JPS5564574A - Preparation of 3-acyl-5-fluorouarcil - Google Patents
Preparation of 3-acyl-5-fluorouarcilInfo
- Publication number
- JPS5564574A JPS5564574A JP13731178A JP13731178A JPS5564574A JP S5564574 A JPS5564574 A JP S5564574A JP 13731178 A JP13731178 A JP 13731178A JP 13731178 A JP13731178 A JP 13731178A JP S5564574 A JPS5564574 A JP S5564574A
- Authority
- JP
- Japan
- Prior art keywords
- acyl
- acid
- derivative
- fluorouracil
- acylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To obtain the title compound an antitumor agent or its intermediate, industrially advantageously, by treating an acylated 5-fluorouracil with an acid to convent the acylated derivative other than the objective substance (F) into F and the raw material.
CONSTITUTION: 5-Fluorouracil is acylated, and the reaction product is treated with an acid to give an 3-acyl-5-fluorouracil of formula I: (R is H, lower alkyl, lower alkoxy, nitro or halogen) in high purity and yield. The acid treatment makes the 3-acyl derivative stable to the acid remain, and the 1, 3-diacyl derivative convent into the desired 3-acyl and the 1-acyl derivative into the raw material. The recovered raw material is reusable with a high industrial efficiency.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13731178A JPS5564574A (en) | 1978-11-09 | 1978-11-09 | Preparation of 3-acyl-5-fluorouarcil |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13731178A JPS5564574A (en) | 1978-11-09 | 1978-11-09 | Preparation of 3-acyl-5-fluorouarcil |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5564574A true JPS5564574A (en) | 1980-05-15 |
Family
ID=15195713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13731178A Pending JPS5564574A (en) | 1978-11-09 | 1978-11-09 | Preparation of 3-acyl-5-fluorouarcil |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5564574A (en) |
-
1978
- 1978-11-09 JP JP13731178A patent/JPS5564574A/en active Pending
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