MD4258C1 - Использование координационных соединений меди(II) с 4-(метоксифенил)тиосемикарбазонами 2-бензоилпиридина в качестве ингибиторов Candida albicans - Google Patents
Использование координационных соединений меди(II) с 4-(метоксифенил)тиосемикарбазонами 2-бензоилпиридина в качестве ингибиторов Candida albicans Download PDFInfo
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- MD4258C1 MD4258C1 MDA20120045A MD20120045A MD4258C1 MD 4258 C1 MD4258 C1 MD 4258C1 MD A20120045 A MDA20120045 A MD A20120045A MD 20120045 A MD20120045 A MD 20120045A MD 4258 C1 MD4258 C1 MD 4258C1
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- Moldova
- Prior art keywords
- methoxyphenyl
- copper
- benzoylpyridine
- candida albicans
- iii
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 23
- 241000222122 Candida albicans Species 0.000 title claims abstract description 13
- GCSHUYKULREZSJ-UHFFFAOYSA-N phenyl(pyridin-2-yl)methanone Chemical compound C=1C=CC=NC=1C(=O)C1=CC=CC=C1 GCSHUYKULREZSJ-UHFFFAOYSA-N 0.000 title claims abstract description 12
- 239000003112 inhibitor Substances 0.000 title claims abstract description 7
- 229940042396 direct acting antivirals thiosemicarbazones Drugs 0.000 title claims abstract description 6
- 150000003584 thiosemicarbazones Chemical class 0.000 title claims abstract description 6
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 title claims abstract description 5
- 229940095731 candida albicans Drugs 0.000 title claims description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract description 12
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract description 6
- 229910052802 copper Inorganic materials 0.000 abstract description 6
- 239000010949 copper Substances 0.000 abstract description 6
- 241000233866 Fungi Species 0.000 abstract description 5
- 239000003814 drug Substances 0.000 abstract description 5
- 229910052723 transition metal Inorganic materials 0.000 abstract description 4
- 150000003624 transition metals Chemical class 0.000 abstract description 4
- -1 methoxyphenyl Chemical group 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 7
- 230000001857 anti-mycotic effect Effects 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 4
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 230000000843 anti-fungal effect Effects 0.000 description 3
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 3
- 229910021592 Copper(II) chloride Inorganic materials 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 239000002543 antimycotic Substances 0.000 description 2
- MPTQRFCYZCXJFQ-UHFFFAOYSA-L copper(II) chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Cu+2] MPTQRFCYZCXJFQ-UHFFFAOYSA-L 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- AJKVQEKCUACUMD-UHFFFAOYSA-N 2-Acetylpyridine Chemical group CC(=O)C1=CC=CC=N1 AJKVQEKCUACUMD-UHFFFAOYSA-N 0.000 description 1
- CSDSSGBPEUDDEE-UHFFFAOYSA-N 2-formylpyridine Chemical group O=CC1=CC=CC=N1 CSDSSGBPEUDDEE-UHFFFAOYSA-N 0.000 description 1
- 241000193755 Bacillus cereus Species 0.000 description 1
- 102000015782 Electron Transport Complex III Human genes 0.000 description 1
- 108010024882 Electron Transport Complex III Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241001148132 Salmonella enterica subsp. enterica serovar Abony Species 0.000 description 1
- 241000607760 Shigella sonnei Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 229940115939 shigella sonnei Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к медицине, а именно к использованию биологически активных координационных соединений меди класса тиосемикарбазонатов переходных металлов в качестве ингибиторов грибов вида Candida albicans.Сущность изобретения заключается в использовании в качестве ингибиторов грибов вида Candida albicans координационных соединений меди(II) с 4-(метоксифенил)тиосемикарбазонами 2-бензоилпиридина общей формулы:I-IIII: R1 = OCH3, R2 = R3 = H; II: R1 = R3 = H, R2 = OCH3; III: R1 = R2 = H, R3 = OCH3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20120045A MD4258C1 (ru) | 2012-05-31 | 2012-05-31 | Использование координационных соединений меди(II) с 4-(метоксифенил)тиосемикарбазонами 2-бензоилпиридина в качестве ингибиторов Candida albicans |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20120045A MD4258C1 (ru) | 2012-05-31 | 2012-05-31 | Использование координационных соединений меди(II) с 4-(метоксифенил)тиосемикарбазонами 2-бензоилпиридина в качестве ингибиторов Candida albicans |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4258B1 MD4258B1 (en) | 2013-11-30 |
| MD4258C1 true MD4258C1 (ru) | 2014-06-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20120045A MD4258C1 (ru) | 2012-05-31 | 2012-05-31 | Использование координационных соединений меди(II) с 4-(метоксифенил)тиосемикарбазонами 2-бензоилпиридина в качестве ингибиторов Candida albicans |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4258C1 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4383C1 (ru) * | 2015-03-06 | 2016-06-30 | Государственный Университет Молд0 | Соединение ацетато-(8-формилхинолинтиосемикарбазоно)медь(II), проявляющее антибактериальную активность |
| MD4402C1 (ru) * | 2015-09-04 | 2016-09-30 | Государственный Университет Молд0 | Метил-N'-[(2-гидроксинафтален-1-ил)метилиден]-N-проп-2-ен-1-илгидразонотиоат, проявляющий противогрибковую активность в отношении Candida albicans |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3824276A (en) * | 1963-03-14 | 1974-07-16 | Upjohn Co | Substituted-2-oxobutyraldehyde bis(thiosemicarbazones) |
| US6329378B1 (en) * | 1999-02-10 | 2001-12-11 | Anadys Pharmaceuticals, Inc. | Hydrazone, hydrazine and thiosemicarbazone derivatives as antifungal agents |
| MD1812B1 (en) * | 2000-12-29 | 2001-12-31 | Univ Nicolae Testemitanu | Copper complexes as bacteria and fungi inhibitors |
| MD2003B1 (en) * | 2001-01-10 | 2002-09-30 | Univ Nicolae Testemitanu | Copper chelate compounds(II) with antimicrobial and antimycotic activity |
| US20020188011A1 (en) * | 2001-04-20 | 2002-12-12 | King Ivan C. | Antiviral agents and methods of treating viral infections |
| MD2325F1 (en) * | 2002-07-10 | 2003-12-31 | Univ Nicolae Testemitanu | Chelate copper(II) complexes - growith and multiplication inhibitors of the yeast and mycelium fungi. |
| MD2861F1 (ro) * | 2004-09-20 | 2005-09-30 | Universitatea De Stat Din Moldova | (µ-Imidazol-N,N?)-bis{4-bromo-2-[2-(oxietilimino)-metil]-fenolato(2-)-cupru}, care manifesta activitate antimicotica |
| MD3484F1 (ro) * | 2007-02-12 | 2008-01-31 | Universitatea De Stat Din Moldova | Di-{µ-[N-(2-hidroxietil)-(5-clorosalicilideniminato(-1))]-(O, N, O, Cl}-bis-(nitrato-imidazolcupru) care manifesta activitate antimicotica |
-
2012
- 2012-05-31 MD MDA20120045A patent/MD4258C1/ru not_active IP Right Cessation
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3824276A (en) * | 1963-03-14 | 1974-07-16 | Upjohn Co | Substituted-2-oxobutyraldehyde bis(thiosemicarbazones) |
| US6329378B1 (en) * | 1999-02-10 | 2001-12-11 | Anadys Pharmaceuticals, Inc. | Hydrazone, hydrazine and thiosemicarbazone derivatives as antifungal agents |
| MD1812B1 (en) * | 2000-12-29 | 2001-12-31 | Univ Nicolae Testemitanu | Copper complexes as bacteria and fungi inhibitors |
| MD2003B1 (en) * | 2001-01-10 | 2002-09-30 | Univ Nicolae Testemitanu | Copper chelate compounds(II) with antimicrobial and antimycotic activity |
| US20020188011A1 (en) * | 2001-04-20 | 2002-12-12 | King Ivan C. | Antiviral agents and methods of treating viral infections |
| MD2325F1 (en) * | 2002-07-10 | 2003-12-31 | Univ Nicolae Testemitanu | Chelate copper(II) complexes - growith and multiplication inhibitors of the yeast and mycelium fungi. |
| MD2861F1 (ro) * | 2004-09-20 | 2005-09-30 | Universitatea De Stat Din Moldova | (µ-Imidazol-N,N?)-bis{4-bromo-2-[2-(oxietilimino)-metil]-fenolato(2-)-cupru}, care manifesta activitate antimicotica |
| MD3484F1 (ro) * | 2007-02-12 | 2008-01-31 | Universitatea De Stat Din Moldova | Di-{µ-[N-(2-hidroxietil)-(5-clorosalicilideniminato(-1))]-(O, N, O, Cl}-bis-(nitrato-imidazolcupru) care manifesta activitate antimicotica |
Also Published As
| Publication number | Publication date |
|---|---|
| MD4258B1 (en) | 2013-11-30 |
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| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
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