JOP20200003B1 - أجسام مضادة ثنائية النوعية مثبطة لنقاط مراقبة المناعة - Google Patents

أجسام مضادة ثنائية النوعية مثبطة لنقاط مراقبة المناعة

Info

Publication number
JOP20200003B1
JOP20200003B1 JOP/2020/0003A JOP20200003A JOP20200003B1 JO P20200003 B1 JOP20200003 B1 JO P20200003B1 JO P20200003 A JOP20200003 A JO P20200003A JO P20200003 B1 JOP20200003 B1 JO P20200003B1
Authority
JO
Jordan
Prior art keywords
bispecific antibodies
checkpoint inhibitor
inhibitor bispecific
human
antibodies
Prior art date
Application number
JOP/2020/0003A
Other languages
English (en)
Inventor
Yiwen Li
Igor Edmondo Paolo D'angelo
Gregory D Plowman
Yang Shen
Michael Dewain Kalos
Dale Lincoln Ludwig
Original Assignee
Lilly Co Eli
Zymeworks Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Zymeworks Inc filed Critical Lilly Co Eli
Publication of JOP20200003A1 publication Critical patent/JOP20200003A1/ar
Application granted granted Critical
Publication of JOP20200003B1 publication Critical patent/JOP20200003B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

يتعلق الاختراع الحالي بأجسام مضادة دايمرية غير متجانسة وترتبط بـ PD-L1 بشري وPD-1 بشري، ويمكن أن تكون مفيدة في علاج السرطان بمفردها وفي توليفة مع العلاج الكيميائي وعلاجات السرطان الأخرى.
JOP/2020/0003A 2017-07-10 2018-07-09 أجسام مضادة ثنائية النوعية مثبطة لنقاط مراقبة المناعة JOP20200003B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762530436P 2017-07-10 2017-07-10
PCT/US2018/041205 WO2019014091A1 (en) 2017-07-10 2018-07-09 BISPECIFIC ANTIBODIES AS INHIBITORS OF CONTROL POINTS

Publications (2)

Publication Number Publication Date
JOP20200003A1 JOP20200003A1 (ar) 2020-01-07
JOP20200003B1 true JOP20200003B1 (ar) 2023-03-28

Family

ID=63013165

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0003A JOP20200003B1 (ar) 2017-07-10 2018-07-09 أجسام مضادة ثنائية النوعية مثبطة لنقاط مراقبة المناعة

Country Status (26)

Country Link
US (1) US11203640B2 (ar)
EP (1) EP3652216A1 (ar)
JP (1) JP6953612B2 (ar)
KR (1) KR102309950B1 (ar)
CN (1) CN110914306B (ar)
AR (1) AR112603A1 (ar)
AU (1) AU2018301326B2 (ar)
BR (1) BR112020000162A2 (ar)
CA (1) CA3069254C (ar)
CL (1) CL2020000053A1 (ar)
CO (1) CO2019015100A2 (ar)
CR (1) CR20190576A (ar)
EA (1) EA201992757A1 (ar)
IL (1) IL271347B2 (ar)
JO (1) JOP20200003B1 (ar)
MA (1) MA49563A (ar)
MX (1) MX2020000242A (ar)
MY (1) MY195071A (ar)
NZ (1) NZ760683A (ar)
PE (1) PE20200297A1 (ar)
PH (1) PH12020500075A1 (ar)
SG (1) SG11201911817VA (ar)
TW (1) TWI714864B (ar)
UA (1) UA126032C2 (ar)
WO (1) WO2019014091A1 (ar)
ZA (1) ZA201908549B (ar)

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IL265605B1 (en) 2016-09-29 2024-02-01 Beijing Hanmi Pharmaceutical Co Ltd Heterodimeric immunoglobulin structures, a pharmaceutical preparation containing them, their use and methods for their preparation
CN109963876B (zh) 2016-11-18 2023-11-14 北京韩美药品有限公司 抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备
US11591409B2 (en) * 2017-04-01 2023-02-28 Beijing Hanmi Pharm. Co., Ltd. Anti-PD-L1/anti-PD-1 natural antibody structure-like heterodimeric bispecific antibody and preparation thereof
WO2019153200A1 (zh) 2018-02-08 2019-08-15 北京韩美药品有限公司 抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备
CN112334488B (zh) * 2018-07-19 2023-12-08 伊莱利利公司 靶向免疫检查点的双特异性抗体
TWI760751B (zh) * 2019-05-29 2022-04-11 美商美國禮來大藥廠 Tigit及pd-1/tigit-結合分子
US11083705B2 (en) * 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
TW202130367A (zh) * 2020-01-15 2021-08-16 大陸商信達生物製藥（蘇州）有限公司 結合ｐｄ－１和ｐｄ－ｌ１的雙特異性抗體的製劑及其用途
WO2021213523A1 (zh) * 2020-04-24 2021-10-28 信达生物制药(苏州)有限公司 抗pd-1抗体和抗ctla-4抗体的组合在预防或治疗癌症中的用途
WO2021226984A1 (zh) * 2020-05-15 2021-11-18 三生国健药业（上海）股份有限公司 一种抗pd-1和pd-l1的四价双特异性抗体
JP2023116826A (ja) * 2020-05-20 2023-08-23 中外製薬株式会社 抗原結合分子
CN113754773A (zh) * 2020-06-02 2021-12-07 三生国健药业（上海）股份有限公司 一种抗pd1×pdl1的双特异性抗体
US11865082B2 (en) 2020-09-09 2024-01-09 Hoffmann-La Roche Inc. Combination therapy of PD-1-targeted IL-2 variant immunocytokines and antibodies against human PD-L1
CN114601924A (zh) * 2020-12-09 2022-06-10 信达生物制药(苏州)有限公司 抗pd-1抗体或其抗原结合片段治疗鳞状非小细胞肺癌的方法
WO2023020315A1 (zh) * 2021-08-19 2023-02-23 南京吉盛澳玛生物医药有限公司 靶向pd-l1/pd-1的抗体及其应用
WO2023040804A1 (zh) * 2021-09-14 2023-03-23 信达生物制药(苏州)有限公司 抗pd-1抗体和化疗药的药物组合及其使用方法

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Also Published As

Publication number Publication date
EA201992757A1 (ru) 2020-04-27
NZ760683A (en) 2023-02-24
MY195071A (en) 2023-01-08
IL271347B1 (en) 2023-12-01
US11203640B2 (en) 2021-12-21
JP2020527136A (ja) 2020-09-03
IL271347B2 (en) 2024-04-01
CA3069254A1 (en) 2019-01-17
JOP20200003A1 (ar) 2020-01-07
CN110914306B (zh) 2023-06-02
BR112020000162A2 (pt) 2020-07-14
US20190010232A1 (en) 2019-01-10
IL271347A (en) 2020-01-30
KR102309950B1 (ko) 2021-10-08
MA49563A (fr) 2020-05-20
CL2020000053A1 (es) 2020-10-30
CA3069254C (en) 2023-09-12
KR20200021982A (ko) 2020-03-02
CN110914306A (zh) 2020-03-24
CR20190576A (es) 2020-03-03
ZA201908549B (en) 2021-08-25
PE20200297A1 (es) 2020-02-06
AU2018301326A1 (en) 2019-12-19
SG11201911817VA (en) 2020-01-30
WO2019014091A1 (en) 2019-01-17
PH12020500075A1 (en) 2020-11-09
CO2019015100A2 (es) 2020-04-24
JP6953612B2 (ja) 2021-10-27
AU2018301326B2 (en) 2021-05-13
TWI714864B (zh) 2021-01-01
MX2020000242A (es) 2020-08-10
AR112603A1 (es) 2019-11-20
UA126032C2 (uk) 2022-08-03
TW201920263A (zh) 2019-06-01
EP3652216A1 (en) 2020-05-20

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