JPS54157566A - Preparation of nucleoside - Google Patents
Preparation of nucleosideInfo
- Publication number
- JPS54157566A JPS54157566A JP6640678A JP6640678A JPS54157566A JP S54157566 A JPS54157566 A JP S54157566A JP 6640678 A JP6640678 A JP 6640678A JP 6640678 A JP6640678 A JP 6640678A JP S54157566 A JPS54157566 A JP S54157566A
- Authority
- JP
- Japan
- Prior art keywords
- nucleoside
- sugar
- reacted
- benzoxazolium
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
Abstract
PURPOSE: To prepare nucleoside useful as medicines, pesticides, or their intermediates, in high yield under mild conditions of reaction temperature, etc. without using heavy metal or acid catalysts, by using a benzoxazolium salt.
CONSTITUTION: A benzoxazolium salt, e.g. 3-ethyl-2-chlorobenzoxazolium tetrafluroborate, is reacted with a nucleoside base, e.g. imidazole, in the presence of a tertiary amine, e.g. triethylamine, in an inert solvent at room temperature W 100°C. The reaction mixture is then treated with a triethyloxonium tetrafluoroborate to remove the remaining chloride ions, and sugar, e.g. 1-hydroxy-sugar, is reacted under the same reaction conditions as described above to form the objective nucleoside. The raw materials are used in amounts equimolar with the starting material.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6640678A JPS54157566A (en) | 1978-06-02 | 1978-06-02 | Preparation of nucleoside |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6640678A JPS54157566A (en) | 1978-06-02 | 1978-06-02 | Preparation of nucleoside |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54157566A true JPS54157566A (en) | 1979-12-12 |
JPS6244557B2 JPS6244557B2 (en) | 1987-09-21 |
Family
ID=13314877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6640678A Granted JPS54157566A (en) | 1978-06-02 | 1978-06-02 | Preparation of nucleoside |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54157566A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111961380A (en) * | 2020-07-25 | 2020-11-20 | 候伟强 | Household water-based paint and preparation method thereof |
-
1978
- 1978-06-02 JP JP6640678A patent/JPS54157566A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111961380A (en) * | 2020-07-25 | 2020-11-20 | 候伟强 | Household water-based paint and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS6244557B2 (en) | 1987-09-21 |
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