KR101335746B1 - 이치환된 프탈라진 헷지호그 경로 길항제 - Google Patents

이치환된 프탈라진 헷지호그 경로 길항제 Download PDF

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Publication number
KR101335746B1
KR101335746B1 KR1020117010063A KR20117010063A KR101335746B1 KR 101335746 B1 KR101335746 B1 KR 101335746B1 KR 1020117010063 A KR1020117010063 A KR 1020117010063A KR 20117010063 A KR20117010063 A KR 20117010063A KR 101335746 B1 KR101335746 B1 KR 101335746B1
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South Korea
Prior art keywords
fluoro
hydrogen
mmol
fluorophenyl
cancer
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Expired - Fee Related
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KR1020117010063A
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English (en)
Korean (ko)
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KR20110066212A (ko
Inventor
졸리 앤 바스티안
필립 아서 힙스킨드
다니엘 존 샐
타카코 윌슨
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일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020117010063A 2008-11-03 2009-10-22 이치환된 프탈라진 헷지호그 경로 길항제 Expired - Fee Related KR101335746B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11070308P 2008-11-03 2008-11-03
US61/110,703 2008-11-03
PCT/US2009/061573 WO2010062507A1 (en) 2008-11-03 2009-10-22 Disubstituted phthalazine hedgehog pathway antagonists

Publications (2)

Publication Number Publication Date
KR20110066212A KR20110066212A (ko) 2011-06-16
KR101335746B1 true KR101335746B1 (ko) 2013-12-12

Family

ID=41566219

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117010063A Expired - Fee Related KR101335746B1 (ko) 2008-11-03 2009-10-22 이치환된 프탈라진 헷지호그 경로 길항제

Country Status (29)

Country Link
US (1) US8404687B2 (enExample)
EP (1) EP2364185B1 (enExample)
JP (1) JP2012507535A (enExample)
KR (1) KR101335746B1 (enExample)
CN (1) CN102202737B (enExample)
AU (1) AU2009320251C1 (enExample)
BR (1) BRPI0921437A2 (enExample)
CA (1) CA2742539C (enExample)
CL (1) CL2011000979A1 (enExample)
CO (1) CO6382123A2 (enExample)
CR (1) CR20110202A (enExample)
CY (1) CY1114023T1 (enExample)
DK (1) DK2364185T3 (enExample)
EA (1) EA018931B1 (enExample)
EC (1) ECSP11011021A (enExample)
ES (1) ES2418479T3 (enExample)
HR (1) HRP20130527T1 (enExample)
IL (1) IL211841A0 (enExample)
MA (1) MA32726B1 (enExample)
MX (1) MX2011004683A (enExample)
NZ (1) NZ591945A (enExample)
PE (1) PE20110433A1 (enExample)
PL (1) PL2364185T3 (enExample)
PT (1) PT2364185E (enExample)
SI (1) SI2364185T1 (enExample)
TN (1) TN2011000166A1 (enExample)
UA (1) UA102115C2 (enExample)
WO (1) WO2010062507A1 (enExample)
ZA (1) ZA201102448B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2137162T3 (en) * 2007-03-15 2018-11-26 Novartis Ag Organic compounds and their applications
KR101260116B1 (ko) 2008-04-29 2013-05-02 일라이 릴리 앤드 캄파니 이치환된 프탈라진 헤지호그 경로 길항제
US20100041663A1 (en) * 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
ES2392759T3 (es) 2008-11-17 2012-12-13 Eli Lilly And Company Piridazina tetrasustituida como antagonistas de la vía Hedgehog.
EA018372B1 (ru) 2008-11-17 2013-07-30 Эли Лилли Энд Компани Тетразамещенные пиридазины в качестве антагонистов пути hedgehog
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2015073691A1 (en) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of bmp signaling
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
KR20230107568A (ko) 2020-10-13 2023-07-17 엔데버 바이오메디신스, 인크. 섬유증 치료 방법
US20240124451A1 (en) * 2022-09-23 2024-04-18 Merck Sharp & Dohme Llc Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
WO2025188802A1 (en) 2024-03-05 2025-09-12 Endeavor Biomedicines, Inc. Methods of improving lung function

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
WO2006028958A2 (en) * 2004-09-02 2006-03-16 Genentech, Inc. Pyridyl inhibitors of hedgehog signalling
WO2008110611A1 (en) 2007-03-15 2008-09-18 Novartis Ag Organic compounds and their uses

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
MY117098A (en) 1996-01-15 2004-05-31 Janssen Pharmaceutica Nv Angiogenesis inhibiting pyridazinamines
JP4073961B2 (ja) * 1996-10-01 2008-04-09 協和醗酵工業株式会社 含窒素複素環化合物
US6432970B2 (en) 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
WO1999052534A1 (en) 1998-04-09 1999-10-21 Johns Hopkins University School Of Medicine Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways
GB0013674D0 (en) 1999-06-08 2000-07-26 Lorantis Ltd Therapeutic use
EP1997494A3 (en) 2002-04-22 2009-06-10 Johns Hopkins University School of Medicine Modulators of hedgehog signaling pathways, compositions and uses related thereto
AU2003265853A1 (en) 2002-08-29 2004-03-19 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
TW200533356A (en) 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
JP5221952B2 (ja) 2004-05-08 2013-06-26 ノバルティス・インターナショナル・ファーマシューティカル・リミテッド ３−アリール−５，６−ジ置換ピリダジン類
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
CA2690378A1 (en) 2007-06-25 2008-12-31 Amgen Inc. Phthalazine compounds, compositions and methods of use
WO2009035568A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
KR101260116B1 (ko) 2008-04-29 2013-05-02 일라이 릴리 앤드 캄파니 이치환된 프탈라진 헤지호그 경로 길항제
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
EA018372B1 (ru) 2008-11-17 2013-07-30 Эли Лилли Энд Компани Тетразамещенные пиридазины в качестве антагонистов пути hedgehog
ES2392759T3 (es) 2008-11-17 2012-12-13 Eli Lilly And Company Piridazina tetrasustituida como antagonistas de la vía Hedgehog.
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
WO2006028958A2 (en) * 2004-09-02 2006-03-16 Genentech, Inc. Pyridyl inhibitors of hedgehog signalling
WO2008110611A1 (en) 2007-03-15 2008-09-18 Novartis Ag Organic compounds and their uses

Also Published As

Publication number Publication date
CO6382123A2 (es) 2012-02-15
CN102202737A (zh) 2011-09-28
CA2742539C (en) 2014-05-06
DK2364185T3 (da) 2013-06-03
AU2009320251C1 (en) 2013-08-15
CY1114023T1 (el) 2016-07-27
HRP20130527T1 (en) 2013-07-31
AU2009320251B2 (en) 2013-01-24
ES2418479T3 (es) 2013-08-14
EA018931B1 (ru) 2013-11-29
NZ591945A (en) 2012-10-26
PE20110433A1 (es) 2011-07-09
PT2364185E (pt) 2013-07-24
MA32726B1 (fr) 2011-10-02
WO2010062507A1 (en) 2010-06-03
BRPI0921437A2 (pt) 2018-10-30
TN2011000166A1 (en) 2012-12-17
ECSP11011021A (es) 2011-06-30
HK1159010A1 (en) 2012-07-27
US20110190304A1 (en) 2011-08-04
EP2364185A1 (en) 2011-09-14
MX2011004683A (es) 2011-06-20
CA2742539A1 (en) 2010-06-03
PL2364185T3 (pl) 2013-10-31
SI2364185T1 (sl) 2013-07-31
EP2364185B1 (en) 2013-05-22
EA201170640A1 (ru) 2011-12-30
JP2012507535A (ja) 2012-03-29
UA102115C2 (ru) 2013-06-10
CR20110202A (es) 2011-06-09
ZA201102448B (en) 2012-09-26
AU2009320251A1 (en) 2010-06-03
CN102202737B (zh) 2014-03-26
CL2011000979A1 (es) 2011-10-07
KR20110066212A (ko) 2011-06-16
US8404687B2 (en) 2013-03-26
IL211841A0 (en) 2011-06-30

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