MX2007014403A - Derivados de fenil-3-{(3-(1h-pirrol-2-il)-[1,2,4]oxadiazol-5-il]pi peridin-1-il}-metanona y compuestos relacionados como moduladores aloestericos positivos de los receptores de glutamato metabotropicos. - Google Patents
Derivados de fenil-3-{(3-(1h-pirrol-2-il)-[1,2,4]oxadiazol-5-il]pi peridin-1-il}-metanona y compuestos relacionados como moduladores aloestericos positivos de los receptores de glutamato metabotropicos.Info
- Publication number
- MX2007014403A MX2007014403A MX2007014403A MX2007014403A MX2007014403A MX 2007014403 A MX2007014403 A MX 2007014403A MX 2007014403 A MX2007014403 A MX 2007014403A MX 2007014403 A MX2007014403 A MX 2007014403A MX 2007014403 A MX2007014403 A MX 2007014403A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- formula
- allosteric modulators
- positive allosteric
- 0xadiaz0l
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000003281 allosteric effect Effects 0.000 title abstract 2
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 title 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 title 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 title 1
- 102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 abstract 3
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 208000015114 central nervous system disease Diseases 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004366 heterocycloalkenyl group Chemical group 0.000 abstract 2
- 102000006239 metabotropic receptors Human genes 0.000 abstract 2
- 108020004083 metabotropic receptors Proteins 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 230000006999 cognitive decline Effects 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000027232 peripheral nervous system disease Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0510141.5A GB0510141D0 (en) | 2005-05-18 | 2005-05-18 | Novel compounds B3 |
| PCT/IB2006/002047 WO2006123257A2 (en) | 2005-05-18 | 2006-05-17 | Phenyl-3-{(3-(1h-pyrrol-2-yl)-[1, 2 , 4]0xadiaz0l-5-yl]piperidin-1-yl}-methanone derivatives and related compounds as positive allosteric modulators of metabotropic glutamate receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007014403A true MX2007014403A (es) | 2008-04-21 |
Family
ID=34708379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007014403A MX2007014403A (es) | 2005-05-18 | 2006-05-17 | Derivados de fenil-3-{(3-(1h-pirrol-2-il)-[1,2,4]oxadiazol-5-il]pi peridin-1-il}-metanona y compuestos relacionados como moduladores aloestericos positivos de los receptores de glutamato metabotropicos. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20090203737A1 (enExample) |
| EP (1) | EP1912979B1 (enExample) |
| JP (2) | JP2008540637A (enExample) |
| KR (1) | KR20080014046A (enExample) |
| CN (1) | CN101218234B (enExample) |
| AT (1) | ATE513828T1 (enExample) |
| AU (1) | AU2006248657B2 (enExample) |
| BR (1) | BRPI0610059A2 (enExample) |
| CA (1) | CA2608324A1 (enExample) |
| CY (1) | CY1111859T1 (enExample) |
| DK (1) | DK1912979T3 (enExample) |
| EA (1) | EA014081B1 (enExample) |
| ES (1) | ES2367663T3 (enExample) |
| GB (1) | GB0510141D0 (enExample) |
| IL (1) | IL187187A0 (enExample) |
| MX (1) | MX2007014403A (enExample) |
| NO (1) | NO20076480L (enExample) |
| NZ (1) | NZ564202A (enExample) |
| PL (1) | PL1912979T3 (enExample) |
| PT (1) | PT1912979E (enExample) |
| UA (1) | UA92494C2 (enExample) |
| WO (1) | WO2006123257A2 (enExample) |
| ZA (1) | ZA200710279B (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080027463A (ko) * | 2005-05-18 | 2008-03-27 | 아덱스 파마 에스에이 | 대사성 글루타메이트 수용체의 양성 알로스테릭조절자로서의 치환된 옥사디아졸 유도체 |
| GB0510139D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| GB0510140D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B2 |
| GB0510141D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
| GB0510142D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
| GB0622202D0 (en) * | 2006-11-07 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel compounds |
| EA201070143A1 (ru) | 2007-07-13 | 2010-08-30 | Аддекс Фарма С.А. | Новые гетероароматические производные и их использование в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов |
| CN101801954B (zh) | 2007-09-20 | 2013-10-09 | Irm责任有限公司 | 作为gpr119活性调节剂的化合物和组合物 |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| US8273900B2 (en) | 2008-08-07 | 2012-09-25 | Novartis Ag | Organic compounds |
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| US20100317630A1 (en) * | 2009-02-04 | 2010-12-16 | Recordati Ireland Limited | Novel heterocyclic compounds as mglu5 antagonists |
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| AU2020417293A1 (en) | 2020-01-03 | 2022-09-01 | Berg Llc | Polycyclic amides as UBE2K modulators for treating cancer |
| WO2022069953A1 (en) * | 2020-09-29 | 2022-04-07 | Ranjith Siddaraj | Synthesis and characterization of (s)-3-(5- fluoropyridin-2-yl)-5-(piperidin-3-yl)-l,2,4-oxadiazole derivatives and their secretory phospholipase a2 (spla2) inhibitor activity |
| DK4347031T3 (da) | 2021-06-04 | 2025-12-01 | Vertex Pharma | N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler |
| WO2024059207A2 (en) * | 2022-09-15 | 2024-03-21 | Vanderbilt University | Pyrazoloether analogs as mglu5 negative allosteric modulators and methods of making and using the same |
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2005
- 2005-05-18 GB GBGB0510141.5A patent/GB0510141D0/en not_active Ceased
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2006
- 2006-05-17 EP EP06779899A patent/EP1912979B1/en not_active Not-in-force
- 2006-05-17 PL PL06779899T patent/PL1912979T3/pl unknown
- 2006-05-17 KR KR1020077029429A patent/KR20080014046A/ko not_active Ceased
- 2006-05-17 UA UAA200714061A patent/UA92494C2/ru unknown
- 2006-05-17 MX MX2007014403A patent/MX2007014403A/es active IP Right Grant
- 2006-05-17 WO PCT/IB2006/002047 patent/WO2006123257A2/en not_active Ceased
- 2006-05-17 NZ NZ564202A patent/NZ564202A/en not_active IP Right Cessation
- 2006-05-17 CN CN2006800251802A patent/CN101218234B/zh not_active Expired - Fee Related
- 2006-05-17 BR BRPI0610059-7A patent/BRPI0610059A2/pt not_active IP Right Cessation
- 2006-05-17 AT AT06779899T patent/ATE513828T1/de active
- 2006-05-17 US US11/920,490 patent/US20090203737A1/en not_active Abandoned
- 2006-05-17 DK DK06779899.1T patent/DK1912979T3/da active
- 2006-05-17 AU AU2006248657A patent/AU2006248657B2/en not_active Expired - Fee Related
- 2006-05-17 ES ES06779899T patent/ES2367663T3/es active Active
- 2006-05-17 CA CA002608324A patent/CA2608324A1/en not_active Abandoned
- 2006-05-17 PT PT06779899T patent/PT1912979E/pt unknown
- 2006-05-17 EA EA200702470A patent/EA014081B1/ru not_active IP Right Cessation
- 2006-05-17 JP JP2008511823A patent/JP2008540637A/ja active Pending
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2007
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2011
- 2011-09-22 CY CY20111100921T patent/CY1111859T1/el unknown
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- 2012-05-24 JP JP2012118718A patent/JP2012184254A/ja not_active Withdrawn
Also Published As
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| EP1912979B1 (en) | 2011-06-22 |
| AU2006248657B2 (en) | 2012-07-19 |
| US20090203737A1 (en) | 2009-08-13 |
| WO2006123257A2 (en) | 2006-11-23 |
| PT1912979E (pt) | 2011-08-22 |
| EA200702470A1 (ru) | 2008-06-30 |
| CN101218234B (zh) | 2011-12-14 |
| UA92494C2 (ru) | 2010-11-10 |
| CA2608324A1 (en) | 2006-11-23 |
| IL187187A0 (en) | 2008-02-09 |
| WO2006123257A3 (en) | 2007-05-03 |
| CY1111859T1 (el) | 2015-11-04 |
| ES2367663T3 (es) | 2011-11-07 |
| AU2006248657A1 (en) | 2006-11-23 |
| CN101218234A (zh) | 2008-07-09 |
| PL1912979T3 (pl) | 2011-11-30 |
| ATE513828T1 (de) | 2011-07-15 |
| NZ564202A (en) | 2011-04-29 |
| JP2012184254A (ja) | 2012-09-27 |
| WO2006123257A8 (en) | 2007-03-15 |
| NO20076480L (no) | 2008-01-28 |
| DK1912979T3 (da) | 2011-08-22 |
| HK1112909A1 (en) | 2008-09-19 |
| GB0510141D0 (en) | 2005-06-22 |
| JP2008540637A (ja) | 2008-11-20 |
| EA014081B1 (ru) | 2010-08-30 |
| KR20080014046A (ko) | 2008-02-13 |
| BRPI0610059A2 (pt) | 2010-05-25 |
| ZA200710279B (en) | 2009-03-25 |
| EP1912979A2 (en) | 2008-04-23 |
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