MD2517C2 - Procedeu de producere a compozitelor antibiotice si utilizarea lor - Google Patents

Procedeu de producere a compozitelor antibiotice si utilizarea lor Download PDF

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Publication number
MD2517C2
MD2517C2 MDA20020074A MD20020074A MD2517C2 MD 2517 C2 MD2517 C2 MD 2517C2 MD A20020074 A MDA20020074 A MD A20020074A MD 20020074 A MD20020074 A MD 20020074A MD 2517 C2 MD2517 C2 MD 2517C2
Authority
MD
Moldova
Prior art keywords
antibiotics
composite
organic
production
composites
Prior art date
Application number
MDA20020074A
Other languages
English (en)
Russian (ru)
Other versions
MD20020074A (ro
MD2517B2 (ro
Inventor
Себастиан ВОГТ
Маттиас ШНАБЕЛЬРАУХ
Клаус-Дитер КУН
Original Assignee
ХЕРАУС КУЛЦЕР ГмбХ и Ко. КГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ХЕРАУС КУЛЦЕР ГмбХ и Ко. КГ filed Critical ХЕРАУС КУЛЦЕР ГмбХ и Ко. КГ
Publication of MD20020074A publication Critical patent/MD20020074A/ro
Publication of MD2517B2 publication Critical patent/MD2517B2/ro
Publication of MD2517C2 publication Critical patent/MD2517C2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Glanulating (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Invenţia se referă la un procedeu de producere a compozitelor antibiotice, care pot fi utilizate ca implanturi în medicină şi în medicina veterinară pentru tratamentul infecţiilor microbiene locale din ţesuturile tari sau moi.Procedeul constă în aceea că fixarea componentelor anorganice şi/sau organice ale compozitelor şi respectiv modelarea compozitelor la amestecarea cu apă se efectuează cu un liant, care reprezintă o sare deformabilă plastic constituită din cel puţin un component cationic al unui antibiotic protonat din grupa de aminoglicozide, lincosamide şi tetracicline şi cel puţin un component anionic din grupa de sulfaţi organici şi/sau sulfonaţi organici şi/sau esteri ai acizilor graşi, în special prin presare, extruziune, vălţuire, calandrare.
MDA20020074A 2001-03-22 2002-02-13 Procedeu de producere a compozitelor antibiotice si utilizarea lor MD2517C2 (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10114364A DE10114364A1 (de) 2001-03-22 2001-03-22 Verfahren zur Herstellung von antibiotischen Kompositen

Publications (3)

Publication Number Publication Date
MD20020074A MD20020074A (ro) 2002-11-30
MD2517B2 MD2517B2 (ro) 2004-08-31
MD2517C2 true MD2517C2 (ro) 2005-03-31

Family

ID=7678771

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20020074A MD2517C2 (ro) 2001-03-22 2002-02-13 Procedeu de producere a compozitelor antibiotice si utilizarea lor

Country Status (29)

Country Link
US (1) US6942877B2 (ro)
EP (1) EP1243255B1 (ro)
JP (1) JP3950721B2 (ro)
CN (1) CN1221248C (ro)
AT (1) ATE311860T1 (ro)
AU (1) AU766912B2 (ro)
BG (1) BG65499B1 (ro)
BR (1) BR0201224A (ro)
CA (1) CA2378436C (ro)
CZ (1) CZ2002869A3 (ro)
DE (2) DE10114364A1 (ro)
DK (1) DK1243255T3 (ro)
EE (1) EE200200156A (ro)
ES (1) ES2249502T3 (ro)
GE (1) GEP20053449B (ro)
HR (1) HRP20020239B1 (ro)
HU (1) HUP0201044A2 (ro)
IL (1) IL148637A (ro)
MD (1) MD2517C2 (ro)
MX (1) MXPA02003004A (ro)
NO (1) NO20021391L (ro)
NZ (1) NZ517919A (ro)
PL (1) PL204984B1 (ro)
RU (1) RU2241490C2 (ro)
SA (1) SA02230035B1 (ro)
SK (1) SK286868B6 (ro)
UA (1) UA71992C2 (ro)
YU (1) YU18002A (ro)
ZA (1) ZA200202256B (ro)

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DE10114245A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung
DE10227935B4 (de) 2002-06-21 2007-10-04 Heraeus Kulzer Gmbh Verfahren zur Herstellung einer antibiotische Beschichtung von porösen Körpern sowie Verwendung
DE10307103A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE10318991A1 (de) * 2003-04-25 2004-11-18 Heraeus Kulzer Gmbh & Co. Kg Poröser Körper mit antibiotischer Beschichtung, Verfahren zur Herstellung sowie Verwendung
DE102004060666B3 (de) 2004-12-15 2006-03-30 Heraeus Kulzer Gmbh Antibiotikum/Antibiotika enthaltendes Knochenersatzmaterial mit retardierender Wirkstofffreisetzung
DE102005002703C5 (de) * 2005-01-19 2013-07-04 Heraeus Kulzer Gmbh Antibiotische Beschichtung von Implantaten sowie Verfahren zur antibiotischen Beschichtung
DE102005061290B4 (de) * 2005-12-20 2021-03-18 Heraeus Medical Gmbh Verfahren zur Herstellung von Antibiotikum-/Antibiotika-Partikeln und deren Verwendung
US9603941B2 (en) * 2006-01-24 2017-03-28 Minghui Chai Method of preparing dendritic drugs
DE102006007245A1 (de) * 2006-02-15 2007-08-23 Heraeus Kulzer Gmbh Implantatmaterial
BRPI0602372B8 (pt) 2006-05-18 2021-06-22 Einco Biomaterial Ltda processo de preparação de compósitos em base de biocerâmicas e polímeros biodegradáveis e produto derivado
WO2008006083A2 (en) 2006-07-07 2008-01-10 Surmodics, Inc. Beaded wound spacer device
US20080063681A1 (en) * 2006-09-11 2008-03-13 Ebi, L.P. Therapeutic bone replacement material
EP1908754B1 (en) * 2006-09-19 2009-01-28 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knöll-Institut Antibiotic maduraphthalazin salts with delayed release of the active substance and their use
DE102006060938A1 (de) * 2006-12-20 2008-06-26 Wolter, Dietmar F., Prof. Dr. Materialdepot zur Abgabe eines antibakteriellen Wirkstoffmaterials
DE102007039871A1 (de) 2007-08-21 2009-02-26 Friedrich-Baur-Gmbh Weichgewebe-Implantat mit antibakterieller Wirkung
WO2014062839A1 (en) 2012-10-16 2014-04-24 Surmodics, Inc. Wound packing device and methods
RU2535067C1 (ru) * 2013-08-19 2014-12-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Саратовский государственный аграрный университет имени Н.И. Вавилова" Биоинтегрируемый композитный материал и способ формирования покрытия на изделиях медицинского назначения с использованием биоинтегрируемого композитного материала
US10201457B2 (en) 2014-08-01 2019-02-12 Surmodics, Inc. Wound packing device with nanotextured surface
CN106721083A (zh) * 2016-12-21 2017-05-31 驻马店华中正大有限公司 一种土霉素预混剂及其制备方法
RU2729025C1 (ru) * 2019-07-19 2020-08-03 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр травматологии и ортопедии имени Н.Н. Приорова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТО им. Н.Н. Приорова" Минздрава России) Способ хирургического лечения гнойно-воспалительных процессов костных и мягкотканых структур опорно-двигательной системы пациента с использованием мягких спейсеров, импрегнированных антибактериальными средствами

Citations (2)

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Publication number Priority date Publication date Assignee Title
US3536759A (en) * 1967-06-06 1970-10-27 Lab Hosbon Sa Tetracycline sulfamate and derivatives thereof
DE3248328A1 (de) * 1982-12-28 1984-06-28 Bayer Ag, 5090 Leverkusen Schwerloesliche salze von aminoglykosiden sowie diese enthaltende formulierungen mit verzoegerter wirkstoff-freigabe

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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536759A (en) * 1967-06-06 1970-10-27 Lab Hosbon Sa Tetracycline sulfamate and derivatives thereof
DE3248328A1 (de) * 1982-12-28 1984-06-28 Bayer Ag, 5090 Leverkusen Schwerloesliche salze von aminoglykosiden sowie diese enthaltende formulierungen mit verzoegerter wirkstoff-freigabe

Also Published As

Publication number Publication date
CN1221248C (zh) 2005-10-05
DE50205147D1 (de) 2006-01-12
JP3950721B2 (ja) 2007-08-01
ZA200202256B (en) 2002-10-11
CA2378436C (en) 2007-12-18
UA71992C2 (en) 2005-01-17
US6942877B2 (en) 2005-09-13
EP1243255A3 (de) 2002-12-18
IL148637A0 (en) 2002-09-12
PL352923A1 (en) 2002-09-23
YU18002A (sh) 2004-11-25
HRP20020239A2 (en) 2002-12-31
CZ2002869A3 (cs) 2002-11-13
HRP20020239B1 (en) 2006-12-31
BG106457A (bg) 2002-10-31
ES2249502T3 (es) 2006-04-01
NZ517919A (en) 2003-08-29
EP1243255A2 (de) 2002-09-25
SK3942002A3 (en) 2002-10-08
IL148637A (en) 2006-10-31
MD20020074A (ro) 2002-11-30
DE10114364A1 (de) 2002-10-02
HU0201044D0 (ro) 2002-05-29
EE200200156A (et) 2002-12-16
AU2755702A (en) 2002-09-26
BR0201224A (pt) 2002-12-10
DK1243255T3 (da) 2006-03-27
HUP0201044A2 (hu) 2003-02-28
SA02230035B1 (ar) 2007-04-15
US20020192279A1 (en) 2002-12-19
MXPA02003004A (es) 2003-08-20
NO20021391L (no) 2002-09-23
AU766912B2 (en) 2003-10-23
PL204984B1 (pl) 2010-02-26
JP2002338472A (ja) 2002-11-27
ATE311860T1 (de) 2005-12-15
SK286868B6 (sk) 2009-06-05
MD2517B2 (ro) 2004-08-31
EP1243255B1 (de) 2005-12-07
GEP20053449B (en) 2005-02-25
NO20021391D0 (no) 2002-03-20
RU2241490C2 (ru) 2004-12-10
CA2378436A1 (en) 2002-09-22
CN1376459A (zh) 2002-10-30
BG65499B1 (bg) 2008-10-31

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Legal Events

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KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees