SG11201911817VA - Checkpoint inhibitor bispecific antibodies - Google Patents
Checkpoint inhibitor bispecific antibodiesInfo
- Publication number
- SG11201911817VA SG11201911817VA SG11201911817VA SG11201911817VA SG11201911817VA SG 11201911817V A SG11201911817V A SG 11201911817VA SG 11201911817V A SG11201911817V A SG 11201911817VA SG 11201911817V A SG11201911817V A SG 11201911817VA SG 11201911817V A SG11201911817V A SG 11201911817VA
- Authority
- SG
- Singapore
- Prior art keywords
- bispecific antibodies
- checkpoint inhibitor
- inhibitor bispecific
- checkpoint
- antibodies
- Prior art date
Links
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 title 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762530436P | 2017-07-10 | 2017-07-10 | |
PCT/US2018/041205 WO2019014091A1 (en) | 2017-07-10 | 2018-07-09 | Checkpoint inhibitor bispecific antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201911817VA true SG11201911817VA (en) | 2020-01-30 |
Family
ID=63013165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201911817VA SG11201911817VA (en) | 2017-07-10 | 2018-07-09 | Checkpoint inhibitor bispecific antibodies |
Country Status (26)
Country | Link |
---|---|
US (1) | US11203640B2 (en) |
EP (1) | EP3652216A1 (en) |
JP (1) | JP6953612B2 (en) |
KR (1) | KR102309950B1 (en) |
CN (1) | CN110914306B (en) |
AR (1) | AR112603A1 (en) |
AU (1) | AU2018301326B2 (en) |
BR (1) | BR112020000162A2 (en) |
CA (1) | CA3069254C (en) |
CL (1) | CL2020000053A1 (en) |
CO (1) | CO2019015100A2 (en) |
CR (1) | CR20190576A (en) |
EA (1) | EA201992757A1 (en) |
IL (1) | IL271347B2 (en) |
JO (1) | JOP20200003B1 (en) |
MA (1) | MA49563A (en) |
MX (1) | MX2020000242A (en) |
MY (1) | MY195071A (en) |
NZ (1) | NZ760683A (en) |
PE (1) | PE20200297A1 (en) |
PH (1) | PH12020500075A1 (en) |
SG (1) | SG11201911817VA (en) |
TW (1) | TWI714864B (en) |
UA (1) | UA126032C2 (en) |
WO (1) | WO2019014091A1 (en) |
ZA (1) | ZA201908549B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2019003563A (en) | 2016-09-29 | 2019-08-12 | Beijing Hanmi Pharmaceutical Co Ltd | Heterodimeric immunoglobulin constructs and preparation methods thereof. |
JP7031810B2 (en) | 2016-11-18 | 2022-03-08 | ベイジン・ハンミ・ファーマシューティカル・カンパニー・リミテッド | Anti-PD-1 / anti-HER2 natural antibody structural form heterodimeric bispecific antibody and method for producing the same. |
US11591409B2 (en) * | 2017-04-01 | 2023-02-28 | Beijing Hanmi Pharm. Co., Ltd. | Anti-PD-L1/anti-PD-1 natural antibody structure-like heterodimeric bispecific antibody and preparation thereof |
WO2019153200A1 (en) | 2018-02-08 | 2019-08-15 | 北京韩美药品有限公司 | Anti-pd-1/anti-her2 natural antibody structure-like bispecific antibody in heterodimeric form and preparation thereof |
EP3823988A1 (en) * | 2018-07-19 | 2021-05-26 | Eli Lilly and Company | Bispecific antibodies targeting immune checkpoints |
TWI760751B (en) * | 2019-05-29 | 2022-04-11 | 美商美國禮來大藥廠 | Tigit and pd-1/tigit-binding molecules |
US11083705B2 (en) * | 2019-07-26 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
TW202130367A (en) * | 2020-01-15 | 2021-08-16 | 大陸商信達生物製藥(蘇州)有限公司 | Preparation and use of bispecific antibodies binding pd-1 and pd-l1 |
WO2021213523A1 (en) * | 2020-04-24 | 2021-10-28 | 信达生物制药(苏州)有限公司 | Uses of combination of anti-pd-1 antibody and anti-ctla-4 antibody in preventing or treating cancer |
WO2021226984A1 (en) * | 2020-05-15 | 2021-11-18 | 三生国健药业(上海)股份有限公司 | Tetravalent bispecific antibody against pd-1 and pd-l1 |
JP2023116826A (en) * | 2020-05-20 | 2023-08-23 | 中外製薬株式会社 | antigen binding molecule |
CN113754773A (en) * | 2020-06-02 | 2021-12-07 | 三生国健药业(上海)股份有限公司 | Bispecific antibody for resisting PD1 XPDL 1 |
US11865082B2 (en) | 2020-09-09 | 2024-01-09 | Hoffmann-La Roche Inc. | Combination therapy of PD-1-targeted IL-2 variant immunocytokines and antibodies against human PD-L1 |
CN114601924A (en) * | 2020-12-09 | 2022-06-10 | 信达生物制药(苏州)有限公司 | Methods of treating squamous non-small cell lung cancer with anti-PD-1 antibodies or antigen-binding fragments thereof |
WO2023020315A1 (en) * | 2021-08-19 | 2023-02-23 | 南京吉盛澳玛生物医药有限公司 | Antibody targeting pd-l1/pd-1 and use thereof |
WO2023040804A1 (en) * | 2021-09-14 | 2023-03-23 | 信达生物制药(苏州)有限公司 | Pharmaceutical composition of anti-pd-1 antibody and chemotherapy agent and method for using same |
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US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
DE69830901T2 (en) | 1997-05-02 | 2006-05-24 | Genentech Inc., San Francisco | A method for producing multispecific antibodies having heteromultimeric and common components |
EP3623473A1 (en) | 2005-03-31 | 2020-03-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
PT1999154E (en) | 2006-03-24 | 2013-01-24 | Merck Patent Gmbh | Engineered heterodimeric protein domains |
WO2007147901A1 (en) | 2006-06-22 | 2007-12-27 | Novo Nordisk A/S | Production of bispecific antibodies |
DK2235064T3 (en) | 2008-01-07 | 2016-01-11 | Amgen Inc | A process for the preparation of heterodimeric Fc molecules using electrostatic control effects |
CN102459346B (en) | 2009-04-27 | 2016-10-26 | 昂考梅德药品有限公司 | The method manufacturing heteromultimers molecule |
WO2011066342A2 (en) * | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
ME02505B (en) | 2009-12-29 | 2017-02-20 | Aptevo Res & Development Llc | Heterodimer binding proteins and uses thereof |
WO2011120134A1 (en) | 2010-03-29 | 2011-10-06 | Zymeworks, Inc. | Antibodies with enhanced or suppressed effector function |
EP2569337A1 (en) | 2010-05-14 | 2013-03-20 | Rinat Neuroscience Corp. | Heterodimeric proteins and methods for producing and purifying them |
AU2011305018B2 (en) | 2010-09-24 | 2014-12-11 | Zymeworks Inc. | System for molecular packing calculations |
AU2011308042B2 (en) | 2010-09-30 | 2015-07-16 | Zymeworks Inc. | Simplifying residue relationships in protein design |
RS59589B1 (en) | 2010-11-05 | 2019-12-31 | Zymeworks Inc | Stable heterodimeric antibody design with mutations in the fc domain |
ES2676878T3 (en) | 2011-03-03 | 2018-07-25 | Zymeworks Inc. | Multivalent heteromultimer frame design and constructs |
WO2014067011A1 (en) | 2012-11-02 | 2014-05-08 | Zymeworks Inc. | Crystal structures of heterodimeric fc domains |
CN104080811B (en) | 2011-11-04 | 2019-09-27 | 酵活有限公司 | There is the antibody design of the stabilization heterodimeric of mutation in Fc structural domain |
DK2794905T3 (en) | 2011-12-20 | 2020-07-06 | Medimmune Llc | MODIFIED POLYPEPTIDES FOR BISPECIFIC ANTIBODY BASIC STRUCTURES |
NZ772318A (en) | 2012-04-20 | 2023-06-30 | Merus Nv | Methods and means for the production of ig-like molecules |
CA2872540A1 (en) | 2012-05-10 | 2013-11-14 | Zymeworks Inc. | Heteromultimer constructs of immunoglobulin heavy chains with mutations in the fc domain |
CA2873720A1 (en) | 2012-05-10 | 2013-11-14 | Zymeworks Inc. | Single-arm monovalent antibody constructs and uses thereof |
WO2014012082A2 (en) | 2012-07-13 | 2014-01-16 | Zymeworks Inc. | Multivalent heteromultimer scaffold design an constructs |
WO2014012085A2 (en) | 2012-07-13 | 2014-01-16 | Zymeworks Inc. | Bispecific asymmetric heterodimers comprising anti-cd3 constructs |
US20140072581A1 (en) | 2012-07-23 | 2014-03-13 | Zymeworks Inc. | Immunoglobulin Constructs Comprising Selective Pairing of the Light and Heavy Chains |
JP6581505B2 (en) | 2012-10-03 | 2019-09-25 | ザイムワークス,インコーポレイテッド | Methods for quantifying heavy and light chain polypeptide pairs |
CA2893562C (en) | 2012-11-28 | 2023-09-12 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
CA2936785A1 (en) | 2014-01-15 | 2015-07-23 | Zymeworks Inc. | Bi-specific cd3 and cd19 antigen-binding constructs |
JOP20200094A1 (en) * | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | Antibody molecules to pd-1 and uses thereof |
EP3107938B1 (en) | 2014-05-28 | 2022-05-04 | Zymeworks Inc. | Modified antigen binding polypeptide constructs and uses thereof |
BR112017007379A2 (en) * | 2014-10-14 | 2017-12-19 | Dana Farber Cancer Inst Inc | antibody molecules to pd-l1 and uses thereof |
TN2017000554A1 (en) * | 2015-07-29 | 2019-04-12 | Novartis Ag | Novel combination for use in the treatment of cancer |
WO2017024465A1 (en) * | 2015-08-10 | 2017-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
AR105654A1 (en) * | 2015-08-24 | 2017-10-25 | Lilly Co Eli | ANTIBODIES PD-L1 (LINKING 1 OF PROGRAMMED CELL DEATH) |
WO2017087547A1 (en) | 2015-11-17 | 2017-05-26 | Oncomed Pharmaceuticals, Inc. | Pd-l1-binding agents and uses thereof |
-
2018
- 2018-06-26 AR ARP180101760 patent/AR112603A1/en unknown
- 2018-06-27 TW TW107121984A patent/TWI714864B/en active
- 2018-07-09 EA EA201992757A patent/EA201992757A1/en unknown
- 2018-07-09 IL IL271347A patent/IL271347B2/en unknown
- 2018-07-09 PE PE2019002612A patent/PE20200297A1/en unknown
- 2018-07-09 JP JP2020500803A patent/JP6953612B2/en active Active
- 2018-07-09 KR KR1020207000726A patent/KR102309950B1/en active IP Right Grant
- 2018-07-09 BR BR112020000162-7A patent/BR112020000162A2/en unknown
- 2018-07-09 CA CA3069254A patent/CA3069254C/en active Active
- 2018-07-09 MA MA049563A patent/MA49563A/en unknown
- 2018-07-09 UA UAA201912223A patent/UA126032C2/en unknown
- 2018-07-09 WO PCT/US2018/041205 patent/WO2019014091A1/en active Search and Examination
- 2018-07-09 US US16/029,979 patent/US11203640B2/en active Active
- 2018-07-09 NZ NZ760683A patent/NZ760683A/en unknown
- 2018-07-09 SG SG11201911817VA patent/SG11201911817VA/en unknown
- 2018-07-09 CN CN201880045977.1A patent/CN110914306B/en active Active
- 2018-07-09 JO JOP/2020/0003A patent/JOP20200003B1/en active
- 2018-07-09 EP EP18745803.9A patent/EP3652216A1/en active Pending
- 2018-07-09 MX MX2020000242A patent/MX2020000242A/en unknown
- 2018-07-09 CR CR20190576A patent/CR20190576A/en unknown
- 2018-07-09 AU AU2018301326A patent/AU2018301326B2/en active Active
- 2018-07-09 MY MYPI2020000114A patent/MY195071A/en unknown
-
2019
- 2019-12-20 ZA ZA2019/08549A patent/ZA201908549B/en unknown
- 2019-12-30 CO CONC2019/0015100A patent/CO2019015100A2/en unknown
-
2020
- 2020-01-08 CL CL2020000053A patent/CL2020000053A1/en unknown
- 2020-01-09 PH PH12020500075A patent/PH12020500075A1/en unknown
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