MD1592B2 - Cristale de enzimă reticulate şi aplicarea lor în dispozitiv extracorporal, în biosensor şi pentru obţinerea produsului selectat - Google Patents
Cristale de enzimă reticulate şi aplicarea lor în dispozitiv extracorporal, în biosensor şi pentru obţinerea produsului selectatInfo
- Publication number
- MD1592B2 MD1592B2 MD94-0406A MD940406A MD1592B2 MD 1592 B2 MD1592 B2 MD 1592B2 MD 940406 A MD940406 A MD 940406A MD 1592 B2 MD1592 B2 MD 1592B2
- Authority
- MD
- Moldova
- Prior art keywords
- reticulated
- crystals
- enzym
- obtaining
- selected product
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6448—Elastases, e.g. pancreatic elastase (3.4.21.36); leukocyte elastase (3.4.31.37)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C12N9/82—Asparaginase (3.5.1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
- C12Q1/003—Functionalisation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Liquid Crystal Substances (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Piezo-Electric Or Mechanical Vibrators, Or Delay Or Filter Circuits (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Invenţia se referă la cristale de enzimă reticulate care manifestă rezistenţă la protează. Prezenta invenţie prevede utilizarea cristalelor reticulate de enzimă în dispozitive extracorporale, biosensori pentru detectarea analitului şi în calitate de catalizator enzimic pentru obţinerea produsului selectat.Esenţa invenţiei constă în faptul că cristalele de enzimă se reticulează cu un agent multifuncţional de reticulare, iar cristalele reticulate de enzimă posedă rezistenţă la proteoliza exogenă, astfel încât cristalele reticulate menţionate păstrează cel puţin 91% din activitatea lor iniţială după incubare pentru 3 ore în prezenţa pronazei (PronaseTM), în aceleaşi condiţii forma solubilă nereticulată de enzimă cristalizabilă, pierde cel puţin 94 % din activitatea sa iniţială.Rezultatul invenţiei constă în includerea în cristalele de enzimă a legăturilor intermoleculare transversale, care ameliorează semnificativ proprietăţile acestor cristale ceea ce permite extinderea domeniului de utilizare a lor în medicină, în condiţii industriale rigide şi depozitarea lor îndelungată cu menţinerea activităţii.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56228090A | 1990-08-03 | 1990-08-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
MD1592B2 true MD1592B2 (ro) | 2001-01-31 |
Family
ID=24245600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD94-0406A MD1592B2 (ro) | 1990-08-03 | 1994-07-14 | Cristale de enzimă reticulate şi aplicarea lor în dispozitiv extracorporal, în biosensor şi pentru obţinerea produsului selectat |
Country Status (26)
Country | Link |
---|---|
EP (2) | EP0550450B1 (ro) |
JP (2) | JPH05508549A (ro) |
AT (2) | ATE240391T1 (ro) |
AU (1) | AU662104B2 (ro) |
BR (1) | BR9106732A (ro) |
CA (1) | CA2087730C (ro) |
CZ (1) | CZ12393A3 (ro) |
DE (2) | DE69133258T2 (ro) |
DK (2) | DK0550450T3 (ro) |
ES (2) | ES2263187T3 (ro) |
FI (1) | FI120099B (ro) |
HK (2) | HK1023362A1 (ro) |
HU (2) | HUT65904A (ro) |
IE (1) | IE912767A1 (ro) |
IL (1) | IL99046A (ro) |
LT (1) | LT3366B (ro) |
LV (1) | LV10304B (ro) |
MD (1) | MD1592B2 (ro) |
NO (1) | NO930360L (ro) |
PT (1) | PT98564B (ro) |
RU (1) | RU2124052C1 (ro) |
SG (1) | SG70966A1 (ro) |
SK (1) | SK283185B6 (ro) |
TJ (1) | TJ210R3 (ro) |
UA (1) | UA27035C2 (ro) |
WO (1) | WO1992002617A1 (ro) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5932212A (en) * | 1996-05-24 | 1999-08-03 | Altus Biologics, Inc. | Crosslinked protein crystal formulations and their use as catalysts in organic solvents |
WO1998013119A1 (en) * | 1996-09-24 | 1998-04-02 | Altus Biologics Inc. | Crosslinked protein crystals as universal separation media |
US6140475A (en) * | 1997-04-11 | 2000-10-31 | Altus Biologics Inc. | Controlled dissolution crosslinked protein crystals |
US6500933B1 (en) | 1997-09-05 | 2002-12-31 | Altus Biologics Inc. | Methods of preparing carbohydrate crosslinked glycoprotein crystals |
EP1009759B1 (en) | 1997-09-05 | 2008-05-28 | Altus Pharmaceuticals Inc. | Carbohydrate crosslinked glycoprotein crystals |
US6979561B1 (en) | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
GB9823334D0 (en) | 1998-10-23 | 1998-12-23 | Darwin Discovery Ltd | Enzyme coupling |
CA2442524A1 (en) * | 2001-02-16 | 2002-09-12 | Guiyi Zhang-Sun | Matrix stabilized enzyme crystals and methods of use |
US7241272B2 (en) | 2001-11-13 | 2007-07-10 | Baxter International Inc. | Method and composition for removing uremic toxins in dialysis processes |
US20090035828A1 (en) * | 2004-01-01 | 2009-02-05 | Tholath Emilia Abraham | Method For the Preparation of Cross Linked Protein Crystals |
PT1729797E (pt) | 2004-03-22 | 2008-12-17 | Solvay Pharm Gmbh | Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos |
CN101068565B (zh) | 2004-10-14 | 2010-11-17 | 胞囊纤维化基础治疗公司 | 治疗胰腺功能不全的包含脂酶、蛋白酶和淀粉酶的组合物 |
AU2006274835B2 (en) | 2005-07-29 | 2012-05-24 | Abbott Laboratories Gmbh | Processes for the manufacture of sterilized pancreatin powder |
US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
WO2010134642A1 (ja) * | 2009-05-22 | 2010-11-25 | サンヨー食品株式会社 | 不斉酸化反応を有する蛋白質複合体およびその製造方法 |
BR112012005869A2 (pt) * | 2009-09-15 | 2017-01-31 | Althea Tech Inc | cristais da proteína a, cristais reticulados e métodos de utilização dos mesmos |
WO2012026493A1 (ja) * | 2010-08-26 | 2012-03-01 | アイシン精機株式会社 | 酵素結晶固定化電極及び酵素結晶固定化電極の製造方法、並びに酵素結晶固定化電極を備えるバイオ電池及びバイオセンサー |
CA2913476A1 (en) | 2013-06-07 | 2014-12-11 | Allena Pharmaceuticals, Inc. | Compositions, methods, and devices for dialysis |
US20180028454A1 (en) | 2015-02-04 | 2018-02-01 | Abbvie Inc. | Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency |
WO2018232273A1 (en) * | 2017-06-15 | 2018-12-20 | The University Of Chicago | Methods and compositions for treating cancer |
WO2023194615A1 (en) * | 2022-04-07 | 2023-10-12 | Need4Health B.V. | Method for determining insulin dosage |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0341503A2 (en) * | 1988-05-13 | 1989-11-15 | Stabra AG | Cross-linked glucose isomerase |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3664926A (en) | 1970-02-26 | 1972-05-23 | Merck & Co Inc | Crystallization of l-asparaginase |
DE2801238C2 (de) | 1977-01-27 | 1986-06-05 | (Zaidanhojin) Sagami Chemical Research Center, Tokio/Tokyo | Verfahren zur Herstellung von Salzen aus L,L-Dipeptiden und Phenylalaninestern |
US4373023A (en) * | 1980-10-14 | 1983-02-08 | Massachusetts Institute Of Technology | Process for neutralizing heparin |
DK182483A (da) * | 1982-04-23 | 1983-10-24 | Wako Pure Chem Ind Ltd | Fremgangsmaade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved |
US4411996A (en) * | 1982-06-30 | 1983-10-25 | Nabisco Brands, Inc. | Process for isomerizing glucose |
AU3889685A (en) * | 1984-01-20 | 1985-08-09 | Eye Products Ltd. Partnership | Method for cleaning contact lenses |
FR2566798B1 (fr) * | 1984-06-27 | 1986-12-12 | Centre Nat Rech Scient | Membrane porteuse de la luciferase pour le dosage de l'atp et son procede de production |
US4650758A (en) * | 1984-09-21 | 1987-03-17 | Cetus Corporation | Stabilization of enzymes useful in the production of glucosone and other enzymatic processes |
JPS6317691A (ja) * | 1986-07-09 | 1988-01-25 | Agency Of Ind Science & Technol | アスパルテ−ム製造用固定化酵素 |
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1991
- 1991-07-30 UA UA93002104A patent/UA27035C2/uk unknown
- 1991-07-30 ES ES98105856T patent/ES2263187T3/es not_active Expired - Lifetime
- 1991-07-30 WO PCT/US1991/005415 patent/WO1992002617A1/en active IP Right Grant
- 1991-07-30 DK DK91914256T patent/DK0550450T3/da active
- 1991-07-30 AT AT91914256T patent/ATE240391T1/de not_active IP Right Cessation
- 1991-07-30 SG SG1996002857A patent/SG70966A1/en unknown
- 1991-07-30 CA CA002087730A patent/CA2087730C/en not_active Expired - Lifetime
- 1991-07-30 SK SK59-93A patent/SK283185B6/sk not_active IP Right Cessation
- 1991-07-30 RU RU93005166A patent/RU2124052C1/ru active
- 1991-07-30 ES ES91914256T patent/ES2199933T3/es not_active Expired - Lifetime
- 1991-07-30 IE IE276791A patent/IE912767A1/en not_active IP Right Cessation
- 1991-07-30 EP EP91914256A patent/EP0550450B1/en not_active Expired - Lifetime
- 1991-07-30 AU AU83154/91A patent/AU662104B2/en not_active Expired
- 1991-07-30 AT AT98105856T patent/ATE323158T1/de not_active IP Right Cessation
- 1991-07-30 HU HU9300275A patent/HUT65904A/hu unknown
- 1991-07-30 JP JP91513405A patent/JPH05508549A/ja not_active Withdrawn
- 1991-07-30 DE DE69133258T patent/DE69133258T2/de not_active Expired - Lifetime
- 1991-07-30 DK DK98105856T patent/DK0861888T3/da active
- 1991-07-30 BR BR919106732A patent/BR9106732A/pt not_active Application Discontinuation
- 1991-07-30 EP EP98105856A patent/EP0861888B1/en not_active Expired - Lifetime
- 1991-07-30 DE DE69133521T patent/DE69133521T2/de not_active Expired - Lifetime
- 1991-08-01 IL IL9904691A patent/IL99046A/en not_active IP Right Cessation
- 1991-08-02 PT PT98564A patent/PT98564B/pt not_active IP Right Cessation
-
1993
- 1993-02-02 NO NO93930360A patent/NO930360L/no not_active Application Discontinuation
- 1993-02-02 FI FI930454A patent/FI120099B/fi not_active IP Right Cessation
- 1993-02-02 CZ CZ93123A patent/CZ12393A3/cs unknown
- 1993-06-30 LV LVP-93-807A patent/LV10304B/en unknown
- 1993-09-22 LT LTIP1077A patent/LT3366B/lt not_active IP Right Cessation
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1994
- 1994-04-11 TJ TJ94000012A patent/TJ210R3/xx unknown
- 1994-07-14 MD MD94-0406A patent/MD1592B2/ro unknown
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1995
- 1995-06-30 HU HU95P/P00666P patent/HU211521A9/hu unknown
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1998
- 1998-12-15 HK HK00100409A patent/HK1023362A1/xx not_active IP Right Cessation
- 1998-12-15 HK HK98113369A patent/HK1012411A1/xx not_active IP Right Cessation
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2003
- 2003-05-26 JP JP2003148217A patent/JP2004000230A/ja not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0341503A2 (en) * | 1988-05-13 | 1989-11-15 | Stabra AG | Cross-linked glucose isomerase |
Non-Patent Citations (52)
Title |
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[10] Klibanov A.M., Acc. Chem.Res. vol. 23:114-120 (1990). * |
[11] Nagasava T. şi Yamada H., Trends in Biotechnology, vol. 7:153-158 (1989). * |
[12] Hall, "BIOSENSORS" Open University Pres, 1990. * |
[13] Klein M. şi Langer R., Trends in Biotechnology 4:153-158 (1986). * |
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