ME00094B - Dimeri i derivati artimisinina, njihovo dobijanje i njihov a terapeutska primjena - Google Patents

Dimeri i derivati artimisinina, njihovo dobijanje i njihov a terapeutska primjena

Info

Publication number
ME00094B
ME00094B MEP-2008-123A MEP12308A ME00094B ME 00094 B ME00094 B ME 00094B ME P12308 A MEP12308 A ME P12308A ME 00094 B ME00094 B ME 00094B
Authority
ME
Montenegro
Prior art keywords
preparation
dimers
therapeutic use
artemisinin derivatives
derivatives
Prior art date
Application number
MEP-2008-123A
Other languages
English (en)
Inventor
Jidong Zhang
Augustin Hittinger
Alain Commercon
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MEP12308A publication Critical patent/MEP12308A/xx
Publication of ME00094B publication Critical patent/ME00094B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/04—Seven-membered rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/04—Seven-membered rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Ovaj pronalazak odnosi se na nove dimere specifičnih artemisinin derivata, njihovu pripremu, nafarmaceutske oblike koji ih sadrže, njihovu primenu kao leka a posebno kao antikancerogenihage nasa.
MEP-2008-123A 2006-04-11 2007-04-06 Dimeri i derivati artimisinina, njihovo dobijanje i njihov a terapeutska primjena ME00094B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0603209A FR2899586B1 (fr) 2006-04-11 2006-04-11 Dimeres de derives d'artemisinine, leur preparation et leur application en therapeutique
PCT/FR2007/000585 WO2007116135A1 (fr) 2006-04-11 2007-04-06 Dimeres de derives d'artemisinine, leur préparation et leur application en thérapeutique

Publications (2)

Publication Number Publication Date
MEP12308A MEP12308A (en) 2010-06-10
ME00094B true ME00094B (me) 2010-10-10

Family

ID=37429238

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-123A ME00094B (me) 2006-04-11 2007-04-06 Dimeri i derivati artimisinina, njihovo dobijanje i njihov a terapeutska primjena

Country Status (40)

Country Link
US (1) US8314142B2 (me)
EP (1) EP2007769B1 (me)
JP (1) JP5265518B2 (me)
KR (1) KR101357523B1 (me)
CN (1) CN101421276B (me)
AR (1) AR060400A1 (me)
AT (1) ATE512970T1 (me)
AU (1) AU2007235813B2 (me)
BR (1) BRPI0710152A2 (me)
CA (1) CA2641138C (me)
CR (1) CR10247A (me)
CY (1) CY1111833T1 (me)
DK (1) DK2007769T3 (me)
EA (1) EA015607B1 (me)
EC (1) ECSP088792A (me)
ES (1) ES2367715T3 (me)
FR (1) FR2899586B1 (me)
GT (1) GT200800206A (me)
HK (1) HK1131779A1 (me)
HN (1) HN2008001521A (me)
HR (1) HRP20110654T1 (me)
IL (1) IL194655A0 (me)
JO (1) JO2721B1 (me)
MA (1) MA30410B1 (me)
ME (1) ME00094B (me)
MX (1) MX2008012732A (me)
MY (1) MY154970A (me)
NO (1) NO20084352L (me)
NZ (1) NZ571342A (me)
PE (1) PE20080055A1 (me)
PL (1) PL2007769T3 (me)
PT (1) PT2007769E (me)
RS (1) RS51952B (me)
SI (1) SI2007769T1 (me)
TN (1) TNSN08321A1 (me)
TW (1) TWI423979B (me)
UA (1) UA94744C2 (me)
UY (1) UY30276A1 (me)
WO (1) WO2007116135A1 (me)
ZA (1) ZA200808025B (me)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2925495B1 (fr) * 2007-12-21 2010-09-10 Pf Medicament Derives dimeriques d'artemisinine et application en therapie anticancereuse
FR2934593B1 (fr) * 2008-07-29 2010-09-10 Pf Medicament Derives dimeriques d'artemisinine et application en therapie anticancereuse
US8883765B2 (en) * 2009-12-08 2014-11-11 The John Hopkins University Anti-cytomegalovirus activity of artemisinin-derived dimers
US8815942B2 (en) 2010-10-20 2014-08-26 The Royal Institution For The Advancement Of Learning/Mcgill University Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease
CN102010422B (zh) * 2010-11-23 2014-11-26 沈阳药科大学 含有胍基的青蒿素类衍生物及其应用
CN102614168A (zh) * 2011-01-31 2012-08-01 上海交通大学医学院附属瑞金医院 一种青蒿素衍生物及其药用盐的应用
US9006467B2 (en) 2011-02-14 2015-04-14 Councel of Scientific & Industrial Research 1,2,3-triazole containing artemisinin compounds and process for preparation thereof
CN103570738B (zh) * 2012-08-07 2016-04-13 中国科学院上海生命科学研究院 新型青蒿素衍生物及其制法和应用
CN106928274B (zh) * 2017-02-28 2019-09-10 东南大学 一种双氢青蒿素二倍体衍生物、其药物组合物及应用
CN110240605B (zh) * 2018-03-08 2021-12-31 中国科学院上海药物研究所 青蒿素二聚物的制备方法
CN109467565B (zh) * 2018-08-16 2020-07-10 云白药征武科技(上海)有限公司 双氢青蒿素三聚体及其制备方法和应用
EP3911311A4 (en) * 2019-02-26 2023-01-25 Mahmoud A. Elsohly SELECTED ARTEMISININ DIMERS FOR THE TREATMENT OF LEISHMANIA
CN115073496B (zh) * 2022-06-16 2023-10-24 云南苏理生物医药科技有限公司 一种含硫类青蒿素二聚体、其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1084333C (zh) 1998-06-17 2002-05-08 中国科学院上海药物研究所 新的青蒿素化合物,其制备方法以及含有它们的药物组合物
FR2831538B1 (fr) * 2001-10-26 2004-01-16 Centre Nat Rech Scient Nouveaux derives de l'artemisinine, et leurs utilisations dans le traitement du paludisme
US6790863B2 (en) * 2002-10-15 2004-09-14 University Of Mississippi Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents
JP5140416B2 (ja) * 2004-06-21 2013-02-06 ユニヴァーシティー オブ ミシシッピ 望ましい化学的官能基を有する抗がん及び抗原虫ジヒドロアーテミシニン及びジヒドロアーテミシテンダイマー
CN101125142A (zh) 2007-07-24 2008-02-20 北京中医药大学东直门医院 青蒿素在制备抗肿瘤多药耐药药物中的应用

Also Published As

Publication number Publication date
RS51952B (en) 2012-02-29
MA30410B1 (fr) 2009-05-04
FR2899586B1 (fr) 2008-06-20
CR10247A (es) 2008-11-26
TNSN08321A1 (en) 2009-12-29
PT2007769E (pt) 2011-09-14
BRPI0710152A2 (pt) 2011-08-02
AU2007235813B2 (en) 2011-11-10
MX2008012732A (es) 2008-10-17
EA200870421A1 (ru) 2009-02-27
ES2367715T3 (es) 2011-11-07
MEP12308A (en) 2010-06-10
HN2008001521A (es) 2011-04-25
US20090082426A1 (en) 2009-03-26
UY30276A1 (es) 2007-11-30
CA2641138A1 (fr) 2007-10-18
UA94744C2 (ru) 2011-06-10
AU2007235813A1 (en) 2007-10-18
CN101421276B (zh) 2012-11-14
CY1111833T1 (el) 2015-10-07
NO20084352L (no) 2008-10-16
JO2721B1 (en) 2013-09-15
EP2007769A1 (fr) 2008-12-31
EA015607B1 (ru) 2011-10-31
FR2899586A1 (fr) 2007-10-12
TW200815456A (en) 2008-04-01
ECSP088792A (es) 2008-11-27
ATE512970T1 (de) 2011-07-15
NZ571342A (en) 2011-01-28
KR20090009199A (ko) 2009-01-22
JP5265518B2 (ja) 2013-08-14
SI2007769T1 (sl) 2011-10-28
CA2641138C (fr) 2012-10-02
DK2007769T3 (da) 2011-10-03
JP2009533398A (ja) 2009-09-17
MY154970A (en) 2015-08-28
AR060400A1 (es) 2008-06-11
ZA200808025B (en) 2009-12-30
EP2007769B1 (fr) 2011-06-15
PE20080055A1 (es) 2008-03-24
HK1131779A1 (en) 2010-02-05
PL2007769T3 (pl) 2011-11-30
IL194655A0 (en) 2009-08-03
CN101421276A (zh) 2009-04-29
WO2007116135A1 (fr) 2007-10-18
GT200800206A (es) 2008-12-04
KR101357523B1 (ko) 2014-02-03
TWI423979B (zh) 2014-01-21
US8314142B2 (en) 2012-11-20
HRP20110654T1 (hr) 2011-10-31

Similar Documents

Publication Publication Date Title
ME00094B (me) Dimeri i derivati artimisinina, njihovo dobijanje i njihov a terapeutska primjena
ECSP099320A (es) Compuestos de tetrahidropirrolopiracina sustituida y su aplicación en medicamentos
DK2120878T3 (da) Doseringsform indeholdende to aktive farmaceutiske ingredienser i forskellige fysiske former
BR122020008544B8 (pt) uso de 4-aril-1,4-di-hidro-1,6-naftiridinamidas substituídas, e medicamento
DE602004017510D1 (de) Medizinprodukt vom kapseltyp
FR2894145B1 (fr) Utilisation de facteur h du complement a titre de medicament
DOP2006000096A (es) Pirrolopiridinas sustituidas, composiciones que las contienen, proceso de fabricacion y utilizacion
TW200732340A (en) Novel forms of tiotropium bromide and processes for preparation thereof
BRPI0809667A2 (pt) Composto, medicamento e composição farmacêutica que o contém e uso do composto
UY31484A1 (es) Piperidinas heteroaril-sustituidas
CO7160008A2 (es) Derivados de estra- 1,3,5(10),16- tetraeno 3-sustituidos, métodos para su preparación, prepara-ciones farmaceúticas que los contienen, así como su uso para la preparación de medicamentos
CY1113551T1 (el) Υποκατεστημενες ενωσεις νικοτιναμιδιου και η χρησιμοποιηση τους σε φαρμακα
DOP2006000015A (es) Pirazolo piridinas sustituidas, composiciones que las contienen, procedimiento de fabricación
BRPI0408848B8 (pt) composições farmacêuticas de complexo de ciclodextrina-cladribina complexo, usos do referido complexo, bem como processos para a sua preparação
BRPI0915482A2 (pt) derivados de 2-oxo-alquil-1-piperazin-2-ona, seus processos de preparação e usos, e composições farmacêuticas e medicamentos compreendendo os mesmos
ECSP13012481A (es) Composiciones de anticuerpo anti-vegfr-3
UY29371A1 (es) Pirroles sustituídos, composiciones que los contienen, proceso de fabricación y utilización
SE0300457D0 (sv) Novel compounds
MX2010004734A (es) Nueva combinacion anti-retrovirica.
EA200870567A1 (ru) Производные 2-алкокси-3,4,5-тригидроксиалкиламида, их получение, композиции, их содержащие, и применение
UY30368A1 (es) 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su preparacion, composiciones que las contienen y utilizacion
TR200907915A2 (tr) Kuru toz formunda farmasötik bileşim.
CR10428A (es) 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzotiazepinas, su preparacion, composiciones que las contienen y utilizacion
CN302434580S (zh) 塑料药瓶（1）
CN302230175S (zh) 药品包装袋（500ml5%葡萄糖注射液）