JOP20170064B1 - أجسام مضادة لـ TNF-a وشظايا وظيفية منها - Google Patents

أجسام مضادة لـ TNF-a وشظايا وظيفية منها

Info

Publication number
JOP20170064B1
JOP20170064B1 JOP/2017/0064A JOP20170064A JOP20170064B1 JO P20170064 B1 JOP20170064 B1 JO P20170064B1 JO P20170064 A JOP20170064 A JO P20170064A JO P20170064 B1 JOP20170064 B1 JO P20170064B1
Authority
JO
Jordan
Prior art keywords
tnfa
functional fragments
antibodies
binding
processes
Prior art date
Application number
JOP/2017/0064A
Other languages
English (en)
Inventor
Gunde Tea
Meyer Sebastian
Maria Furrer Esther
Original Assignee
Tillotts Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tillotts Pharma Ag filed Critical Tillotts Pharma Ag
Application granted granted Critical
Publication of JOP20170064B1 publication Critical patent/JOP20170064B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

يتعلق الاختراع الحالي بجزيئات أجسام مضادة وشظايا وظيفية منها، قادرة على الارتباط بعامل تنكرز الورم ألفا (TNFa)، وبعمليات لإنتاجها واستخدامها علاجيا.andnbsp;
JOP/2017/0064A 2016-03-17 2017-03-16 أجسام مضادة لـ TNF-a وشظايا وظيفية منها JOP20170064B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16160907.8A EP3219726B1 (en) 2016-03-17 2016-03-17 Anti-tnf alpha-antibodies and functional fragments thereof

Publications (1)

Publication Number Publication Date
JOP20170064B1 true JOP20170064B1 (ar) 2021-08-17

Family

ID=55542576

Family Applications (2)

Application Number Title Priority Date Filing Date
JOP/2017/0064A JOP20170064B1 (ar) 2016-03-17 2017-03-16 أجسام مضادة لـ TNF-a وشظايا وظيفية منها
JOP/2021/0085A JOP20210085A1 (ar) 2016-03-17 2021-04-22 أجسام مضادة لـ TNF- alpha وشظايا وظيفية منها

Family Applications After (1)

Application Number Title Priority Date Filing Date
JOP/2021/0085A JOP20210085A1 (ar) 2016-03-17 2021-04-22 أجسام مضادة لـ TNF- alpha وشظايا وظيفية منها

Country Status (38)

Country Link
US (3) US11459383B2 (ar)
EP (3) EP3219726B1 (ar)
JP (2) JP7129398B2 (ar)
KR (2) KR102470235B1 (ar)
CN (1) CN109071650B (ar)
AR (1) AR107917A1 (ar)
BR (1) BR112018016667A2 (ar)
CA (1) CA3011784C (ar)
CL (1) CL2018002649A1 (ar)
CO (1) CO2018009783A2 (ar)
CR (1) CR20180448A (ar)
CY (1) CY1123784T1 (ar)
DK (2) DK3219726T3 (ar)
EA (1) EA039760B1 (ar)
ES (2) ES2836349T3 (ar)
FI (1) FI3430043T3 (ar)
GE (1) GEP20217307B (ar)
HR (2) HRP20231464T1 (ar)
HU (2) HUE052773T2 (ar)
IL (1) IL261031A (ar)
JO (2) JOP20170064B1 (ar)
LT (2) LT3219726T (ar)
MA (1) MA43717B1 (ar)
MD (1) MD3430043T2 (ar)
MX (1) MX2018011258A (ar)
MY (1) MY194041A (ar)
PH (1) PH12018501907A1 (ar)
PL (2) PL3219726T3 (ar)
PT (2) PT3219726T (ar)
RS (2) RS61374B1 (ar)
SA (1) SA518400027B1 (ar)
SG (1) SG11201807062RA (ar)
SI (2) SI3219726T1 (ar)
TN (1) TN2018000298A1 (ar)
TW (2) TWI784945B (ar)
UY (1) UY37157A (ar)
WO (1) WO2017158092A1 (ar)
ZA (4) ZA202108601B (ar)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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HUE052869T2 (hu) 2016-03-17 2021-05-28 Tillotts Pharma Ag TNF-ellenes alfa-antitestek és ezek funkcionális fragmentjei
US10759852B2 (en) 2016-03-17 2020-09-01 Numab Innovation Ag Anti-TNF-alpha-antibodies and functional fragments thereof
ES2836349T3 (es) * 2016-03-17 2021-06-24 Tillotts Pharma Ag Anticuerpos anti-TNF-alfa y fragmentos funcionales de los mismos
WO2017158079A1 (en) 2016-03-17 2017-09-21 Numab Innovation Ag Anti-tnfalpha-antibodies and functional fragments thereof
EP3456738A1 (en) * 2017-09-19 2019-03-20 Tillotts Pharma Ag Antibody variants
ES2873650T3 (es) * 2017-09-19 2021-11-03 Tillotts Pharma Ag Variantes de anticuerpos
EP3456737B1 (en) * 2017-09-19 2024-02-14 Tillotts Pharma Ag Antibody variants
WO2020114616A1 (en) 2018-12-07 2020-06-11 Tillotts Pharma Ag Topical treatment of immune checkpoint inhibitor induced diarrhoea, colitis or enterocolitis using antibodies and fragments thereof

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Also Published As

Publication number Publication date
HRP20210123T1 (hr) 2021-03-05
GEP20217307B (en) 2021-10-25
TW201739766A (zh) 2017-11-16
WO2017158092A1 (en) 2017-09-21
TWI784945B (zh) 2022-12-01
MY194041A (en) 2022-11-09
MD3430043T2 (ro) 2024-02-29
PT3430043T (pt) 2023-11-23
JP2022130407A (ja) 2022-09-06
EA201891788A1 (ru) 2019-01-31
PT3219726T (pt) 2020-12-15
EP4275745A3 (en) 2023-12-20
ES2836349T3 (es) 2021-06-24
ZA202108599B (en) 2022-03-30
SA518400027B1 (ar) 2022-03-06
LT3219726T (lt) 2021-01-25
JOP20210085A1 (ar) 2023-01-30
DK3219726T3 (da) 2020-12-07
CR20180448A (es) 2019-01-25
HUE064238T2 (hu) 2024-02-28
US20230279091A1 (en) 2023-09-07
AR107917A1 (es) 2018-06-28
ZA202108601B (en) 2022-03-30
ZA202108600B (en) 2022-03-30
IL261031A (en) 2018-10-31
TWI829444B (zh) 2024-01-11
CN109071650A (zh) 2018-12-21
JP7129398B2 (ja) 2022-09-01
MA43717B1 (fr) 2023-11-30
CO2018009783A2 (es) 2018-09-28
CA3011784C (en) 2024-04-23
SI3219726T1 (sl) 2021-02-26
MX2018011258A (es) 2019-02-13
TN2018000298A1 (en) 2020-01-16
AU2017235387A1 (en) 2018-09-27
EP4275745A2 (en) 2023-11-15
BR112018016667A2 (pt) 2019-02-05
PL3430043T3 (pl) 2024-03-11
ZA202108602B (en) 2022-03-30
CN109071650B (zh) 2022-05-13
DK3430043T3 (da) 2023-11-27
RS64830B1 (sr) 2023-12-29
HRP20231464T1 (hr) 2024-03-01
CY1123784T1 (el) 2022-05-27
PH12018501907A1 (en) 2019-06-17
SG11201807062RA (en) 2018-09-27
FI3430043T3 (fi) 2023-11-17
EP3430043A1 (en) 2019-01-23
UY37157A (es) 2017-10-31
EP3430043B1 (en) 2023-08-30
US20210198353A1 (en) 2021-07-01
US20230272059A1 (en) 2023-08-31
TW202311288A (zh) 2023-03-16
JP2019512268A (ja) 2019-05-16
KR20220158877A (ko) 2022-12-01
KR102470235B1 (ko) 2022-11-24
KR20180120149A (ko) 2018-11-05
US11459383B2 (en) 2022-10-04
CA3011784A1 (en) 2017-09-21
CL2018002649A1 (es) 2018-11-09
ES2963221T3 (es) 2024-03-26
PL3219726T3 (pl) 2021-07-19
EP3219726B1 (en) 2020-12-02
EP3219726A1 (en) 2017-09-20
EA039760B1 (ru) 2022-03-10
LT3430043T (lt) 2023-12-27
RS61374B1 (sr) 2021-02-26
MA43717A (fr) 2018-11-28
HUE052773T2 (hu) 2021-05-28
SI3430043T1 (sl) 2024-01-31

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