MA33138B1 - Derives de benzothiazines, leur preparation et leur application a titre de medicaments - Google Patents
Derives de benzothiazines, leur preparation et leur application a titre de medicamentsInfo
- Publication number
- MA33138B1 MA33138B1 MA34191A MA34191A MA33138B1 MA 33138 B1 MA33138 B1 MA 33138B1 MA 34191 A MA34191 A MA 34191A MA 34191 A MA34191 A MA 34191A MA 33138 B1 MA33138 B1 MA 33138B1
- Authority
- MA
- Morocco
- Prior art keywords
- representing
- group
- benzotiaziazine
- drugs
- derivatives prepared
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Abstract
CETTE INVENTION CONCERNE DES DÉRIVÉS DES BENZOTHIAZINES CAPABLES D'INHIBER L'ENZYME 11ß-HSD1 NON SEULEMENT AU NIVEAU ENZYMATIQUE MAIS AUSSI AU NIVEAU CELLULAIRE. LES COMPOSÉS DE L'INVENTION SONT DE FORMULE GÉNÉRALE (I), R1 REPRÉSENTANT HYDROGÈNE OU OR1 REPRÉSENTANT UN ESTER OU UN ÉTHER, R2 REPRÉSENTANT UN GROUPE NAPHTYLE OU UN GROUPE 1,2,3,4-TÉTRAHYDRONAPHTALÈNE OU UN DIPHÉNYLE OU UN GROUPE PHÉNYLPYRIDINE OU UN GROUPE PHÉNYLE SUBSTITUÉ, R3 REPRÉSENTANT UN GROUPE MÉTHYLE OU ÉTHYLE, R4 ET R'4 REPRÉSENTANT HYDROGÈNE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0951336A FR2942797B1 (fr) | 2009-03-03 | 2009-03-03 | Derives de benzothiazines, leur preparation et leur application a titre de medicaments |
PCT/EP2010/052609 WO2010100139A1 (fr) | 2009-03-03 | 2010-03-02 | Dérivés des benzothiazines, leur préparation et leur application en tant que médicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33138B1 true MA33138B1 (fr) | 2012-03-01 |
Family
ID=40790339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34191A MA33138B1 (fr) | 2009-03-03 | 2010-03-02 | Derives de benzothiazines, leur preparation et leur application a titre de medicaments |
Country Status (29)
Country | Link |
---|---|
US (1) | US9187438B2 (fr) |
EP (1) | EP2403840B1 (fr) |
JP (1) | JP5650139B2 (fr) |
KR (1) | KR101701531B1 (fr) |
CN (1) | CN102341379B (fr) |
AR (1) | AR075777A1 (fr) |
AU (1) | AU2010220335B2 (fr) |
BR (1) | BRPI1010243A2 (fr) |
CA (1) | CA2753630C (fr) |
CL (1) | CL2011002171A1 (fr) |
CO (1) | CO6501175A2 (fr) |
ES (1) | ES2483516T3 (fr) |
FR (1) | FR2942797B1 (fr) |
GE (1) | GEP20135832B (fr) |
HK (1) | HK1165802A1 (fr) |
IL (1) | IL214907A (fr) |
MA (1) | MA33138B1 (fr) |
MX (1) | MX2011008942A (fr) |
MY (1) | MY160819A (fr) |
NZ (1) | NZ595276A (fr) |
PL (1) | PL2403840T3 (fr) |
RU (1) | RU2523791C2 (fr) |
SA (1) | SA110310181B1 (fr) |
SG (1) | SG174208A1 (fr) |
TN (1) | TN2011000429A1 (fr) |
TW (1) | TWI495636B (fr) |
UA (1) | UA105040C2 (fr) |
WO (1) | WO2010100139A1 (fr) |
ZA (1) | ZA201107104B (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2350077B1 (es) | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
CN103271923B (zh) * | 2013-06-28 | 2014-11-26 | 安徽中医学院 | 一种苯并噻嗪衍生物的医药用途 |
CN103304513B (zh) * | 2013-06-28 | 2015-02-04 | 安徽中医学院 | 一类1,2-苯并噻嗪类化合物、制备方法及其应用 |
CN103275035B (zh) * | 2013-06-28 | 2014-11-26 | 安徽中医学院 | 苯并噻嗪类化合物、其制备方法及其抗肿瘤用途 |
FR3035326B1 (fr) * | 2015-04-21 | 2017-05-12 | Pf Medicament | Utilisation de la (4-hydroxy-2-methyl-1,1-dioxido-2h-benzo[e][1,2]thiazin-3-yl)(naphtalen-2-yl)methanone dans la prevention et/ou le traitement de la steatohepatite non-alcoolique |
CN106243046B (zh) * | 2016-08-02 | 2019-07-05 | 南京工业大学 | 一种甲基二磺隆的制备方法 |
CA3057261A1 (fr) | 2017-04-06 | 2018-10-11 | Inventiva | Nouveaux composes inhibiteurs de l'interaction yap/taz-tead et leur utilisation dans le traitement du mesotheliome malin |
EP3632908A1 (fr) | 2018-10-02 | 2020-04-08 | Inventiva | Inhibiteurs de l'interaction yap / taz-tead et leur utilisation dans le traitement du cancer |
WO2023154412A1 (fr) * | 2022-02-12 | 2023-08-17 | Miralogx Llc | Composés anti-inflammatoires, compositions pharmaceutiques et méthodes de traitement |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
US3808205A (en) * | 1971-09-10 | 1974-04-30 | Warner Lambert Co | Process for the preparation of 4-hydroxy-3-carbamyl-2h-1,2-benzothiazine 1,1-dioxides and 4-hydroxy-3(2h)-1,2-benzothiazine carboxylate-1,1-dioxides |
US4289879A (en) * | 1980-09-29 | 1981-09-15 | Pfizer Inc. | Synthetic method and intermediate for piroxicam |
FR2694295B1 (fr) * | 1992-07-28 | 1994-09-02 | Adir | Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent. |
US5599811A (en) * | 1995-02-21 | 1997-02-04 | Warner-Lambert Company | Benzothiazine dioxides as endothelin antagonists |
AU2002212672A1 (en) * | 2000-10-12 | 2002-04-22 | Dr. Reddy's Research Foundation | Salts of benzothiazine and benzoxazine derivatives and pharmaceutical compositions containing them |
GB0224830D0 (en) * | 2002-10-24 | 2002-12-04 | Sterix Ltd | Compound |
DK1615647T3 (da) * | 2003-04-11 | 2010-04-06 | High Point Pharmaceuticals Llc | Farmaceutisk anvendelse af kondenserede 1,2,4-triazoler |
PL372356A1 (pl) * | 2005-01-20 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
US7981910B2 (en) * | 2005-10-20 | 2011-07-19 | Merck Sharp & Dohme Corp. | Triazole derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase-1 |
CN101312951A (zh) * | 2005-11-21 | 2008-11-26 | 盐野义制药株式会社 | 具有Ⅰ型11β羟基类固醇脱氢酶抑制活性的杂环化合物 |
JP2007197369A (ja) * | 2006-01-26 | 2007-08-09 | Sankyo Co Ltd | ベンゾチアジン誘導体 |
-
2009
- 2009-03-03 FR FR0951336A patent/FR2942797B1/fr not_active Expired - Fee Related
-
2010
- 2010-03-02 AR ARP100100618A patent/AR075777A1/es active IP Right Grant
- 2010-03-02 AU AU2010220335A patent/AU2010220335B2/en not_active Ceased
- 2010-03-02 MA MA34191A patent/MA33138B1/fr unknown
- 2010-03-02 KR KR1020117022812A patent/KR101701531B1/ko active IP Right Grant
- 2010-03-02 UA UAA201111590A patent/UA105040C2/uk unknown
- 2010-03-02 MX MX2011008942A patent/MX2011008942A/es active IP Right Grant
- 2010-03-02 WO PCT/EP2010/052609 patent/WO2010100139A1/fr active Application Filing
- 2010-03-02 EP EP10706624.3A patent/EP2403840B1/fr active Active
- 2010-03-02 NZ NZ595276A patent/NZ595276A/xx not_active IP Right Cessation
- 2010-03-02 RU RU2011139014/04A patent/RU2523791C2/ru not_active IP Right Cessation
- 2010-03-02 BR BRPI1010243A patent/BRPI1010243A2/pt not_active Application Discontinuation
- 2010-03-02 CN CN201080010207.7A patent/CN102341379B/zh not_active Expired - Fee Related
- 2010-03-02 US US13/254,473 patent/US9187438B2/en not_active Expired - Fee Related
- 2010-03-02 JP JP2011552415A patent/JP5650139B2/ja not_active Expired - Fee Related
- 2010-03-02 CA CA2753630A patent/CA2753630C/fr not_active Expired - Fee Related
- 2010-03-02 GE GEAP201012398A patent/GEP20135832B/en unknown
- 2010-03-02 SA SA110310181A patent/SA110310181B1/ar unknown
- 2010-03-02 ES ES10706624.3T patent/ES2483516T3/es active Active
- 2010-03-02 MY MYPI2011004096A patent/MY160819A/en unknown
- 2010-03-02 SG SG2011063146A patent/SG174208A1/en unknown
- 2010-03-02 PL PL10706624T patent/PL2403840T3/pl unknown
- 2010-03-03 TW TW099106123A patent/TWI495636B/zh not_active IP Right Cessation
-
2011
- 2011-08-19 TN TN2011000429A patent/TN2011000429A1/fr unknown
- 2011-08-31 IL IL214907A patent/IL214907A/en active IP Right Grant
- 2011-09-02 CL CL2011002171A patent/CL2011002171A1/es unknown
- 2011-09-29 ZA ZA2011/07104A patent/ZA201107104B/en unknown
- 2011-09-29 CO CO11128125A patent/CO6501175A2/es active IP Right Grant
-
2012
- 2012-07-06 HK HK12106611.2A patent/HK1165802A1/xx not_active IP Right Cessation
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