MA40241A - Compositions enrichies stéréochimiquement pour l'administration d'acides nucléiques - Google Patents

Compositions enrichies stéréochimiquement pour l'administration d'acides nucléiques

Info

Publication number
MA40241A
MA40241A MA040241A MA40241A MA40241A MA 40241 A MA40241 A MA 40241A MA 040241 A MA040241 A MA 040241A MA 40241 A MA40241 A MA 40241A MA 40241 A MA40241 A MA 40241A
Authority
MA
Morocco
Prior art keywords
formula
delivery
chemical entities
nucleic acids
enriched compositions
Prior art date
Application number
MA040241A
Other languages
English (en)
Inventor
Frank Derosa
Michael Heartlein
Shrirang Karve
Original Assignee
Shire Human Genetic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies
Publication of MA40241A publication Critical patent/MA40241A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La présente invention concerne en partie une composition comprenant une ou plusieurs entités chimiques de formule i, chacune d'entre elles étant un composé de formule (i) : un sel pharmaceutiquement acceptable de celui-ci, un solvate de celui-ci, ou un solvate d'un sel pharmaceutiquement acceptable de celui-ci, la composition étant caractérisée en ce que supérieures à une première valeur de seuil de la quantité totale d'entités chimiques de formule i dans la composition : sont des entités chimiques de formule i.A, la première quantité de seuil étant de 50 %; ou sont des entités chimiques de formule i.B.1, la première quantité de seuil étant de 25 %; ou sont des entités chimiques de formule i.B.2, la première quantité de seuil étant de 25 %, les entités chimiques de formules i.A, i.B.1, et i.B.2, étant décrites ici, et des procédés d'utilisation desdites compositions, par exemple, pour l'administration d'un polynucléotide
MA040241A 2014-06-24 2015-06-24 Compositions enrichies stéréochimiquement pour l'administration d'acides nucléiques MA40241A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462016512P 2014-06-24 2014-06-24

Publications (1)

Publication Number Publication Date
MA40241A true MA40241A (fr) 2017-05-03

Family

ID=54929772

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040241A MA40241A (fr) 2014-06-24 2015-06-24 Compositions enrichies stéréochimiquement pour l'administration d'acides nucléiques

Country Status (18)

Country Link
US (3) US10138213B2 (fr)
EP (1) EP3160959B1 (fr)
JP (1) JP6599373B2 (fr)
KR (3) KR102511554B1 (fr)
CN (3) CN111588695A (fr)
AU (4) AU2015279968B2 (fr)
CA (1) CA2952824C (fr)
CL (1) CL2016003263A1 (fr)
EA (1) EA033966B1 (fr)
ES (1) ES2964588T3 (fr)
IL (1) IL249615A0 (fr)
MA (1) MA40241A (fr)
MX (3) MX2017000143A (fr)
NZ (1) NZ727281A (fr)
PE (1) PE20171238A1 (fr)
SG (1) SG11201610670WA (fr)
UA (1) UA121863C2 (fr)
WO (1) WO2015200465A1 (fr)

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US9629804B2 (en) * 2013-10-22 2017-04-25 Shire Human Genetic Therapies, Inc. Lipid formulations for delivery of messenger RNA
MA48050A (fr) 2014-05-30 2020-02-12 Translate Bio Inc Lipides biodégradables pour l'administration d'acides nucléiques
EP3576760A2 (fr) * 2017-02-01 2019-12-11 The Trustees Of The University Of Pennsylvania Thérapie génique pour le traitement de citrullinémie
WO2018157141A1 (fr) 2017-02-27 2018-08-30 Translate Bio, Inc. Procédés de purification d'arn messager
EP3971291A1 (fr) 2017-02-27 2022-03-23 Translate Bio, Inc. Procédés de purification d'arn messager
EP3746496A1 (fr) 2018-02-02 2020-12-09 Translate Bio, Inc. Polymères cationiques
WO2019222277A1 (fr) * 2018-05-15 2019-11-21 Translate Bio, Inc. Administration sous-cutanée d'arn messager
AU2019325702A1 (en) 2018-08-24 2021-02-25 Translate Bio, Inc. Methods for purification of messenger RNA
BR112021006539A2 (pt) 2018-10-09 2021-07-06 Univ British Columbia composições e sistemas competentes de vesículas competentes para transfecção isentas de solventes e detergentes orgânicos e métodos relacionados às mesmas
EP3877538A1 (fr) 2018-11-08 2021-09-15 Translate Bio, Inc. Procédés et compositions pour purification d'arn messager
WO2020219427A1 (fr) * 2019-04-22 2020-10-29 Translate Bio, Inc. Lipides cationiques de thioester
CN114901360A (zh) 2019-12-20 2022-08-12 库瑞瓦格股份公司 用于递送核酸的新型脂质纳米颗粒
CN111658782A (zh) * 2020-06-10 2020-09-15 深圳近邻生物科技有限公司 mRNA疫苗递送载体及制备方法、mRNA疫苗及制备方法
WO2022066916A1 (fr) * 2020-09-23 2022-03-31 Translate Bio, Inc. Lipides cationiques à base de pipérazine
WO2022099003A1 (fr) 2020-11-06 2022-05-12 Sanofi Nanoparticules lipidiques pour l'administration de vaccins à arnm
IL309505A (en) 2021-09-03 2024-02-01 CureVac SE Lipid nanoparticles for nucleic acid delivery
WO2023073228A1 (fr) 2021-10-29 2023-05-04 CureVac SE Arn circulaire amélioré pour exprimer des protéines thérapeutiques
WO2023144330A1 (fr) 2022-01-28 2023-08-03 CureVac SE Inhibiteurs de facteurs de transcription codés par un acide nucleique
WO2023227608A1 (fr) 2022-05-25 2023-11-30 Glaxosmithkline Biologicals Sa Vaccin à base d'acide nucléique codant pour un polypeptide antigénique fimh d'escherichia coli

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MX2022001291A (es) 2022-02-22
EP3160959A1 (fr) 2017-05-03
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US20220048867A1 (en) 2022-02-17
US10138213B2 (en) 2018-11-27
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