MA39139B1 - Spiro-oxazolones - Google Patents

Spiro-oxazolones

Info

Publication number
MA39139B1
MA39139B1 MA39139A MA39139A MA39139B1 MA 39139 B1 MA39139 B1 MA 39139B1 MA 39139 A MA39139 A MA 39139A MA 39139 A MA39139 A MA 39139A MA 39139 B1 MA39139 B1 MA 39139B1
Authority
MA
Morocco
Prior art keywords
oxazolones
spiro
disorders
present
obsessive
Prior art date
Application number
MA39139A
Other languages
English (en)
Other versions
MA39139A1 (fr
Inventor
Patrick Schnider
Valerie Runtz-Schmitt
Cosimo Dolente
Bernhard Fasching
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA39139A1 publication Critical patent/MA39139A1/fr
Publication of MA39139B1 publication Critical patent/MA39139B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention porte sur des spiro-oxazolones, qui servent de modulateurs des récepteurs v1a, et en particulier d'antagonistes des récepteurs v1a, sur leur fabrication, sur des compositions pharmaceutiques les contenant et sur leur utilisation comme médicaments. Les composés de la présente invention sont utiles en tant qu'agents thérapeutiques à action périphérique et centrale dans les pathologies du syndrome de sécrétion inappropriée de vasopressine, de l'anxiété, des troubles dépressifs, des troubles obsessionnels compulsifs, des troubles du spectre autistique, de la schizophrénie, d'un comportement agressif et de troubles du sommeil, en particulier en cas de décalage horaire.
MA39139A 2013-12-19 2014-12-16 Spiro-oxazolones MA39139B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13198604 2013-12-19
PCT/EP2014/077858 WO2015091411A1 (fr) 2013-12-19 2014-12-16 Spiro-oxazolones

Publications (2)

Publication Number Publication Date
MA39139A1 MA39139A1 (fr) 2018-05-31
MA39139B1 true MA39139B1 (fr) 2019-01-31

Family

ID=49876427

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39139A MA39139B1 (fr) 2013-12-19 2014-12-16 Spiro-oxazolones

Country Status (35)

Country Link
US (3) US10479796B2 (fr)
EP (1) EP3083633B1 (fr)
JP (1) JP6530407B2 (fr)
KR (1) KR102353431B1 (fr)
CN (1) CN105814062B (fr)
AR (1) AR098783A1 (fr)
AU (1) AU2014364729B2 (fr)
BR (1) BR112016013058B1 (fr)
CA (1) CA2932063C (fr)
CL (1) CL2016001495A1 (fr)
CR (1) CR20160215A (fr)
DK (1) DK3083633T3 (fr)
EA (1) EA029167B1 (fr)
ES (1) ES2657994T3 (fr)
HK (1) HK1223920A1 (fr)
HR (1) HRP20180160T1 (fr)
HU (1) HUE036203T2 (fr)
IL (1) IL245464B (fr)
LT (1) LT3083633T (fr)
MA (1) MA39139B1 (fr)
MX (1) MX370663B (fr)
MY (1) MY177313A (fr)
NO (1) NO3083633T3 (fr)
NZ (1) NZ719765A (fr)
PE (1) PE20160864A1 (fr)
PH (1) PH12016500919B1 (fr)
PL (1) PL3083633T3 (fr)
PT (1) PT3083633T (fr)
RS (1) RS56791B1 (fr)
SG (1) SG11201604915PA (fr)
SI (1) SI3083633T1 (fr)
TW (1) TWI548639B (fr)
UA (1) UA117273C2 (fr)
WO (1) WO2015091411A1 (fr)
ZA (1) ZA201603221B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201600522A (zh) * 2014-02-20 2016-01-01 赫孚孟拉羅股份公司 螺－唑酮
WO2017191117A1 (fr) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Antagonistes du récepteur v1a destinés à une utilisation dans le traitement de maladies rénales
AR127706A1 (es) 2021-11-19 2024-02-21 Hoffmann La Roche Síntesis de 2’-(7,7-dimetil-1’h,7h-espiro[furo[3,4-b]piridin-5,4’-piperidin]-1’-il)-1,3-dihidro-4’h-espiro[inden-2,5’-[1,3]oxazol]-4’-ona

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003302640B2 (en) * 2002-11-29 2009-09-24 Banyu Pharmaceutical Co., Ltd. Novel azole derivatives
US7351706B2 (en) 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives
CA2670671A1 (fr) * 2006-12-07 2008-06-12 F. Hoffmann-La Roche Ag Derives de spiro-piperidine
JP2010513385A (ja) * 2006-12-22 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー スピロ−ピペリジン誘導体
ATE536356T1 (de) * 2007-01-12 2011-12-15 Hoffmann La Roche Spiropiperidin-glycinamid-derivate
SI2356123T1 (sl) * 2008-11-13 2013-01-31 F. Hoffmann-La Roche Ag Piro-5,6-dihidro-4h-2,3,5,10b-tetraaza-benzo(e)azuleni

Also Published As

Publication number Publication date
IL245464B (en) 2019-10-31
JP2017502028A (ja) 2017-01-19
RS56791B1 (sr) 2018-04-30
PE20160864A1 (es) 2016-09-03
EA201691189A1 (ru) 2016-10-31
MY177313A (en) 2020-09-11
AU2014364729A1 (en) 2016-05-26
CN105814062B (zh) 2018-04-24
ES2657994T3 (es) 2018-03-07
TW201536790A (zh) 2015-10-01
US10479796B2 (en) 2019-11-19
CR20160215A (es) 2016-07-15
US20200039997A1 (en) 2020-02-06
IL245464A0 (en) 2016-06-30
WO2015091411A1 (fr) 2015-06-25
PT3083633T (pt) 2018-01-25
CA2932063C (fr) 2023-03-07
AU2014364729B2 (en) 2018-11-22
BR112016013058B1 (pt) 2021-02-23
MX2016007809A (es) 2016-09-07
CL2016001495A1 (es) 2016-12-16
HRP20180160T1 (hr) 2018-02-23
EP3083633A1 (fr) 2016-10-26
HUE036203T2 (hu) 2018-06-28
MA39139A1 (fr) 2018-05-31
US11578077B2 (en) 2023-02-14
US20170008901A1 (en) 2017-01-12
PH12016500919A1 (en) 2016-06-27
PH12016500919B1 (en) 2016-06-27
EP3083633B1 (fr) 2017-11-29
KR102353431B1 (ko) 2022-01-20
EA029167B1 (ru) 2018-02-28
KR20160098490A (ko) 2016-08-18
JP6530407B2 (ja) 2019-06-12
TWI548639B (zh) 2016-09-11
HK1223920A1 (zh) 2017-08-11
CN105814062A (zh) 2016-07-27
PL3083633T3 (pl) 2018-04-30
SI3083633T1 (en) 2018-02-28
SG11201604915PA (en) 2016-07-28
NO3083633T3 (fr) 2018-04-28
MX370663B (es) 2019-12-19
DK3083633T3 (da) 2018-01-29
CA2932063A1 (fr) 2015-06-25
US20230106150A1 (en) 2023-04-06
LT3083633T (lt) 2018-02-12
NZ719765A (en) 2022-04-29
AR098783A1 (es) 2016-06-15
ZA201603221B (en) 2022-05-25
UA117273C2 (uk) 2018-07-10

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