MX9710029A - Derivados novedosos de un espiro [2h-1 benzopiran-2,4'-piperidina]- 4(3h), uno sales de adicion acida del mismo y composiciones farmaceuticas que los contienen. - Google Patents
Derivados novedosos de un espiro [2h-1 benzopiran-2,4'-piperidina]- 4(3h), uno sales de adicion acida del mismo y composiciones farmaceuticas que los contienen.Info
- Publication number
- MX9710029A MX9710029A MX9710029A MX9710029A MX9710029A MX 9710029 A MX9710029 A MX 9710029A MX 9710029 A MX9710029 A MX 9710029A MX 9710029 A MX9710029 A MX 9710029A MX 9710029 A MX9710029 A MX 9710029A
- Authority
- MX
- Mexico
- Prior art keywords
- benzopyran
- piperidine
- derivatives
- pharmaceutical compositions
- acid addition
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- QHNDQKSXDVVXIB-UHFFFAOYSA-N spiro[3h-chromene-2,4'-piperidine]-4-one Chemical class O1C2=CC=CC=C2C(=O)CC21CCNCC2 QHNDQKSXDVVXIB-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 230000000371 effect on dementia Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invencion se refiere a derivados novedosos de un espiro [2H-1benzopiran-2,4'-piperidinal- 4(3H) de la formula (1) en donde R representa el halogeno, grupo nitro o un grupo alquilo C16 de cadena recta o ramificada y sus sales de adicion ácida así como sus sales cuaternarias de la formula (1a), en donde R y R' son el mismo o diferente y son idénticos para el proposito de dicho (anterior) R o pueden significar también hidrogeno, y Z representa un equivalente de un anion. Los compuestos de las formulas (1) y (1a) ejercen un efecto mejorador sobre las demencias de diversos orígenes patologicos y los síntomas que acompañan a las mismas. Además la invencion se refiere a un proceso para la preparacion de compuestos de las formulas (1) y (1a); a las composiciones farmacéuticas contienen como agentes activos los compuestos anteriores de las formulas (1) y (1a); y a un método de tratamiento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9600928A HUP9600928A3 (en) | 1996-04-10 | 1996-04-10 | Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation |
| HU9600928 | 1996-04-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9710029A true MX9710029A (es) | 1998-09-30 |
| MXPA97010029A MXPA97010029A (es) | 1998-11-16 |
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