BRPI0715298A2 - Compostos substuídos de tetrahidropirrolipiperazina tendo afinidade com o canal kcnq2/3 k+ e sua aplicação em medicamentos. - Google Patents
Compostos substuídos de tetrahidropirrolipiperazina tendo afinidade com o canal kcnq2/3 k+ e sua aplicação em medicamentos.Info
- Publication number
- BRPI0715298A2 BRPI0715298A2 BRPI0715298-1A2A BRPI0715298A BRPI0715298A2 BR PI0715298 A2 BRPI0715298 A2 BR PI0715298A2 BR PI0715298 A BRPI0715298 A BR PI0715298A BR PI0715298 A2 BRPI0715298 A2 BR PI0715298A2
- Authority
- BR
- Brazil
- Prior art keywords
- tetrahydropyrolipiperazine
- substructed
- kcnq2
- affinity
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006049452A DE102006049452A1 (de) | 2006-10-17 | 2006-10-17 | Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln |
PCT/EP2007/008957 WO2008046582A1 (de) | 2006-10-17 | 2007-10-16 | Substituierte tetrahydropyrrolopyrazin-verbindungen mit affinität zum kcnq2/3 k+ kanal und deren verwendung in arzneimitteln |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0715298A2 true BRPI0715298A2 (pt) | 2014-10-29 |
Family
ID=39125609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0715298-1A2A BRPI0715298A2 (pt) | 2006-10-17 | 2007-10-16 | Compostos substuídos de tetrahidropirrolipiperazina tendo afinidade com o canal kcnq2/3 k+ e sua aplicação em medicamentos. |
Country Status (17)
Country | Link |
---|---|
US (3) | US7625900B2 (pt) |
EP (2) | EP2112993A1 (pt) |
JP (1) | JP5256203B2 (pt) |
KR (1) | KR20090084873A (pt) |
CN (1) | CN101547925A (pt) |
AU (1) | AU2007312557B2 (pt) |
BR (1) | BRPI0715298A2 (pt) |
CA (1) | CA2666647A1 (pt) |
CO (1) | CO6160331A2 (pt) |
DE (1) | DE102006049452A1 (pt) |
EC (1) | ECSP099320A (pt) |
IL (1) | IL198073A (pt) |
MX (1) | MX2009004108A (pt) |
NO (1) | NO20091509L (pt) |
NZ (1) | NZ576021A (pt) |
RU (1) | RU2469037C2 (pt) |
WO (2) | WO2008046581A2 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2350093E (pt) * | 2008-10-24 | 2012-11-02 | Gruenenthal Gmbh | 4,5,6,7-tetra-hidrotienopiridinas substituídas como moduladores de kcnq2/3 para tratamento da dor, epilepsia e incontinência urinária |
US8367700B2 (en) | 2008-12-17 | 2013-02-05 | Gruenenthal Gmbh | Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators |
US20110301143A1 (en) * | 2009-02-23 | 2011-12-08 | Elise Isabel | Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
TWI504395B (zh) | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
TW201038565A (en) | 2009-03-12 | 2010-11-01 | Gruenenthal Gmbh | Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators |
NZ604745A (en) | 2010-08-27 | 2015-01-30 | Gruenenthal Chemie | Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators |
EP2609086B1 (en) | 2010-08-27 | 2015-02-25 | Grünenthal GmbH | Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators |
JP5887346B2 (ja) | 2010-08-27 | 2016-03-16 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Kcnq2/3調節因子としての置換キノリン−3−カルボキサミド |
US8470852B2 (en) | 2010-08-27 | 2013-06-25 | Gruenenthal Gmbh | Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators |
MX2013002295A (es) | 2010-09-01 | 2013-05-09 | Gruenenthal Gmbh | 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3. |
KR101820645B1 (ko) | 2010-10-20 | 2018-01-22 | 그뤼넨탈 게엠베하 | Kcnq2/3 조절제로서의 치환된 6아미노니코틴아미드 |
US9168259B2 (en) | 2010-10-20 | 2015-10-27 | Grünenthal GmbH | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators |
WO2012061698A2 (en) | 2010-11-05 | 2012-05-10 | Senomyx, Inc. | Compounds useful as modulators of trpm8 |
CN102229610B (zh) * | 2011-04-22 | 2014-10-29 | 中山大学 | 一种光学纯手性1,2,3,4-四氢吡咯并[1,2-a]吡嗪化合物的合成方法 |
AU2013248638A1 (en) | 2012-04-18 | 2014-12-04 | Grünenthal GmbH | Substituted 4-aminobenzamides as KCNQ2/3 modulators |
JP6033403B2 (ja) | 2012-04-18 | 2016-11-30 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Kcnq2/3調節因子としてのoh含有基を有する置換6−アミノ−ニコチンアミド類 |
AU2013351551A1 (en) | 2012-11-28 | 2015-07-16 | Grunenthal Gmbh | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
US9248122B2 (en) | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
AU2013351550A1 (en) | 2012-11-28 | 2015-07-16 | Grünenthal GmbH | Specific carboxamides as KCNQ2/3 modulators |
AU2014365915C1 (en) * | 2013-12-19 | 2019-04-04 | Merck Patent Gmbh | Tetrahydro-tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors |
US10392371B2 (en) | 2015-10-01 | 2019-08-27 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
CN110709523B (zh) * | 2017-04-12 | 2023-07-11 | 豪夫迈·罗氏有限公司 | 使用经pictet spengler反应获得的加标签的核苷的测序反应方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4188389A (en) * | 1978-11-03 | 1980-02-12 | Ayerst Mckenna & Harrison, Inc. | 1,2,3,4-Tetrahydropyrrolo(1,2-A)pyrazines |
TW224974B (pt) * | 1991-07-02 | 1994-06-11 | Hoffmann La Roche | |
EP0572863A1 (de) * | 1992-06-05 | 1993-12-08 | F. Hoffmann-La Roche Ag | ZNS Pyrazinoindole |
US5378846A (en) * | 1993-06-11 | 1995-01-03 | Russian-American Institute For New Drug Development | 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives |
MXPA03007397A (es) | 2001-02-20 | 2003-12-04 | Bristol Myers Squibb Co | Moduladores de canales de potasio kcnq y uso de los mismos en tratamiento de migrana y enfermedades mecanicamente relacionadas. |
CA2466243A1 (en) * | 2001-09-19 | 2003-03-27 | Aventis Pharma S.A. | Indolizines as kinase protein inhibitors |
UA77515C2 (en) * | 2002-04-04 | 2006-12-15 | Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity | |
SE524324C2 (sv) * | 2002-04-20 | 2004-07-27 | Sqs Ab | Förfarande och anordning vid ett värdeutrymme |
PL376056A1 (en) * | 2002-09-27 | 2005-12-12 | Janssen Pharmaceutica N.V. | 3,4-disubstituted pyrroles and their for use in treating inflammatory diseases |
US7247628B2 (en) * | 2002-12-12 | 2007-07-24 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
US8362264B2 (en) * | 2003-08-22 | 2013-01-29 | Dendreon Corporation | Compositions and methods for the treatment of disease associated with Trp-p8 expression |
US20090093463A1 (en) * | 2004-11-02 | 2009-04-09 | Agouron Pharmaceuticals Inc. | Novel compounds of substituted and unsubtituted adamantyl amides |
-
2006
- 2006-10-17 DE DE102006049452A patent/DE102006049452A1/de not_active Withdrawn
-
2007
- 2007-10-16 WO PCT/EP2007/008956 patent/WO2008046581A2/de active Application Filing
- 2007-10-16 AU AU2007312557A patent/AU2007312557B2/en not_active Expired - Fee Related
- 2007-10-16 BR BRPI0715298-1A2A patent/BRPI0715298A2/pt not_active IP Right Cessation
- 2007-10-16 CA CA002666647A patent/CA2666647A1/en not_active Abandoned
- 2007-10-16 EP EP07819027A patent/EP2112993A1/de not_active Withdrawn
- 2007-10-16 EP EP07819026A patent/EP2144913A2/de not_active Withdrawn
- 2007-10-16 RU RU2009118491/04A patent/RU2469037C2/ru not_active IP Right Cessation
- 2007-10-16 WO PCT/EP2007/008957 patent/WO2008046582A1/de active Application Filing
- 2007-10-16 KR KR1020097010089A patent/KR20090084873A/ko not_active Application Discontinuation
- 2007-10-16 NZ NZ576021A patent/NZ576021A/en not_active IP Right Cessation
- 2007-10-16 MX MX2009004108A patent/MX2009004108A/es active IP Right Grant
- 2007-10-16 CN CNA2007800447102A patent/CN101547925A/zh active Pending
- 2007-10-16 JP JP2009532715A patent/JP5256203B2/ja not_active Expired - Fee Related
- 2007-10-17 US US11/873,574 patent/US7625900B2/en not_active Expired - Fee Related
-
2009
- 2009-04-07 IL IL198073A patent/IL198073A/en not_active IP Right Cessation
- 2009-04-17 NO NO20091509A patent/NO20091509L/no not_active Application Discontinuation
- 2009-04-17 CO CO09038945A patent/CO6160331A2/es unknown
- 2009-04-17 US US12/425,873 patent/US7879858B2/en not_active Expired - Fee Related
- 2009-05-11 EC EC2009009320A patent/ECSP099320A/es unknown
- 2009-09-11 US US12/558,008 patent/US8017772B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP5256203B2 (ja) | 2013-08-07 |
US20090258880A1 (en) | 2009-10-15 |
NZ576021A (en) | 2011-03-31 |
IL198073A0 (en) | 2009-12-24 |
US7625900B2 (en) | 2009-12-01 |
US20100004252A1 (en) | 2010-01-07 |
WO2008046582A1 (de) | 2008-04-24 |
CN101547925A (zh) | 2009-09-30 |
EP2112993A1 (de) | 2009-11-04 |
NO20091509L (no) | 2009-05-28 |
CA2666647A1 (en) | 2008-04-24 |
US7879858B2 (en) | 2011-02-01 |
RU2469037C2 (ru) | 2012-12-10 |
IL198073A (en) | 2013-03-24 |
AU2007312557B2 (en) | 2013-06-13 |
CO6160331A2 (es) | 2010-05-20 |
KR20090084873A (ko) | 2009-08-05 |
AU2007312557A8 (en) | 2009-06-25 |
JP2010506869A (ja) | 2010-03-04 |
RU2009118491A (ru) | 2010-11-27 |
EP2144913A2 (de) | 2010-01-20 |
DE102006049452A1 (de) | 2008-05-08 |
ECSP099320A (es) | 2009-06-30 |
AU2007312557A1 (en) | 2008-04-24 |
MX2009004108A (es) | 2009-04-28 |
WO2008046581A2 (de) | 2008-04-24 |
US8017772B2 (en) | 2011-09-13 |
WO2008046581A3 (de) | 2008-06-12 |
US20080167315A1 (en) | 2008-07-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |