MX174306B - Un proceso para producir un producto metabolico - Google Patents

Un proceso para producir un producto metabolico

Info

Publication number
MX174306B
MX174306B MX026823A MX2682383A MX174306B MX 174306 B MX174306 B MX 174306B MX 026823 A MX026823 A MX 026823A MX 2682383 A MX2682383 A MX 2682383A MX 174306 B MX174306 B MX 174306B
Authority
MX
Mexico
Prior art keywords
metabolic product
gene
produce
dna
culturing
Prior art date
Application number
MX026823A
Other languages
English (en)
Inventor
Motoko Kageyama Morim Yagisawa
Tamio Mizukami
Seiga Itoh
Tetsuo Oka
Akira Furuya
Ryoichi Katsumata
Akio Azaki
Toru Mizukami
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16613637&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX174306(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of MX174306B publication Critical patent/MX174306B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Abstract

La presente invención se refiere a un proceso para producir un producto metabólico, caracterizado porque comprende transformar un microoganismo huesped que pertenece al género Corynebacterium o Brevibacterium con un ADN contiene al menos un gen responsable de la biosíntesis del producto metabólico y obtenido de un microorganismo de Escherichia coli o Bacillus subtilis que se inserta en un vector ADN, cultivar el transformante en un medio nutriente, acumular el metabolito resultante del gen en el medio de cultivo y depues recuperar el metabolito desde aquel.
MX026823A 1981-12-29 1983-01-03 Un proceso para producir un producto metabolico MX174306B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56211908A JPS58126789A (ja) 1981-12-29 1981-12-29 レースレオニンの製造法

Publications (1)

Publication Number Publication Date
MX174306B true MX174306B (es) 1994-05-04

Family

ID=16613637

Family Applications (1)

Application Number Title Priority Date Filing Date
MX026823A MX174306B (es) 1981-12-29 1983-01-03 Un proceso para producir un producto metabolico

Country Status (9)

Country Link
EP (1) EP0088166B2 (es)
JP (1) JPS58126789A (es)
AT (1) ATE41677T1 (es)
AU (1) AU557228B2 (es)
CA (1) CA1202257A (es)
DE (2) DE88166T1 (es)
ES (1) ES518665A0 (es)
IL (1) IL67614A (es)
MX (1) MX174306B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL67510A (en) * 1981-12-17 1988-08-31 Kyowa Hakko Kogyo Kk Recombinant vector plasmids autonomously replicable in microorganisms belonging to the genus corynebacterium or brevibacterium and process for the production thereof
JPS59156294A (ja) * 1983-02-17 1984-09-05 Kyowa Hakko Kogyo Co Ltd ヒスチジンの製造法
DE3486147T2 (de) * 1983-02-17 1993-10-28 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von L-Isoleucin.
JPS6066989A (ja) * 1983-09-24 1985-04-17 Kyowa Hakko Kogyo Co Ltd Ｌ−アルギニンの製造法
JPS59156292A (ja) * 1983-02-17 1984-09-05 Kyowa Hakko Kogyo Co Ltd トリプトフアンの製造法
JPH0732710B2 (ja) * 1983-05-28 1995-04-12 協和醗酵工業株式会社 フエニ−ルアラニンの製造法
JPH0783714B2 (ja) * 1983-08-29 1995-09-13 味の素株式会社 発酵法によるｌ―アミノ酸の製造法
JPS6062983A (ja) * 1983-09-14 1985-04-11 Ajinomoto Co Inc 発酵法によるｌ―ヒスチジンの製造法
JPS6062982A (ja) * 1983-09-14 1985-04-11 Ajinomoto Co Inc 組換えｄνａ，該組換えｄνａを有する細菌及び該細菌を用いるｌ−スレオニン又はｌ−イソロイシンの製造法
JPS6066984A (ja) * 1983-09-22 1985-04-17 Ajinomoto Co Inc 発酵法によるｌ−フェニルアラニンの製造法
JPS60210994A (ja) * 1984-04-06 1985-10-23 Kyowa Hakko Kogyo Co Ltd ヒスチジンの製造法
CA1277931C (en) * 1984-06-05 1990-12-18 Shimon Ulitzur Detection and/or identification of microorganisms in a test sample usingbioluminescence or other exogenous genetically-introduced marker
JPH06102029B2 (ja) * 1984-07-31 1994-12-14 味の素株式会社 Ｌ−トリプトフアンの製造法
GB2165546B (en) * 1984-08-21 1989-05-17 Asahi Chemical Ind A plasmid containing a gene for tetracycline resistance and dna fragments derived therefrom
JPH0746994B2 (ja) * 1984-10-04 1995-05-24 味の素株式会社 発酵法によるｌ−アミノ酸の製造法
JPH0655149B2 (ja) * 1985-03-12 1994-07-27 協和醗酵工業株式会社 Ｌ―リジンの製造法
JPS6236196A (ja) * 1985-04-15 1987-02-17 Ajinomoto Co Inc アラニンの製造法
FR2581653B1 (fr) * 1985-05-10 1989-06-30 Asahi Chemical Ind Fragment d'adn contenant un gene codant pour la phosphoenolpyruvate carboxylase, adn recombinant le contenant et micro-organisme contenant ce dernier
DE204326T1 (de) * 1985-06-05 1987-07-02 Kyowa Hakko Kogyo Co., Ltd., Tokio/Tokyo, Jp Verfahren zur herstellung von l-threonin und l-isoleucin.
JPH06102028B2 (ja) * 1985-10-04 1994-12-14 協和醗酵工業株式会社 アミノ酸の製造法
FR2590592B1 (fr) * 1985-11-26 1989-12-22 Asahi Chemical Ind Fragment d'adn contenant un gene codant pour une enzyme catalysant une reaction dans le cycle tca et adn recombinant le contenant.
US4920054A (en) * 1986-07-25 1990-04-24 Allelix, Inc. Shuttle vectors from rhodococcus equi
JPS63273469A (ja) * 1986-12-13 1988-11-10 Kyowa Hakko Kogyo Co Ltd 乳糖資化性を有する新規微生物
US6649379B1 (en) 1987-06-12 2003-11-18 Massachusetts Institute Of Technology Method and deregulated enzyme for threonine production
WO1988009819A2 (en) * 1987-06-12 1988-12-15 Massachusetts Institute Of Technology C. glutamicum threonine biosynthetic pathway
EP0312089B1 (en) * 1987-10-15 1994-03-02 Mitsubishi Petrochemical Co., Ltd. Method for producing L-threonine
DE3908201A1 (de) * 1989-03-14 1990-09-27 Degussa Verfahren zur fermentativen herstellung von l-lysin
FR2747131B1 (fr) * 1996-04-09 1998-06-26 Orsan Procede de production d'amino acide par fermentation de corynebacterie exprimant une activite trehalase
DE19912384A1 (de) * 1999-03-19 2000-09-21 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
DE19924364A1 (de) * 1999-05-27 2000-11-30 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
US6586214B1 (en) 1999-09-15 2003-07-01 Degussa Ag Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)
US7368266B2 (en) 2001-02-13 2008-05-06 Cj Corporation Method for L-threonine production
BRPI0518845A2 (pt) 2004-12-06 2008-12-09 Sage Biosciences Inc mÉtodo para aumentar a resistÊncia À inativaÇço ruminal de uma cepa de bactÉrias gram-positivas produtoras de lisina, suplemento alimentÍcio de lisina protegido no rémen, e, mÉtodos para aumentar o teor de lisina metabolicamente disponÍvel de uma raÇço alimentÍcia para ruminantes, e in vitro para avaliar a resistÊncia de uma cepa de bactÉrias produtoras de lisina para inativaÇço ruminal in vivo

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56160997A (en) * 1980-05-16 1981-12-11 Ajinomoto Co Inc Preparation of l-lysine by fermenaition method
JPS56148296A (en) * 1980-04-17 1981-11-17 Ajinomoto Co Inc Preparation of l-glutamic acid by fermentation method
JPS56148295A (en) * 1980-04-17 1981-11-17 Ajinomoto Co Inc Preparation of l-glutamic acid by fermentation method
GB2076853B (en) * 1980-04-17 1983-12-21 Ajinomoto Kk L-glutamic acid producing microorganisms
JPS57134500A (en) * 1981-02-12 1982-08-19 Kyowa Hakko Kogyo Co Ltd Plasmid pcg1
JPS57183799A (en) * 1981-04-17 1982-11-12 Kyowa Hakko Kogyo Co Ltd Novel plasmid
JPS57186496A (en) * 1981-05-11 1982-11-16 Ajinomoto Co Inc Preparation of l-threonine by fermentation
JPS58893A (ja) * 1981-06-25 1983-01-06 Ajinomoto Co Inc 発酵法によるｌ−イソロイシンの製造法
JPS5835197A (ja) * 1981-08-26 1983-03-01 Kyowa Hakko Kogyo Co Ltd プラスミドｐｃｇ２
JPS5867699A (ja) * 1981-10-16 1983-04-22 Ajinomoto Co Inc プラスミド
IL67510A (en) * 1981-12-17 1988-08-31 Kyowa Hakko Kogyo Kk Recombinant vector plasmids autonomously replicable in microorganisms belonging to the genus corynebacterium or brevibacterium and process for the production thereof
ES522029A0 (es) * 1982-05-04 1984-07-16 Ajinomoto Kk Procedimiento para preparar un plasmido compuesto.

Also Published As

Publication number Publication date
EP0088166B1 (en) 1989-03-22
EP0088166A2 (en) 1983-09-14
EP0088166B2 (en) 1997-06-25
CA1202257A (en) 1986-03-25
JPS58126789A (ja) 1983-07-28
JPH0138475B2 (es) 1989-08-14
ATE41677T1 (de) 1989-04-15
EP0088166A3 (en) 1984-04-25
IL67614A (en) 1990-11-29
IL67614A0 (en) 1983-05-15
DE88166T1 (de) 1984-03-15
AU9191982A (en) 1983-07-07
AU557228B2 (en) 1986-12-11
ES8404409A1 (es) 1984-04-16
DE3279568D1 (en) 1989-04-27
ES518665A0 (es) 1984-04-16

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