MD980029A - Derivati noi de spiro-[2H-1-benzopiran-2,4'-piperidina]-4(3H)-ona, saruri acide de aditie ale acestora si compozitii far-maceutice ce le contin - Google Patents
Derivati noi de spiro-[2H-1-benzopiran-2,4'-piperidina]-4(3H)-ona, saruri acide de aditie ale acestora si compozitii far-maceutice ce le continInfo
- Publication number
- MD980029A MD980029A MD98-0029A MD980029A MD980029A MD 980029 A MD980029 A MD 980029A MD 980029 A MD980029 A MD 980029A MD 980029 A MD980029 A MD 980029A
- Authority
- MD
- Moldova
- Prior art keywords
- benzopyrane
- spiro
- acid
- pharmaceutical compositions
- piperidin
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000000654 additive Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000000371 effect on dementia Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9600928A HUP9600928A3 (en) | 1996-04-10 | 1996-04-10 | Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation |
| PCT/HU1997/000012 WO1997037630A2 (en) | 1996-04-10 | 1997-04-03 | Spiro(2h-1-benzopyran-2,4'-piperidine)-4(3h)-one derivatives, acid addition salts thereof and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD980029A true MD980029A (ro) | 1999-08-30 |
| MD1837B2 MD1837B2 (ro) | 2002-01-31 |
Family
ID=89993875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD98-0029A MD1837B2 (ro) | 1996-04-10 | 1997-04-03 | Derivaţi de spiro-[2H-1-benzopiran-2,4'-piperidin]-4(3H)-onă, săruri acide de adiţie şi cuaternare ale acestora şi compoziţii farmaceutice ce le conţin |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6140336A (ro) |
| EP (1) | EP0863904A2 (ro) |
| JP (1) | JP3048068B2 (ro) |
| KR (1) | KR19990022807A (ro) |
| AU (1) | AU715104B2 (ro) |
| BG (1) | BG102171A (ro) |
| CA (1) | CA2224212A1 (ro) |
| CZ (1) | CZ7698A3 (ro) |
| EE (1) | EE9700334A (ro) |
| FI (1) | FI974470A (ro) |
| HU (1) | HUP9600928A3 (ro) |
| ID (1) | ID16582A (ro) |
| IL (1) | IL122542A (ro) |
| IS (1) | IS4632A (ro) |
| LT (1) | LT4417B (ro) |
| LV (1) | LV12017B (ro) |
| MD (1) | MD1837B2 (ro) |
| NO (1) | NO975781L (ro) |
| NZ (1) | NZ329359A (ro) |
| PL (1) | PL327412A1 (ro) |
| SI (1) | SI9720006A (ro) |
| SK (1) | SK178697A3 (ro) |
| TR (1) | TR199701627T1 (ro) |
| WO (1) | WO1997037630A2 (ro) |
| ZA (1) | ZA972905B (ro) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI243173B (en) | 1999-11-17 | 2005-11-11 | Akzo Nobel Nv | Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives |
| EP1716147B1 (en) * | 2004-01-08 | 2007-11-14 | F.Hoffmann-La Roche Ag | Diaza-spiropiperidine derivatives as inhibitors of glycine transporter 1 and glycine transporter 2 |
| WO2007088462A1 (en) * | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Spirochromane antagonists of the h-3 receptor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2745306A1 (de) * | 1977-10-07 | 1979-04-19 | Bayer Ag | Insektizide mittel |
| JPS55143980A (en) * | 1979-04-27 | 1980-11-10 | Dai Ichi Seiyaku Co Ltd | Anti-allergic preparation |
| IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
-
1996
- 1996-04-10 HU HU9600928A patent/HUP9600928A3/hu unknown
-
1997
- 1997-04-03 CA CA002224212A patent/CA2224212A1/en not_active Abandoned
- 1997-04-03 WO PCT/HU1997/000012 patent/WO1997037630A2/en not_active Application Discontinuation
- 1997-04-03 NZ NZ329359A patent/NZ329359A/xx unknown
- 1997-04-03 JP JP9535989A patent/JP3048068B2/ja not_active Expired - Lifetime
- 1997-04-03 EP EP97914497A patent/EP0863904A2/en not_active Withdrawn
- 1997-04-03 CZ CZ9876A patent/CZ7698A3/cs unknown
- 1997-04-03 SK SK1786-97A patent/SK178697A3/sk unknown
- 1997-04-03 SI SI9720006A patent/SI9720006A/sl unknown
- 1997-04-03 IL IL12254297A patent/IL122542A/xx active IP Right Grant
- 1997-04-03 PL PL97327412A patent/PL327412A1/xx unknown
- 1997-04-03 EE EE9700334A patent/EE9700334A/xx unknown
- 1997-04-03 US US08/973,612 patent/US6140336A/en not_active Expired - Fee Related
- 1997-04-03 TR TR97/01627T patent/TR199701627T1/xx unknown
- 1997-04-03 MD MD98-0029A patent/MD1837B2/ro unknown
- 1997-04-03 KR KR1019970709276A patent/KR19990022807A/ko not_active Application Discontinuation
- 1997-04-03 AU AU21734/97A patent/AU715104B2/en not_active Ceased
- 1997-04-04 ZA ZA9702905A patent/ZA972905B/xx unknown
- 1997-04-10 ID IDP971182A patent/ID16582A/id unknown
- 1997-12-09 NO NO975781A patent/NO975781L/no not_active Application Discontinuation
- 1997-12-09 FI FI974470A patent/FI974470A/fi unknown
- 1997-12-09 IS IS4632A patent/IS4632A/is unknown
- 1997-12-10 LT LT97-193A patent/LT4417B/lt not_active IP Right Cessation
- 1997-12-24 LV LVP-97-253A patent/LV12017B/en unknown
-
1998
- 1998-01-09 BG BG102171A patent/BG102171A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD99 | Pending application |