MD4258C1 - Utilizarea compuşilor coordinativi ai cuprului(II) cu 4-(metoxifenil)tiosemicarbazonele 2-benzoilpiridinei în calitate de inhibitori ai Candida albicans - Google Patents
Utilizarea compuşilor coordinativi ai cuprului(II) cu 4-(metoxifenil)tiosemicarbazonele 2-benzoilpiridinei în calitate de inhibitori ai Candida albicans Download PDFInfo
- Publication number
- MD4258C1 MD4258C1 MDA20120045A MD20120045A MD4258C1 MD 4258 C1 MD4258 C1 MD 4258C1 MD A20120045 A MDA20120045 A MD A20120045A MD 20120045 A MD20120045 A MD 20120045A MD 4258 C1 MD4258 C1 MD 4258C1
- Authority
- MD
- Moldova
- Prior art keywords
- methoxyphenyl
- copper
- benzoylpyridine
- candida albicans
- iii
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 23
- 241000222122 Candida albicans Species 0.000 title claims abstract description 13
- GCSHUYKULREZSJ-UHFFFAOYSA-N phenyl(pyridin-2-yl)methanone Chemical compound C=1C=CC=NC=1C(=O)C1=CC=CC=C1 GCSHUYKULREZSJ-UHFFFAOYSA-N 0.000 title claims abstract description 12
- 239000003112 inhibitor Substances 0.000 title claims abstract description 7
- 229940042396 direct acting antivirals thiosemicarbazones Drugs 0.000 title claims abstract description 6
- 150000003584 thiosemicarbazones Chemical class 0.000 title claims abstract description 6
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 title claims abstract description 5
- 229940095731 candida albicans Drugs 0.000 title claims description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract description 12
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract description 6
- 229910052802 copper Inorganic materials 0.000 abstract description 6
- 239000010949 copper Substances 0.000 abstract description 6
- 241000233866 Fungi Species 0.000 abstract description 5
- 239000003814 drug Substances 0.000 abstract description 5
- 229910052723 transition metal Inorganic materials 0.000 abstract description 4
- 150000003624 transition metals Chemical class 0.000 abstract description 4
- -1 methoxyphenyl Chemical group 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 7
- 230000001857 anti-mycotic effect Effects 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 4
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 230000000843 anti-fungal effect Effects 0.000 description 3
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 3
- 229910021592 Copper(II) chloride Inorganic materials 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 239000002543 antimycotic Substances 0.000 description 2
- MPTQRFCYZCXJFQ-UHFFFAOYSA-L copper(II) chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Cu+2] MPTQRFCYZCXJFQ-UHFFFAOYSA-L 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- AJKVQEKCUACUMD-UHFFFAOYSA-N 2-Acetylpyridine Chemical group CC(=O)C1=CC=CC=N1 AJKVQEKCUACUMD-UHFFFAOYSA-N 0.000 description 1
- CSDSSGBPEUDDEE-UHFFFAOYSA-N 2-formylpyridine Chemical group O=CC1=CC=CC=N1 CSDSSGBPEUDDEE-UHFFFAOYSA-N 0.000 description 1
- 241000193755 Bacillus cereus Species 0.000 description 1
- 102000015782 Electron Transport Complex III Human genes 0.000 description 1
- 108010024882 Electron Transport Complex III Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241001148132 Salmonella enterica subsp. enterica serovar Abony Species 0.000 description 1
- 241000607760 Shigella sonnei Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 229940115939 shigella sonnei Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20120045A MD4258C1 (ro) | 2012-05-31 | 2012-05-31 | Utilizarea compuşilor coordinativi ai cuprului(II) cu 4-(metoxifenil)tiosemicarbazonele 2-benzoilpiridinei în calitate de inhibitori ai Candida albicans |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20120045A MD4258C1 (ro) | 2012-05-31 | 2012-05-31 | Utilizarea compuşilor coordinativi ai cuprului(II) cu 4-(metoxifenil)tiosemicarbazonele 2-benzoilpiridinei în calitate de inhibitori ai Candida albicans |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4258B1 MD4258B1 (en) | 2013-11-30 |
| MD4258C1 true MD4258C1 (ro) | 2014-06-30 |
Family
ID=49724417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20120045A MD4258C1 (ro) | 2012-05-31 | 2012-05-31 | Utilizarea compuşilor coordinativi ai cuprului(II) cu 4-(metoxifenil)tiosemicarbazonele 2-benzoilpiridinei în calitate de inhibitori ai Candida albicans |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4258C1 (mo) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4383C1 (ro) * | 2015-03-06 | 2016-06-30 | Государственный Университет Молд0 | Compusul acetato-(8-formilchinolintiosemicarbazono)cupru(II) care manifestă activitate antibacteriană |
| MD4402C1 (ro) * | 2015-09-04 | 2016-09-30 | Государственный Университет Молд0 | Metil-N'-[(2-hidroxinaftalen-1-il)metiliden]-N-prop-2-en-1-ilhidrazonotioat, care manifestă activitate antimicotică faţă de Candida albicans |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3824276A (en) * | 1963-03-14 | 1974-07-16 | Upjohn Co | Substituted-2-oxobutyraldehyde bis(thiosemicarbazones) |
| US6329378B1 (en) * | 1999-02-10 | 2001-12-11 | Anadys Pharmaceuticals, Inc. | Hydrazone, hydrazine and thiosemicarbazone derivatives as antifungal agents |
| MD1812B1 (en) * | 2000-12-29 | 2001-12-31 | Univ Nicolae Testemitanu | Copper complexes as bacteria and fungi inhibitors |
| MD2003B1 (en) * | 2001-01-10 | 2002-09-30 | Univ Nicolae Testemitanu | Copper chelate compounds(II) with antimicrobial and antimycotic activity |
| US20020188011A1 (en) * | 2001-04-20 | 2002-12-12 | King Ivan C. | Antiviral agents and methods of treating viral infections |
| MD2325F1 (en) * | 2002-07-10 | 2003-12-31 | Univ Nicolae Testemitanu | Chelate copper(II) complexes - growith and multiplication inhibitors of the yeast and mycelium fungi. |
| MD2861F1 (ro) * | 2004-09-20 | 2005-09-30 | Universitatea De Stat Din Moldova | (µ-Imidazol-N,N?)-bis{4-bromo-2-[2-(oxietilimino)-metil]-fenolato(2-)-cupru}, care manifesta activitate antimicotica |
| MD3484F1 (ro) * | 2007-02-12 | 2008-01-31 | Universitatea De Stat Din Moldova | Di-{µ-[N-(2-hidroxietil)-(5-clorosalicilideniminato(-1))]-(O, N, O, Cl}-bis-(nitrato-imidazolcupru) care manifesta activitate antimicotica |
-
2012
- 2012-05-31 MD MDA20120045A patent/MD4258C1/ro not_active IP Right Cessation
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3824276A (en) * | 1963-03-14 | 1974-07-16 | Upjohn Co | Substituted-2-oxobutyraldehyde bis(thiosemicarbazones) |
| US6329378B1 (en) * | 1999-02-10 | 2001-12-11 | Anadys Pharmaceuticals, Inc. | Hydrazone, hydrazine and thiosemicarbazone derivatives as antifungal agents |
| MD1812B1 (en) * | 2000-12-29 | 2001-12-31 | Univ Nicolae Testemitanu | Copper complexes as bacteria and fungi inhibitors |
| MD2003B1 (en) * | 2001-01-10 | 2002-09-30 | Univ Nicolae Testemitanu | Copper chelate compounds(II) with antimicrobial and antimycotic activity |
| US20020188011A1 (en) * | 2001-04-20 | 2002-12-12 | King Ivan C. | Antiviral agents and methods of treating viral infections |
| MD2325F1 (en) * | 2002-07-10 | 2003-12-31 | Univ Nicolae Testemitanu | Chelate copper(II) complexes - growith and multiplication inhibitors of the yeast and mycelium fungi. |
| MD2861F1 (ro) * | 2004-09-20 | 2005-09-30 | Universitatea De Stat Din Moldova | (µ-Imidazol-N,N?)-bis{4-bromo-2-[2-(oxietilimino)-metil]-fenolato(2-)-cupru}, care manifesta activitate antimicotica |
| MD3484F1 (ro) * | 2007-02-12 | 2008-01-31 | Universitatea De Stat Din Moldova | Di-{µ-[N-(2-hidroxietil)-(5-clorosalicilideniminato(-1))]-(O, N, O, Cl}-bis-(nitrato-imidazolcupru) care manifesta activitate antimicotica |
Also Published As
| Publication number | Publication date |
|---|---|
| MD4258B1 (en) | 2013-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Joseph et al. | Novel metal based anti-tuberculosis agent: synthesis, characterization, catalytic and pharmacological activities of copper complexes | |
| Smoleński et al. | New water-soluble polypyridine silver (I) derivatives of 1, 3, 5-triaza-7-phosphaadamantane (PTA) with significant antimicrobial and antiproliferative activities | |
| MD4133C1 (ro) | [(2-Carbamotioilhidrazon)propionato(2-)]-(4-aminobenzensulfamid)cupru, care manifestă activitate antimicrobiană faţă de bacteriile din genul Bacillus cereus | |
| Rauf et al. | Synthesis, pH dependent photometric and electrochemical investigation, redox mechanism and biological applications of novel Schiff base and its metallic derivatives | |
| Sumrra et al. | Complexes of imino-1, 2, 4-triazole derivative with transition metals: synthesis and antibacterial study | |
| MD4127C1 (ro) | Utilizare a di(µ-S)-bis{cloro-[1-(piridin-2-il)etanon-4-metiltiosemicarbazonato(1-)]cupru} în calitate de substanţă cu activitate antimicrobiană faţă de Staphylococcus aureus | |
| Shobana et al. | Synthesis, structural elucidation, biological, antioxidant and nuclease activities of some 5-Fluorouracil–amino acid mixed ligand complexes | |
| MD4194C1 (ro) | Compus coordinativ trinuclear al cuprului: tris{µ-[3,5-dibromo-2-hidroxibenziliden-4′-(piridin-2-il)-tiosemicarbazido(2-)]cupru} hidrat, care manifestă activitate antimicotică faţă de Candida albicans | |
| Patil et al. | Synthesis, characterization, fluorescence and biological studies of Mn (II), Fe (III) and Zn (II) complexes of Schiff bases derived from Isatin and 3-substituted-4-amino-5-mercapto-1, 2, 4-triazoles | |
| Đurić et al. | Silver (I) complexes with 1, 10-phenanthroline-based ligands: The influence of epoxide function on the complex structure and biological activity | |
| Glišić et al. | Synthesis, structural characterization and biological evaluation of dinuclear gold (III) complexes with aromatic nitrogen-containing ligands: antimicrobial activity in relation to the complex nuclearity | |
| Zheng et al. | A new 3D POMOF built upon Keggin clusters and flexible n-heterocycle carboxylate ligands for catalytic and antimicrobial properties | |
| MD4132C1 (ro) | Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar | |
| CN102573859B (zh) | 银/聚缩二胍配合物、其制备方法以及含有所述银/聚缩二胍配合物作为活性成分的抗细菌组合物 | |
| Călinescu et al. | Synthesis and characterization of new copper (II) complex compounds with chlorhexidine. Part I | |
| Nejadmirfathi et al. | Novel N3-Schiff base and its zinc halide/pseudohalide complexes: Antimicrobial, antioxidant, cytotoxicity and burn wound healing activities | |
| CN105669973B (zh) | 一种具抑菌活性的化合物及其制备和应用 | |
| US20140107344A1 (en) | Zinc salt of isothiazolone compound, method for reducing irritation caused by isothiazolone compound, antibacterial and antifungal method using zinc salt of isothiazolone compound, and antibacterial and antifungal composition | |
| Kopel et al. | Synthesis, characterization and screening of biological activity of Zn (II), Fe (II) and Mn (II) complexes with trithiocyanuric acid | |
| MD4842C1 (ro) | Nitrato-{N-(prop-2-en-1-il)-N'-[1-(piridin-2-il)-etiliden]carbamohidrazontioato}cupru, care manifestă activitate antimicrobiană faţă de bacteriile din specia Streptococcus pneumoniae | |
| MD4652C1 (ro) | Complecşii sulfatului de cupru(II) cu 2-(2-hidroxibenziliden)-N-(metoxifenil)hidrazincarbotioamide, care manifestă activitate antimicrobiană faţă de microorganismele gram-pozitive | |
| MD4402C1 (ro) | Metil-N'-[(2-hidroxinaftalen-1-il)metiliden]-N-prop-2-en-1-ilhidrazonotioat, care manifestă activitate antimicotică faţă de Candida albicans | |
| RO127465A2 (ro) | Complecşi metalici ai clorhexidinei şi procedeu de obţinere a acestora | |
| MD4707C1 (ro) | [N`-(3,5-dibromo-2-oxidobenziliden)-N-(prop-2-en-1-il)carbamohidrazonotioato]piridincupru, care manifestă activitate antimicrobiană faţă de bacteriile din speciile Bacillus cereus şi Bacillus subtilis | |
| MD4936C1 (ro) | N-(biciclo[2,2,1]heptan-2-il)-2-[(piridin-2-il)metiliden]-hidrazin-1-carbotioamida, care manifestă activitate antimicotică faţă de fungii din specia Candida albicans |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |