000 title abstract 3
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 108010073466 Bombesin Receptors Proteins 0.000 abstract 1
- 101000695054 Homo sapiens Bombesin receptor subtype-3 Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85319306P | 2006-10-20 | 2006-10-20 | |
| PCT/US2007/022087 WO2008051406A2 (en) | 2006-10-20 | 2007-10-16 | Substituted imidazoles as bombesin receptor subtype-3 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009004112A true MX2009004112A (es) | 2009-05-11 |
Family
ID=39325111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009004112A MX2009004112A (es) | 2006-10-20 | 2007-10-16 | Imidazoles sustituidos como moduladores del receptor de bombesina subtipo-3. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8193228B2 (https=) |
| EP (1) | EP2091937A2 (https=) |
| JP (1) | JP5047299B2 (https=) |
| KR (1) | KR20090064458A (https=) |
| CN (1) | CN101528730A (https=) |
| AU (1) | AU2007309570B2 (https=) |
| BR (1) | BRPI0717976A2 (https=) |
| CA (1) | CA2666310C (https=) |
| IL (1) | IL198004A0 (https=) |
| MX (1) | MX2009004112A (https=) |
| NO (1) | NO20091957L (https=) |
| RU (1) | RU2009118935A (https=) |
| WO (1) | WO2008051406A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010506916A (ja) | 2006-10-20 | 2010-03-04 | メルク エンド カムパニー インコーポレーテッド | ボンベシンレセプターサブタイプ３モジュレーターとしての置換イミダゾール |
| WO2008051405A1 (en) | 2006-10-20 | 2008-05-02 | Merck & Co., Inc. | Substituted imidazoles as bombesin receptor subtype-3 modulators |
| WO2009123164A1 (ja) * | 2008-04-02 | 2009-10-08 | 塩野義製薬株式会社 | 血管内皮リパーゼ阻害活性を有するヘテロ環誘導体 |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013135674A1 (en) * | 2012-03-12 | 2013-09-19 | Syngenta Participations Ag | Insecticidal 2-aryl-acetamide compounds |
| CN103497159B (zh) * | 2013-09-18 | 2015-08-12 | 苏州岚云医药科技有限公司 | 1,2-二取代-5-磺酰基咪唑类化合物的制备方法 |
| HUE061437T2 (hu) | 2015-10-23 | 2023-06-28 | Navitor Pharm Inc | A Sestrin-GATOR2 kölcsönhatás modulátorai és ezek alkalmazásai |
| US10912750B2 (en) | 2017-04-26 | 2021-02-09 | Navitor Pharmaceuticals, Inc. | Modulators of Sestrin-GATOR2 interaction and uses thereof |
| CN113164414A (zh) | 2018-10-24 | 2021-07-23 | 纳维托制药有限公司 | 多晶型化合物和其用途 |
| CA3156436A1 (en) | 2019-11-01 | 2021-05-06 | Steven LEVENTER | Methods of treatment using an mtorc1 modulator |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4962117A (en) * | 1987-11-25 | 1990-10-09 | Merck Frosst Canada, Inc. | Heterazole dialkanoic acids |
| WO1993017681A1 (en) | 1992-03-02 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
| JPH07243068A (ja) | 1994-03-08 | 1995-09-19 | Murata:Kk | 金属表面の電解処理方法 |
| WO1997040017A2 (en) | 1996-04-19 | 1997-10-30 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| CN1246847A (zh) | 1996-12-23 | 2000-03-08 | 杜邦药品公司 | 作为Xa因子抑制剂的含氮杂芳族化合物 |
| JPH11217348A (ja) | 1997-10-15 | 1999-08-10 | Otsuka Pharmaceut Co Ltd | フルオレノン誘導体の製造法 |
| IL136637A0 (en) | 1997-12-22 | 2001-06-14 | Du Pont Pharm Co | Nitrogen containing heteroaromatics with ortho-substituted pi's as factor xa inhibitors |
| AR024077A1 (es) * | 1999-05-25 | 2002-09-04 | Smithkline Beecham Corp | Compuestos antibacterianos |
| JP3842976B2 (ja) * | 2000-03-17 | 2006-11-08 | 富士通株式会社 | 分布帰還型半導体レーザとその製造方法 |
| US6787552B2 (en) | 2000-08-11 | 2004-09-07 | Nippon Chemiphar Co., Ltd. | PPAR delta activators |
| WO2002098840A1 (en) | 2001-06-04 | 2002-12-12 | Eisai Co., Ltd. | Carboxylic acid derivative and medicine comprising salt or ester of the same |
| AU2002323776B2 (en) | 2001-08-10 | 2008-07-31 | Nippon Chemiphar Co., Ltd. | Activator for peroxisome proliferator-responsive receptor Delta |
| AU2003209388A1 (en) * | 2002-01-29 | 2003-09-02 | Merck And Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
| JP2003321455A (ja) | 2002-02-28 | 2003-11-11 | Nissan Chem Ind Ltd | ｏ−置換ベンゾイル化合物及びこれを有効成分とする除草剤 |
| DE10224844A1 (de) | 2002-06-05 | 2004-01-08 | Solvay Pharmaceuticals Gmbh | Nicht-peptidische BRS-3-Agonisten |
| AU2003281039A1 (en) | 2002-07-10 | 2004-02-02 | Sumitomo Pharmaceuticals Co., Ltd. | Imidazole derivative |
| AU2003267728A1 (en) * | 2002-10-18 | 2004-05-04 | Pfizer Products Inc. | Cannabinoid receptor ligands and uses thereof |
| ATE455096T1 (de) | 2002-11-19 | 2010-01-15 | Galderma Res & Dev | Biaromatische verbindungen die ppar-gamma rezeptoren aktivieren und deren anwendungen in kosmetischen oder pharmazeutischen zusammensetzungen |
| PL376736A1 (pl) | 2002-11-25 | 2006-01-09 | Galderma Research & Development, S.N.C. | Nowe związki diaromatyczne, które aktywują receptor typu PPAR<$Egamma> i ich zastosowanie w kompozycjach kosmetycznych lub farmaceutycznych |
| CN1747949A (zh) | 2002-12-20 | 2006-03-15 | 法马西亚公司 | 无环吡唑化合物 |
| JP2006518738A (ja) * | 2003-02-12 | 2006-08-17 | トランス テック ファーマ，インコーポレイテッド | 治療薬としての置換アゾール誘導体 |
| WO2004071509A1 (ja) | 2003-02-12 | 2004-08-26 | Nippon Chemiphar Co., Ltd. | オリゴデンドロサイト分化促進剤 |
| US20040167188A1 (en) * | 2003-02-14 | 2004-08-26 | Zhili Xin | Protein-tyrosine phosphatase inhibitors and uses thereof |
| JP4847868B2 (ja) | 2003-05-14 | 2011-12-28 | ニューロジェネティック ファーマシューティカルズ、 インコーポレイテッド | 化合物、及び、アミロイドベータの調節におけるその使用 |
| US7141596B2 (en) * | 2003-10-08 | 2006-11-28 | Incyte Corporation | Inhibitors of proteins that bind phosphorylated molecules |
| WO2005061459A1 (en) * | 2003-12-04 | 2005-07-07 | Wyeth | Biaryl sulfonamides and methods for using same |
| GB0328796D0 (en) | 2003-12-12 | 2004-01-14 | Biofocus Plc | Compounds which interact with the G-protein coupled receptor family |
| US7605171B2 (en) | 2003-12-17 | 2009-10-20 | Merck & Co., Inc. | (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists |
| JP4898458B2 (ja) * | 2004-02-12 | 2012-03-14 | トランス テック ファーマ，インコーポレイテッド | 置換アゾール誘導体、組成物及び使用方法 |
| GB0403578D0 (en) | 2004-02-18 | 2004-03-24 | Biofocus Discovery Ltd | Compounds which interact with the G-protein coupled receptor family |
| US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| WO2008051405A1 (en) | 2006-10-20 | 2008-05-02 | Merck & Co., Inc. | Substituted imidazoles as bombesin receptor subtype-3 modulators |
| JP2010506916A (ja) * | 2006-10-20 | 2010-03-04 | メルク エンド カムパニー インコーポレーテッド | ボンベシンレセプターサブタイプ３モジュレーターとしての置換イミダゾール |
-
2007
- 2007-10-16 WO PCT/US2007/022087 patent/WO2008051406A2/en not_active Ceased
- 2007-10-16 EP EP07839615A patent/EP2091937A2/en not_active Withdrawn
- 2007-10-16 CN CNA2007800387313A patent/CN101528730A/zh active Pending
- 2007-10-16 AU AU2007309570A patent/AU2007309570B2/en not_active Ceased
- 2007-10-16 KR KR1020097008073A patent/KR20090064458A/ko not_active Withdrawn
- 2007-10-16 JP JP2009533350A patent/JP5047299B2/ja not_active Expired - Fee Related
- 2007-10-16 MX MX2009004112A patent/MX2009004112A/es unknown
- 2007-10-16 US US12/311,487 patent/US8193228B2/en active Active
- 2007-10-16 CA CA2666310A patent/CA2666310C/en not_active Expired - Fee Related
- 2007-10-16 RU RU2009118935/04A patent/RU2009118935A/ru not_active Application Discontinuation
- 2007-10-16 BR BRPI0717976-6A patent/BRPI0717976A2/pt not_active Application Discontinuation
-
2009
- 2009-04-05 IL IL198004A patent/IL198004A0/en unknown
- 2009-05-19 NO NO20091957A patent/NO20091957L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010506919A (ja) | 2010-03-04 |
| CA2666310A1 (en) | 2008-05-02 |
| AU2007309570B2 (en) | 2012-07-12 |
| WO2008051406A3 (en) | 2008-07-24 |
| CN101528730A (zh) | 2009-09-09 |
| JP5047299B2 (ja) | 2012-10-10 |
| EP2091937A2 (en) | 2009-08-26 |
| WO2008051406A2 (en) | 2008-05-02 |
| US8193228B2 (en) | 2012-06-05 |
| CA2666310C (en) | 2012-07-31 |
| RU2009118935A (ru) | 2010-11-27 |
| AU2007309570A1 (en) | 2008-05-02 |
| NO20091957L (no) | 2009-07-17 |
| KR20090064458A (ko) | 2009-06-18 |
| BRPI0717976A2 (pt) | 2013-11-12 |
| IL198004A0 (en) | 2009-12-24 |
| US20100022598A1 (en) | 2010-01-28 |
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