CA3060086A1 - Methods of preparing indolinobenzodiazepine derivatives - Google Patents

Methods of preparing indolinobenzodiazepine derivatives Download PDF

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Publication number
CA3060086A1
CA3060086A1 CA3060086A CA3060086A CA3060086A1 CA 3060086 A1 CA3060086 A1 CA 3060086A1 CA 3060086 A CA3060086 A CA 3060086A CA 3060086 A CA3060086 A CA 3060086A CA 3060086 A1 CA3060086 A1 CA 3060086A1
Authority
CA
Canada
Prior art keywords
compound
formula
reaction
carried out
equivalent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3060086A
Other languages
English (en)
French (fr)
Inventor
Baudouin Gerard
Richard A. Silva
Michael Louis Miller
Manami Shizuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunogen Inc
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of CA3060086A1 publication Critical patent/CA3060086A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA3060086A 2017-04-20 2018-04-19 Methods of preparing indolinobenzodiazepine derivatives Pending CA3060086A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762487695P 2017-04-20 2017-04-20
US62/487,695 2017-04-20
PCT/US2018/028253 WO2018195245A1 (en) 2017-04-20 2018-04-19 Methods of preparing indolinobenzodiazepine derivatives

Publications (1)

Publication Number Publication Date
CA3060086A1 true CA3060086A1 (en) 2018-10-25

Family

ID=62117004

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3060086A Pending CA3060086A1 (en) 2017-04-20 2018-04-19 Methods of preparing indolinobenzodiazepine derivatives

Country Status (12)

Country Link
US (4) US10442809B2 (https=)
EP (1) EP3612533A1 (https=)
JP (2) JP7170663B2 (https=)
KR (2) KR102595714B1 (https=)
CN (2) CN115448926A (https=)
AU (2) AU2018254463B2 (https=)
CA (1) CA3060086A1 (https=)
IL (4) IL270008B (https=)
MA (1) MA51510A (https=)
SG (1) SG11201909564XA (https=)
TW (2) TWI840039B (https=)
WO (1) WO2018195245A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3612533A1 (en) 2017-04-20 2020-02-26 Immunogen, Inc. Methods of preparing indolinobenzodiazepine derivatives
EP4384502A1 (en) * 2021-08-13 2024-06-19 ImmunoGen, Inc. Improved methods for preparing cytotoxic benzodiazepine derivatives
KR20250031149A (ko) 2022-06-30 2025-03-06 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3453266A (en) 1966-03-14 1969-07-01 American Home Prod 1,2,5-benzothiadiazepine 1,1-dioxides
US3506646A (en) 1966-06-27 1970-04-14 American Home Prod Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides
US3875162A (en) 1973-07-26 1975-04-01 Squibb & Sons Inc Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds
US4003905A (en) 1974-12-11 1977-01-18 E. R. Squibb & Sons, Inc. Diels-alder adducts of benzdiazepines
US4444688A (en) 1981-05-11 1984-04-24 Ciba-Geigy Corporation Imidazobenzothiadiazepines
JP2920385B2 (ja) 1988-08-18 1999-07-19 武田薬品工業株式会社 １，２，５‐ベンゾチアジアゼピン誘導体，その製造法および用途
JP3006615B2 (ja) * 1989-02-08 2000-02-07 電気化学工業株式会社 Ｄ―β―ヒドロキシアミノ酸の製造法
US6660856B2 (en) * 2002-03-08 2003-12-09 Kaohsiung Medical University Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
RU2338747C2 (ru) 2003-03-31 2008-11-20 Каунсил Оф Сайентифик Энд Индастриал Рисерч ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ
RU2314309C2 (ru) 2003-03-31 2008-01-10 Каунсил Оф Сайентифик Энд Индастриал Рисерч Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе
CN102365021B (zh) * 2009-02-05 2015-07-15 伊缪诺金公司 新型苯并二氮杂*衍生物
JP6049642B2 (ja) * 2011-02-15 2016-12-21 イミュノジェン・インコーポレーテッド 複合体の調製方法
GB201201100D0 (en) * 2012-01-20 2012-03-07 Medical Res Council Polypeptides and methods
ES2815353T3 (es) 2014-09-03 2021-03-29 Immunogen Inc Derivados de benzodiazepina citotóxicos
EP3189057A1 (en) 2014-09-03 2017-07-12 ImmunoGen, Inc. Cytotoxic benzodiazepine derivatives
JP6676058B2 (ja) 2015-01-14 2020-04-08 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ヘテロアリーレン架橋したベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法
EP3612533A1 (en) 2017-04-20 2020-02-26 Immunogen, Inc. Methods of preparing indolinobenzodiazepine derivatives
KR20210098470A (ko) * 2018-11-12 2021-08-10 이뮤노젠 아이엔씨 세포독성 벤조디아제핀 유도체의 제조 방법

Also Published As

Publication number Publication date
US11760759B2 (en) 2023-09-19
IL270008B (en) 2022-06-01
JP2023015178A (ja) 2023-01-31
EP3612533A1 (en) 2020-02-26
US20180339989A1 (en) 2018-11-29
AU2022215237B2 (en) 2024-05-02
US20200109145A1 (en) 2020-04-09
WO2018195245A1 (en) 2018-10-25
RU2019136798A (ru) 2021-05-20
US20240067652A1 (en) 2024-02-29
CN110573510B (zh) 2022-10-11
SG11201909564XA (en) 2019-11-28
CN115448926A (zh) 2022-12-09
IL293192A (en) 2022-07-01
IL293192B2 (en) 2024-01-01
US20210292329A1 (en) 2021-09-23
TW202337888A (zh) 2023-10-01
CN110573510A (zh) 2019-12-13
AU2018254463B2 (en) 2022-05-12
IL311609A (en) 2024-05-01
US10968228B2 (en) 2021-04-06
RU2019136798A3 (https=) 2021-09-23
AU2022215237A1 (en) 2022-09-01
JP7170663B2 (ja) 2022-11-14
TW201838998A (zh) 2018-11-01
IL293192B1 (en) 2023-09-01
US10442809B2 (en) 2019-10-15
AU2018254463A1 (en) 2019-11-07
KR20190140977A (ko) 2019-12-20
IL305224B2 (en) 2024-09-01
JP2020517625A (ja) 2020-06-18
MA51510A (fr) 2020-11-11
KR102595714B1 (ko) 2023-10-31
TWI790228B (zh) 2023-01-21
IL305224B1 (en) 2024-05-01
IL305224A (en) 2023-10-01
KR20230154089A (ko) 2023-11-07
TWI840039B (zh) 2024-04-21

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