HRPK20031074B3 - Method for the preparation of escitalopram - Google Patents
Method for the preparation of escitalopramInfo
- Publication number
- HRPK20031074B3 HRPK20031074B3 HR20031074A HRP20031074A HRPK20031074B3 HR PK20031074 B3 HRPK20031074 B3 HR PK20031074B3 HR 20031074 A HR20031074 A HR 20031074A HR P20031074 A HRP20031074 A HR P20031074A HR PK20031074 B3 HRPK20031074 B3 HR PK20031074B3
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- escitalopram
- citalopram
- formula
- chromatography
- Prior art date
Links
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 title abstract 2
- 229960004341 escitalopram Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 abstract 2
- 229960001653 citalopram Drugs 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004811 liquid chromatography Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
- C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101101 | 2001-07-13 | ||
| DKPA200101852 | 2001-12-11 | ||
| DKPA200101851 | 2001-12-11 | ||
| PCT/DK2002/000491 WO2003006449A1 (en) | 2001-07-13 | 2002-07-12 | Method for the preparation of escitalopram |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20031074A2 HRP20031074A2 (en) | 2004-04-30 |
| HRPK20031074B3 true HRPK20031074B3 (en) | 2009-10-31 |
Family
ID=27222518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20031074A HRPK20031074B3 (en) | 2001-07-13 | 2003-12-23 | Method for the preparation of escitalopram |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20050065207A1 (xx) |
| EP (1) | EP1409472A1 (xx) |
| JP (1) | JP2004538276A (xx) |
| KR (4) | KR20080108628A (xx) |
| CN (2) | CN100457746C (xx) |
| AR (1) | AR034759A1 (xx) |
| AU (1) | AU2009200448A1 (xx) |
| BG (1) | BG108572A (xx) |
| BR (1) | BR0210817A (xx) |
| CA (1) | CA2451124C (xx) |
| CO (1) | CO5550496A2 (xx) |
| EA (1) | EA014823B1 (xx) |
| HK (1) | HK1069386A1 (xx) |
| HR (1) | HRPK20031074B3 (xx) |
| HU (1) | HUP0401451A3 (xx) |
| IL (1) | IL159183A0 (xx) |
| IS (1) | IS7064A (xx) |
| ME (1) | MEP2008A (xx) |
| MX (1) | MXPA04000205A (xx) |
| MY (1) | MY144333A (xx) |
| NO (1) | NO328561B1 (xx) |
| PE (1) | PE20030253A1 (xx) |
| PL (1) | PL366383A1 (xx) |
| RS (1) | RS1804A (xx) |
| TW (1) | TWI268926B (xx) |
| UA (1) | UA84258C2 (xx) |
| UY (1) | UY27379A1 (xx) |
| WO (1) | WO2003006449A1 (xx) |
| ZA (1) | ZA200309471B (xx) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20040991A1 (es) | 2002-08-12 | 2004-12-27 | Lundbeck & Co As H | Separacion de intermediarios para la preparacion de escitalopram |
| US7390913B2 (en) | 2002-12-23 | 2008-06-24 | H. Lundbeck A/S | Process for the preparation of racemic citalopram diol and/or S- or R-citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram |
| FR2853650B1 (fr) * | 2003-04-10 | 2006-07-07 | Merck Sante Sas | Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance |
| ES2228274B1 (es) * | 2003-09-24 | 2006-06-01 | Astur Pharma, S.A. | Sintesis quimioenzimatica de (+)-citalopram y (-)-citalopram. |
| TWI339651B (en) * | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| US20050196453A1 (en) | 2004-03-05 | 2005-09-08 | H. Lundbeck A/S | Crystalline composition containing escitalopram |
| ITMI20040717A1 (it) | 2004-04-09 | 2004-07-09 | Adorkem Technology Spa | Procedimento chemo-enzimatico per la preparazione dell'escitalopram |
| JP2006008603A (ja) * | 2004-06-25 | 2006-01-12 | Sumitomo Chemical Co Ltd | 光学活性シタロプラムの製造方法、その中間体およびその製造方法 |
| US7989645B2 (en) * | 2004-08-23 | 2011-08-02 | Sun Pharma Global Fze | Process for preparation of citalopram and enantiomers |
| WO2006021971A2 (en) | 2004-08-23 | 2006-03-02 | Sun Pharmaceutical Industries Limited | 'process for preparation of citalopram and enantiomers' |
| ITMI20041872A1 (it) * | 2004-10-01 | 2005-01-01 | Adorkem Technology Spa | Processo per la preparazione di citalopram e di scitalopram |
| EP1877394A1 (en) * | 2005-04-04 | 2008-01-16 | Jubilant Organosys Limited | Process for the preparation of escitalopram or its acid addition salts |
| TWI347942B (en) | 2005-06-22 | 2011-09-01 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| US7834201B2 (en) | 2005-06-22 | 2010-11-16 | H. Lundbeck A/S | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| JP2009511606A (ja) | 2005-10-14 | 2009-03-19 | ハー・ルンドベック・アクチエゼルスカベット | エスシタロプラムおよびブプロピオンの低用量の併用を用いる中枢神経系障害の治療方法 |
| EP1951726A2 (en) * | 2005-11-14 | 2008-08-06 | H.Lundbeck A/S | Method for the preparation of escitalopram |
| GB0601286D0 (en) | 2006-01-23 | 2006-03-01 | Sandoz Ag | Asymmetric synthesis |
| EP1988086B2 (en) | 2007-04-23 | 2014-11-26 | Synthon B.V. | Process for resolving citalopram via its (S)-enriched citalopram tartrate compound. |
| EP2017271A1 (en) | 2007-07-06 | 2009-01-21 | Aurobindo Pharma Limited | Process for the preparation of escitalopram |
| FI121570B (fi) | 2007-09-11 | 2011-01-14 | Lundbeck & Co As H | Menetelmä essitalopraamin valmistamiseksi |
| US8022232B2 (en) | 2007-09-11 | 2011-09-20 | H. Lundbeck A/S | Method for manufacture of escitalopram |
| CN106568863A (zh) * | 2016-11-04 | 2017-04-19 | 北京万全德众医药生物技术有限公司 | 一种用高效液相色谱法分离测定草酸艾司西肽普兰中间体光学异构体的方法 |
| CN107941962A (zh) * | 2017-12-28 | 2018-04-20 | 北京和合医学诊断技术股份有限公司 | 检测血液中艾司西酞普兰药物含量的液相色谱分析方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| JP3010816B2 (ja) | 1991-08-22 | 2000-02-21 | ダイセル化学工業株式会社 | 光学分割における光学異性体と溶媒との回収方法、溶媒の循環使用方法、および光学異性体の再利用方法 |
| US5514818A (en) * | 1993-09-17 | 1996-05-07 | Daicel Chemical Industries, Ltd. | Resolution of stereoisomers of aliphatic epoxides |
| US5889180A (en) * | 1997-11-10 | 1999-03-30 | Uop Llc | Use of small pore silicas as a support for a chiral stationary phase |
| FR2805812A1 (fr) * | 2000-02-24 | 2001-09-07 | Lundbeck & Co As H | Procede de preparation du citalopram |
| US6967259B2 (en) * | 2001-09-24 | 2005-11-22 | Pharmachem Technologies Limited | Process for the preparation of Citalopram intermediate |
| US6764200B1 (en) * | 2003-01-15 | 2004-07-20 | Hsiang Lan Wu Liu | Decorative lantern |
-
2002
- 2002-07-10 AR ARP020102574A patent/AR034759A1/es not_active Application Discontinuation
- 2002-07-11 PE PE2002000617A patent/PE20030253A1/es not_active Application Discontinuation
- 2002-07-11 TW TW091115430A patent/TWI268926B/zh not_active IP Right Cessation
- 2002-07-12 EP EP02750836A patent/EP1409472A1/en not_active Withdrawn
- 2002-07-12 UY UY27379A patent/UY27379A1/es not_active Application Discontinuation
- 2002-07-12 KR KR1020087029126A patent/KR20080108628A/ko not_active Application Discontinuation
- 2002-07-12 WO PCT/DK2002/000491 patent/WO2003006449A1/en active Application Filing
- 2002-07-12 EA EA200400177A patent/EA014823B1/ru not_active IP Right Cessation
- 2002-07-12 RS YU1804A patent/RS1804A/sr unknown
- 2002-07-12 BR BR0210817-8A patent/BR0210817A/pt not_active Application Discontinuation
- 2002-07-12 KR KR1020087029127A patent/KR20080108629A/ko not_active Application Discontinuation
- 2002-07-12 US US10/483,824 patent/US20050065207A1/en not_active Abandoned
- 2002-07-12 CN CNB028139984A patent/CN100457746C/zh not_active Expired - Lifetime
- 2002-07-12 CN CNA2008100930541A patent/CN101265199A/zh active Pending
- 2002-07-12 KR KR1020107004689A patent/KR20100036387A/ko not_active Application Discontinuation
- 2002-07-12 MX MXPA04000205A patent/MXPA04000205A/es active IP Right Grant
- 2002-07-12 HU HU0401451A patent/HUP0401451A3/hu unknown
- 2002-07-12 ME MEP-20/08A patent/MEP2008A/xx unknown
- 2002-07-12 KR KR1020047000502A patent/KR100956260B1/ko not_active IP Right Cessation
- 2002-07-12 PL PL02366383A patent/PL366383A1/xx unknown
- 2002-07-12 CA CA002451124A patent/CA2451124C/en not_active Expired - Fee Related
- 2002-07-12 JP JP2003512221A patent/JP2004538276A/ja active Pending
- 2002-07-12 IL IL15918302A patent/IL159183A0/xx unknown
- 2002-07-13 MY MYPI20022664A patent/MY144333A/en unknown
- 2002-12-07 UA UA20031211985A patent/UA84258C2/ru unknown
-
2003
- 2003-12-04 IS IS7064A patent/IS7064A/is unknown
- 2003-12-05 ZA ZA200309471A patent/ZA200309471B/xx unknown
- 2003-12-23 HR HR20031074A patent/HRPK20031074B3/xx not_active IP Right Cessation
-
2004
- 2004-01-05 NO NO20040027A patent/NO328561B1/no not_active IP Right Cessation
- 2004-02-04 CO CO04008776A patent/CO5550496A2/es not_active Application Discontinuation
- 2004-02-09 BG BG108572A patent/BG108572A/bg unknown
-
2005
- 2005-03-02 HK HK05101842.3A patent/HK1069386A1/xx not_active IP Right Cessation
-
2009
- 2009-02-06 AU AU2009200448A patent/AU2009200448A1/en not_active Abandoned
-
2010
- 2010-05-17 US US12/781,048 patent/US20110065938A1/en not_active Abandoned
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| AKOB | Publication of a request for the grant of a patent not including a substantive examination of a patent application (a consensual patent) | ||
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