MEP2008A - Postupak za pripremanje escitaloprama - Google Patents
Postupak za pripremanje escitalopramaInfo
- Publication number
- MEP2008A MEP2008A MEP-20/08A MEP2008A MEP2008A ME P2008 A MEP2008 A ME P2008A ME P2008 A MEP2008 A ME P2008A ME P2008 A MEP2008 A ME P2008A
- Authority
- ME
- Montenegro
- Prior art keywords
- escitalopram
- preparation
- citalopram
- novel
- chiral
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 title abstract 3
- 229960004341 escitalopram Drugs 0.000 title abstract 3
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 abstract 2
- 229960001653 citalopram Drugs 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 230000005526 G1 to G0 transition Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000013375 chromatographic separation Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
- C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101101 | 2001-07-13 | ||
| DKPA200101851 | 2001-12-11 | ||
| DKPA200101852 | 2001-12-11 | ||
| PCT/DK2002/000491 WO2003006449A1 (en) | 2001-07-13 | 2002-07-12 | Method for the preparation of escitalopram |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MEP2008A true MEP2008A (xx) | 2010-02-10 |
Family
ID=27222518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-20/08A MEP2008A (xx) | 2001-07-13 | 2002-07-12 | Postupak za pripremanje escitaloprama |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US20050065207A1 (es) |
| EP (1) | EP1409472A1 (es) |
| JP (1) | JP2004538276A (es) |
| KR (4) | KR20080108629A (es) |
| CN (2) | CN100457746C (es) |
| AR (1) | AR034759A1 (es) |
| AU (1) | AU2009200448A1 (es) |
| BG (1) | BG108572A (es) |
| BR (1) | BR0210817A (es) |
| CA (1) | CA2451124C (es) |
| CO (1) | CO5550496A2 (es) |
| EA (1) | EA014823B1 (es) |
| HR (1) | HRPK20031074B3 (es) |
| HU (1) | HUP0401451A3 (es) |
| IL (1) | IL159183A0 (es) |
| IS (1) | IS7064A (es) |
| ME (1) | MEP2008A (es) |
| MX (1) | MXPA04000205A (es) |
| MY (1) | MY144333A (es) |
| NO (1) | NO328561B1 (es) |
| PE (1) | PE20030253A1 (es) |
| PL (1) | PL366383A1 (es) |
| RS (1) | RS1804A (es) |
| TW (1) | TWI268926B (es) |
| UA (1) | UA84258C2 (es) |
| UY (1) | UY27379A1 (es) |
| WO (1) | WO2003006449A1 (es) |
| ZA (1) | ZA200309471B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI306846B (en) | 2002-08-12 | 2009-03-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| MXPA05006783A (es) | 2002-12-23 | 2005-09-08 | Lundbeck & Co As H | Un proceso para la preparacion de diol de citalopram racemico y/o dioles de citalopram s o r y el uso de tales dioles para la preparacion de citalopram racemico, citalopram r y/o citalopram s. |
| FR2853650B1 (fr) * | 2003-04-10 | 2006-07-07 | Merck Sante Sas | Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance |
| ES2228274B1 (es) * | 2003-09-24 | 2006-06-01 | Astur Pharma, S.A. | Sintesis quimioenzimatica de (+)-citalopram y (-)-citalopram. |
| TWI339651B (en) * | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| US20050196453A1 (en) | 2004-03-05 | 2005-09-08 | H. Lundbeck A/S | Crystalline composition containing escitalopram |
| ITMI20040717A1 (it) | 2004-04-09 | 2004-07-09 | Adorkem Technology Spa | Procedimento chemo-enzimatico per la preparazione dell'escitalopram |
| JP2006008603A (ja) * | 2004-06-25 | 2006-01-12 | Sumitomo Chemical Co Ltd | 光学活性シタロプラムの製造方法、その中間体およびその製造方法 |
| US7989645B2 (en) * | 2004-08-23 | 2011-08-02 | Sun Pharma Global Fze | Process for preparation of citalopram and enantiomers |
| EP1797060A2 (en) | 2004-08-23 | 2007-06-20 | Sun Pharmaceutical Industries Limited | "process for preparation of citalopram and enantiomers" |
| ITMI20041872A1 (it) * | 2004-10-01 | 2005-01-01 | Adorkem Technology Spa | Processo per la preparazione di citalopram e di scitalopram |
| WO2006106531A1 (en) * | 2005-04-04 | 2006-10-12 | Jubilant Organosys Ltd | Process for the preparation of escitalopram or its acid addition salts |
| TWI358407B (en) | 2005-06-22 | 2012-02-21 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersibl |
| US7834201B2 (en) | 2005-06-22 | 2010-11-16 | H. Lundbeck A/S | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| CA2625835A1 (en) | 2005-10-14 | 2007-05-10 | Forest Laboratories, Inc. | Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion |
| EP1951726A2 (en) * | 2005-11-14 | 2008-08-06 | H.Lundbeck A/S | Method for the preparation of escitalopram |
| GB0601286D0 (en) | 2006-01-23 | 2006-03-01 | Sandoz Ag | Asymmetric synthesis |
| EP1988086B2 (en) | 2007-04-23 | 2014-11-26 | Synthon B.V. | Process for resolving citalopram via its (S)-enriched citalopram tartrate compound. |
| EP2017271A1 (en) | 2007-07-06 | 2009-01-21 | Aurobindo Pharma Limited | Process for the preparation of escitalopram |
| NZ570884A (en) | 2007-09-11 | 2010-03-26 | Lundbeck & Co As H | Fractionally crystallising 4-[4-(dimethyl amino)-1-(4'-fluorophenyl)-1-hydroxybutyI]-3-(hydroxymethyl)-benzonitrile and manufacturing escitalopram therefrom |
| US8022232B2 (en) * | 2007-09-11 | 2011-09-20 | H. Lundbeck A/S | Method for manufacture of escitalopram |
| CN106568863A (zh) * | 2016-11-04 | 2017-04-19 | 北京万全德众医药生物技术有限公司 | 一种用高效液相色谱法分离测定草酸艾司西肽普兰中间体光学异构体的方法 |
| CN107941962A (zh) * | 2017-12-28 | 2018-04-20 | 北京和合医学诊断技术股份有限公司 | 检测血液中艾司西酞普兰药物含量的液相色谱分析方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| JP3010816B2 (ja) * | 1991-08-22 | 2000-02-21 | ダイセル化学工業株式会社 | 光学分割における光学異性体と溶媒との回収方法、溶媒の循環使用方法、および光学異性体の再利用方法 |
| US5514818A (en) * | 1993-09-17 | 1996-05-07 | Daicel Chemical Industries, Ltd. | Resolution of stereoisomers of aliphatic epoxides |
| US5889180A (en) * | 1997-11-10 | 1999-03-30 | Uop Llc | Use of small pore silicas as a support for a chiral stationary phase |
| NL1017415C1 (nl) * | 2000-02-24 | 2001-05-18 | Lundbeck & Co As H | Werkwijze voor de bereiding van Citalopram. |
| US6967259B2 (en) * | 2001-09-24 | 2005-11-22 | Pharmachem Technologies Limited | Process for the preparation of Citalopram intermediate |
| US6764200B1 (en) * | 2003-01-15 | 2004-07-20 | Hsiang Lan Wu Liu | Decorative lantern |
-
2002
- 2002-07-10 AR ARP020102574A patent/AR034759A1/es not_active Application Discontinuation
- 2002-07-11 TW TW091115430A patent/TWI268926B/zh not_active IP Right Cessation
- 2002-07-11 PE PE2002000617A patent/PE20030253A1/es not_active Application Discontinuation
- 2002-07-12 CN CNB028139984A patent/CN100457746C/zh not_active Expired - Lifetime
- 2002-07-12 CN CNA2008100930541A patent/CN101265199A/zh active Pending
- 2002-07-12 IL IL15918302A patent/IL159183A0/xx unknown
- 2002-07-12 RS YU1804A patent/RS1804A/sr unknown
- 2002-07-12 CA CA002451124A patent/CA2451124C/en not_active Expired - Fee Related
- 2002-07-12 WO PCT/DK2002/000491 patent/WO2003006449A1/en not_active Ceased
- 2002-07-12 KR KR1020087029127A patent/KR20080108629A/ko not_active Withdrawn
- 2002-07-12 HR HR20031074A patent/HRPK20031074B3/xx not_active IP Right Cessation
- 2002-07-12 MX MXPA04000205A patent/MXPA04000205A/es active IP Right Grant
- 2002-07-12 KR KR1020047000502A patent/KR100956260B1/ko not_active Expired - Fee Related
- 2002-07-12 US US10/483,824 patent/US20050065207A1/en not_active Abandoned
- 2002-07-12 UY UY27379A patent/UY27379A1/es not_active Application Discontinuation
- 2002-07-12 BR BR0210817-8A patent/BR0210817A/pt not_active Application Discontinuation
- 2002-07-12 PL PL02366383A patent/PL366383A1/xx unknown
- 2002-07-12 EA EA200400177A patent/EA014823B1/ru not_active IP Right Cessation
- 2002-07-12 KR KR1020087029126A patent/KR20080108628A/ko not_active Withdrawn
- 2002-07-12 ME MEP-20/08A patent/MEP2008A/xx unknown
- 2002-07-12 KR KR1020107004689A patent/KR20100036387A/ko not_active Withdrawn
- 2002-07-12 HU HU0401451A patent/HUP0401451A3/hu unknown
- 2002-07-12 JP JP2003512221A patent/JP2004538276A/ja active Pending
- 2002-07-12 EP EP02750836A patent/EP1409472A1/en not_active Withdrawn
- 2002-07-13 MY MYPI20022664A patent/MY144333A/en unknown
- 2002-12-07 UA UA20031211985A patent/UA84258C2/ru unknown
-
2003
- 2003-12-04 IS IS7064A patent/IS7064A/is unknown
- 2003-12-05 ZA ZA200309471A patent/ZA200309471B/xx unknown
-
2004
- 2004-01-05 NO NO20040027A patent/NO328561B1/no not_active IP Right Cessation
- 2004-02-04 CO CO04008776A patent/CO5550496A2/es not_active Application Discontinuation
- 2004-02-09 BG BG108572A patent/BG108572A/bg unknown
-
2009
- 2009-02-06 AU AU2009200448A patent/AU2009200448A1/en not_active Abandoned
-
2010
- 2010-05-17 US US12/781,048 patent/US20110065938A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MEP2008A (xx) | Postupak za pripremanje escitaloprama | |
| MY118906A (en) | Novel process and intermediates | |
| DK0443449T3 (da) | Fremgangsmåde til fremstilling af oxetanoner | |
| IL172692A0 (en) | Method for dehydrating substituted 4-dimethylamino-2-aryl-butan-2-ol compounds and method for producing substituted dimethyl-(3-aryl-butyl)-amine compounds by means of heterogeneous catalysis | |
| IS5884A (is) | Aðferð til framleiðslu á hreinu sítalóprami | |
| BG105348A (en) | PROCESS FOR OBTAINING HMG-CoA REDUCTASE INHIBITORS OF HIGH PURITY | |
| IL159229A0 (en) | Process for the preparation of racemic citalopram and/or s-or r-citalopram by separation of a mixture of r- and s-citalopram | |
| IS2167B (is) | Aðferð til framleiðslu á sítalóprami | |
| EP2604614A3 (en) | Oxidized phospholipids | |
| DK1206452T3 (da) | Fremgangsmåde til fremstilling af benzoperhydro-isoindolforbindelser | |
| DE69909091D1 (de) | Chirale stationäre phasen für die trennung von enantiomeren und ihre herstellung | |
| DK1280752T3 (da) | Fremgangsmåde til fremstilling af 2-alkyl-3-chlorphenoler | |
| ES2175630T3 (es) | Soportes quirales y su utilizacion en la preparacion o separacion de enantiomeros. | |
| AU1517601A (en) | Method for production of benzofuranone oximes | |
| DK0934256T3 (da) | Fremgangsmåde til fremstilling af cyanocinnamamider | |
| Fujita et al. | Asymmetric [2, 3] Sigmatropic Rearrangement of Optically Active Allylic Selenides | |
| NO20030640L (no) | Fremgangsmåte for fremstilling av bicykliske forbindelser og mellomprodukter derfor | |
| DK1082449T3 (da) | Fremgangsmåder til stereoselektiv fremstilling af substituerede cyclohexylcyanhydriner | |
| MXPA05009153A (es) | Proceso para preparar 2-metilpirrolidina y enantiomeros especificos de la misma. | |
| MXPA05009720A (es) | Procedimiento quimioenzimatico estereoselectivo para preparar fenilglicidatos opticamente enriquecidos. | |
| AU2003288004A1 (en) | Process for the preparation of an enantiomerically enriched schiff base | |
| MXPA03006718A (es) | Nuevos polimeros basados en ligandos de n-carbamil-n'- dimetilsilil metil-piperacina sin trazas para sintesis en fase solida de bibliotecas basadas en fenilo. |