MD4402C1 - Metil-N'-[(2-hidroxinaftalen-1-il)metiliden]-N-prop-2-en-1-ilhidrazonotioat, care manifestă activitate antimicotică faţă de Candida albicans - Google Patents

Metil-N'-[(2-hidroxinaftalen-1-il)metiliden]-N-prop-2-en-1-ilhidrazonotioat, care manifestă activitate antimicotică faţă de Candida albicans

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Publication number
MD4402C1
MD4402C1 MDA20150084A MD20150084A MD4402C1 MD 4402 C1 MD4402 C1 MD 4402C1 MD A20150084 A MDA20150084 A MD A20150084A MD 20150084 A MD20150084 A MD 20150084A MD 4402 C1 MD4402 C1 MD 4402C1
Authority
MD
Moldova
Prior art keywords
ylhydrazonothioate
hydroxynaphthalene
methylidene
prop
methyl
Prior art date
Application number
MDA20150084A
Other languages
English (en)
Russian (ru)
Other versions
MD4402B1 (ro
Inventor
Василий ГРАУР
Елена ЗАРИЧУК
Ирина УСАТАЯ
Виктор ЦАПКОВ
Валериу РУДИК
Аурелиан ГУЛЯ
Original Assignee
Государственный Университет Молд0
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Государственный Университет Молд0 filed Critical Государственный Университет Молд0
Priority to MDA20150084A priority Critical patent/MD4402C1/ro
Publication of MD4402B1 publication Critical patent/MD4402B1/ro
Publication of MD4402C1 publication Critical patent/MD4402C1/ro

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Invenţia se referă la chimie şi medicină, şi anume la un compus organic biologic activ din clasa tiosemicarbazonelor.Esenţa invenţiei constă în sinteza compusului metil-N'-[(2-hidroxinaftalen-1-il)metiliden]-N-prop-2-en-1-ilhidrazonotioat cu formula:Compusul manifestă activitate antimicotică faţă de Candida albicans şi poate găsi aplicare în medicină şi medicina veterinară la profilaxia şi tratamentul micozelor.
MDA20150084A 2015-09-04 2015-09-04 Metil-N'-[(2-hidroxinaftalen-1-il)metiliden]-N-prop-2-en-1-ilhidrazonotioat, care manifestă activitate antimicotică faţă de Candida albicans MD4402C1 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20150084A MD4402C1 (ro) 2015-09-04 2015-09-04 Metil-N'-[(2-hidroxinaftalen-1-il)metiliden]-N-prop-2-en-1-ilhidrazonotioat, care manifestă activitate antimicotică faţă de Candida albicans

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20150084A MD4402C1 (ro) 2015-09-04 2015-09-04 Metil-N'-[(2-hidroxinaftalen-1-il)metiliden]-N-prop-2-en-1-ilhidrazonotioat, care manifestă activitate antimicotică faţă de Candida albicans

Publications (2)

Publication Number Publication Date
MD4402B1 MD4402B1 (ro) 2016-02-29
MD4402C1 true MD4402C1 (ro) 2016-09-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20150084A MD4402C1 (ro) 2015-09-04 2015-09-04 Metil-N'-[(2-hidroxinaftalen-1-il)metiliden]-N-prop-2-en-1-ilhidrazonotioat, care manifestă activitate antimicotică faţă de Candida albicans

Country Status (1)

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MD (1) MD4402C1 (ro)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4452C1 (ro) * 2016-02-29 2017-07-31 Государственный Университет Молд0 Utilizarea N-(2,4-dimetilfenil)-2-(2-hidroxibenziliden)-hidrazincarbotioamidei în calitate de inhibitor al proliferării fungilor din specia Candida albicans

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD1812B1 (ro) * 2000-12-29 2001-12-31 Univ Nicolae Testemitanu Complecsi de cupru ca inhibitori de bacterii si fungi
MD2003B1 (ro) * 2001-01-10 2002-09-30 Univ Nicolae Testemitanu Complecsi interni de cupru(II) cu actiune antimicrobiana si antimicotica
MD4194B1 (ro) * 2012-01-23 2013-01-31 Univ De Stat Din Moldova Compus coordinativ trinuclear al cuprului: tris{µ-¢3,5-dibromo-2-hidroxibenziliden-4′-(piridin-2-il)-tiosemicarbazido(2-)]cupru} hidrat, care manifesta activitate antimicotica fata de Candida albicans
MD4258B1 (ro) * 2012-05-31 2013-11-30 Univ De Stat Din Moldova Utilizarea compusilor coordinativi ai cuprului(II) cu 4-(metoxifenil)tiosemicarbazonele 2-benzoilpiridinei în calitate de inhibitori ai Candida albicans

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD1812B1 (ro) * 2000-12-29 2001-12-31 Univ Nicolae Testemitanu Complecsi de cupru ca inhibitori de bacterii si fungi
MD2003B1 (ro) * 2001-01-10 2002-09-30 Univ Nicolae Testemitanu Complecsi interni de cupru(II) cu actiune antimicrobiana si antimicotica
MD4194B1 (ro) * 2012-01-23 2013-01-31 Univ De Stat Din Moldova Compus coordinativ trinuclear al cuprului: tris{µ-¢3,5-dibromo-2-hidroxibenziliden-4′-(piridin-2-il)-tiosemicarbazido(2-)]cupru} hidrat, care manifesta activitate antimicotica fata de Candida albicans
MD4258B1 (ro) * 2012-05-31 2013-11-30 Univ De Stat Din Moldova Utilizarea compusilor coordinativi ai cuprului(II) cu 4-(metoxifenil)tiosemicarbazonele 2-benzoilpiridinei în calitate de inhibitori ai Candida albicans

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
He Huang, Qin Chen, Xin Ku, Linghua Meng, Liping Lin, Xiang Wang, Caihua Zhu, Yi Wang, Zhi Chen, Ming Li, Hualiang Jiang, Kaixian Chen, Jian Ding, Hong Liu. A Series of a-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase IIa Catalytic Activity. Journal of Medicinal Chemistry, 2010, vol. 53, p. 3048-3064 *
Liberta A., West D. Antifungal and antitumor activity of heterocyclic thiosemicarbazones and their metal complexes: current status. BioMetals, 1992, p. 121-126 (regăsit în Internet la 2015.11.23 URL:<http://www.ncbi.nlm.nih.gov/pubmed/1525478>) *
Pahontu E., Julea F., Rosu T., Purcarea V., Chumakov Yu., Petrenco P., Gulea A. Antibacterial, antifungal and in vitro antileukaemia activity of metal complexes with thiosemicarbazones. Journal of Cellular and Molecular Medicine, 2015 April, p. 865-878 (regăsit în Internet la 2015.12.01 URL:<http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395200/>) *

Also Published As

Publication number Publication date
MD4402B1 (ro) 2016-02-29

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Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees