ECSP099320A - Compuestos de tetrahidropirrolopiracina sustituida y su aplicación en medicamentos - Google Patents

Compuestos de tetrahidropirrolopiracina sustituida y su aplicación en medicamentos

Info

Publication number
ECSP099320A
ECSP099320A EC2009009320A ECSP099320A ECSP099320A EC SP099320 A ECSP099320 A EC SP099320A EC 2009009320 A EC2009009320 A EC 2009009320A EC SP099320 A ECSP099320 A EC SP099320A EC SP099320 A ECSP099320 A EC SP099320A
Authority
EC
Ecuador
Prior art keywords
tetrahydropyrrolopyrazine
medicines
application
substituted compounds
production
Prior art date
Application number
EC2009009320A
Other languages
English (en)
Inventor
Stefan Oberboersch
Beatrix Merla
Wolfgang Schroeder
Sven Kuhnert
Thomas Christoph
Robert Frank
Gregor Bahrenberg
Klaus Schiene
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of ECSP099320A publication Critical patent/ECSP099320A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención presentada se refiere a los compuestos de tetrahidropirrolopiperacina sustituida, el procedimiento para su producción, los medicamentos que los contienen y, además, la utilización de éstos en la producción de medicamentos.
EC2009009320A 2006-10-17 2009-05-11 Compuestos de tetrahidropirrolopiracina sustituida y su aplicación en medicamentos ECSP099320A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006049452A DE102006049452A1 (de) 2006-10-17 2006-10-17 Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln

Publications (1)

Publication Number Publication Date
ECSP099320A true ECSP099320A (es) 2009-06-30

Family

ID=39125609

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009320A ECSP099320A (es) 2006-10-17 2009-05-11 Compuestos de tetrahidropirrolopiracina sustituida y su aplicación en medicamentos

Country Status (17)

Country Link
US (3) US7625900B2 (es)
EP (2) EP2144913A2 (es)
JP (1) JP5256203B2 (es)
KR (1) KR20090084873A (es)
CN (1) CN101547925A (es)
AU (1) AU2007312557B2 (es)
BR (1) BRPI0715298A2 (es)
CA (1) CA2666647A1 (es)
CO (1) CO6160331A2 (es)
DE (1) DE102006049452A1 (es)
EC (1) ECSP099320A (es)
IL (1) IL198073A (es)
MX (1) MX2009004108A (es)
NO (1) NO20091509L (es)
NZ (1) NZ576021A (es)
RU (1) RU2469037C2 (es)
WO (2) WO2008046581A2 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
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DK2350093T3 (da) * 2008-10-24 2012-11-12 Gruenenthal Gmbh Substituerede 4,5,6,7-tetrahydrothienopyridiner som KCNQ2/3-modulatorer til behandling af smerte, epilepsi og urininkontinens.
US8367700B2 (en) 2008-12-17 2013-02-05 Gruenenthal Gmbh Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators
JP2012518603A (ja) * 2009-02-23 2012-08-16 メルク カナダ インコーポレイテッド ステアロイル−コエンザイムａデルタ−９デサチュラーゼの阻害剤としての複素環誘導体
TWI504395B (zh) 2009-03-10 2015-10-21 Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier
TW201038565A (en) 2009-03-12 2010-11-01 Gruenenthal Gmbh Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators
TWI461197B (zh) 2009-03-12 2014-11-21 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier
TWI565465B (zh) 2010-08-27 2017-01-11 歌林達股份有限公司 作為ｋｃｎｑ２／３調節劑之被取代之喹啉－３－甲醯胺
TW201211007A (en) 2010-08-27 2012-03-16 Gruenenthal Gmbh Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators
BR112013004690A2 (pt) 2010-08-27 2016-05-10 Gruenenthal Gmbh 2-oxo-e 2-tioxo-di-hidroquinolina-3-carboxamidas substituídas como moduladores kcnq2/3
KR20130100300A (ko) 2010-08-27 2013-09-10 그뤼넨탈 게엠베하 Ｋｃｎｑ２／３ 조절제로서의 치환된 ２-옥시-퀴놀린-３-카복스아미드
AU2011297937B2 (en) 2010-09-01 2015-10-01 Grunenthal Gmbh Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators
US8552200B2 (en) 2010-10-20 2013-10-08 Gruenenthal Gmbh Substituted 6-amino-nicotinamides as KCNQ2/3 modulators
US9168259B2 (en) 2010-10-20 2015-10-27 Grünenthal GmbH Substituted 6-amino-nicotinamides as KCNQ2/3 modulators
PH12013500907A1 (en) 2010-11-05 2013-07-08 Firmenich Incorporated Compounds useful as modulators of trpm8
CN102229610B (zh) * 2011-04-22 2014-10-29 中山大学 一种光学纯手性1,2,3,4-四氢吡咯并[1,2-a]吡嗪化合物的合成方法
MX2014012491A (es) 2012-04-18 2014-11-14 Grünenthal GmbH 4-aminobenzamidas sustituidas como moduladores de kcnq2/3.
BR112014025840A2 (pt) 2012-04-18 2017-07-18 Gruenenthal Gmbh 6-amino-nicotinamidas substituídas tendo um grupo contendo oh como moduladores de kcnq2/3.
EP2925759A1 (en) 2012-11-28 2015-10-07 Grünenthal GmbH Heteroquinoline-3-carboxamides as kcnq2/3 modulators
US9284286B2 (en) 2012-11-28 2016-03-15 Grünenthal GmbH Specific carboxamides as KCNQ2/3 modulators
US9248122B2 (en) 2012-11-28 2016-02-02 Grünenthal GmbH Heteroquinoline-3-carboxamides as KCNQ2/3 modulators
JP6463362B2 (ja) * 2013-12-19 2019-01-30 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ＲＯＲ−ガンマ阻害剤としてのテトラヒドロ−テトラゾロ［１，５−ａ］ピラジン
EP3356356B1 (en) 2015-10-01 2021-05-26 Firmenich Incorporated Compounds useful as modulators of trpm8
WO2018191389A1 (en) * 2017-04-12 2018-10-18 Roche Sequencing Solutions, Inc. A method for sequencing reaction with tagged nucleoside obtained via pictet spengler reaction

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US4188389A (en) * 1978-11-03 1980-02-12 Ayerst Mckenna & Harrison, Inc. 1,2,3,4-Tetrahydropyrrolo(1,2-A)pyrazines
TW224974B (es) * 1991-07-02 1994-06-11 Hoffmann La Roche
EP0572863A1 (de) 1992-06-05 1993-12-08 F. Hoffmann-La Roche Ag ZNS Pyrazinoindole
US5378846A (en) * 1993-06-11 1995-01-03 Russian-American Institute For New Drug Development 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives
MXPA03007397A (es) * 2001-02-20 2003-12-04 Bristol Myers Squibb Co Moduladores de canales de potasio kcnq y uso de los mismos en tratamiento de migrana y enfermedades mecanicamente relacionadas.
AU2002337142B2 (en) * 2001-09-19 2007-10-11 Aventis Pharma S.A. Indolizines as kinase protein inhibitors
UA77515C2 (en) * 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
SE524324C2 (sv) * 2002-04-20 2004-07-27 Sqs Ab Förfarande och anordning vid ett värdeutrymme
WO2004029040A1 (en) * 2002-09-27 2004-04-08 Janssen Pharmaceutica N.V. 3,4-disubstituted pyrroles and their for use in treating inflammatory diseases
US7247628B2 (en) * 2002-12-12 2007-07-24 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
CA2535265C (en) * 2003-08-22 2014-01-28 Dendreon Corporation Compositions and methods for the treatment of disease associated with trp-p8 expression
US20090093463A1 (en) * 2004-11-02 2009-04-09 Agouron Pharmaceuticals Inc. Novel compounds of substituted and unsubtituted adamantyl amides

Also Published As

Publication number Publication date
NZ576021A (en) 2011-03-31
CA2666647A1 (en) 2008-04-24
EP2144913A2 (de) 2010-01-20
CN101547925A (zh) 2009-09-30
US7625900B2 (en) 2009-12-01
WO2008046582A1 (de) 2008-04-24
JP2010506869A (ja) 2010-03-04
AU2007312557B2 (en) 2013-06-13
US7879858B2 (en) 2011-02-01
AU2007312557A8 (en) 2009-06-25
US20090258880A1 (en) 2009-10-15
WO2008046581A3 (de) 2008-06-12
JP5256203B2 (ja) 2013-08-07
KR20090084873A (ko) 2009-08-05
IL198073A (en) 2013-03-24
AU2007312557A1 (en) 2008-04-24
US20080167315A1 (en) 2008-07-10
IL198073A0 (en) 2009-12-24
US20100004252A1 (en) 2010-01-07
BRPI0715298A2 (pt) 2014-10-29
RU2009118491A (ru) 2010-11-27
WO2008046581A2 (de) 2008-04-24
EP2112993A1 (de) 2009-11-04
RU2469037C2 (ru) 2012-12-10
US8017772B2 (en) 2011-09-13
DE102006049452A1 (de) 2008-05-08
MX2009004108A (es) 2009-04-28
CO6160331A2 (es) 2010-05-20
NO20091509L (no) 2009-05-28

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