MC1193A1 - Composes polyeniques - Google Patents

Composes polyeniques

Info

Publication number
MC1193A1
MC1193A1 MC781300A MC1300A MC1193A1 MC 1193 A1 MC1193 A1 MC 1193A1 MC 781300 A MC781300 A MC 781300A MC 1300 A MC1300 A MC 1300A MC 1193 A1 MC1193 A1 MC 1193A1
Authority
MC
Monaco
Prior art keywords
polyene compounds
polyene
compounds
Prior art date
Application number
MC781300A
Other languages
English (en)
Inventor
P Loeliger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1193A1 publication Critical patent/MC1193A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/38—Alcohols containing six-membered aromatic rings and other rings and having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MC781300A 1977-05-04 1978-05-02 Composes polyeniques MC1193A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU77254A LU77254A1 (fr) 1977-05-04 1977-05-04

Publications (1)

Publication Number Publication Date
MC1193A1 true MC1193A1 (fr) 1979-02-23

Family

ID=19728555

Family Applications (1)

Application Number Title Priority Date Filing Date
MC781300A MC1193A1 (fr) 1977-05-04 1978-05-02 Composes polyeniques

Country Status (32)

Country Link
US (1) US4193931A (fr)
JP (1) JPS53137940A (fr)
AR (1) AR220704A1 (fr)
AT (1) AT356647B (fr)
AU (1) AU522598B2 (fr)
BE (1) BE866651A (fr)
BR (1) BR7802807A (fr)
CA (1) CA1114830A (fr)
CH (2) CH641755A5 (fr)
CS (1) CS214853B2 (fr)
CU (1) CU21105A (fr)
DE (1) DE2819213A1 (fr)
DK (1) DK155730C (fr)
ES (2) ES469394A1 (fr)
FI (1) FI66587C (fr)
FR (1) FR2390428A1 (fr)
GB (2) GB1600914A (fr)
GR (1) GR74426B (fr)
HU (1) HU183088B (fr)
IE (1) IE46946B1 (fr)
IL (2) IL54590A (fr)
IT (1) IT1096278B (fr)
LU (1) LU77254A1 (fr)
MC (1) MC1193A1 (fr)
MY (1) MY8500250A (fr)
NL (1) NL7804773A (fr)
NO (1) NO148290C (fr)
NZ (1) NZ187114A (fr)
PH (1) PH14216A (fr)
PT (1) PT67988B (fr)
SE (1) SE436644B (fr)
ZA (1) ZA782415B (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216312A (en) 1978-08-24 1980-08-05 Hoffmann-La Roche Inc. Furyl substituted polyenes
FI67386C (fi) * 1979-06-21 1985-03-11 Hoffmann La Roche Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sockerderivat
CH651007A5 (de) * 1982-06-24 1985-08-30 Hoffmann La Roche Polyenverbindungen.
DK158947C (da) * 1982-07-06 1991-01-21 Hoffmann La Roche Tetrahydronaphthalin-,benzofuran- og benzothiophenderivater, fremstilling og anvendelse deraf samt rodenticid indeholdende saadanne derivater
US4529600A (en) * 1982-09-09 1985-07-16 Sri International Pentadeuterioretinoids
US4439614A (en) * 1982-09-22 1984-03-27 Sri International 5,6-Methano-5,6-dihydroretinoids
US4464389A (en) * 1982-10-20 1984-08-07 Sri International Esters of retinoic acid and pentaerythritol and monobenzal acetals thereof
US4539154A (en) * 1983-06-15 1985-09-03 Hoffmann-La Roche Inc. Polyene compounds
CH661516A5 (de) * 1983-12-08 1987-07-31 Hoffmann La Roche Phenylnonatetraenoylzuckerderivate.
US4783549A (en) * 1984-09-05 1988-11-08 L'oreal Benzonorbornene derivatives, processes for their preparation and medicinal and cosmetic compositions containing them
FR2580277B1 (fr) * 1985-04-15 1988-06-10 Oreal Nouveaux derives naphtaleniques a action retinoique, le ur procede de preparation et compositions medicamenteuse et cosmetique les contenant
US5030765A (en) * 1986-05-23 1991-07-09 Hoffmann-La Roche Inc. Novel tetrahydronaphthalene and indane derivatives
US5030764A (en) * 1986-05-23 1991-07-09 Hoffmann-La Roche Inc. Novel tetrahydronaphthalene and indane derivatives
ZW7487A1 (en) * 1986-05-23 1987-12-16 Hoffmann La Roche Tetrahydronaphthaline and indane derivatives
AT388728B (de) * 1987-03-17 1989-08-25 Hoffmann La Roche Neue tetrahydronaphthalin- und indanderivate
US5250562A (en) * 1988-02-24 1993-10-05 Hoffmann-La Roche Inc. Stilbene derivatives
US5248696A (en) * 1991-04-18 1993-09-28 World Research Institute For Science And Technology, Inc. Composition and method for treating tumors
US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US5780676A (en) * 1992-04-22 1998-07-14 Ligand Pharmaceuticals Incorporated Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
CA2129773C (fr) * 1993-09-02 2007-05-01 Michael Klaus Derives d'acides carboxyliques aromatiques
FR2719041B1 (fr) * 1994-04-26 1996-05-31 Cird Galderma Nouveaux composés polyéniques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
JP4001913B2 (ja) * 1994-12-30 2007-10-31 リガンド・ファーマシューティカルズ・インコーポレイテッド 新規なトリエンレチノイド化合物および方法
US7115728B1 (en) 1995-01-30 2006-10-03 Ligand Pharmaceutical Incorporated Human peroxisome proliferator activated receptor γ
ATE236115T1 (de) 1995-10-06 2003-04-15 Ligand Pharm Inc Dimer-selektive rxr modulatoren und verfahren zu ihrer verwendung
US6112489A (en) * 1995-12-12 2000-09-05 Monotech International, Inc. Monocoque concrete structures
AU4080597A (en) * 1996-08-23 1998-03-06 Board Of Regents For Oklahoma State University, The Heteroarotinoids-anticancer agents with receptor specificity and tgase activity
FR2752837B1 (fr) * 1996-09-02 1999-11-12 Cird Galderma Nouveaux composes modulateurs des recepteurs hormonaux, les compositions les comprenant et leur utilisation en therapie
WO1999005161A1 (fr) * 1997-07-25 1999-02-04 Ligand Pharmaceuticals Incorporated SEQUENCES REGULATRICES DU GENE HUMAIN PPARη (RECEPTEUR GAMMA ACTIVE DE LA PROLIFERATION DES PEROXYSOMES) ET LEURS UTILISATIONS
US6534545B1 (en) 1997-09-25 2003-03-18 Galderma Research & Development Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and cosmetics
FR2768731B1 (fr) * 1997-09-25 1999-12-10 Cird Galderma Derives insatures en position -4 du 6-tert-butyl-1,1- dimethylindane et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetique
CA2334545A1 (fr) * 1998-06-12 1999-12-16 Ligand Pharmaceuticals Incorporated Traitement du cancer du sein resistant aux anti-oestrogenes avec des modulateurs de rxr
AU6941200A (en) 1999-08-27 2001-03-26 Ligand Pharmaceuticals Incorporated 8-substituted-6-trifluoromethyl-9-pyrido(3,2-g)quinoline compounds as androgen receptor modulators
WO2001016139A1 (fr) * 1999-08-27 2001-03-08 Ligand Pharmaceuticals Incorporated Composes de modulation du recepteur androgene et procedes d'utilisation
US6566372B1 (en) * 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
CO5200852A1 (es) * 1999-09-14 2002-09-27 Lilly Co Eli Moduladores rxr con mejorado perfil farmacologico ceptores x de los retinoides
US7842727B2 (en) * 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US6495719B2 (en) 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US6586460B1 (en) 2001-04-02 2003-07-01 The Board Of Regents For Oklahoma State University Heteroarotinoids containing urea or thiourea linker
EP1511477A4 (fr) * 2002-05-22 2008-04-09 Errant Gene Therapeutics Llc Inhibiteurs d'histone desacetylase bases sur des composes alpha-ceto-epoxydes
WO2004046104A2 (fr) * 2002-11-20 2004-06-03 Errant Gene Therapeutics, Llc Traitement de cellules pulmonaires avec des inhibiteurs d'histone deacetylase
US9050310B2 (en) * 2004-06-25 2015-06-09 Minas Theodore Coroneo Treatment of ocular lesions
EP1817020A4 (fr) * 2004-11-08 2012-11-21 Errant Gene Therapeutics Inc Inhibiteurs d'histone deacetylase
US20060204474A1 (en) * 2005-02-25 2006-09-14 Coroneo Minas T Treatment of epithelial layer lesions
WO2012076842A1 (fr) * 2010-12-09 2012-06-14 University Of Durham Rétinoïdes synthétiques pour le contrôle de la différenciation des cellules
US11045441B2 (en) 2015-10-13 2021-06-29 Wisconsin Alumni Research Foundation Use of retinoic acid and analogs thereof to treat central neural apneas
WO2019064109A1 (fr) * 2017-09-28 2019-04-04 Johnson & Johnson Consumer Inc. Compositions cosmétiques et procédé de traitement de la peau
US11197841B2 (en) 2019-07-23 2021-12-14 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US10966948B2 (en) 2019-07-23 2021-04-06 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
BR112021000724A2 (pt) 2018-07-27 2021-04-13 Johnson & Johnson Surgical Vision, Inc. Composições e métodos para tratar os olhos
US11969454B2 (en) 2019-11-19 2024-04-30 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452085A (en) * 1966-02-11 1969-06-24 Carbo Erba Spa Alpha-(5-indanyl)-butyric acid
US3781314A (en) * 1971-07-14 1973-12-25 Hoffmann La Roche Polyene compounds
BE793108A (fr) * 1971-12-22 1973-06-21 Hoffmann La Roche Derives polyeniques
DE2431198A1 (de) * 1973-07-02 1975-01-23 Takeda Chemical Industries Ltd Chinonderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittelzubereitungen
CH582668A5 (fr) * 1973-08-10 1976-12-15 Hoffmann La Roche
CH585709A5 (fr) * 1973-08-24 1977-03-15 Hoffmann La Roche
CH592598A5 (fr) * 1973-10-30 1977-10-31 Hexachimie
AR206619A1 (es) * 1974-02-07 1976-08-06 Hexachimie Procedimiento para peparar acidos 5-indanilaceticos
FR2276035A1 (fr) * 1974-06-28 1976-01-23 Lipha Nouveaux derives de l'indane
JPS51125235A (en) * 1974-09-26 1976-11-01 Hoffmann La Roche Preparation of polyene compounds
US4054589A (en) * 1974-09-26 1977-10-18 Hoffmann-La Roche Inc. Novel 9-substituted phenyl-3,7-dimethyl-nona-2,4,6,8-tetraene esters

Also Published As

Publication number Publication date
AU522598B2 (en) 1982-06-17
CA1114830A (fr) 1981-12-22
AT356647B (de) 1980-05-12
ES469394A1 (es) 1979-02-01
AU3576278A (en) 1979-11-08
US4193931A (en) 1980-03-18
SE7805136L (sv) 1978-11-05
BR7802807A (pt) 1979-01-02
CS214853B2 (en) 1982-06-25
FR2390428A1 (fr) 1978-12-08
GB1600914A (en) 1981-10-21
FI781227A (fi) 1978-11-05
ES475240A1 (es) 1979-05-16
FR2390428B1 (fr) 1983-03-04
DK155730B (da) 1989-05-08
SE436644B (sv) 1985-01-14
NO148290C (no) 1983-09-14
BE866651A (fr) 1978-11-03
GB1600915A (en) 1981-10-21
DK155730C (da) 1989-10-02
PT67988B (en) 1980-05-05
PT67988A (en) 1978-06-01
DE2819213A1 (de) 1978-11-16
IT1096278B (it) 1985-08-26
NL7804773A (nl) 1978-11-07
CH642380A5 (de) 1984-04-13
IL61697A0 (en) 1981-01-30
GR74426B (fr) 1984-06-28
HU183088B (en) 1984-04-28
AR220704A1 (es) 1980-11-28
IT7823003A0 (it) 1978-05-04
ATA320478A (de) 1979-10-15
IE780864L (en) 1978-11-04
JPS53137940A (en) 1978-12-01
NO781586L (no) 1978-11-07
ZA782415B (en) 1979-04-25
CU21105A (es) 1981-12-04
DK195378A (da) 1978-11-05
MY8500250A (en) 1985-12-31
IE46946B1 (en) 1983-11-16
NO148290B (no) 1983-06-06
IL54590A (en) 1982-02-28
FI66587B (fi) 1984-07-31
FI66587C (fi) 1984-11-12
PH14216A (en) 1981-04-02
LU77254A1 (fr) 1979-01-18
DE2819213C2 (fr) 1987-09-24
IL54590A0 (en) 1978-07-31
NZ187114A (en) 1980-11-14
JPS6332777B2 (fr) 1988-07-01
CH641755A5 (de) 1984-03-15

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