MA32726B1 - Antagonistes phtalazine disubstituee de la voie de signalisation hedgehog - Google Patents

Antagonistes phtalazine disubstituee de la voie de signalisation hedgehog

Info

Publication number
MA32726B1
MA32726B1 MA33790A MA33790A MA32726B1 MA 32726 B1 MA32726 B1 MA 32726B1 MA 33790 A MA33790 A MA 33790A MA 33790 A MA33790 A MA 33790A MA 32726 B1 MA32726 B1 MA 32726B1
Authority
MA
Morocco
Prior art keywords
phtalazine
disubstituted
antagonists
signaling path
hedgehog signaling
Prior art date
Application number
MA33790A
Other languages
Arabic (ar)
English (en)
French (fr)
Inventor
Jolie Anne Bastian
Philip Arthur Hipskind
Daniel Jon Sall
Takako Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32726(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA32726B1 publication Critical patent/MA32726B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MA33790A 2008-11-03 2011-04-22 Antagonistes phtalazine disubstituee de la voie de signalisation hedgehog MA32726B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11070308P 2008-11-03 2008-11-03
PCT/US2009/061573 WO2010062507A1 (en) 2008-11-03 2009-10-22 Disubstituted phthalazine hedgehog pathway antagonists

Publications (1)

Publication Number Publication Date
MA32726B1 true MA32726B1 (fr) 2011-10-02

Family

ID=41566219

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33790A MA32726B1 (fr) 2008-11-03 2011-04-22 Antagonistes phtalazine disubstituee de la voie de signalisation hedgehog

Country Status (29)

Country Link
US (1) US8404687B2 (enExample)
EP (1) EP2364185B1 (enExample)
JP (1) JP2012507535A (enExample)
KR (1) KR101335746B1 (enExample)
CN (1) CN102202737B (enExample)
AU (1) AU2009320251C1 (enExample)
BR (1) BRPI0921437A2 (enExample)
CA (1) CA2742539C (enExample)
CL (1) CL2011000979A1 (enExample)
CO (1) CO6382123A2 (enExample)
CR (1) CR20110202A (enExample)
CY (1) CY1114023T1 (enExample)
DK (1) DK2364185T3 (enExample)
EA (1) EA018931B1 (enExample)
EC (1) ECSP11011021A (enExample)
ES (1) ES2418479T3 (enExample)
HR (1) HRP20130527T1 (enExample)
IL (1) IL211841A0 (enExample)
MA (1) MA32726B1 (enExample)
MX (1) MX2011004683A (enExample)
NZ (1) NZ591945A (enExample)
PE (1) PE20110433A1 (enExample)
PL (1) PL2364185T3 (enExample)
PT (1) PT2364185E (enExample)
SI (1) SI2364185T1 (enExample)
TN (1) TN2011000166A1 (enExample)
UA (1) UA102115C2 (enExample)
WO (1) WO2010062507A1 (enExample)
ZA (1) ZA201102448B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2137162T3 (en) * 2007-03-15 2018-11-26 Novartis Ag Organic compounds and their applications
KR101260116B1 (ko) 2008-04-29 2013-05-02 일라이 릴리 앤드 캄파니 이치환된 프탈라진 헤지호그 경로 길항제
US20100041663A1 (en) * 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
ES2392759T3 (es) 2008-11-17 2012-12-13 Eli Lilly And Company Piridazina tetrasustituida como antagonistas de la vía Hedgehog.
EA018372B1 (ru) 2008-11-17 2013-07-30 Эли Лилли Энд Компани Тетразамещенные пиридазины в качестве антагонистов пути hedgehog
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2015073691A1 (en) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of bmp signaling
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
KR20230107568A (ko) 2020-10-13 2023-07-17 엔데버 바이오메디신스, 인크. 섬유증 치료 방법
US20240124451A1 (en) * 2022-09-23 2024-04-18 Merck Sharp & Dohme Llc Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
WO2025188802A1 (en) 2024-03-05 2025-09-12 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
MY117098A (en) 1996-01-15 2004-05-31 Janssen Pharmaceutica Nv Angiogenesis inhibiting pyridazinamines
JP4073961B2 (ja) * 1996-10-01 2008-04-09 協和醗酵工業株式会社 含窒素複素環化合物
US6432970B2 (en) 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
WO1999052534A1 (en) 1998-04-09 1999-10-21 Johns Hopkins University School Of Medicine Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways
GB0013674D0 (en) 1999-06-08 2000-07-26 Lorantis Ltd Therapeutic use
EP1997494A3 (en) 2002-04-22 2009-06-10 Johns Hopkins University School of Medicine Modulators of hedgehog signaling pathways, compositions and uses related thereto
AU2003265853A1 (en) 2002-08-29 2004-03-19 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
TW200533356A (en) 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
JP5221952B2 (ja) 2004-05-08 2013-06-26 ノバルティス・インターナショナル・ファーマシューティカル・リミテッド ３−アリール−５，６−ジ置換ピリダジン類
KR20150002863A (ko) * 2004-09-02 2015-01-07 제넨테크, 인크. 헤지호그 신호전달에 대한 피리딜 억제제
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
DK2137162T3 (en) * 2007-03-15 2018-11-26 Novartis Ag Organic compounds and their applications
CA2690378A1 (en) 2007-06-25 2008-12-31 Amgen Inc. Phthalazine compounds, compositions and methods of use
WO2009035568A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
KR101260116B1 (ko) 2008-04-29 2013-05-02 일라이 릴리 앤드 캄파니 이치환된 프탈라진 헤지호그 경로 길항제
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
EA018372B1 (ru) 2008-11-17 2013-07-30 Эли Лилли Энд Компани Тетразамещенные пиридазины в качестве антагонистов пути hedgehog
ES2392759T3 (es) 2008-11-17 2012-12-13 Eli Lilly And Company Piridazina tetrasustituida como antagonistas de la vía Hedgehog.
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
CO6382123A2 (es) 2012-02-15
CN102202737A (zh) 2011-09-28
CA2742539C (en) 2014-05-06
DK2364185T3 (da) 2013-06-03
AU2009320251C1 (en) 2013-08-15
CY1114023T1 (el) 2016-07-27
HRP20130527T1 (en) 2013-07-31
AU2009320251B2 (en) 2013-01-24
ES2418479T3 (es) 2013-08-14
EA018931B1 (ru) 2013-11-29
NZ591945A (en) 2012-10-26
PE20110433A1 (es) 2011-07-09
PT2364185E (pt) 2013-07-24
WO2010062507A1 (en) 2010-06-03
BRPI0921437A2 (pt) 2018-10-30
TN2011000166A1 (en) 2012-12-17
ECSP11011021A (es) 2011-06-30
HK1159010A1 (en) 2012-07-27
US20110190304A1 (en) 2011-08-04
EP2364185A1 (en) 2011-09-14
KR101335746B1 (ko) 2013-12-12
MX2011004683A (es) 2011-06-20
CA2742539A1 (en) 2010-06-03
PL2364185T3 (pl) 2013-10-31
SI2364185T1 (sl) 2013-07-31
EP2364185B1 (en) 2013-05-22
EA201170640A1 (ru) 2011-12-30
JP2012507535A (ja) 2012-03-29
UA102115C2 (ru) 2013-06-10
CR20110202A (es) 2011-06-09
ZA201102448B (en) 2012-09-26
AU2009320251A1 (en) 2010-06-03
CN102202737B (zh) 2014-03-26
CL2011000979A1 (es) 2011-10-07
KR20110066212A (ko) 2011-06-16
US8404687B2 (en) 2013-03-26
IL211841A0 (en) 2011-06-30

Similar Documents

Publication Publication Date Title
MA32726B1 (fr) Antagonistes phtalazine disubstituee de la voie de signalisation hedgehog
MA33363B1 (fr) Antagonistes de la voie de signalisation hedgehog a base de phtalazine disubstituee
MA32349B1 (fr) Antagonistes de la voie hedgehog a base de phtalazines disubstituees
CY1122988T1 (el) Υπογλωσσια υμενια
CY1121327T1 (el) Τροποποιημενα αντισωματα anti-il-23p19
TR200906131T1 (tr) Aktivin -actrIIa antagonistleri ve göğüs kanserinin tedavi e
MX338884B (es) Composiciones y metodos que comprenden variantes de proteasa.
BRPI0814772A2 (pt) Indazóis substituídos por 5-piridinona
EA201101520A1 (ru) Способы диагностики онкологических заболеваний, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
NO20083492L (no) 11-Beta HSD1 inhibitorer
EA201170212A1 (ru) Охлаждение и обработка материалов
EA201171367A1 (ru) Винилиндазолильные соединения
EA201170699A1 (ru) Тетразамещенные пиридазины в качестве антагонистов пути hedgehog
NO20084458L (no) IL-8-reseptorantagonister
FR23C1002I2 (fr) 2,4,6-trifluoro-n-ý6-(l-méthyl-pipéridin-4- carbonyl)-pyridin-2-yl]-benzamide destiné au traitement de la migraine par la voie orale ou intraveineuse
EA200971068A1 (ru) Триазолиламинопиримидиновые соединения
MX2009012767A (es) Metodos de tratamiento de infecciones fungicas.
EA201170700A1 (ru) Тетразамещенные пиридазины в качестве антагонистов пути hedgehog
EA200971067A1 (ru) Триазолиламинопиримидиновые соединения
EA200800342A1 (ru) ИНГИБИТОРЫ Glepp-1 ДЛЯ ЛЕЧЕНИЯ АУТОИММУННЫХ И/ИЛИ ВОСПАЛИТЕЛЬНЫХ РАССТРОЙСТВ
ATE499138T1 (de) Implantierbare vorrichtung
TN2010000489A1 (en) Disubstituted phthalazine hedgehog pathway antagonists
CY1114078T1 (el) Ανταγωνιστες διυποκατεστημενης φθαλαζινης του μονοπατιου hedgehog
CY1115900T1 (el) Αντισωματα αντι-ephb4 και μεθοδοι χρησης αυτων
ITFR20090010U1 (it) Trashpositore semoplificato degli accordi musicali (miglioramento del brevetto nr.0000262432 del 24.04.2009)