MA43717A - Anticorps anti-tnf et fragments fonctionnels de ceux-ci - Google Patents

Anticorps anti-tnf et fragments fonctionnels de ceux-ci

Info

Publication number
MA43717A
MA43717A MA043717A MA43717A MA43717A MA 43717 A MA43717 A MA 43717A MA 043717 A MA043717 A MA 043717A MA 43717 A MA43717 A MA 43717A MA 43717 A MA43717 A MA 43717A
Authority
MA
Morocco
Prior art keywords
functional fragments
tnf antibodies
tnf
antibodies
fragments
Prior art date
Application number
MA043717A
Other languages
English (en)
Other versions
MA43717B1 (fr
Inventor
Esther Maria Furrer
Tea Gunde
Sebastian Meyer
Original Assignee
Tillotts Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tillotts Pharma Ag filed Critical Tillotts Pharma Ag
Publication of MA43717A publication Critical patent/MA43717A/fr
Publication of MA43717B1 publication Critical patent/MA43717B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626Diabody or triabody
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA43717A 2016-03-17 2017-03-16 Anticorps anti-tnf alpha et fragments fonctionnels de ceux-ci MA43717B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16160907.8A EP3219726B1 (fr) 2016-03-17 2016-03-17 Anticorps anti-tnf alpha et fragments fonctionnels de ceux-ci
PCT/EP2017/056237 WO2017158092A1 (fr) 2016-03-17 2017-03-16 Anticorps anti-tnfα et fragments fonctionnels de ceux-ci

Publications (2)

Publication Number Publication Date
MA43717A true MA43717A (fr) 2018-11-28
MA43717B1 MA43717B1 (fr) 2023-11-30

Family

ID=55542576

Family Applications (1)

Application Number Title Priority Date Filing Date
MA43717A MA43717B1 (fr) 2016-03-17 2017-03-16 Anticorps anti-tnf alpha et fragments fonctionnels de ceux-ci

Country Status (39)

Country Link
US (3) US11459383B2 (fr)
EP (3) EP3219726B1 (fr)
JP (2) JP7129398B2 (fr)
KR (2) KR20220158877A (fr)
CN (1) CN109071650B (fr)
AR (1) AR107917A1 (fr)
AU (1) AU2017235387B2 (fr)
BR (1) BR112018016667A2 (fr)
CA (1) CA3011784C (fr)
CL (1) CL2018002649A1 (fr)
CO (1) CO2018009783A2 (fr)
CR (1) CR20180448A (fr)
CY (1) CY1123784T1 (fr)
DK (2) DK3219726T3 (fr)
EA (1) EA039760B1 (fr)
ES (2) ES2836349T3 (fr)
FI (1) FI3430043T3 (fr)
GE (1) GEP20217307B (fr)
HR (2) HRP20231464T1 (fr)
HU (2) HUE052773T2 (fr)
IL (1) IL261031A (fr)
JO (2) JOP20170064B1 (fr)
LT (2) LT3219726T (fr)
MA (1) MA43717B1 (fr)
MD (1) MD3430043T2 (fr)
MX (1) MX2018011258A (fr)
MY (1) MY194041A (fr)
PH (1) PH12018501907A1 (fr)
PL (2) PL3219726T3 (fr)
PT (2) PT3219726T (fr)
RS (2) RS61374B1 (fr)
SA (1) SA518400027B1 (fr)
SG (1) SG11201807062RA (fr)
SI (2) SI3219726T1 (fr)
TN (1) TN2018000298A1 (fr)
TW (2) TWI784945B (fr)
UY (1) UY37157A (fr)
WO (1) WO2017158092A1 (fr)
ZA (4) ZA202108599B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS61412B1 (sr) 2016-03-17 2021-03-31 Tillotts Pharma Ag Anti-tnf alfa-antitela i njihovi funkcionalni fragmenti
DK3219726T3 (da) * 2016-03-17 2020-12-07 Tillotts Pharma Ag Anti-TNF-alfa-antistoffer og funktionelle fragmenter deraf
US10759852B2 (en) 2016-03-17 2020-09-01 Numab Innovation Ag Anti-TNF-alpha-antibodies and functional fragments thereof
US10787508B2 (en) 2016-03-17 2020-09-29 Numab Innovation Ag Anti-TNFα-antibodies and functional fragments thereof
LT3456736T (lt) * 2017-09-19 2021-06-10 Tillotts Pharma Ag Antikūnų variantai
EP3456737B1 (fr) * 2017-09-19 2024-02-14 Tillotts Pharma Ag Variantes d'anticorps
EP3456738A1 (fr) * 2017-09-19 2019-03-20 Tillotts Pharma Ag Variantes d'anticorps
WO2020114616A1 (fr) 2018-12-07 2020-06-11 Tillotts Pharma Ag Traitement topique d'une diarrhée, d'une colite ou d'une entérocolite induite par un inhibiteur de point de contrôle immunitaire au moyen d'anticorps et de fragments de ceux-ci

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DK3219726T3 (da) * 2016-03-17 2020-12-07 Tillotts Pharma Ag Anti-TNF-alfa-antistoffer og funktionelle fragmenter deraf
US10787508B2 (en) 2016-03-17 2020-09-29 Numab Innovation Ag Anti-TNFα-antibodies and functional fragments thereof
US10759852B2 (en) 2016-03-17 2020-09-01 Numab Innovation Ag Anti-TNF-alpha-antibodies and functional fragments thereof
RS61412B1 (sr) 2016-03-17 2021-03-31 Tillotts Pharma Ag Anti-tnf alfa-antitela i njihovi funkcionalni fragmenti

Also Published As

Publication number Publication date
HRP20210123T1 (hr) 2021-03-05
SI3219726T1 (sl) 2021-02-26
CL2018002649A1 (es) 2018-11-09
MY194041A (en) 2022-11-09
BR112018016667A2 (pt) 2019-02-05
PT3430043T (pt) 2023-11-23
CR20180448A (es) 2019-01-25
EP3430043A1 (fr) 2019-01-23
CA3011784A1 (fr) 2017-09-21
ES2836349T3 (es) 2021-06-24
US20210198353A1 (en) 2021-07-01
PH12018501907A1 (en) 2019-06-17
IL261031A (en) 2018-10-31
SA518400027B1 (ar) 2022-03-06
SI3430043T1 (sl) 2024-01-31
LT3430043T (lt) 2023-12-27
US11459383B2 (en) 2022-10-04
HUE052773T2 (hu) 2021-05-28
JP2022130407A (ja) 2022-09-06
TW202311288A (zh) 2023-03-16
PL3430043T3 (pl) 2024-03-11
MA43717B1 (fr) 2023-11-30
EP3430043B1 (fr) 2023-08-30
DK3219726T3 (da) 2020-12-07
HRP20231464T1 (hr) 2024-03-01
AU2017235387A1 (en) 2018-09-27
JP2019512268A (ja) 2019-05-16
EP3219726A1 (fr) 2017-09-20
US20230272059A1 (en) 2023-08-31
US20230279091A1 (en) 2023-09-07
ES2963221T3 (es) 2024-03-26
ZA202108600B (en) 2022-03-30
CA3011784C (fr) 2024-04-23
EP3219726B1 (fr) 2020-12-02
HUE064238T2 (hu) 2024-02-28
UY37157A (es) 2017-10-31
DK3430043T3 (da) 2023-11-27
CY1123784T1 (el) 2022-05-27
KR102470235B1 (ko) 2022-11-24
CN109071650B (zh) 2022-05-13
EP4275745A2 (fr) 2023-11-15
JOP20210085A1 (ar) 2023-01-30
ZA202108602B (en) 2022-03-30
MD3430043T2 (ro) 2024-02-29
TN2018000298A1 (en) 2020-01-16
AR107917A1 (es) 2018-06-28
JOP20170064B1 (ar) 2021-08-17
FI3430043T3 (fi) 2023-11-17
EA039760B1 (ru) 2022-03-10
JP7129398B2 (ja) 2022-09-01
RS64830B1 (sr) 2023-12-29
KR20180120149A (ko) 2018-11-05
CN109071650A (zh) 2018-12-21
ZA202108601B (en) 2022-03-30
TWI784945B (zh) 2022-12-01
EP4275745A3 (fr) 2023-12-20
GEP20217307B (en) 2021-10-25
CO2018009783A2 (es) 2018-09-28
TW201739766A (zh) 2017-11-16
WO2017158092A1 (fr) 2017-09-21
PT3219726T (pt) 2020-12-15
AU2017235387B2 (en) 2024-06-27
MX2018011258A (es) 2019-02-13
SG11201807062RA (en) 2018-09-27
KR20220158877A (ko) 2022-12-01
TWI829444B (zh) 2024-01-11
RS61374B1 (sr) 2021-02-26
ZA202108599B (en) 2022-03-30
LT3219726T (lt) 2021-01-25
PL3219726T3 (pl) 2021-07-19
EA201891788A1 (ru) 2019-01-31

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