KR102595714B1 - 인돌리노벤조다이아제핀 유도체를 제조하는 방법 - Google Patents

인돌리노벤조다이아제핀 유도체를 제조하는 방법 Download PDF

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KR102595714B1
KR102595714B1 KR1020197033777A KR20197033777A KR102595714B1 KR 102595714 B1 KR102595714 B1 KR 102595714B1 KR 1020197033777 A KR1020197033777 A KR 1020197033777A KR 20197033777 A KR20197033777 A KR 20197033777A KR 102595714 B1 KR102595714 B1 KR 102595714B1
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KR20190140977A (ko
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보두앙 제라드
리차드 에이. 실바
마이클 루이스 밀러
마나미 시즈카
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이뮤노젠 아이엔씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020197033777A 2017-04-20 2018-04-19 인돌리노벤조다이아제핀 유도체를 제조하는 방법 Active KR102595714B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237036717A KR20230154089A (ko) 2017-04-20 2018-04-19 인돌리노벤조다이아제핀 유도체를 제조하는 방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762487695P 2017-04-20 2017-04-20
US62/487,695 2017-04-20
PCT/US2018/028253 WO2018195245A1 (en) 2017-04-20 2018-04-19 Methods of preparing indolinobenzodiazepine derivatives

Related Child Applications (1)

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KR1020237036717A Division KR20230154089A (ko) 2017-04-20 2018-04-19 인돌리노벤조다이아제핀 유도체를 제조하는 방법

Publications (2)

Publication Number Publication Date
KR20190140977A KR20190140977A (ko) 2019-12-20
KR102595714B1 true KR102595714B1 (ko) 2023-10-31

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Application Number Title Priority Date Filing Date
KR1020197033777A Active KR102595714B1 (ko) 2017-04-20 2018-04-19 인돌리노벤조다이아제핀 유도체를 제조하는 방법
KR1020237036717A Pending KR20230154089A (ko) 2017-04-20 2018-04-19 인돌리노벤조다이아제핀 유도체를 제조하는 방법

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Country Status (12)

Country Link
US (4) US10442809B2 (https=)
EP (1) EP3612533A1 (https=)
JP (2) JP7170663B2 (https=)
KR (2) KR102595714B1 (https=)
CN (2) CN115448926A (https=)
AU (2) AU2018254463B2 (https=)
CA (1) CA3060086A1 (https=)
IL (4) IL270008B (https=)
MA (1) MA51510A (https=)
SG (1) SG11201909564XA (https=)
TW (2) TWI840039B (https=)
WO (1) WO2018195245A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3612533A1 (en) 2017-04-20 2020-02-26 Immunogen, Inc. Methods of preparing indolinobenzodiazepine derivatives
EP4384502A1 (en) * 2021-08-13 2024-06-19 ImmunoGen, Inc. Improved methods for preparing cytotoxic benzodiazepine derivatives
KR20250031149A (ko) 2022-06-30 2025-03-06 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3453266A (en) 1966-03-14 1969-07-01 American Home Prod 1,2,5-benzothiadiazepine 1,1-dioxides
US3506646A (en) 1966-06-27 1970-04-14 American Home Prod Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides
US3875162A (en) 1973-07-26 1975-04-01 Squibb & Sons Inc Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds
US4003905A (en) 1974-12-11 1977-01-18 E. R. Squibb & Sons, Inc. Diels-alder adducts of benzdiazepines
US4444688A (en) 1981-05-11 1984-04-24 Ciba-Geigy Corporation Imidazobenzothiadiazepines
JP2920385B2 (ja) 1988-08-18 1999-07-19 武田薬品工業株式会社 １，２，５‐ベンゾチアジアゼピン誘導体，その製造法および用途
JP3006615B2 (ja) * 1989-02-08 2000-02-07 電気化学工業株式会社 Ｄ―β―ヒドロキシアミノ酸の製造法
US6660856B2 (en) * 2002-03-08 2003-12-09 Kaohsiung Medical University Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
RU2338747C2 (ru) 2003-03-31 2008-11-20 Каунсил Оф Сайентифик Энд Индастриал Рисерч ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ
RU2314309C2 (ru) 2003-03-31 2008-01-10 Каунсил Оф Сайентифик Энд Индастриал Рисерч Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе
CN102365021B (zh) * 2009-02-05 2015-07-15 伊缪诺金公司 新型苯并二氮杂*衍生物
JP6049642B2 (ja) * 2011-02-15 2016-12-21 イミュノジェン・インコーポレーテッド 複合体の調製方法
GB201201100D0 (en) * 2012-01-20 2012-03-07 Medical Res Council Polypeptides and methods
ES2815353T3 (es) 2014-09-03 2021-03-29 Immunogen Inc Derivados de benzodiazepina citotóxicos
EP3189057A1 (en) 2014-09-03 2017-07-12 ImmunoGen, Inc. Cytotoxic benzodiazepine derivatives
JP6676058B2 (ja) 2015-01-14 2020-04-08 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ヘテロアリーレン架橋したベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法
EP3612533A1 (en) 2017-04-20 2020-02-26 Immunogen, Inc. Methods of preparing indolinobenzodiazepine derivatives
KR20210098470A (ko) * 2018-11-12 2021-08-10 이뮤노젠 아이엔씨 세포독성 벤조디아제핀 유도체의 제조 방법

Also Published As

Publication number Publication date
US11760759B2 (en) 2023-09-19
IL270008B (en) 2022-06-01
JP2023015178A (ja) 2023-01-31
EP3612533A1 (en) 2020-02-26
US20180339989A1 (en) 2018-11-29
AU2022215237B2 (en) 2024-05-02
US20200109145A1 (en) 2020-04-09
WO2018195245A1 (en) 2018-10-25
RU2019136798A (ru) 2021-05-20
US20240067652A1 (en) 2024-02-29
CN110573510B (zh) 2022-10-11
SG11201909564XA (en) 2019-11-28
CN115448926A (zh) 2022-12-09
IL293192A (en) 2022-07-01
IL293192B2 (en) 2024-01-01
CA3060086A1 (en) 2018-10-25
US20210292329A1 (en) 2021-09-23
TW202337888A (zh) 2023-10-01
CN110573510A (zh) 2019-12-13
AU2018254463B2 (en) 2022-05-12
IL311609A (en) 2024-05-01
US10968228B2 (en) 2021-04-06
RU2019136798A3 (https=) 2021-09-23
AU2022215237A1 (en) 2022-09-01
JP7170663B2 (ja) 2022-11-14
TW201838998A (zh) 2018-11-01
IL293192B1 (en) 2023-09-01
US10442809B2 (en) 2019-10-15
AU2018254463A1 (en) 2019-11-07
KR20190140977A (ko) 2019-12-20
IL305224B2 (en) 2024-09-01
JP2020517625A (ja) 2020-06-18
MA51510A (fr) 2020-11-11
TWI790228B (zh) 2023-01-21
IL305224B1 (en) 2024-05-01
IL305224A (en) 2023-10-01
KR20230154089A (ko) 2023-11-07
TWI840039B (zh) 2024-04-21

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