JPS5564574A - Preparation of 3-acyl-5-fluorouarcil - Google Patents

Preparation of 3-acyl-5-fluorouarcil

Info

Publication number
JPS5564574A
JPS5564574A JP13731178A JP13731178A JPS5564574A JP S5564574 A JPS5564574 A JP S5564574A JP 13731178 A JP13731178 A JP 13731178A JP 13731178 A JP13731178 A JP 13731178A JP S5564574 A JPS5564574 A JP S5564574A
Authority
JP
Japan
Prior art keywords
acyl
acid
derivative
fluorouracil
acylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13731178A
Other languages
Japanese (ja)
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Kikuo Wakizaka
Yasuo Nagamatsu
Hideo Sugi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP13731178A priority Critical patent/JPS5564574A/en
Publication of JPS5564574A publication Critical patent/JPS5564574A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To obtain the title compound an antitumor agent or its intermediate, industrially advantageously, by treating an acylated 5-fluorouracil with an acid to convent the acylated derivative other than the objective substance (F) into F and the raw material.
CONSTITUTION: 5-Fluorouracil is acylated, and the reaction product is treated with an acid to give an 3-acyl-5-fluorouracil of formula I: (R is H, lower alkyl, lower alkoxy, nitro or halogen) in high purity and yield. The acid treatment makes the 3-acyl derivative stable to the acid remain, and the 1, 3-diacyl derivative convent into the desired 3-acyl and the 1-acyl derivative into the raw material. The recovered raw material is reusable with a high industrial efficiency.
COPYRIGHT: (C)1980,JPO&Japio
JP13731178A 1978-11-09 1978-11-09 Preparation of 3-acyl-5-fluorouarcil Pending JPS5564574A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13731178A JPS5564574A (en) 1978-11-09 1978-11-09 Preparation of 3-acyl-5-fluorouarcil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13731178A JPS5564574A (en) 1978-11-09 1978-11-09 Preparation of 3-acyl-5-fluorouarcil

Publications (1)

Publication Number Publication Date
JPS5564574A true JPS5564574A (en) 1980-05-15

Family

ID=15195713

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13731178A Pending JPS5564574A (en) 1978-11-09 1978-11-09 Preparation of 3-acyl-5-fluorouarcil

Country Status (1)

Country Link
JP (1) JPS5564574A (en)

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