MA51510A - Procédés de préparation de dérivés d'indolinobenzodiazépine - Google Patents

Procédés de préparation de dérivés d'indolinobenzodiazépine

Info

Publication number
MA51510A
MA51510A MA051510A MA51510A MA51510A MA 51510 A MA51510 A MA 51510A MA 051510 A MA051510 A MA 051510A MA 51510 A MA51510 A MA 51510A MA 51510 A MA51510 A MA 51510A
Authority
MA
Morocco
Prior art keywords
processes
preparation
indolinobenzodiazepine
derivatives
indolinobenzodiazepine derivatives
Prior art date
Application number
MA051510A
Other languages
English (en)
French (fr)
Inventor
Baudouin Gérard
Michael Louis Miller
Manami Shizuka
Richard A Silva
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of MA51510A publication Critical patent/MA51510A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
MA051510A 2017-04-20 2018-04-19 Procédés de préparation de dérivés d'indolinobenzodiazépine MA51510A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762487695P 2017-04-20 2017-04-20

Publications (1)

Publication Number Publication Date
MA51510A true MA51510A (fr) 2020-11-11

Family

ID=62117004

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051510A MA51510A (fr) 2017-04-20 2018-04-19 Procédés de préparation de dérivés d'indolinobenzodiazépine

Country Status (12)

Country Link
US (4) US10442809B2 (https=)
EP (1) EP3612533A1 (https=)
JP (2) JP7170663B2 (https=)
KR (2) KR102595714B1 (https=)
CN (2) CN115448926A (https=)
AU (2) AU2018254463B2 (https=)
CA (1) CA3060086A1 (https=)
IL (4) IL270008B (https=)
MA (1) MA51510A (https=)
SG (1) SG11201909564XA (https=)
TW (2) TWI840039B (https=)
WO (1) WO2018195245A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3612533A1 (en) 2017-04-20 2020-02-26 Immunogen, Inc. Methods of preparing indolinobenzodiazepine derivatives
EP4384502A1 (en) * 2021-08-13 2024-06-19 ImmunoGen, Inc. Improved methods for preparing cytotoxic benzodiazepine derivatives
KR20250031149A (ko) 2022-06-30 2025-03-06 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3453266A (en) 1966-03-14 1969-07-01 American Home Prod 1,2,5-benzothiadiazepine 1,1-dioxides
US3506646A (en) 1966-06-27 1970-04-14 American Home Prod Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides
US3875162A (en) 1973-07-26 1975-04-01 Squibb & Sons Inc Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds
US4003905A (en) 1974-12-11 1977-01-18 E. R. Squibb & Sons, Inc. Diels-alder adducts of benzdiazepines
US4444688A (en) 1981-05-11 1984-04-24 Ciba-Geigy Corporation Imidazobenzothiadiazepines
JP2920385B2 (ja) 1988-08-18 1999-07-19 武田薬品工業株式会社 １，２，５‐ベンゾチアジアゼピン誘導体，その製造法および用途
JP3006615B2 (ja) * 1989-02-08 2000-02-07 電気化学工業株式会社 Ｄ―β―ヒドロキシアミノ酸の製造法
US6660856B2 (en) * 2002-03-08 2003-12-09 Kaohsiung Medical University Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
RU2338747C2 (ru) 2003-03-31 2008-11-20 Каунсил Оф Сайентифик Энд Индастриал Рисерч ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ
RU2314309C2 (ru) 2003-03-31 2008-01-10 Каунсил Оф Сайентифик Энд Индастриал Рисерч Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе
CN102365021B (zh) * 2009-02-05 2015-07-15 伊缪诺金公司 新型苯并二氮杂*衍生物
JP6049642B2 (ja) * 2011-02-15 2016-12-21 イミュノジェン・インコーポレーテッド 複合体の調製方法
GB201201100D0 (en) * 2012-01-20 2012-03-07 Medical Res Council Polypeptides and methods
ES2815353T3 (es) 2014-09-03 2021-03-29 Immunogen Inc Derivados de benzodiazepina citotóxicos
EP3189057A1 (en) 2014-09-03 2017-07-12 ImmunoGen, Inc. Cytotoxic benzodiazepine derivatives
JP6676058B2 (ja) 2015-01-14 2020-04-08 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ヘテロアリーレン架橋したベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法
EP3612533A1 (en) 2017-04-20 2020-02-26 Immunogen, Inc. Methods of preparing indolinobenzodiazepine derivatives
KR20210098470A (ko) * 2018-11-12 2021-08-10 이뮤노젠 아이엔씨 세포독성 벤조디아제핀 유도체의 제조 방법

Also Published As

Publication number Publication date
US11760759B2 (en) 2023-09-19
IL270008B (en) 2022-06-01
JP2023015178A (ja) 2023-01-31
EP3612533A1 (en) 2020-02-26
US20180339989A1 (en) 2018-11-29
AU2022215237B2 (en) 2024-05-02
US20200109145A1 (en) 2020-04-09
WO2018195245A1 (en) 2018-10-25
RU2019136798A (ru) 2021-05-20
US20240067652A1 (en) 2024-02-29
CN110573510B (zh) 2022-10-11
SG11201909564XA (en) 2019-11-28
CN115448926A (zh) 2022-12-09
IL293192A (en) 2022-07-01
IL293192B2 (en) 2024-01-01
CA3060086A1 (en) 2018-10-25
US20210292329A1 (en) 2021-09-23
TW202337888A (zh) 2023-10-01
CN110573510A (zh) 2019-12-13
AU2018254463B2 (en) 2022-05-12
IL311609A (en) 2024-05-01
US10968228B2 (en) 2021-04-06
RU2019136798A3 (https=) 2021-09-23
AU2022215237A1 (en) 2022-09-01
JP7170663B2 (ja) 2022-11-14
TW201838998A (zh) 2018-11-01
IL293192B1 (en) 2023-09-01
US10442809B2 (en) 2019-10-15
AU2018254463A1 (en) 2019-11-07
KR20190140977A (ko) 2019-12-20
IL305224B2 (en) 2024-09-01
JP2020517625A (ja) 2020-06-18
KR102595714B1 (ko) 2023-10-31
TWI790228B (zh) 2023-01-21
IL305224B1 (en) 2024-05-01
IL305224A (en) 2023-10-01
KR20230154089A (ko) 2023-11-07
TWI840039B (zh) 2024-04-21

Similar Documents

Publication Publication Date Title
EP3504196A4 (en) METHOD FOR PRODUCING OLAPARIB
MA49752A (fr) Procédés de préparation de composés de pyrrolidine
EP3709973A4 (en) METHOD FOR PRODUCING MSC-DERIVED EXOSOMES
EP3402787A4 (en) PROCESS FOR THE PREPARATION OF 2,5-FURANDIC ACETIC ACID AND INTERMEDIATES AND DERIVATIVES THEREOF
EP3277381C0 (en) Nitrobenzene derivatives of anticancer drugs
EP3331896A4 (en) PROCESS FOR THE PRODUCTION OF GALLENIC ACID AND DERIVATIVES THEREOF
MA45155A (fr) Procédés de préparation d'oligomères morpholino de phosphorodiamidate
EP3683205A4 (en) PROCESS FOR THE PRODUCTION OF ALIPHATIC ISOCYANATE
MA49700A (fr) Procédé amélioré pour la préparation de dérivés d'aminopyrimidine
MA45183A (fr) Procédés de préparation d'oligomères morpholino de phosphorodiamidate
MA45154A (fr) Procédés de préparation d'oligomères
EP2970037A4 (en) PROCESS FOR THE PREPARATION OF ALKYLFURANES
EP3481201A4 (en) METHOD FOR PRODUCING 4-ALKOXY-3- (ACYL OR ALKYL) OXYPICOLINAMIDES
MA45362A (fr) Procédés de préparation d'oligomères morpholino de phosphorodiamidate
EP3431520A4 (en) METHOD FOR PRODUCING OXYMETHYLENE COPOLYMER
EP3645548A4 (en) METHOD FOR PRODUCING BALIC ACIDS
EP3390368A4 (en) PROCESS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYL BENZO [F] ISOCHINOLINE-2-AMINE
EP3511313A4 (en) METHOD FOR PRODUCING 1,3-CYCLOHEXANDIMETHANOL
MA51510A (fr) Procédés de préparation de dérivés d'indolinobenzodiazépine
EP3445370A4 (en) METHOD AND DEVICE FOR PRODUCING OBETICHOLIC ACID AND DERIVATIVES THEREOF
EP3411359A4 (en) PROCESS FOR PREPARING HYDROXYLAMINE DERIVATIVES USEFUL IN THE PREPARATION OF INFECTION PROTECTION AGENTS
EP3902792A4 (en) PROCESS FOR THE PREPARATION OF ANTHRANILAMIDES
EP3314001A4 (en) METHOD AND COMPOSITIONS FOR PREPARING EPHEDRINE AND ASSOCIATED ALKALOID COMPOUNDS
EP3533856A4 (en) METHOD FOR PRODUCING HEXADECAHYDROPYRENE
EP3655379A4 (en) Methods for preparing bis-tetrahydroisoquinoline-containing compounds