AR127706A1 - Síntesis de 2-(7,7-dimetil-1h,7h-espiro[furo[3,4-b]piridin-5,4-piperidin]-1-il)-1,3-dihidro-4h-espiro[inden-2,5-[1,3]oxazol]-4-ona - Google Patents
Síntesis de 2-(7,7-dimetil-1h,7h-espiro[furo[3,4-b]piridin-5,4-piperidin]-1-il)-1,3-dihidro-4h-espiro[inden-2,5-[1,3]oxazol]-4-onaInfo
- Publication number
- AR127706A1 AR127706A1 ARP220103168A ARP220103168A AR127706A1 AR 127706 A1 AR127706 A1 AR 127706A1 AR P220103168 A ARP220103168 A AR P220103168A AR P220103168 A ARP220103168 A AR P220103168A AR 127706 A1 AR127706 A1 AR 127706A1
- Authority
- AR
- Argentina
- Prior art keywords
- spiro
- furo
- inden
- piperidin
- oxazole
- Prior art date
Links
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención proporciona procesos para elaborar 2-(7,7-dimetil-1H,7H-espiro[furo[3,4-b]piridin-5,4-piperidin]-1-il)-1,3-dihidro-4H-espiro[inden-2,5-[1,3]oxazol]-4-ona sustituida. También se divulgan compuestos útiles como intermediarios en los métodos de la invención. Reivindicación 1: Una forma cristalina de un compuesto de fórmula (I). Reivindicación 2: La forma cristalina A del compuesto de fórmula (I) de acuerdo con la reivindicación 1, caracterizada por un patrón de difracción de rayos X de polvo que tiene los picos característicos expresados en valores de grados 2-q a aproximadamente (± 0,20 grado 2-q). @@@@@@@@@
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21209197 | 2021-11-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR127706A1 true AR127706A1 (es) | 2024-02-21 |
Family
ID=78709265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP220103168A AR127706A1 (es) | 2021-11-19 | 2022-11-17 | Síntesis de 2-(7,7-dimetil-1h,7h-espiro[furo[3,4-b]piridin-5,4-piperidin]-1-il)-1,3-dihidro-4h-espiro[inden-2,5-[1,3]oxazol]-4-ona |
Country Status (4)
Country | Link |
---|---|
CN (1) | CN118251396A (es) |
AR (1) | AR127706A1 (es) |
TW (1) | TW202334162A (es) |
WO (1) | WO2023088996A1 (es) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY33001A (es) * | 2009-11-06 | 2011-05-31 | Boehringer Ingelheim Int | Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina |
JPWO2013176220A1 (ja) | 2012-05-25 | 2016-01-14 | 国立大学法人京都大学 | 概日リズム調整 |
SI3083633T1 (en) | 2013-12-19 | 2018-02-28 | F. Hoffmann-La Roche Ag | Spiro-oxazolones |
-
2022
- 2022-11-17 CN CN202280076135.9A patent/CN118251396A/zh active Pending
- 2022-11-17 AR ARP220103168A patent/AR127706A1/es unknown
- 2022-11-17 WO PCT/EP2022/082192 patent/WO2023088996A1/en active Application Filing
- 2022-11-18 TW TW111144236A patent/TW202334162A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
TW202334162A (zh) | 2023-09-01 |
WO2023088996A1 (en) | 2023-05-25 |
CN118251396A (zh) | 2024-06-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MD3464285T2 (ro) | Procedeu pentru prepararea N-(5-(3-(7-(3-fluorfenil)-3H-imidazo[4,5-c]piridin-2-il)-1H-indazol-5-il)piridin-3-il)-3-metilbutanamidei | |
CO2019008868A2 (es) | Derivados de pirrolo[1,2-b]piridazina | |
CL2012000953A1 (es) | Procedimientos de preparacion de derivados espiro[furo[2,3-f][1,3]benzodioxol-7,3`-indol]-2`(1`h)-onas. | |
PE20120172A1 (es) | Compuestos heterociclicos fusionados que contiene nitrogeno como inhibidores de la produccion de beta-amiloide | |
PH12015501934B1 (en) | New octahydro - pyrrolo [3,4-c] - pyrrole derivatives and analogs thereof as autotaxin inhibitors | |
NZ599040A (en) | 2,4-disubstituted pyrido[4,3-d]pyrimidin-5(6h)-one compounds for selective inhibitors of lrrk2 and syk kinases | |
ES2618939T3 (es) | Sal de camsilato | |
UY32142A (es) | Preparación de una quinoliniloxidifenilciclopropanodicarboxamida | |
PE20210002A1 (es) | Sales de derivados de pirrolotriazina utiles como inhibidores tam | |
AR047088A1 (es) | Polimorfo cristalino de piridinetilennaftofurano como antagonista del receptor de trombina, metodo de obtencion y composiciones farmaceuticas | |
CU24402B1 (es) | 2,6 purinas di-sustituidas útiles en el tratamiento de trastornos proliferativos tales como cáncer | |
UY32096A (es) | Derivados de 2-carboxamida - cicloamino - urea especìficos, sus sales farmacèuticamente aceptables, composiciones contenièndolos, pro-farmacos de los mismos, procesos para su produciòn y aplicaciones | |
PE20050769A1 (es) | Formas polimorficas de un agonista de gabaa | |
CR20110427A (es) | Derivados de triazolo [4,3-b] piridazina y sus usos para el cáncer de próstata | |
AR050536A1 (es) | Derivados de pirimidina, procesos de preparacion y composiciones farmaceuticas que los comprenden | |
ECSP099441A (es) | Nuevos intermediarios y procesos útiles en la preparación de {2-[1-(3,5-bis-trifluorometil-bencil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]-piridin-3-il}-(2-clorofenil)-metanona | |
PE20221340A1 (es) | Compuestos heterociclicos | |
AR088246A1 (es) | Derivados de etinilo | |
CO6241119A2 (es) | Compuestos de pirido 2,3-d pirimidina-7-ona como inhibidores de pi3k-alfa para el tratamiento del cancer | |
ECSP11010744A (es) | PROCESO PARA LA PREPARACIÓN DE DERIVADOS DE BENZOIMIDAZOL-2-Il PIRIMIDINA | |
AR105091A1 (es) | Procedimiento para la síntesis de derivados de rapamicina | |
AR127706A1 (es) | Síntesis de 2-(7,7-dimetil-1h,7h-espiro[furo[3,4-b]piridin-5,4-piperidin]-1-il)-1,3-dihidro-4h-espiro[inden-2,5-[1,3]oxazol]-4-ona | |
CL2020002139A1 (es) | Compuestos de sulfonimidoilpurinona 7-sustituidos y sus derivados para el tratamiento y prevención del cáncer de hígado. | |
CL2021000454A1 (es) | Método para preparar 2-[(3r)-3--metilmofolin--4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina | |
MA41802B1 (fr) | Fabrication de 4,5,6,7-tétrahydroisozaxolo[5,4-c]pyridine-3-ol |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |