MD226C2 - Procedeu de obtinere a derivatilor acidului 7-(2-(2-aminotiazolil-4)-2-alcoxiiminoacetamido)-3-cefem-4-carbonic - Google Patents
Procedeu de obtinere a derivatilor acidului 7-(2-(2-aminotiazolil-4)-2-alcoxiiminoacetamido)-3-cefem-4-carbonicInfo
- Publication number
- MD226C2 MD226C2 MD94-0270A MD940270A MD226C2 MD 226 C2 MD226 C2 MD 226C2 MD 940270 A MD940270 A MD 940270A MD 226 C2 MD226 C2 MD 226C2
- Authority
- MD
- Moldova
- Prior art keywords
- acid
- alkoxyiminoacetamido
- aminothiazolyl
- cefem
- temperature
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000004649 carbonic acid derivatives Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 1-methyl-tetrazolyl Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
Invenţia se referă la procedeul de obţinere a noilor antibiotice cefalosporinice - derivaţi al acidului 7-[2-(2-aminotiazolil-4)-2-alcoxiiminoacetamido]-3cefem-4carbonic cu formula generalăsub formă de sin-izomeri, în care R reprezintă radical-CH2-S-R3 în care R3 reprezintă C2-C4-acil; 2-metil-1,3,4-tridiazolil sau 1-metil-tetrazolil, sau R reprezintă C1-C5-alchil; R1 reprezintă atom de hidrogen sau atom de metal alcalin sau echivalentul aminei organice.Sarcina invenţiei constă în prepararea noilor compuşi sefalosporinici, care extind arsenalul remediilor, ce acţionează asupra organismului viu.Procedeul se realizează prin tratarea cu formula:în care R are valorile sus-menţionate şi A1 reprezintă atom de hidrogen sau grupa ce formează grupa eterică mixtă, cu un acid cu formula:sau cu derivatul funcţional al acestui acid, în care R2 reprezintă cloracetilul sau grupa de protecţie, aşa ca tritilul, şi R1 are valorile sus-menţionate, în mediu de solvent la temperatura de la (-35)°C până la cea a camerei. Compusul obţinut se tratează cu tiouree şi/sau se expune hidrolizei acide, care se poate efectua în mediu de solvent de la temperatura camerei până la cea de fierbere a amestecului de reacţie. Produsul cu destinaţie specială se separă sub formă de acid liber sau de sare de metal alcalin sau de amină organică.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7608690A FR2345153A1 (fr) | 1976-03-25 | 1976-03-25 | Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
| SU772462904A SU791246A3 (ru) | 1976-03-25 | 1977-03-23 | Способ получени производных 7-/2-(2аминотиазолил-4)-2-алкоксииминоацетамидо/-3-цефем-4-карбоновой кислоты |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD226B1 MD226B1 (ro) | 1995-06-30 |
| MD226C2 true MD226C2 (ro) | 1995-11-30 |
Family
ID=26219370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0270A MD226C2 (ro) | 1976-03-25 | 1994-09-08 | Procedeu de obtinere a derivatilor acidului 7-(2-(2-aminotiazolil-4)-2-alcoxiiminoacetamido)-3-cefem-4-carbonic |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD226C2 (ro) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1109525A (en) * | 1965-01-18 | 1968-04-10 | Ciba Ltd | Cyano-acylated cephalosporin derivatives and process for their manufacture |
-
1994
- 1994-09-08 MD MD94-0270A patent/MD226C2/ro unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1109525A (en) * | 1965-01-18 | 1968-04-10 | Ciba Ltd | Cyano-acylated cephalosporin derivatives and process for their manufacture |
Also Published As
| Publication number | Publication date |
|---|---|
| MD226B1 (ro) | 1995-06-30 |
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Legal Events
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|---|---|---|---|
| 1K4A | Payment of annual fees |