MD1837B2 - Derivaţi de spiro-[2H-1-benzopiran-2,4'-piperidin]-4(3H)-onă, săruri acide de adiţie şi cuaternare ale acestora şi compoziţii farmaceutice ce le conţin - Google Patents
Derivaţi de spiro-[2H-1-benzopiran-2,4'-piperidin]-4(3H)-onă, săruri acide de adiţie şi cuaternare ale acestora şi compoziţii farmaceutice ce le conţinInfo
- Publication number
- MD1837B2 MD1837B2 MD98-0029A MD980029A MD1837B2 MD 1837 B2 MD1837 B2 MD 1837B2 MD 980029 A MD980029 A MD 980029A MD 1837 B2 MD1837 B2 MD 1837B2
- Authority
- MD
- Moldova
- Prior art keywords
- benzopyrane
- spiro
- piperidine
- acid
- pharmaceutical compositions
- Prior art date
Links
- 150000003839 salts Chemical group 0.000 title abstract 3
- 239000000654 additive Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- QHNDQKSXDVVXIB-UHFFFAOYSA-N spiro[3h-chromene-2,4'-piperidine]-4-one Chemical class O1C2=CC=CC=C2C(=O)CC21CCNCC2 QHNDQKSXDVVXIB-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000001743 benzylic group Chemical group 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Invenţia se referă la noi derivaţi de spiro-[2H-1-benzopiran-2,4'-piperidin]-4(3H)-onă cu formula generală (I)în care R reprezintă halogen, grupa nitro sau grupa C1-6 alchil cu catenă liniară sau ramificată, la sărurile lor acide de adiţie, precum şi la sărurile lor cuaternare cu grupare benzilică. Compuşii menţionaţi exercită un efect benefic în demenţele de diversă etiologie patologică şi simptomele ce le însoţesc. În plus, invenţia se referă la compoziţii farmaceutice, care în calitate de agenţi activi conţin aceşti compuşi.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9600928A HUP9600928A3 (en) | 1996-04-10 | 1996-04-10 | Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation |
PCT/HU1997/000012 WO1997037630A2 (en) | 1996-04-10 | 1997-04-03 | Spiro(2h-1-benzopyran-2,4'-piperidine)-4(3h)-one derivatives, acid addition salts thereof and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
MD980029A MD980029A (ro) | 1999-08-30 |
MD1837B2 true MD1837B2 (ro) | 2002-01-31 |
Family
ID=89993875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD98-0029A MD1837B2 (ro) | 1996-04-10 | 1997-04-03 | Derivaţi de spiro-[2H-1-benzopiran-2,4'-piperidin]-4(3H)-onă, săruri acide de adiţie şi cuaternare ale acestora şi compoziţii farmaceutice ce le conţin |
Country Status (25)
Country | Link |
---|---|
US (1) | US6140336A (ro) |
EP (1) | EP0863904A2 (ro) |
JP (1) | JP3048068B2 (ro) |
KR (1) | KR19990022807A (ro) |
AU (1) | AU715104B2 (ro) |
BG (1) | BG102171A (ro) |
CA (1) | CA2224212A1 (ro) |
CZ (1) | CZ7698A3 (ro) |
EE (1) | EE9700334A (ro) |
FI (1) | FI974470A (ro) |
HU (1) | HUP9600928A3 (ro) |
ID (1) | ID16582A (ro) |
IL (1) | IL122542A (ro) |
IS (1) | IS4632A (ro) |
LT (1) | LT4417B (ro) |
LV (1) | LV12017B (ro) |
MD (1) | MD1837B2 (ro) |
NO (1) | NO975781L (ro) |
NZ (1) | NZ329359A (ro) |
PL (1) | PL327412A1 (ro) |
SI (1) | SI9720006A (ro) |
SK (1) | SK178697A3 (ro) |
TR (1) | TR199701627T1 (ro) |
WO (1) | WO1997037630A2 (ro) |
ZA (1) | ZA972905B (ro) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI243173B (en) | 1999-11-17 | 2005-11-11 | Akzo Nobel Nv | Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives |
AU2004313692B2 (en) * | 2004-01-08 | 2011-07-28 | F. Hoffmann-La Roche Ag | Diaza-spiropiperidine derivatives as inhibitors of glycine transporter 1 and glycine transporter 2 |
WO2007088462A1 (en) * | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Spirochromane antagonists of the h-3 receptor |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0431943A2 (en) * | 1989-12-08 | 1991-06-12 | Merck & Co. Inc. | Nitrogen-containing spirocycles |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2745306A1 (de) * | 1977-10-07 | 1979-04-19 | Bayer Ag | Insektizide mittel |
JPS55143980A (en) * | 1979-04-27 | 1980-11-10 | Dai Ichi Seiyaku Co Ltd | Anti-allergic preparation |
-
1996
- 1996-04-10 HU HU9600928A patent/HUP9600928A3/hu unknown
-
1997
- 1997-04-03 CZ CZ9876A patent/CZ7698A3/cs unknown
- 1997-04-03 US US08/973,612 patent/US6140336A/en not_active Expired - Fee Related
- 1997-04-03 AU AU21734/97A patent/AU715104B2/en not_active Ceased
- 1997-04-03 MD MD98-0029A patent/MD1837B2/ro unknown
- 1997-04-03 EP EP97914497A patent/EP0863904A2/en not_active Withdrawn
- 1997-04-03 SK SK1786-97A patent/SK178697A3/sk unknown
- 1997-04-03 PL PL97327412A patent/PL327412A1/xx unknown
- 1997-04-03 EE EE9700334A patent/EE9700334A/xx unknown
- 1997-04-03 WO PCT/HU1997/000012 patent/WO1997037630A2/en not_active Application Discontinuation
- 1997-04-03 NZ NZ329359A patent/NZ329359A/xx unknown
- 1997-04-03 IL IL12254297A patent/IL122542A/xx active IP Right Grant
- 1997-04-03 SI SI9720006A patent/SI9720006A/sl unknown
- 1997-04-03 TR TR97/01627T patent/TR199701627T1/xx unknown
- 1997-04-03 KR KR1019970709276A patent/KR19990022807A/ko not_active Application Discontinuation
- 1997-04-03 JP JP9535989A patent/JP3048068B2/ja not_active Expired - Lifetime
- 1997-04-03 CA CA002224212A patent/CA2224212A1/en not_active Abandoned
- 1997-04-04 ZA ZA9702905A patent/ZA972905B/xx unknown
- 1997-04-10 ID IDP971182A patent/ID16582A/id unknown
- 1997-12-09 NO NO975781A patent/NO975781L/no not_active Application Discontinuation
- 1997-12-09 FI FI974470A patent/FI974470A/fi unknown
- 1997-12-09 IS IS4632A patent/IS4632A/is unknown
- 1997-12-10 LT LT97-193A patent/LT4417B/lt not_active IP Right Cessation
- 1997-12-24 LV LVP-97-253A patent/LV12017B/en unknown
-
1998
- 1998-01-09 BG BG102171A patent/BG102171A/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0431943A2 (en) * | 1989-12-08 | 1991-06-12 | Merck & Co. Inc. | Nitrogen-containing spirocycles |
Non-Patent Citations (1)
Title |
---|
Chem. Pharm. Bull., 1981, vol.29, no.12, p.3494-3498 * |
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Legal Events
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PD99 | Pending application |