MD1716C2 - Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine - Google Patents
Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine Download PDFInfo
- Publication number
- MD1716C2 MD1716C2 MD97-0254A MD970254A MD1716C2 MD 1716 C2 MD1716 C2 MD 1716C2 MD 970254 A MD970254 A MD 970254A MD 1716 C2 MD1716 C2 MD 1716C2
- Authority
- MD
- Moldova
- Prior art keywords
- benzodiazepine
- melatonin
- treatment
- patient
- patients dependent
- Prior art date
Links
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 title abstract 4
- 229940049706 benzodiazepine Drugs 0.000 title abstract 4
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 title abstract 2
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003987 melatonin Drugs 0.000 title abstract 2
- 230000001419 dependent effect Effects 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 208000024891 symptom Diseases 0.000 abstract 2
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/381,535 US6469044B1 (en) | 1995-02-01 | 1995-02-01 | Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies |
| EP95303853A EP0724878B1 (en) | 1995-02-01 | 1995-06-06 | Use of melatonin for treating patients suffering from drug dependencies |
| PCT/IB1996/000082 WO1996023496A1 (en) | 1995-02-01 | 1996-01-29 | Use of melatonin for treating patients suffering from drug addiction |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD970254A MD970254A (en) | 1999-05-31 |
| MD1716B2 MD1716B2 (en) | 2001-08-31 |
| MD1716C2 true MD1716C2 (ro) | 2002-02-28 |
Family
ID=26140195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD97-0254A MD1716C2 (ro) | 1995-02-01 | 1996-01-29 | Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JP4516159B2 (cs) |
| CN (1) | CN1083263C (cs) |
| AT (1) | AT408188B (cs) |
| AU (1) | AU695366B2 (cs) |
| BG (1) | BG62876B1 (cs) |
| BR (1) | BR9607169A (cs) |
| CZ (1) | CZ291349B6 (cs) |
| DK (1) | DK176081B1 (cs) |
| EE (1) | EE03384B1 (cs) |
| FI (1) | FI119586B (cs) |
| IS (1) | IS1980B (cs) |
| LU (1) | LU90118B1 (cs) |
| LV (1) | LV11940B (cs) |
| MD (1) | MD1716C2 (cs) |
| NO (1) | NO312814B1 (cs) |
| NZ (1) | NZ298878A (cs) |
| PL (1) | PL183148B1 (cs) |
| SI (1) | SI9620022A (cs) |
| SK (1) | SK284521B6 (cs) |
| TR (1) | TR199700723T1 (cs) |
| TW (1) | TW483757B (cs) |
| WO (1) | WO1996023496A1 (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4996803B2 (ja) | 2000-01-05 | 2012-08-08 | ニューリム ファーマシューティカルズ（１９９１）リミテッド | 抗高血圧剤に対する抵抗性及び関連状態を処置する方法及び処方物 |
| IL149377A (en) * | 2002-04-28 | 2012-10-31 | Neurim Pharma 1991 | Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds |
| US9119846B2 (en) | 2003-04-29 | 2015-09-01 | Neurim Pharmaceuticals (1991) Ltd. | Method and composition for enhancing cognition in alzheimer's patients |
| IL155666A (en) | 2003-04-29 | 2013-12-31 | Neurim Pharma 1991 | Insomnia treatment |
| US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| ES2646197T3 (es) | 2012-01-26 | 2017-12-12 | Vanda Pharmaceuticals Inc. | Tratamiento de trastornos del ritmo circadiano |
| WO2014100292A1 (en) | 2012-12-18 | 2014-06-26 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
| US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
| SMT202000575T1 (it) * | 2016-10-31 | 2021-01-05 | Neurim Pharma 1991 | Minicompresse di melatonina e loro procedimenti di prepaazione |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0513702A2 (en) * | 1991-05-13 | 1992-11-19 | I.F.L.O. ISTITUTO FARMACOLOGICO LOMBARDO S.A.S. di Giorgio & Aldo Laguzzi & C. | Melatonin derivaties for use in the therapy of sleep disorders and in pre-anaesthetic medication |
| EP0518468A1 (en) * | 1991-05-09 | 1992-12-16 | Neurim Pharmaceuticals (1991) Limited | Melatonin containing compositions |
-
1996
- 1996-01-29 BR BR9607169A patent/BR9607169A/pt not_active Application Discontinuation
- 1996-01-29 AT AT0901396A patent/AT408188B/de not_active IP Right Cessation
- 1996-01-29 NZ NZ298878A patent/NZ298878A/xx not_active IP Right Cessation
- 1996-01-29 WO PCT/IB1996/000082 patent/WO1996023496A1/en active IP Right Grant
- 1996-01-29 SI SI9620022A patent/SI9620022A/sl not_active IP Right Cessation
- 1996-01-29 JP JP52338596A patent/JP4516159B2/ja not_active Expired - Lifetime
- 1996-01-29 MD MD97-0254A patent/MD1716C2/ro not_active IP Right Cessation
- 1996-01-29 SK SK1030-97A patent/SK284521B6/sk unknown
- 1996-01-29 CZ CZ19972405A patent/CZ291349B6/cs not_active IP Right Cessation
- 1996-01-29 AU AU44574/96A patent/AU695366B2/en not_active Expired
- 1996-01-29 CN CN96191750A patent/CN1083263C/zh not_active Expired - Lifetime
- 1996-01-29 EE EE9700166A patent/EE03384B1/xx not_active IP Right Cessation
- 1996-01-29 PL PL96321630A patent/PL183148B1/pl unknown
- 1996-01-29 TR TR97/00723T patent/TR199700723T1/xx unknown
- 1996-04-12 TW TW085104319A patent/TW483757B/zh not_active IP Right Cessation
-
1997
- 1997-07-24 LV LVP-97-144A patent/LV11940B/en unknown
- 1997-07-25 IS IS4532A patent/IS1980B/is unknown
- 1997-07-30 BG BG101803A patent/BG62876B1/bg unknown
- 1997-07-30 DK DK199700896A patent/DK176081B1/da not_active IP Right Cessation
- 1997-07-31 FI FI973185A patent/FI119586B/fi not_active IP Right Cessation
- 1997-07-31 NO NO19973531A patent/NO312814B1/no not_active IP Right Cessation
- 1997-08-01 LU LU90118A patent/LU90118B1/fr active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0518468A1 (en) * | 1991-05-09 | 1992-12-16 | Neurim Pharmaceuticals (1991) Limited | Melatonin containing compositions |
| EP0513702A2 (en) * | 1991-05-13 | 1992-11-19 | I.F.L.O. ISTITUTO FARMACOLOGICO LOMBARDO S.A.S. di Giorgio & Aldo Laguzzi & C. | Melatonin derivaties for use in the therapy of sleep disorders and in pre-anaesthetic medication |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD99 | Pending application | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |