MA49563A - Anticorps bispécifiques en tant qu'inhibiteurs de points de contrôle - Google Patents

Anticorps bispécifiques en tant qu'inhibiteurs de points de contrôle

Info

Publication number
MA49563A
MA49563A MA049563A MA49563A MA49563A MA 49563 A MA49563 A MA 49563A MA 049563 A MA049563 A MA 049563A MA 49563 A MA49563 A MA 49563A MA 49563 A MA49563 A MA 49563A
Authority
MA
Morocco
Prior art keywords
control point
bispecific antibodies
point inhibitors
inhibitors
bispecific
Prior art date
Application number
MA049563A
Other languages
English (en)
Inventor
Igor Edmondo Paolo D'angelo
Michael Dewain Kalos
Yiwen Li
Dale Lincoln Ludwig
Gregory D Plowman
Yang Shen
Original Assignee
Lilly Co Eli
Zymeworks Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Zymeworks Inc filed Critical Lilly Co Eli
Publication of MA49563A publication Critical patent/MA49563A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA049563A 2017-07-10 2018-07-09 Anticorps bispécifiques en tant qu'inhibiteurs de points de contrôle MA49563A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762530436P 2017-07-10 2017-07-10

Publications (1)

Publication Number Publication Date
MA49563A true MA49563A (fr) 2020-05-20

Family

ID=63013165

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049563A MA49563A (fr) 2017-07-10 2018-07-09 Anticorps bispécifiques en tant qu'inhibiteurs de points de contrôle

Country Status (26)

Country Link
US (1) US11203640B2 (fr)
EP (1) EP3652216A1 (fr)
JP (1) JP6953612B2 (fr)
KR (1) KR102309950B1 (fr)
CN (1) CN110914306B (fr)
AR (1) AR112603A1 (fr)
AU (1) AU2018301326B2 (fr)
BR (1) BR112020000162A2 (fr)
CA (1) CA3069254C (fr)
CL (1) CL2020000053A1 (fr)
CO (1) CO2019015100A2 (fr)
CR (1) CR20190576A (fr)
EA (1) EA201992757A1 (fr)
IL (1) IL271347B2 (fr)
JO (1) JOP20200003B1 (fr)
MA (1) MA49563A (fr)
MX (1) MX2020000242A (fr)
MY (1) MY195071A (fr)
NZ (1) NZ760683A (fr)
PE (1) PE20200297A1 (fr)
PH (1) PH12020500075A1 (fr)
SG (1) SG11201911817VA (fr)
TW (1) TWI714864B (fr)
UA (1) UA126032C2 (fr)
WO (1) WO2019014091A1 (fr)
ZA (1) ZA201908549B (fr)

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MY160203A (en) 2009-03-30 2017-02-28 Eisai R&D Man Co Ltd Liposome composition
EP3449921B1 (fr) 2016-04-28 2023-05-31 Eisai R&D Management Co., Ltd. Eribulin pour l' inhibition de croissance tumorale
IL265605B2 (en) 2016-09-29 2024-06-01 Beijing Hanmi Pharmaceutical Co Ltd Heterodimeric immunoglobulin structures, a pharmaceutical preparation containing them, their use and methods for their preparation
TN2019000161A1 (en) 2016-11-18 2020-10-05 Beijing Hanmi Pharmaceutical Co Ltd Anti-pd-1/anti-her2 natural antibody structure-like bispecific antibody of heterodimeric form and preparation thereof
EP3608341A4 (fr) * 2017-04-01 2021-01-06 Beijing Hanmi Pharmaceutical Co., Ltd. Anticorps bispécifique hétérodimère de type structure d'anticorps naturel anti-pd-l1/anti-pd-1 et sa préparation
WO2019153200A1 (fr) 2018-02-08 2019-08-15 北京韩美药品有限公司 Anticorps bispécifique de type structure d'anticorps naturel anti-pd -1/anti-her2 sous forme hétérodimère et sa préparation
CN112334488B (zh) * 2018-07-19 2023-12-08 伊莱利利公司 靶向免疫检查点的双特异性抗体
TWI760751B (zh) * 2019-05-29 2022-04-11 美商美國禮來大藥廠 Tigit及pd-1/tigit-結合分子
US11083705B2 (en) * 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
WO2021143767A1 (fr) * 2020-01-15 2021-07-22 信达生物制药(苏州)有限公司 Préparation d'anticorps bispécifique combinant pd-1 et pd-l1 et son utilisation
WO2021213523A1 (fr) * 2020-04-24 2021-10-28 信达生物制药(苏州)有限公司 Utilisations d'une combinaison d'anticorps anti-pd-1 et d'anticorps anti-ctla-4 dans la prévention ou le traitement du cancer
WO2021226984A1 (fr) * 2020-05-15 2021-11-18 三生国健药业（上海）股份有限公司 Anticorps bispécifique tétravalent contre pd-1 et pd-l1
JP2023116826A (ja) * 2020-05-20 2023-08-23 中外製薬株式会社 抗原結合分子
CN113754773A (zh) * 2020-06-02 2021-12-07 三生国健药业（上海）股份有限公司 一种抗pd1×pdl1的双特异性抗体
US11865082B2 (en) 2020-09-09 2024-01-09 Hoffmann-La Roche Inc. Combination therapy of PD-1-targeted IL-2 variant immunocytokines and antibodies against human PD-L1
CN114601924A (zh) * 2020-12-09 2022-06-10 信达生物制药(苏州)有限公司 抗pd-1抗体或其抗原结合片段治疗鳞状非小细胞肺癌的方法
WO2023020315A1 (fr) * 2021-08-19 2023-02-23 南京吉盛澳玛生物医药有限公司 Anticorps ciblant pd-l1/pd-1 et son utilisation
CN118103067A (zh) * 2021-09-14 2024-05-28 信达生物制药(苏州)有限公司 抗pd-1抗体和化疗药的药物组合及其使用方法

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IL132560A0 (en) 1997-05-02 2001-03-19 Genentech Inc A method for making multispecific antibodies having heteromultimeric and common components
EP3050963B1 (fr) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Procédé pour la production de polypeptide au moyen de la régulation d'un ensemble
EP1999154B1 (fr) 2006-03-24 2012-10-24 Merck Patent GmbH Domaines de proteine heterodimerique d'ingenierie
WO2007147901A1 (fr) 2006-06-22 2007-12-27 Novo Nordisk A/S Production d'anticorps bispécifiques
EP2235064B1 (fr) 2008-01-07 2015-11-25 Amgen Inc. Méthode de fabrication de molécules hétérodimères fc d'anticorps utilisant les effets de conduite électrostatique
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Also Published As

Publication number Publication date
AU2018301326A1 (en) 2019-12-19
AR112603A1 (es) 2019-11-20
NZ760683A (en) 2023-02-24
JP6953612B2 (ja) 2021-10-27
KR20200021982A (ko) 2020-03-02
CN110914306A (zh) 2020-03-24
UA126032C2 (uk) 2022-08-03
CR20190576A (es) 2020-03-03
KR102309950B1 (ko) 2021-10-08
CO2019015100A2 (es) 2020-04-24
US20190010232A1 (en) 2019-01-10
SG11201911817VA (en) 2020-01-30
JOP20200003A1 (ar) 2020-01-07
CA3069254A1 (fr) 2019-01-17
JOP20200003B1 (ar) 2023-03-28
PH12020500075A1 (en) 2020-11-09
WO2019014091A1 (fr) 2019-01-17
JP2020527136A (ja) 2020-09-03
TWI714864B (zh) 2021-01-01
US11203640B2 (en) 2021-12-21
MX2020000242A (es) 2020-08-10
EP3652216A1 (fr) 2020-05-20
TW201920263A (zh) 2019-06-01
ZA201908549B (en) 2021-08-25
EA201992757A1 (ru) 2020-04-27
CA3069254C (fr) 2023-09-12
BR112020000162A2 (pt) 2020-07-14
AU2018301326B2 (en) 2021-05-13
IL271347A (en) 2020-01-30
CN110914306B (zh) 2023-06-02
IL271347B1 (en) 2023-12-01
IL271347B2 (en) 2024-04-01
MY195071A (en) 2023-01-08
PE20200297A1 (es) 2020-02-06
CL2020000053A1 (es) 2020-10-30

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